Medication Guide App

Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Zutripro, Triaminic, Allergy Relief, Coricidin HBP Cough & Cold, Triplex AD, TussiCaps, Show all 786 »Coricidin HBP Maximum Strength Flu, Tylenol Cold, Ceron-DM, Ceron, Coricidin D, Anamine, Chlor-Trimeton Allergy SR, Kolephrin, Rynatan, Theraflu Flu, Cold and Cough Powder, Chlor-Trimeton Allergy Decongestant, Rondec, Naldecon, Sinarest, Denaze, Advil Allergy Sinus, Hydrocodone CP, Stahist, Wal-finate, Contac Cold and Flu Maximum Strength, Norel AD, Norel CS, Ed A-Hist, Alka-Seltzer Plus Cold Formula, Novasus, Triaminic-D Multi-Symptom Cold, DryMax, Cold Medicine Plus, Demazin, Actifed Cold and Allergy, Ralix, Duralex, Hydrocodone HD, Cardec, Simplet, Mintex, Ru-Tuss, Isophen-DF, Brexin LA, Tylenol Allergy Sinus, Teldrin, NoHist DM, M-End DM, Triphenicol, Amilon, Atuss DS, Esocor P, Coughtuss, Xiral SR, Time-Hist QD, Relera, AlleRx, Norel SR, Effective Strength Cough Syrup, Coldex, Phenabid DM, Norel DM, Ed A-Hist DM, NeoTuss Plus, Tritan, Sinucon, Codral Cold and Flu + Cough Day and Night, Genacol Maximum Strength, Triaminic Multi-Symptom Fever, C-Phen DM, Sildec-PE DM, Balamine DM, Multi Symptom Cold Relief, Rescon-DM, Kidcare Cough and Cold, Rentamine, Rondec-DM, Nasohist-DM, Triall, Dehistine, Pyrroxate, XL-3 Cold Medicine, PCM, Rescon Extended Release, Relacon-HC, Zotex-12D, Cheracol Plus, Nohist-DMX, Aller-Chlor, QC Cough/Cold, Endacof-C, Codeprex, Cotab AX, Scot-Tussin DM, Rhinatate, Coldcough Syrup, Chlorex A, Atrohist Pediatric, Codar AR, AlleRx Dose Pack, ChlorTan, Chlorphen, Cotabflu, De-Chlor HC, Histussin HC Liquid, HyTan, Vanex-HD, Enplus-HD, Triant-HC, Ornade Spansules, LoHist-D, Qdall, Dicel, De-Congestine, Deconamine SR, NoHist LQ, Advil Allergy and Congestion Relief, Tricom, Alumadrine, Sinutab Maximum Strength Caplets, Covangesic, Sinutab Ex-Strength, Duadacin, Sinapils, Atrohist Pediatric Capsule, Welltuss HC, Detuss, Rondex, Sudafed PE Sinus & Allergy, NoHist, Sinus & Allergy PE, Hybrid CF, Phenchlor Tannate Pediatric, aeroHist, JayCof-HC, Dexodryl Suspension, R-Tanna, Rhinolar, DuraHist, Lohist, Pediox Chewable, Sudal-12, C-Phed Tannate, Chlor-Mes, Redur-PCM, Ah-chew Ultra, Histatab PH, AlleRx Dose Pack PE (PM Dose), QV-Allergy, Suphedrine PE Sinus & Allergy, Extendryl Seniors, Ricobid NR, Sonahist, Nuhist, Extendryl JR, Novahistine, Dallergy JR, PCM Allergy, Re-Drylex Jr, DriHist, Dallergy PSE, Histex, Chlor-Trimeton Allergy Decongestant SR, ScopoHist, Allerest Maximum Strength, Coldamine, Dallergy ER, Tavist-DA, Dynahist-ER Pediatric, VisRx Dose Pack, Histatab, Allergy AM-PM Dose Pack, Nolamine, Histade, Pseudo CM TR, Allergy DN, PCM-LA, Amdry-C, Hista-Vent PSE, Mescolor, CP-Tannic, Relcof PSE, AllePak, SudoGest Sinus & Allergy, Suclor, Rhinaclear, Re2+30, Suphedrine Plus, Hayfebrol Liquid, RelCof DN PSE, SudaHist, Allerx Dose Pack DF, Dexodryl, Ryneze, RespiVent DF, NoHist EXT, RelCof CPM, AlleRx DF, Allergy DN II, Pseudoephedrine Plus, Duravent, AlleRx