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Collagenase clostridium histolyticum User Reviews & Ratings

Brand names: Xiaflex, Qwo

Collagenase clostridium histolyticum has an average rating of 2.9 out of 10 from a total of 98 reviews on Drugs.com. 17% of reviewers reported a positive experience, while 77% reported a negative experience.

Condition Avg. Rating Reviews Compare
Peyronie's Disease  
2.3
 56 reviews for Peyronie's Disease 1 medications
Dupuytren's contracture  
3.7
 42 reviews for Dupuytren's contracture 1 medications
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Reviews for Collagenase clostridium histolyticum

  • Depre...
  • Taken for 1 to 2 years
  • September 8, 2020

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Xiaflex is horrible. Before the treatment I had about a 30 degree bend. After 4 incredibly painful injections and a hematoma I now have a 45 degree bend, but the worst of all is the incredible shrinkage in both length and girth. This has absolutely destroyed my self confidence. I now have about 5x as much scar tissue as I started with. Don't do these injections. They absolutely will make your condition worse."

1 / 10
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91 Report
  • PW...
  • Taken for 1 to 6 months
  • November 13, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Worst medical decision I’ve ever made! Xiaflex permanently damaged my penis. I haven’t had sex in years now. At least with Perone’s I was able to function sexually, but after Xiaflex, my penis is useless! It literally damaged it to the point where it’s no larger erect than it is flaccid, and flaccid, it’s smaller than the surrounding skin, so I’m constantly having to reach into my pants to pull it back out of the surrounding skin. It’s uncomfortable, embarrassing and humiliating. Things like riding a bike or hiking, or even working around the house are a constant battle with keeping the thing from being “inside out”. I consider the outcome to have been penile mutilation. I had a nice average sized penis before Xiaflex but now, it’s literally a micro-penis! Do you realize how difficult it is just to put that into writing? I cadn't stan what’s happened to me but if this can save someone else the disfigurement and permanent damage then it’s worth it."

1 / 10
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  • Chuck
  • Taken for 6 months to 1 year
  • January 25, 2021

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I went through a course of Xiaflex for Peyronie's honestly I think the drug is a waste of time. Spent over $7000.00 with insurance doctor said it was going to work and be fine. Did not correct it at all. Mine is manageable for sex but my advice is if yours is bad surgery maybe your only option. Imagine spending $7000.00 without any results only drug companies can get away with theses types of scams. It is like buying a car and they don't give you the engine. I chose not to do surgery because I can still function but like I said don't waste your money. I am hoping one day some law firm will do a class action suit for fraudulent claims made by the manufacturers of this product."

1 / 10
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67 Report
  • Ninea...
  • Taken for 6 months to 1 year
  • February 26, 2020

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Hi everyone, after suffering from Peyrones disease with 90 percent curvature I finally agreed with my urologist to have the xiaflex treatment. It was a disaster ,I am worse off than before the injections incredible shrinkage and still curvature I wish I had never gone through with it. Ruined my intimacy with my wife and psychologically messing me up. I highly recommend not having the treatment because it just doesn't work I have had 8 injections."

1 / 10
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79 Report
  • Devas...
  • May 2, 2021

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "This is an absolutely horrible drug and treatment that did nothing to improve my curvature of my penis and actually made things worse. I went through all 8 injections over a 6 month period and followed the instructions to a T but in the end not only did it do nothing to lessen my curve which is about 50 to 60% but it made my penis shorter by about an inch. Peyronies shortens your penis anyway by about an inch to an inch and a half so this just devastated me. In the end my penis is more than 2 inches shorter with the same curve. Additionally, I have had pubic are pain that is intermittent which I attribute to the injections. For 6 to 8 months I had a bruised and swollen penis that I had to stretch as part of the treatment which was excruciating and for 6 months after the last injection all I did was cry because it failed. I know that sounds pathetic to some but this is a very lonely disease to deal with and this company who created xiaflex needs to be held accountable for this."

1 / 10
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Are you taking this medicine?

  • Sexli...
  • Taken for 1 to 2 years
  • August 6, 2019

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I was diagnosed with Peyronie's 2018. My primary physician sent me to a urologist who recommended Xiaflex injections. He said that the success rate was high. Well, that was a false statement. Xiaflex ruined my sex life and now instead of having curvature on the left side of my penis, it's now moved on top which the curvature is worse then ever. This has been an emotional struggle for me and don't know what to do. I'm sure a lot of men with this condition are struggling as well with emotions. My advice to all men with Peyronie's disease. DON'T GET INJECTIONS! IT DOESN'T WORK!"

1 / 10
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70 Report
  • Penis...
  • September 10, 2019

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Warning to men considering this treatment for Peyronie's. I had a curvature to the left which I wish for the love of God I had back. After months of treatments with Xiaflex I now how have it right in the top middle and worse than ever. Penis shrinkage and all. Hurts like hell to have sex, not to mention the emotional part. It is embarrassing. I do not know what to do."

