Lubiprostone Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Constipation - Chronic

Oral: 24 mcg orally twice a day with food and water

Approved indications: For chronic idiopathic constipation in adults; for the treatment of opioid-induced constipation (OIC) in adults with chronic non-cancer pain.

Comments:
-The effectiveness of lubiprostone in the treatment of opioid-induced constipation in patients taking
diphenylheptane opioids (e.g., methadone) has not been established.
-Take each dose with food and water.
-Swallow whole, do not break dose apart or chew.

Usual Adult Dose for Irritable Bowel Syndrome

Oral: 8 mcg orally twice a day with food and water

Approved indications: Irritable bowel syndrome with constipation (IBS-C) in women 18 years of age and older.

Comments:
-Take each dose with food and water.
-Swallow whole, do not break dose apart or chew.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Chronic idiopathic constipation and opioid induced constipation:
Mild hepatic impairment (Child-Pugh class A): No adjustment recommended.
Moderate hepatic impairment (Child-Pugh class B): 16 mcg orally twice a day
Severe hepatic impairment (Child-Pugh class C): 8 mcg orally twice a day

Irritable bowel syndrome with constipation in women 18 years of age and older:
Mild or moderate hepatic impairment (Child-Pugh class A or B): No adjustment recommended.
Severe hepatic impairment (Child-Pugh class C): 8 mcg orally once a day

If the reduced dose is tolerated and an adequate response has not been obtained after an appropriate interval, doses can be escalated to full dosing with appropriate monitoring of patient response.

Dialysis

No adjustment recommended.

Other Comments

Administration of lubiprostone with food may reduce symptoms of nausea.

Physicians and patients should periodically assess the need for continued therapy.

Lubiprostone is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Patients with symptoms suggestive of mechanical gastrointestinal obstruction should be evaluated thoroughly to confirm the absence of such an obstruction prior to initiating lubiprostone treatment.

Lubiprostone should not be administered to patients with severe diarrhea. Patients should be advised to contact their physician if severe diarrhea develops during treatment.

Hide
(web5)