Erlotinib Dosage
This dosage information may not include all the information needed to use Erlotinib safely and effectively. See additional information for Erlotinib.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Non-Small Cell Lung Cancer
Initial dose: 150 mg once a day
The dose should be taken at least one hour before or two hours after ingestion of food.
Treatment should continue until disease progression or unacceptable toxicity occurs. There is no evidence that treatment beyond progression is beneficial.
Usual Adult Dose for Pancreatic Cancer
Initial dose: 100 mg once a day
The dose should be taken at least one hour before or two hours after ingestion of food.
Treatment should continue until disease progression or unacceptable toxicity occurs.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Because erlotinib is eliminated by hepatic metabolism and biliary excretion, caution is recommended when administering erlotinib to patients with hepatic dysfunction. Dose reductions or interruption should be considered if severe adverse reactions occur.
Precautions
Treatment should be interrupted pending diagnostic evaluation in patients who develop an acute onset of new progressive pulmonary symptoms, such as dyspnea, cough, or fever. If interstitial lung disease is diagnosed, erlotinib should be discontinued and appropriate treatment should be instituted if necessary.
Diarrhea can usually be managed with loperamide. Patients with severe diarrhea who are unresponsive to loperamide or who become dehydrated may require dose reduction or temporary interruption of therapy.
Patients with severe skin reactions may also require dose reduction or temporary interruption of therapy.
When dose reduction is necessary, the dose of erlotinib should be reduced in 50 mg decrements.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Data not available
