Glipizide/metformin Pregnancy and Breast Feeding Warnings
Glipizide/metformin is also known as: Metaglip
Overview
If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Glipizide/Metformin while you are pregnant. Glipizide/Metformin should not be used within 1 month before the expected delivery date because it may cause low blood sugar in the baby. It is not known if Glipizide/Metformin is found in breast milk. Do not breast-feed while taking Glipizide/Metformin .
Glipizide/metformin Pregnancy Warnings
Glipizide-metformin has been assigned to pregnancy category C by the FDA. Animal studies of glipizide have revealed evidence of fetotoxicity, most likely a result of maternal hypoglycemia. Animal studies of metformin have not revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Glipizide-metformin is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.
The use of oral sulfonylureas during pregnancy has been reported to result in neonatal hypoglycemia. Insulin remains the mainstay of therapy for gestational diabetes due to the close glucose control it affords. If glipizide-metformin must be used, it should be discontinued at least one month before expected delivery to prevent neonatal side effects.
Glipizide/metformin Lactation Warnings
There are no data on the excretion of glipizide-metformin into human milk. Metformin is excreted into the milk of rats and achieves milk concentrations comparable to those found in plasma.
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