Dose Pack (PM Dose), Allergy DN PE, DuraTan PE, ScopoHist Syrup, RelCof PE, DriHist SR, Nohist PE, RelCof DN PE, Advil Children's Allergy Sinus, Dynahist ER, Tussin-V, Q-V Tussin, A-G Tussin, Hyphed, Hexatussin, Histinex PV, Pediatex HC, Tussend, KG-Tussin, P-V-Tussin Syrup, Cordron-HC NR, Atuss HD, Atuss HS, Cordron-HC, Hydrocof-HC, Hydrotuss HC, Hydron PCS, Nohist Plus, Nohist Plus Jr, AH-Chew, Duradryl, Duradryl JR, Liqui-Allergy, Sudal-12 Chewable, DA II, BP Allergy JR, Sudal-12 Tannate, Drize, Drysec, Durahist PE, Omnihist II LA, AH-Chew II, Norel SD, Chlor-Mes D, Ex-Histine, WE Allergy, Hista-Vent DA, Duravent DA, CPM-PE-MSC, Ah-Chew Ultra Tannate, SymPak PDX, Dallergy PE, Duradryl SR, Dallergy SR, Duradryl Chewable, Aerohist Plus, ScopoHist-PE, Sinodec, Omnihist L.A., Triaminic Softchews Cold and Allergy, AccuHist Drops (old formulation), DA Chewable, Extendryl Chews, Extendryl SR, Prehist D, Aerokid, Rondex Drops, Nalex A 12, AllerTan, Conal, Pyrichlor PE, Tri Tann Pediatric, Phena-Plus, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Poly Hist PD (old formulation), Phena-S 12, Dura-Vent/A, Resaid, Or-Phen-Ade, Rhinolar-EX 12, Time-Hist, MyHist-PD, Rescon-Ed, Chlorafed Timecelles, Triotann Pediatric, Phena-S, Tri-Tannate Pediatric, Rhinatate Pediatric, Url-Tannate Pediatric, Tanamine, Tanamine Pediatric, Tri-Tannate, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, R-Tannamine, Tanoral, Pseudochlor, Ru-Hist Forte, Histatan, Cophene No 2, Anaplex, URL-Tannate, Triotann, Klerist-D, Contac 12 Hour, ARM Allergy Relief, Chlorphedrin SR, Biohist LA (old formulation), Deconamine, Orlenta, Colfed-A, D-Amine-SR, Durafed, Pseudocot-C, Deconomed SR, Novafed A, Duratuss DA, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Tanafed, Fedahist, Fedahist Timecaps, Clorfed, Histalet, Duotan, Chlor-Trimeton Decongestant, Gencold, Rhinolar-EX, Triac, Equi-Nade, Decongex-3, Chlornade, Condrin, Ordrine, Genamin, Allerest 12 Hour, Suphenamine-SR, Rinade-BID, Histade CR, Kronofed-A, ND Clear, Vanex Forte-R, Anamine TD, Chlordrine SR, Triotann-S Pediatric, R-Tannamine Pediatric, PediaTan D, CP Dec, Cardec Drops, P-Tann D, Histadec, Tannate Pediatric, Dec-Chlorphen Drops, C Phen Drops, C Phen, Triaminic Cold & Allergy, Genaphed Plus, Histafed LA, ChlorTan D, Rinate Pediatric, Aller-Chlor Decongestant, Sudogest Plus, Sudogest Cold & Allergy, Ryna Liquid, Neutrahist Drops, Dec-Chlorphen, Dura-Tap/PD, Novahistine Elixir, Histatab Plus, Ed A-Hist LA, Phenylhistine, AccuHist Drops, Ny-Tannic, Rhinatate-NF, Trigofen Drops, Rynatan Pediatric, Nasohist Pediatric, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, Tanahist-D, PD-Hist D, Dallergy Drops, PD-Hist D Drops, Ceron Drops, Ed ChlorPed D, Sildec-PE Drops, Comhist LA, Q-Hist LA, Chlortox, Linhist-L.A., Comhist, Rhinacon A, Clorfed II, NoHist-A, Nalex-A, C-Hist-SR, Nalex-A SR, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannate Pediatric, Rynatan-S Pediatric, West-Decon M, Fedahist