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Ropinirole Pregnancy and Breastfeeding Warnings

Ropinirole is also known as: ReQuip Follow on Pack, ReQuip Starter Pack, Repreve, Requip, Requip Starter Kit, Requip XL

Ropinirole Pregnancy Warnings

Ropinirole has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of adverse effects on embryo-fetal development, including teratogenic effects. There are no controlled data in human pregnancy. Ropinirole is only recommended for use during pregnancy when benefit outweighs risk.

The administration of ropinirole to rats during organogenesis resulted in decreased fetal body weight at 60 mg/kg/day, increased fetal death at 90 mg/kg/day, and digital malformations at 150 mg/kg/day, respectively. (All doses were administered only on selected dates during the pregnancy.)

Ropinirole Breastfeeding Warnings

Animal studies have shown ropinirole and/or its metabolite(s) are excreted into breast milk.

Ropinirole inhibits prolactin secretion in humans and may inhibit lactation. There are no data on the excretion of ropinirole into human milk. Because many drugs are excreted into human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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