Epivir Dosage

Generic name: lamivudine
Dosage form: tablet, film coated and oral solution

This dosage information does not include all the information needed to use Epivir safely and effectively. See full prescribing information for Epivir.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Adults and Adolescents >16 years of age

The recommended oral dose of EPIVIR in HIV-1-infected adults and adolescents aged >16 years is 300 mg daily, administered as either 150 mg twice daily or 300 mg once daily, in combination with other antiretroviral agents. If lamivudine is administered to a patient infected with HIV-1 and HBV, the dosage indicated for HIV-1 therapy should be used as part of an appropriate combination regimen [see Warnings and Precautions (5.2)].

Pediatric Patients

The recommended oral dose of EPIVIR Oral Solution in HIV-1-infected pediatric patients aged 3 months to 16 years is 4 mg/kg twice daily (up to a maximum of 150 mg twice a day), administered in combination with other antiretroviral agents.

EPIVIR is also available as a scored tablet for HIV-1-infected pediatric patients who weigh ≥14 kg and for whom a solid dosage form is appropriate. Before prescribing EPIVIR Tablets, children should be assessed for the ability to swallow tablets. If a child is unable to reliably swallow EPIVIR Tablets, the oral solution formulation should be prescribed. The recommended oral dosage of EPIVIR Tablets for HIV-1-infected pediatric patients is presented in Table 1.

Table 1. Dosing Recommendations for EPIVIR Tablets in Pediatric Patients

Weight

(kg)

Dosage Regimen Using Scored 150-mg Tablet

Total Daily Dose

AM Dose

PM Dose

 

14 to 21

½ tablet (75 mg)

½ tablet (75 mg)

150 mg

>21 to <30

½ tablet (75 mg)

1 tablet (150 mg)

225 mg

≥30

1 tablet (150 mg)

1 tablet (150 mg)

300 mg

Patients With Renal Impairment

Dosing of EPIVIR is adjusted in accordance with renal function. Dosage adjustments are listed in Table 2 [see Clinical Pharmacology (12.3)].

Table 2. Adjustment of Dosage of EPIVIR in Adults and Adolescents (≥30 kg) in Accordance With Creatinine Clearance

Creatinine Clearance (mL/min)

Recommended Dosage of EPIVIR

≥50

       150 mg twice daily or 300 mg once daily

30-49

       150 mg once daily

15-29

       150 mg first dose, then 100 mg once daily

5-14

       150 mg first dose, then 50 mg once daily

<5

         50 mg first dose, then 25 mg once daily

No additional dosing of EPIVIR is required after routine (4-hour) hemodialysis or peritoneal dialysis.

Although there are insufficient data to recommend a specific dose adjustment of EPIVIR in pediatric patients with renal impairment, a reduction in the dose and/or an increase in the dosing interval should be considered.

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