1 / 10
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58 Report
  • Unhappy...
  • June 15, 2023

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Do not undergo this treatment! I wish I had never heard of Xiaflex. My Peyronie's Disease wasn’t great, but I’d give almost anything to go back to the way I was before Xiaflex. It destroyed my penis. Even my urologist was surprised when he witnessed how much length and girth I’d lost. Of course, neither he, the hospital nor the manufacturer helped in any way. Plus, it’s super PAINFUL!! Not worth it!"

1 / 10
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  • Bob
  • May 13, 2019

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I couldn't complete the full treatment of 4 double injection cycles. During the 3rd cycle, after both injection #5 & #6, I developed excruciating pain, radiating from my hips to my knees. Both times, the pain was so intense, I lost control of my legs and fell to the floor. The pain lasted 15 minutes. The doctor told me no other patient had experienced that reaction. During a subsequent visit, I was told that a second patient had. The treatment did decrease the Peyronie's bend from 40º to 30º. Another serious, negative side effect was that flaccid and erect penis length and girth shrank dramatically after treatment. The doctor attributed it to the Peyronie's disease, but I took pictures just before Xiaflex treatment, (10 months after the onset of Peyronie's) and after treatment, and the size difference is dramatic. "

2 / 10
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  • JBano
  • January 30, 2021

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "After considering surgery, I decided instead to have a Xiaflex injection to treat Dupuytren's contracture of the pinky finger of my left (non-dominant) hand. At this time (approximately two months post injection), I am extremely pleased with the result. I did not have to risk the complications and long-healing time of surgery, and the contracture has almost completely disappeared, along with the chords that caused it. Yes, there was some pain and discomfort during the administration of the Xiaflex and again the next day, when a local anesthesia was injected prior to the finger manipulation. These were expected and well tolerated. I recovered full use of my hand within a few days after the procedure. It is important to find an experienced hand surgeon who has had a lot of success doing these injections."

10 / 10
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  • 1stjohn
  • Taken for 1 to 6 months
  • June 4, 2021

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I have completed my 3rd series of Xiaflex, 6 shots... WASTE OF TIME!! Not to mention the pain and swelling. I now more of a curve tin my penis than when I started. Scheduled for a forth series but I will not be going. There has to be a better way. I just hope I haven't gone so far that I can not fix it."

1 / 10
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  • Mark
  • Taken for 6 months to 1 year
  • October 22, 2019

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Have peyronies with 90 degree bend. Did 3 cycles of Xiaflex total of 6 injections. Got a hematoma after the sixth injection. End of Xiaflex treatment. Still have a 92 degree bend up and now a 30 degee bend to the right. Total waste of time and money. Not to mention the pain of the injections and the hematoma. Insurance paid $30,000 for this treatment and total failure."

2 / 10
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44 Report
  • Lost
  • Taken for 1 to 6 months
  • September 23, 2021

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Had mild curvature of 30 35° LOSS OF 0.5 INCHES. First round of xiaflex, mild hematoma, doc said it's normal. Extreme pain and daily discomfort followed, since April 2021. After first round another loss of length and girth and worsening of curvature. Have not measured it cuz I can't bear to even look at my penis anymore. Broke up with my gf cuz sex is too painful and it's disheartening not being able to please her, even after 2 years of this disease, masturbation is still painful and I doubt it is stable now. In my opinion this drug is a last resort only. Consider other options ie surgery. Really take your time about it, do not listen to others about having trust in ur doc, do ur own research about all the side effects. I am 38 years old single and this is what I will be for the rest of my life now. This disease affects us in so many other ways ppl can't even fathom."

1 / 10
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29 Report
  • LA An...
  • November 13, 2020

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "Had Xiaflex injection mid August, it's now end of November. The injection procedures, both Xiaflex drug and Novacain numbing is the most painful thing I have ever experiences. Feel like I survived torture. First week after injection, left hand and arm were swollen and arm turned red/purple, green then yellow for about two weeks. Drug is very expensive and co-pay was almost $2000. After over three months of PT and wearing splint at night (and any other time I'm not using hand) fingers curl back to original 50 degree bend. Concluded that procedure did not work. DO NOT HAVE THIS PROCEDURE. INTEND TO COMPLAIN TO AUTHORITIES-FDA, PHYSICIAN LICENSING, WHO EVER WILL LISTEN."

1 / 10
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36 Report
  • Fred
  • Taken for 6 months to 1 year
  • November 10, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I was on my LAST injection and it sent me to the ER! The other 7 injections did NOTHING!! I’m in so much pain and misery right now! I can barely walk! Swelling and discoloration is the worst right now and every time I walk, it feels like my penis is in a blender or being twisted by a psychopath!!!!! How is this product so expensive and “safe”?!"

