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Erivedge

Generic Name: vismodegib (VIS moe DEG ib)
Brand Names: Erivedge

What is Erivedge?

Erivedge (vismodegib) is a cancer medicine that interferes with the growth of certain cancer cells in the body.

Erivedge is used to treat basal cell carcinoma that has spread to other parts of the body.

Erivedge may also be used for purposes not listed in this medication guide.

Important information

Do not use Erivedge if you are pregnant, or if you are a man and your sexual partner is pregnant. Erivedge use by either parent may cause severe birth defects or death of a baby. If you are pregnant and your sexual partner is taking Erivedge, do not have sex without using a latex condom and spermicide during treatment and for 3 months after your partner stops taking vismodegib.

For Women: Use effective birth control while taking this medicine and for 7 months after your last dose. Call your doctor at once if you quit using birth control, if your period is late, or if you think you might be pregnant.

For Men: Always use a latex condom and spermicide when having sex, even if you have had a vasectomy. Continue using condoms and spermicide for at least 3 months after you stop taking Erivedge.

Call your doctor at once if a pregnancy occurs while either sexual partner is taking vismodegib.

Before taking this medicine

You should not use Erivedge if you are allergic to vismodegib.

To make sure this medicine is safe for you, tell your doctor if you have:

  • liver disease; or

  • kidney disease.

You will need to have a negative pregnancy test within 7 days before you start taking Erivedge.

Do not use Erivedge if you are pregnant, or if you are a man and your sexual partner is pregnant. You must prevent pregnancy while you are taking Erivedge, whether you are a man or a woman. Erivedge can cause severe birth defects or death of a baby if either parent is using this medicine at the time of conception or during pregnancy.

For Women: Use effective birth control while taking Erivedge and for 7 months after your last dose. The birth control method you use must be proven highly effective (at least 99%), such as: hormonal birth control (pills, vaginal ring, implants, or injections), an intrauterine device (IUD), or a tubal ligation. Call your doctor at once if you quit using birth control, if your period is late, or if you think you might be pregnant.

For Men: While you are taking Erivedge you must not have unprotected sex with a pregnant woman, or cause a woman to become pregnant. Erivedge can affect your sperm and may cause harm to the baby at conception or during pregnancy. Always use a latex condom and spermicide when having sex, even if you have had a vasectomy. Continue using condoms and spermicide for at 3 months after you stop taking Erivedge.

Call your doctor at once if a pregnancy occurs while either sexual partner is taking this medicine.

It is not known whether vismodegib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using vismodegib and for 7 months after your last dose.

How should I take Erivedge?

Take Erivedge exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Erivedge is usually taken once per day. You may take the medicine with or without food.

Do not crush, chew, break, or open a capsule. Swallow it whole.

Store at room temperature away from moisture and heat.

Erivedge dosing information

Usual Adult Dose for Basal Cell Carcinoma:

Usual adult dose: 150 mg orally once a day

Duration of therapy: Until disease progression or until unacceptable toxicity.

Use: Treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery, and who are not candidates for radiation.

What happens if I miss a dose?

Skip the missed dose and wait until your next scheduled dose to take the medication. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Erivedge?

Do not donate blood while taking vismodegib and for 7 months after your treatment ends.

Do not donate sperm (semen) while taking vismodegib and for 3 months after your treatment ends.

Vismodegib can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Erivedge side effects

Get emergency medical help if you have signs of an allergic reaction ro Erivedge: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you miss a menstrual period. This could be a side effect, or it may be a sign that you are pregnant.

Common Erivedge side effects may include:

  • nausea, vomiting, decreased appetite;

  • diarrhea, constipation;

  • tired feeling;

  • joint pain, muscle spasms;

  • hair loss;

  • weight loss; or

  • decreased sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Erivedge?

Other drugs may interact with vismodegib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Erivedge.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 2.02. Revision Date: 2015-12-16, 6:36:31 PM.

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