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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Coricidin HBP Cough & Cold, Chlor-Trimeton, Theraflu Flu, Cold and Cough Powder, Coricidin HBP Cold & Flu, Triaminic, Ed A-Hist, Tylenol Cold, Coricidin D, Show all 805 »Norel AD, Deconamine, Ornade Spansules, Chlor-Trimeton Allergy SR, TussiCaps, Tritan, Zutripro, Sinarest, Allergy Relief, Coldcough Syrup, Rondec, C-Phen DM, NoHist DM, CapCof, Sinutab Ex-Strength, Advil Allergy Sinus, Phenagil CH, Comtrex Cold and Flu Maximum Strength Tablet, Dristan Cold Multi Symptom Formula, Allergy Multi-Symptom, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Stahist, Ceron, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Ricotuss, Tanafed, Cold & Cough, Contac 12 Hour, Triplex AD, Wal-finate, R-Tanna, Carbaphen CH, Aller-Chlor, Naldecon, Rentamine, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Tylenol Allergy Multi-Symptom, Hydrocodone HD, Relasin-HC, Triaminic Multi-Symptom Fever, AlleRx Dose Pack, Duadacin, Exo-Tuss, Vituz, Cough Formula M Multi-Symptom, Pancof, Hydro-Tussin DHC, Robitussin Cough & Cold Long-Acting, Triaminic Softchews Cough & Runny Nose, B-Tuss, Tuzistra XR, QV-Allergy, Triall, Colrex, Condrin, Coricidin HBP Day & Night Multi-Symptom Cold, Codral Cold and Flu + Cough Day and Night, Chlorphen, LoHist-D, Isophen-DF, Ceron-DM, Novasus, Lohist, Acta-Tabs PE, ScopoHist, Cardec, Pyrroxate, Quindal HD, H-C Tussive, Allerest PE, Tanamine, Histinex HC, Tanoral, Phena-S, Conal, AlleRx, PCM, Hexatussin, AllePak, Notuss, Coldamine, Resaid, Amdry-C, Dexodryl Suspension, Sinodec, Vanex-HD, DryMax, Rentamine Pediatric, Dexodryl, Triant-HC, Lexuss 210, Dihydro-CP, CP Dec, Nalphen, Scot-Tussin DM, Vicks Children’s NyQuil Cold & Cough, Actifed Cold and Allergy, Novahistine DH, Sildec-PE DM, Phenabid DM, Cardec DM, Rondec-DM, NeoTuss Plus, Sudafed PE Sinus & Allergy, C Phen, Children's Nyquil, Entre-S, Kidcare Cough and Cold, Endacof-C, Liquituss R-DM, Linhist-LA, Histalet Forte, Codahistine-DH Elixir, Rondex, Kidkare Cough/Cold, Triac, Tricode AR, Ny-Tannic, Effective Strength Cough Syrup, Brexin LA, Pseudochlor, Sudogest Cold & Allergy, Allerest Maximum Strength, Chlordrine SR, Duralex, Histalet, Fedahist, Orlenta, Kolephrin, De-Congestine, Theraflu Nighttime Severe Cold & Cough Caplets, Coricidin HBP Multi-Symptom Cold (Night), Cotabflu, Sinapils, Contac Cold and Flu Maximum Strength, Contac Cold + Flu (Night Formula), Dicel, Qdall, Comtrex Flu Therapy, Novafed A, XL-3 Cold Medicine, WE Allergy, Chlor-Mes D, Norel SD, Ex-Histine, Drysec, Duradryl JR, Drize, Ryna Liquid, Durahist PE, Omnihist II LA, Dallergy ER, Extendryl Seniors, Rescon Extended Release, Aerokid, Denaze, AH-Chew II, Ralix, Duradryl, AH-Chew, Prehist D, Extendryl Chews, DA Chewable, Extendryl SR, ScopoHist-PE, Ah-Chew Ultra Tannate, SymPak PDX, Omnihist L.A., Duravent DA, Genaphed Plus, DA II, Liqui-Allergy, SudoGest Sinus & Allergy, Hayfebrol Liquid, Hista-Vent DA, Suphedrine Plus, AlleRx Dose Pack PE (PM Dose), Redur-PCM, Mescolor, Hista-Vent PSE, PCM-LA, Relcof PSE, Dallergy PSE, DuraHist, Xiral SR, RelCof DN PSE, Time-Hist QD, Rhinaclear, Histatab, Amilon, Nolamine, VisRx Dose Pack, Allergy AM-PM Dose Pack, Allergy DN, Pseudo CM TR, Teldrin, Fedahist Gyrocaps, Re-Drylex Jr, Neutrahist Drops, Sudogest Plus, PCM Allergy, Chlor-Mes, Ah-chew Ultra, Histatab PH, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Chlorafed, Curaler, Clorfed