1 / 10
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  • Mongo
  • Taken for 6 months to 1 year
  • June 19, 2019

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Three series of 2 injections (2 injections-1 injection, then the other in 2 days, 3 months between series, had 6 shots in 9 months). Horribly expensive and very uncomfortable during and after injections. No improvement---worthless---a medical businessman's scam. At least a auto mechanic guarantees his work."

1 / 10
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46 Report
  • Joe
  • Taken for 1 to 6 months
  • March 2, 2021

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "4 injections into my plaque by a very experience urologist made my mild deformity much worse. I went from a mild indentation and curve to an extreme curve with a hinge effect. This treatment is overpriced and can make your condition worse. It should be taken off the market. Total rip-off."

1 / 10
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  • JohnFH
  • Taken for less than 1 month
  • May 26, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "This medicine destroyed my penis- It will literally eat away at your penis and you will never reclaim what this drug will take from you.Don't let this drug go anywhere near your dick.- I sure wish I hadn't"

5 / 10
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22 Report
  • Spud
  • Taken for 1 to 6 months
  • February 28, 2021

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Xiaflex worked to a degree as my urethra was partially blocked. But my unit went from a thick 6 inches to an anemic 3 inches at most. 2 years after my final treatment it's embarrassingly small and stretching does nothing. I'm less of a man than I used to be and I remain single now by choice. I would try any other treatment and use Xiaflex only as a last resort."

2 / 10
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  • M Kevin
  • Taken for less than 1 month
  • September 14, 2018

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "I thought I would try this less invasive alternative to hand surgery. I had 45 degree bend in both hands effecting the pinkies. The injection was painful for a few seconds and my hand was wrapped so I could not move the finger. Two days later my surgeon manipulated the finger. He injected me with a numbing agent which again was painful for a few seconds. The manipulation was successful in both hands but one had a skin tear that needed attention post-op. I performed PT afterwards and wore a splint at night for three months. All was fine until the cord returned on both hands to the same degree as before. This occurred within one year. Therefore I rate the result as a one. I subsequently had hand surgery to remove the effected tissue and the results have been exceptional after four years. Basis my experience I would not suggest the Xiaflex treatment alternative. The success rate is too low and the cost and pain too high. Find a good hand surgeon, under go the PT and be happy with the results."

1 / 10
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44 Report
  • Jim...
  • Taken for 6 months to 1 year
  • February 5, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Guys, Do not get your hopes up. This is a very expensive and extremely painful waste of time. I am left a shell of a man. My PD is as bad as ever. 90 degree curve and a year later painful. XIAFLEX IS PURE GARBAGE"

1 / 10
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  • SadSu...
  • Taken for 6 months to 1 year
  • March 24, 2020

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I went through 6 series of shots. A series consisted of get a shot, wait 2 days, get another shot. Then you wait 5 weeks, start the next series. Each time after getting the first shot my penis, scrotum and entire groin area would bruise badly. Real struggle to go in 2 days later for that next shot... Literally one of the hardest things I've had to do in my life was lie there while a needle was stuck in my penis. But getting rid of that curve? Totally worth it - if it had worked, but it didn't. Unlike some of the other reviewers, I guess I should be grateful it's not worse."

1 / 10
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34 Report
  • Hang_...
  • Taken for less than 1 month
  • March 8, 2023

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I had Xiaflex injections at a urologist that specializes in Peyronies treatment. The first couple of shots did get rid of some scar tissue but after the third shot I developed some abdominal pain that only occurred after exercising. It felt like I had a hernia. I went to a doctor for treatment and they could not find anything with xrays or a cat scan. This pain went on for 7 months. I cancelled the rest of my treatments and just use the traction device. I would only recommend this if you catch it early and you have a slight bend. Even the Urologist that gave me the treatment is on camera saying the injections have limited effect. Do your research before you take the treatments."

2 / 10
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13 Report
  • Jack
  • Taken for less than 1 month
  • February 22, 2019

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "Received the injection in my left hand, about 6 hours later ended up in the emergency room with my lymph glands under my left armpit about the size of a baseball. Next day it turned black and blue. Procedure was not successful and following year went under the knife. I would not recommend this expensive alternative."

1 / 10
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  • Dude
  • Taken for less than 1 month
  • January 10, 2019

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "Before 1-07-19 I thought the benchmark for pain was the night I had to undergo an emergency bladder catheterization for another issue. The Xiaflex injection that I just experienced completely erased that unpleasant memory with a brand new horrifying one. The next day when my hand was injected with novocaine before the manipulation was almost as bad as the Xiaflex. I briefly glanced at my hand when the procedure was complete and saw that my fingers were back to their normal position. My point is simple. As medicine advances isn't the comfort of the patient supposed to be a main part of the equation? I had Needle Aponuerotomy on two previous occasions and the discomfort was minor compared to this, not to mention less expensive to all concerned. My other hand is also due and I would rather live under a freeway bridge that go through Xiaflex again. I'm definitely going back to N.A. even if I have to go out of network and pay out of my pocket."

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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.