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Collagenase clostridium histolyticum User Reviews & Ratings (Page 4)

Brand names: Xiaflex, Qwo

Collagenase clostridium histolyticum has an average rating of 2.9 out of 10 from a total of 98 reviews on Drugs.com. 17% of reviewers reported a positive experience, while 77% reported a negative experience.

Reviews for Collagenase clostridium histolyticum

  • Dixie
  • November 8, 2022

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "I had the injection done after my pinkie and ring finger became significantly contracted. I was assured that my research saying it could be a quite painful procedure was wrong. In fact it was incredibly painful and I had swelling and severe bruising in my entire hand and arm clear up to my underarm and lymph nodes; the doctors response was that I had had an abnormal reaction. The waiting period between the injection and manipulation kept me awake with nerve pain. My fingers straightened, but in the five months since the procedure I have weakness, aches and pain in the arm where it bruised. While it appears I need the procedure in the future in my (dominant) right hand I am extremely hesitant to even consider it and will likely evaluate other options."

3 / 10
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  • Anonymous
  • Taken for less than 1 month
  • August 12, 2022

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "Very painful and creepy. Hand mangled bruised, skin ripped open. Took time off work, wore a splint at night. A year after it came back with a vengeance. Twice the scar tissue, fingers crooked up even more."

1 / 10
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  • Barry
  • Taken for 2 to 5 years
  • June 3, 2022

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "I've had 2 injections into each hand to correct my Dupuytren's contracture in my pinkies and it didn't work. Each time the pinky went back to the way it was prior to the injection. I have recently had surgery on my right hand to remove an excess amount of scar tissue, the likes my new doctor had never seen before. Did more damage than good."

1 / 10
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  • Tomb
  • Taken for less than 1 month
  • May 9, 2022

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "Horrible experience with Xiaflex. Worst medical decision in my life. Allowed hand surgeon to talk me into treatment with Xiaflex. After treatment my contracture eventually grew massive, then surgery leaving horrible scar tissue. Today had surgery to remove scar and graft."

1 / 10
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  • Diamo...
  • Taken for 1 to 6 months
  • July 14, 2021

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "Had left hand done in May and now having right hand manipulated tomorrow. Xiaflex injections are somewhat painful but worth it. The local injections are worse but tolerable, manipulation is nothing. Had minor bruising but no problems otherwise. My right hand has swollen and been a little more painful since Xiaflex injection earlier but I am right handed and use it more. Find a good doctor and get this done, nothing to it!!!"

10 / 10
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  • Spike
  • Taken for less than 1 month
  • October 11, 2022

For Dupuytren's contracture "Not for me. It worked ok in terms of quickly almost straightening finger. But clostridium histolyticum worries me....there was nothing in the warning about side effects but if that stuff gets to your brain watch out. I hope one day someone will prove what happens when that stuff goes to your brain. What happened to me was a nightmare."

1 / 10
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  • Alex
  • Taken for less than 1 month
  • September 6, 2022

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "I had it done 5 years ago (the first finger hurt like hell, the second finger I demanded a local). So now one finger is fine and the other is about 20 degrees but ok. So now I have 3 more fingers that are problematic and I go in tomorrow with apprehension due to the pain...local will be demanded. Also, after the first finger was done I had pain for a couple of weeks. The second finger was fine???"

8 / 10
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  • MFK
  • October 9, 2022

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "I was treated for Dupuytren contraction for the ring and pinky finger on my left hand. I had significant discomfort with the Xiaflex injection on fingers, subsequent swelling of the left hand and minor discomfort in the left armpit, which also turned red. However, after two weeks the improvement to the fingers has been almost 100% and it appears to be continuing to improve. Hopefully, I never have to have it again. However, if necessary, I would. Be advised, I’m a 69 year old male in good health."

10 / 10
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  • firec...
  • Taken for less than 1 month
  • June 10, 2022

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "It hurts like anything but is well worth it. Pain is only while you are receiving the injections. Almost normal after 3 days. I think finding a doctor that does this a lot is key and catching it early. My shots were paid for by a grant except for $150. which the company selling the drug took care of."

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  • XIAFL...
  • Taken for 1 to 6 months
  • October 26, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Made slight positive improvement but I lost a lot of length. Now penis looks stubby. Very unhappy!! I went from being well endowed to looking pitiful. Grrrrrrrrr!!"

1 / 10
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  • CR2
  • Taken for 1 to 6 months
  • September 20, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Wasted lots of time and lots of money. At the end of the day condition got worse. Probably combination of the drug and the provider. Bottom line stay away."

1 / 10
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  • Didnt...
  • Taken for 1 to 6 months
  • November 20, 2019

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Went though 2 cycles of shots. My 30 degree bend turned into a 90 degree bend. Sex is impossible now."

1 / 10
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  • Mike
  • Taken for 1 to 6 months
  • March 24, 2019

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Useless after five shots :("

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  • Keith
  • Taken for 6 months to 1 year
  • February 29, 2020

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I went through 3 sets of injections they came out with the bill before the last set of injections $51,000 dollars and didn’t help at all."

1 / 10
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  • Tim
  • July 26, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "I went through the entire series of 8 shots and no change to my 70 degree upward curve, just pain and bruising….."

1 / 10
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10 Report
  • Bent...
  • Taken for less than 1 month
  • February 11, 2021

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "My 5th round of injections ruined my penis. It has shrunken down to half it size and is bent almost 90%. Xiaflex is too dangerous."

1 / 10
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  • Carl
  • Taken for 6 months to 1 year
  • June 21, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Completely worthless a waste of time and money. I had hopes however my condition worsened."

1 / 10
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  • Anonymous
  • February 5, 2022

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Zero help. It’s detroyed my personality. Do not use this treatment for Peyronies, I had 10% improvement and horrible side effects. My zest for life has been destroyed."

1 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • August 29, 2021

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Worthless treatment.Now, I have an added twist along with the bend."

1 / 10
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  • Amelia...
  • Taken for 2 to 5 years
  • July 28, 2016

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "A very positive experience without noside effects."

10 / 10
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  • Unhappy...
  • October 9, 2021

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "Had injection. Painful. But no side effects. In fact, no effects at all. Xiaflex did not work for me. Went on the have surgery which resulted in 80% improvement."

1 / 10
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  • Anonymous
  • Taken for less than 1 month
  • May 28, 2023

Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture "Had this procedure done 2 weeks ago and… it’s coming back. Waste of time and money. Extremely painful and stressful."

1 / 10
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  • Bingo...
  • December 29, 2016

Xiaflex (collagenase clostridium histolyticum) for Peyronie's Disease "Never had it, but need it."

4 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.