Levetiracetam Dosage

This dosage information may not include all the information needed to use Levetiracetam safely and effectively. See additional information for Levetiracetam.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Seizures

16 years of age and older:

Initial Dose: 1000 mg daily by either immediate release oral or intravenous administration, given as 500 mg twice daily. Additional dosing increments may be given (1000 mg/day additional every 2 weeks) to a maximum recommended daily dose of 3000 mg. There is no evidence that doses greater than 3000 mg/day confer additional benefit.

Extended release:
Initial dose: 1000 mg orally once daily
This dose may be increased every 2 weeks by 1000 mg/day to a maximum of 3000 mg once daily.

Usual Pediatric Dose for Seizures

Myoclonic seizures:
Oral:
Children 12 years and older: Immediate release: Initial: 500 mg twice daily; may increase every 2 weeks by 500 mg/dose to the recommended dose of 1500 mg twice daily. Efficacy of doses greater than 3000 mg/day has not been established.

Partial onset seizures:
Oral:
Children 1 month to less than 6 months old: Immediate release: 7 mg/kg/dose given twice daily (14 mg/kg/day); may increase every 2 weeks by increments of 14 mg/kg to the recommended daily dose of 42 mg/kg.
Children 6 months to less than 4 years old: Immediate release: 10 mg/kg given twice daily (20 mg/kg/day); may increase in 2 weeks by an increment of 20 mg/kg to the recommended daily dose of 50 mg/kg (25 mg/kg twice daily). The daily dose of 50 mg/kg may be reduced in patients who cannot tolerate this dose.
Children 4 to less than 16 years: Immediate release: 10 mg/kg/dose given twice daily; may increase every 2 weeks by 10 mg/kg/dose to the recommended dose of 30 mg/kg/dose twice daily (60 mg/kg/daily). The daily dose of 60 mg/kg may be reduced in patients who cannot tolerate this dose.
Children 16 years and older: Refer to adult dosing.
Maximum dose: 3000 mg/day

Tonic-clonic seizures:
Oral:
Children 6 to less than 16 years: Immediate release: Initial: 10 mg/kg dose given twice daily; may increase every 2 weeks by 10 mg/kg/dose to the recommended dose of 30 mg/kg twice daily. Efficacy of doses greater than 60 mg/kg/day has not been established.
Children 16 years and older: Refer to adult dosing.
Maximum dose: 3000 mg/day

Renal Dose Adjustments

Dosage should be reduced in patients with impaired renal function.

For adult patients:
Immediate Release:
Creatinine clearance: greater than 80 mL/min, give 500 to 1500 mg every 12 hours.

Creatinine clearance: 50 to 80 mL/min, give 500 to 1000 every 12 hours.

Creatinine clearance: 30 to 50 mL/min, give 250 to 750 mg every 12 hours.

Creatinine clearance: less than 30 mL/min, give 250 to 500 mg every 12 hours.

For adult patients:
Extended release tablets:
Creatinine clearance: greater than 80 mL/min, give 1000 to 3000 mg every 24 hours.

Creatinine clearance: 50 to 80 mL/min, give 1000 to 2000 mg every 24 hours.

Creatinine clearance: 30 to 50 mL/min, give 500 to 1500 mg every 24 hours.

Creatinine clearance: less than 30 mL/min, give 500 to 1000 mg every 24 hours.

For pediatric patients:
Creatinine clearance less than 50 mL/min/1.73 m2: Administer 50% of the dose

Liver Dose Adjustments

Data not available

Dialysis

The immediate release product should be used in end-stage renal disease patients using dialysis.

Supplemental doses should be given to patients after dialysis.

For adult patients:
For end stage renal disease patients using dialysis: 500 to 1,000 mg dose every 24 hours.

Following dialysis, a 250 to 500 mg supplemental dose is recommended.

Standard hemodialysis procedures result in significant clearance of levetiracetam (approximately 50% in 4 hours).

For pediatric patients:
Peritoneal Dialysis: Administer 50% of normal dose.

Other Comments

Levetiracetam tablets should be swallowed whole, not chewed or crushed.

Levetiracetam is given orally with or without food.

The oral solution is recommended for pediatric patients with body weight 20 kg or less. The oral solution or tablets is recommended for pediatric patients with body weight above 20 kg.

When using the oral solution in pediatric patients, dosing is weight-based (mg per kg) and a calibrated measuring device should be used (not a household teaspoon or tablespoon).

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