Gyrocaps, Codimal-LA Half, Vanex Forte, Curaler, Notuss, Nalphen, Nalda-Relief Pediatric, Chlorafed, Hista-Vadrin, Acta-Tabs PE, Sildec-PE, Ry-Tann, Nalgestic Pediatric, Sinucon Pediatric, Naldelate, Andecon Pediatric Drops, Histalet Forte, Prop-A-Hist, Uni Decon, Nalgest, West-Decon, Nalspan, Allerest PE, Endal-HD Plus, XiraTuss, Tanni-Hist 12 RF, Exratuss, Carbaphen CH, Tannate-12, Carbaphen 12, Quad Tann Pediatric, Quad Tann, Tannic-12, DryMax AF, Ricobid H, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Chlo-Amine, Pharbechlor, Topco Allergy, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Quad Tuss Pediatric, Tetra Tannate Pediatric, Tustan 12S, Tussi-12S, Tannic-12 S, Tussi-12, SymPak II, Respa-AR, Ex-Tuss, AccuHist LA, Bellahist-D LA, Tussizone-12 RF, Tannate 12 S, Rynatuss, Rentamine Pediatric, Tuss Tan, Tuss Tan Pediatric, Quadratuss, Rynatuss Pediatric, Trionate, C-Tanna 12, Quad-Tuss, PediaTan, Chlorpheniramine (Allergy), Tricodene SF, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Vicks Children’s NyQuil Cold & Cough, Codahistine-DH Elixir, Novadyne DH, Co-Histine DH, Ryna-C, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Triaminic Night Time Cough & Runny Nose, St. Joseph HBP Cough & Cold, SymPak DM, Broncopectol, Vicks Pediatric Formula 44m Cough & Cold Relief, Vicks Children's Nyquil, Robitussin Cough & Cold Long-Acting, Carepanto, Cold & Cough, Phenylhistine DH Expectorant, Codehist DH, Lexuss 210 Liquid, TL-Hist CM, Cotab A, Notuss-AC, Zodryl AC, Z-Tuss AC, Ed Chlor-Tan, Allergy Time, Chlor-Phenit, CapCof, Endal CD, Tricode AR, Zodryl DAC, Phenylhistine DH, Decohistine DH, Dihistine DH, Demi-Cof, T- Koff, Pediacof, Pedituss, Protuss Tablet, Rolatuss-SR, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Dimetapp Children's Nighttime Flu, Alka-Seltzer Plus Flu Formula, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Alka-Seltzer Plus-D, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Contac Cold + Flu (Night Formula), Co-Apap, Allpanto-S, Comtrex Cold and Flu Maximum Strength Liquid, Childrens Tylenol Cold Plus Cough, Theraflu Flu & Cough, Dimetapp Children's Multi-Symptom Cold & Flu, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Mapap Cough & Sinus Formula, Vicks NyQuil Cold & Flu Relief (Alcohol Free), Congestant, Colrex Compound, Colrex, Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Plus Children's Multi-Symptom Cold, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Tylenol Cold Head Congestion Nighttime, Tylenol Cold Multi-Symptom Nighttime, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Alka-Seltzer Plus Cold & Cough Formula Liquid, ConRx Allergy Sinus, Allergy Pain Relief, Codimal, Allerest Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus, Singlet, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Allerest Headache Strength, Sinarest Extra Strength, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula, Atrohist Plus, Deconhist