II, Rhinolar, Histafed LA, Extendryl JR, DriHist, CPM-PE-MSC, Atrohist Pediatric Capsule, Cordron-HC NR, Atuss HD, Atuss HS, Cordron-HC, Hydrocof-HC, P-V-Tussin Syrup, Hydrotuss HC, Hydron PCS, Advil Allergy and Congestion Relief, Pseudoephedrine Plus, AlleRx DF, Allergy DN II, NoHist EXT, RelCof CPM, Triaminic Softchews Cold and Allergy, Advil Children's Allergy Sinus, Demazin, KG-Tussin, A-G Tussin, Dynahist ER, Or-Phen-Ade, Notuss-Forte, Dura-Vent/A, Relacon-HC, Z-Cof HC, Maxi-Tuss HCX, Detuss, Histinex PV, Hyphed, Tussin-V, Q-V Tussin, Welltuss HC, Tussend, JayCof-HC, Pediatex HC, RespiVent DF, aeroHist, Sudal-12, Re2+30, Suclor, Pediox Chewable, ARM Allergy Relief, Dallergy SR, Duradryl Chewable, C-Phed Tannate, Mintex, Histade, Dynahist-ER Pediatric, Tavist-DA, Chlor-Trimeton Allergy Decongestant SR, Dallergy PE, Duradryl SR, CP-Tannic, Aerohist Plus, Nohist Plus Jr, Nohist Plus, Sudal-12 Tannate, Sudal-12 Chewable, Duravent, SudaHist, AccuHist Drops (old formulation), Allerx Dose Pack DF, Ryneze, Dehistine, DriHist SR, AlleRx Dose Pack (PM Dose), Allergy DN PE, DuraTan PE, ScopoHist Syrup, RelCof PE, Nohist PE, RelCof DN PE, Codimal-LA Half, Klerist-D, Nalex A 12, NoHist-A, Nalex-A, AllerTan, Vanex Forte, Naldelate, Andecon Pediatric Drops, Pyrichlor PE, Rhinacon A, Comhist, Nalex-A SR, Tri Tann Pediatric, Phena-Plus, C-Hist-SR, Chlortox, Comhist LA, Q-Hist LA, Poly Hist PD (old formulation), Histade CR, Durafed, Duotan, Chlor-Trimeton Decongestant, Biohist LA (old formulation), Deconamine SR, Duratuss DA, DroTuss-CP, Nalda-Relief Pediatric, Nalgestic Pediatric, Uni Decon, Prop-A-Hist, Sinucon, Nalspan, West-Decon, Sinucon Pediatric, Nalgest, Chlornade, Chlorex A, Equi-Nade, Decongex-3, Equitan Pediatric, Tanoral Pediatric, Gencold, Allerest 12 Hour, Genamin, Rhinolar-EX, Triple Tannate Pediatric, Tri-Tannate, Url-Tannate Pediatric, R-Tannamine, URL-Tannate, Rhinatate, Rhinatate Pediatric, Tanamine Pediatric, Tri-Tannate Pediatric, Vanex Forte-R, Ru-Hist Forte, Tri-Gestan S, Chlorex-A 12, Triotann Pediatric, Tri-Hist Pediatric, Ordrine, Coldex, West-Decon M, Histatan, Atrohist Pediatric, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, R-Tannate, Gelhist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Clorfed, Chlorafed HS Timecelles, Rynatan, Rhinatate-NF, Trigofen Drops, Virdec, BP Allergy JR, Sonahist, Ricobid NR, Suphedrine PE Sinus & Allergy, AccuHist Drops, Phenylhistine, Phenchlor Tannate Pediatric, Nasohist Pediatric, Dallergy Drops, Rynatan Pediatric, Ed A-Hist LA, Novahistine Elixir, Histatab Plus, NoHist LQ, Relera, Chlorafed Timecelles, Time-Hist, Anamine TD, Rescon-Ed, Cophene No 2, Anamine, Anaplex, ND Clear, MyHist-PD, Nuhist, Novahistine, Dallergy JR, Suphenamine-SR, Kronofed-A, Phena-S 12, Rhinolar-EX 12, Sinus & Allergy PE, PD-Hist D Drops, Cardec Drops, P-Tann D, Triaminic Cold & Allergy, PediaTan D, Histadec, Dec-Chlorphen Drops, C Phen Drops, Tannate Pediatric, ChlorTan D, Rinate Pediatric, Maxichlor PEH, Ry-Tann, Hista-Vadrin, NoHist, Sildec-PE, Ed ChlorPed D, Sildec-PE Drops, Dec-Chlorphen, Codimal-LA, CP Dec Drops, Chlor-Mes Jr, Rondex Drops, Allan Tannate Pediatric, Tanahist-D, Ceron Drops, PD-Hist D, Rinade-BID, Pseudocot-C, Fedahist Timecaps, Dura-Tap/PD, Kronofed-A-Jr, Chlorphedrin SR, Colfed-A, Deconomed SR, D-Amine-SR, Triotann, Cyndal HD, Quad Tann Pediatric, Quad Tann, Tannic-12, Carbaphen 12, Quad Tuss Pediatric, Tetra Tannate