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Ropinirole Dosage

Medically reviewed by Drugs.com. Last updated on Aug 4, 2023.

Applies to the following strengths: 12 mg; 6 mg; 2 mg; 4 mg; 8 mg; 0.25 mg; 0.5 mg; 1 mg; 5 mg; 3 mg; 0.25 mg-0.5 mg-1 mg

Usual Adult Dose for Parkinson's Disease

Immediate-release tablets:
Initial: 0.25 mg orally three times daily

After 1 week, the dose may be titrated up in weekly increments based on individual efficacy and tolerability:
Week 2: give 0.5 mg orally 3 times daily
Week 3: give 0.75 mg orally 3 times daily
Week 4: give 1 mg orally 3 times daily
After week 4, increase by 1.5 mg/day on a weekly basis up to a dose of 9 mg/day, then increase by 3 mg/day on a weekly basis up to a maximum daily dose of 24 mg
Maximum Dose: 8 mg orally three times a day

Extended-release tablets:
Initial: 2 mg orally once daily for 1 to 2 weeks, followed by increases of 2 mg/day at 1-week or longer intervals, depending on therapeutic response and tolerability
Maximum dose: 24 mg orally once a day

Patients may switch from immediate-release to extended-release: The initial dose of extended-release tablet should most closely match the total daily dose of immediate-release formulation. Following conversion, adjust dose depending on response and tolerability.

Comments:


Use: For the treatment of Parkinson's disease.

Usual Adult Dose for Restless Legs Syndrome

Immediate-release tablets:
Initial: 0.25 mg orally once a day on Day 1 and Day 2
Dose titration: May titrate as follows based on individual efficacy and tolerability:
Days 3 to 7: give 0.5 mg orally once a day

Maximum Dose: 4 mg orally once a day

Comments:

Use: For the treatment of moderate to severe Restless Legs Syndrome.

Renal Dose Adjustments

Parkinson's disease:
Moderate renal impairment (CrCl 30 to 50 mL/mi): No dosage adjustment is necessary
Severe renal impairment without regular dialysis: No data available

Restless Leg Syndrome:
Moderate renal impairment (CrCl 30 to 50 mL/min): No dosage adjustment is necessary
Severe renal impairment without regular dialysis: No data available

Liver Dose Adjustments

Dose adjustments may be required; however, no specific guidelines have been suggested. Caution is recommended.

Dose Adjustments

Doses are individually titrated based on efficacy and tolerability.

Parkinson's disease:


Drug interruption:

Drug discontinuation:

Precautions

Safety and efficacy of ropinirole have not been established in patients younger than 18 years.

Safety and efficacy of the extended-release product have not been established in patients with Restless Legs Syndrome (RLS).

Consult WARNINGS section for additional precautions.

Dialysis

Peritoneal dialysis: Data not available

End stage renal disease (ESRD) on hemodialysis:
Parkinson's disease, Immediate-release:


Parkinson's disease, Extended-release:

Restless Leg Syndrome:

Comments: Supplemental doses after dialysis are not required.

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.