Glipizide / Metformin Dosage
Applies to the following strength(s): 2.5 mg-500 mg ; 5 mg-500 mg ; 2.5 mg-250 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Diabetes Type 2
1 tablet (2.5 mg-250 mg) orally once or twice daily with meals.
For patients with FBG 280 to 320 mg/dL:
1 tablet (2.5 mg-500 mg) orally twice daily with meals.
The maximum recommended daily dose is 10 mg-2000 mg per day.
Previously treated patients:
1 tablet (2.5 mg-500 mg) orally twice daily with meals or 1 tablet (5 mg- 500 mg) orally twice daily with meals.
The maximum recommended daily dose is 20 mg-2000 mg per day.
Comments: Glipizide-metformin should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glipizide-metformin.
Renal Dose Adjustments
Metformin, when used in patients with renal insufficiency (based on an estimated creatinine clearance <80 mL/min), can precipitate lactic acidosis. Because of this potentially life-threatening metabolic effect, the use of metformin in patients with renal disease is not recommended.
Liver Dose Adjustments
Because metformin can precipitate lactic acidosis and because liver disease may decrease the elimination of lactate, the use of metformin in patients with liver disease is not recommended.
Dosages may be gradually titrated to achieve the desired antihyperglycemic effect. Dosage increases should be made in increments of 2.5 mg-250 mg per day every two weeks. The maximum recommended daily dose is 20 mg-2000 mg per day.
Metformin treatment should not be initiated in patients 80 or more years of age unless measurement of creatinine clearance demonstrates that renal function is not reduced.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Data not available
Transfer of patients from other oral hypoglycemic agents should be done conservatively. Although no waiting period between agents is necessary, patients switched from longer acting agents, such as chlorpropamide, should be carefully monitored for hypoglycemia during the first two weeks of therapy. The initial dosage of glipizide-metformin as second-line therapy recommended for previously treated patients is 2.5 mg-500 mg or 5 mg-500 mg twice a day with the morning and evening meals. The starting dose of glipizide-metformin should not exceed the daily doses of glipizide or metformin already being taken. The daily dosage should be titrated in increments of not more than 5 mg-500 mg.
More about glipizide/metformin
- Other brands: Metaglip