Glipizide / metformin Pregnancy and Breastfeeding Warnings
Glipizide / metformin is also known as: Metaglip
Glipizide / metformin Pregnancy Warnings
The use of oral sulfonylureas during pregnancy has been reported to result in neonatal hypoglycemia. Insulin remains the mainstay of therapy for gestational diabetes due to the close glucose control it affords. If glipizide-metformin must be used, it should be discontinued at least one month before expected delivery to prevent neonatal side effects.
Glipizide-metformin has been assigned to pregnancy category C by the FDA. Animal studies of glipizide have revealed evidence of fetotoxicity, most likely a result of maternal hypoglycemia. Animal studies of metformin have not revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Glipizide-metformin is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.
Glipizide / metformin Breastfeeding Warnings
There are no data on the excretion of glipizide-metformin into human milk. Metformin is excreted into the milk of rats and achieves milk concentrations comparable to those found in plasma.
See Also...
- glipizide/metformin Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
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