LA, Quelidrine, Rolatuss, Triaminicin, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Sinulin, Rhinogesic, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, GNP Cold Relief Plus, Onset Forte, Allergy Sinus PE Pain Relief, Allergy Multi-Symptom, Robitussin Peak Cold Nighttime Nasal Relief, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, HEB Allergy, Dryphen, Trital SR, Alka-Seltzer Plus Cold & Flu, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Tylenol Plus Children's Cold, Protid, Sine-Off Sinus/Cold, ChlorDex GP, Qual-Tussin, Rindal-HD, Ed-TLC, Efasin-HD, Guiaphen HD, Iodal HD, Chemdal HD, S-T Forte 2, Vituz, Endagen-HD, Mintuss MS, Chemdal HD Plus, Hyphen-HD, Tuss-PD, KG-Dal HD, Endotuss-HD, Cyndal HD, Ed-Tuss HC, Nasatuss, Iotussin HC, Chlorgest HD, Hydrocodone GF, Lemohist Plus, Duohist DH, Tusscough DHC, Pancof, Tricof, Despec-PD, Pancof-PD, Novahistine DH, DiHydro-PE, Coldcough PD, Hydro-Tussin DHC, Dihydro-CP, SymPak, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Z-Tuss 2, Allfen A, Uni-Cof, Bronkotuss, Ana-Kit, Ditussin-HC, Chemtussin HC, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, De-Chlor HD, Hydron CP, Tussive HC, B-Tuss, Hydro-PC II, Echotuss-HC, Phendal-HD, Relasin-HC, DroTuss-CP, Z-Cof HC, Maxi-Tuss HCX, Liquicough HC, Poly-Tussin HD, Relacon-HC NR, Tusana-D, Neo HC, Liquitussin HC Syrup, Duradal HD, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Ventuss Syrup, Tuss-HC, Exo-Tuss, Hycomine Compound, Comtussin HC, Highland HC, Uni Tuss HC, Quindal HD, Hi-Tuss HC, Chlorphen HD, Quindal HD Plus, Efasin-HD Plus, H-C Tussive, Cytuss HC, Tuss-DS, T-Tanna DM, Duotan DM, Ricotuss, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Poly-Tussin DM, ED DM, EndaCof Drops, PE-Hist DM, Maxichlor PEH DM, Virdec DM, Zoden DM Drops, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Quartuss DM, DM-PE-Chlor, Donatussin DM Drops, Sonahist-DM, RE DCP Drops, Bronkids, DCP Drops, Sildec-PE DM Drops, Ceron-DM Drops, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Donatussin DM, Extendryl DM, Quartuss, Genelan NF, Zotex-DM, Dec-Chlorphen DM Drops, HistadecDM, Tussplex DM, Cardec DM, Robitussin Cough & Allergy, C-Phen DM Drops, Reme Tussin DM, Cardec DM Drops, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, NoHist-PDX, Relahist-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Children's Nyquil, Tanafed-DM, Vicks 44M Pediatric, Rhinosyn-DM, Therahist, Kophane, Threamine DM, C-Phed DM, Atuss-12 DM, AccuHist PDX Drops, CPM-PSE DM Drops, Mesehist DM, Allres DS, Neutrahist PDX Drops, Kidkare Cough/Cold, Dicel DM, Entre-S, Maxichlor PSE DM, Tricodene NN, Tricodene Forte, Centergy DM, Atuss DM, Father John's Medicine Plus, De-Chlor DM, Liquituss R-DM, Tussar DM, Albatussin SR, Cerose DM, Maxiphen ADT, De-Chlor DR, Coldtuss-DR, Trital DM, P Chlor DM, Dex PC, Mintuss DR, Uni-Tuss DM, Tri-Vent DPC, Atuss DR, Corfen-DM, Notuss-Forte

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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