Chlorpheniramine Dosage

This dosage information may not include all the information needed to use Chlorpheniramine safely and effectively. See additional information for Chlorpheniramine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Allergic Rhinitis

Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed.
Maximum dose 32 mg/day.

Usual Adult Dose for Cold Symptoms

Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed.
Maximum dose 32 mg/day.

Usual Adult Dose for Urticaria

Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed.
Maximum dose 32 mg/day.

Usual Adult Dose for Allergic Reaction

Injectable solution:
Allergic reactions to blood or plasma infusions: 10 to 20 mg by intravenous, intramuscular, or subcutaneous injection as a single dose.

Anaphylaxis: 10 to 20 mg intravenous injection as a single dose.

Uncomplicated Allergic Conditions: 5 to 20 mg by intravenous, intramuscular, or subcutaneous injection as a single dose.

Maximum dose by injection is 40 mg/day.

Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed.
Maximum dose 32 mg/day.

Usual Pediatric Dose for Allergic Rhinitis

3 months to 5 months:
Sustained-release syrup: 0.5 mg orally every 12 hours.

6 months to 8 months:
Sustained-release syrup: 1 mg orally every 12 hours.

9 months to 18 months:
Sustained-release syrup: 1 to 1.5 mg orally every 12 hours.

18 months to 6 years:
Sustained-release syrup: 2 mg orally every 12 hours.

2 to 5 years:
Tablets or syrup: 1 mg every 4 to 6 hours.
Sustained-release: 2 mg orally two times a day, not to exceed 8 mg in 24 hours.
Maximum dose 6 mg/day.

6 to 11 years:
Tablets or syrup: 2 mg every 4 to 6 hours.
Sustained-release: 4 to 8 mg orally two times a day, not to exceed 16 mg in 24 hours or 8 mg orally at bedtime or during the day as indicated.
Maximum dose 16 mg/day.

12 years or older:
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed
Maximum dose 32 mg/day.

Usual Pediatric Dose for Cold Symptoms

3 months to 5 months:
Sustained-release syrup: 0.5 mg orally every 12 hours.

6 months to 8 months:
Sustained-release syrup: 1 mg orally every 12 hours.

9 months to 18 months:
Sustained-release syrup: 1 to 1.5 mg orally every 12 hours.

18 months to 6 years:
Sustained-release syrup: 2 mg orally every 12 hours.

2 to 5 years:
Tablets or syrup: 1 mg every 4 to 6 hours.
Sustained-release: 2 mg orally two times a day, not to exceed 8 mg in 24 hours.
Maximum dose 6 mg/day.

6 to 11 years:
Tablets or syrup: 2 mg every 4 to 6 hours.
Sustained-release: 4 to 8 mg orally two times a day, not to exceed 16 mg in 24 hours or 8 mg orally at bedtime or during the day as indicated.
Maximum dose 16 mg/day.

12 years or older:
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed
Maximum dose 32 mg/day.

Usual Pediatric Dose for Urticaria

3 months to 5 months:
Sustained-release syrup: 0.5 mg orally every 12 hours.

6 months to 8 months:
Sustained-release syrup: 1 mg orally every 12 hours.

9 months to 18 months:
Sustained-release syrup: 1 to 1.5 mg orally every 12 hours.

18 months to 6 years:
Sustained-release syrup: 2 mg orally every 12 hours.

2 to 5 years:
Tablets or syrup: 1 mg every 4 to 6 hours.
Sustained-release: 2 mg orally two times a day, not to exceed 8 mg in 24 hours.
Maximum dose 6 mg/day.

6 to 11 years:
Tablets or syrup: 2 mg every 4 to 6 hours.
Sustained-release: 4 to 8 mg orally two times a day, not to exceed 16 mg in 24 hours or 8 mg orally at bedtime or during the day as indicated.
Maximum dose 16 mg/day.

12 years or older:
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed
Maximum dose 32 mg/day.

Usual Pediatric Dose for Allergic Reaction

Injectable solution:
2 years to 11 years: 0.35 mg/kg/day in divided doses every 4 to 6 hours as needed.
12 years or older:
Allergic reactions to blood or plasma infusions: 10 to 20 mg by intravenous, intramuscular, or subcutaneous injection as a single dose.
Anaphylaxis: 10 to 20 mg intravenous injection as a single dose.
Uncomplicated Allergic Conditions: 5 to 20 mg by intravenous, intramuscular, or subcutaneous injection as a single dose.
Maximum dose by injection is 40 mg/day.

Tablets or syrup:
2 to 5 years: 1 mg every 4 to 6 hours.
Maximum dose 6 mg/day.
Sustained-release: 2 mg orally two times a day, not to exceed 8 mg in 24 hours.

6 to 11 years: 2 mg every 4 to 6 hours.
Sustained-release: 4 to 8 mg orally two times a day, not to exceed 16 mg in 24 hours or 8 mg at bedtime or during the day as indicated.
Maximum dose 16 mg/day.

12 years or older: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed
Maximum dose 32 mg/day.

Renal Dose Adjustments

The elimination of chlorpheniramine may be prolonged in patients with renal dysfunction. These patients should be monitored for excessive sedation and other adverse effects that may result from chlorpheniramine accumulation.

Liver Dose Adjustments

Data not available

Precautions

Use chlorpheniramine with caution in patients with asthma.

Chlorpheniramine should not be used in premature or newborn infants.

Dialysis

Data not available

Other Comments

The 100 mg/mL injection is for IM or subcutaneous use only.
The 10 mg/mL injection is for IV, IM, or subcutaneous use.

Watch this video series to learn about managing severe allergies (anaphylaxis).

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