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Glipizide / metformin Pregnancy and Breastfeeding Warnings

Glipizide / metformin is also known as: Metaglip

Glipizide / metformin Pregnancy Warnings

The use of oral sulfonylureas during pregnancy has been reported to result in neonatal hypoglycemia. Insulin remains the mainstay of therapy for gestational diabetes due to the close glucose control it affords. If glipizide-metformin must be used, it should be discontinued at least one month before expected delivery to prevent neonatal side effects.

Glipizide-metformin has been assigned to pregnancy category C by the FDA. Animal studies of glipizide have revealed evidence of fetotoxicity, most likely a result of maternal hypoglycemia. Animal studies of metformin have not revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Glipizide-metformin is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

See references

Glipizide / metformin Breastfeeding Warnings

There are no data on the excretion of glipizide-metformin into human milk. Metformin is excreted into the milk of rats and achieves milk concentrations comparable to those found in plasma.

See references

References for pregnancy information

  1. "Product Information. Metaglip (glipizide-metformin)." Bristol-Myers Squibb, Princeton, NJ.

References for breastfeeding information

  1. "Product Information. Metaglip (glipizide-metformin)." Bristol-Myers Squibb, Princeton, NJ.

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