Collagenase Clostridium Histolyticum Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Dupuytren's Contracture

0.58 mg as a single injection into the target cord, followed by a finger extension procedure approximately 24 hours later to facilitate disruption of the cord in those individuals who did not experience spontaneous disruption, and up to two follow-up injections at 4 week intervals, if necessary.

Additional cords are to be handled sequentially

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Collagenase clostridium histolyticum is injected directly into the collagen cord of the hand and should be administered only by a health care professional experienced with injections of the hand, because tendon ruptures may occur.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

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