Medication Guide App

Fluorouracil Topical Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Skin Cancer

Superficial basal cell carcinoma:

Apply 5% cream or solution to lesions twice daily with gloves or nonmetal applicators.

Treatment should continue for at least 3 to 6 weeks, and may be required for as long as 10 to 12 weeks to resolve the lesions.

Usual Adult Dose for Keratosis

Actinic or solar keratosis:
0.5% cream (microsphere formulation): Apply to the affected area once a day. May be applied with the fingers and hands should be washed immediately afterward.

1%, 2%, 5% cream or 2%, 5% solution: Apply to the affected area twice daily with gloves or nonmetallic applicator, using sufficient amount to cover the lesions.

The usual duration of therapy is 2 to 4 weeks, until the inflammatory response reaches the erosion state, at which time treatment is discontinued. Lesions may not heal completely for 1 to 2 months after fluorouracil therapy has been discontinued.

Solar keratoses which do not respond to treatment should be biopsied to confirm the diagnosis.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

The 0.5%, 1% and 2% strengths should not be used in the treatment of basal cell carcinoma.

Contraindicated during pregnancy and in patients with dihydropyrimidine dehydrogenase enzyme deficiency.

Avoid contact with mucous membranes, eyelids,eyes, nostrils, or mouth.

Do not use occlusive dressings.

Avoid prolonged exposure to ultraviolet light or sunlight.

Hands should be washed immediately after application.

Dialysis

Data not available

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