Pediatric, Quadratuss, Rynatuss, Tuss Tan, Tuss Tan Pediatric, Tannate-12, XiraTuss, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Ricobid H, DryMax AF, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), Rynatuss Pediatric, Quad-Tuss, Ex-Tuss, AccuHist LA, Bellahist-D LA, Histacol LA, Protuss Tablet, Rolatuss-SR, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Atrohist Plus, Deconhist LA, Ru-Tuss, Respa-AR, Tussizone-12 RF, Tannate 12 S, Trionate, C-Tanna 12, Tussi-12, Tannic-12 S, SymPak II, Tustan 12S, Tussi-12S, Topco Allergy, Pharbechlor, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Decohistine DH, Phenylhistine DH, Pedituss, Demi-Cof, Dihistine DH, Zodryl DAC, Ryna-C, Tricodene SF, Carepanto, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, St. Joseph HBP Cough & Cold, Robitussin Children's Cough & Cold Long-Acting, Dimetapp Children's Long Acting Cough Plus Cold, QC Cough/Cold, Primatuss 4, Tricodene Sugar Free, Pediacof, T- Koff, Chlorpheniramine (Allergy), ChlorTan, Ed Chlor-Tan, Allergy Time, PediaTan, Chlo-Amine, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Chlor-Phenit, Z-Tuss AC, Cotab AX, Codeprex, Notuss-AC, Endal CD, Cotab A, TL-Hist CM, Zodryl AC, Tuxarin ER, Codar AR, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Dimetapp Children's Nighttime Flu, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Co-Apap, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Allpanto-S, Theraflu Flu & Cough, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Cold Multi-Symptom (Nighttime), XL-3 Xtra Cold and Cough, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Tylenol Plus Children's Cough & Runny Nose, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Mapap Cough & Sinus Formula, Coricidin HBP Maximum Strength Flu, Congestant, Colrex Compound, PediaCare Cough & Runny Nose Plus Acetaminophen, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Tylenol Cold Multi-Symptom Nighttime, PediaCare Flu Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, ConRx Allergy Sinus, Allergy Pain Relief, Codimal, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus, Tricom, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Singlet, Simplet, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Actifed Cold & Sinus, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Cold Medicine Plus, Allergy Sinus Maximum Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Chlor-Trimeton Sinus, Sinulin, Gendecon, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Tylenol Plus Children's Cold, GNP Cold Relief Plus, Onset Forte, Allergy Sinus PE Pain Relief, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Protid, Hybrid CF, Norel SR, Trital SR, Rhinogesic, Alumadrine, Covangesic, Dryphen, Sine-Off Sinus/Cold, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Lemohist Plus, Hydrocodone GF, S-T Forte 2, HyTan, Qual-Tussin Pediatric, Donatussin Pediatric, Allfen A, Z-Tuss 2, SymPak, P Chlor GG, Endagen-HD, Chemdal HD, Mintuss MS, Chemdal HD Plus, Nasatuss, Iotussin HC, Guiaphen HD, Efasin-HD, Iodal HD, Rindal-HD, Ed-TLC, Ana-Kit, Bronkotuss, CPM-PSE DM Drops, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, AccuHist PDX Drops, Neutrahist PDX Drops, Dicel DM, Atuss DS, Maxichlor PSE DM, Allres DS, Duotan DM, Duohist DH, Tusscough DHC, Tricof, Uni-Cof, Despec-PD, Pancof-PD, T-Tanna DM, DiHydro-PE, Coldcough PD, Chlorgest HD, Ed-Tuss HC, Tussive HC, Hydro-PC II, Hydron CP, De-Chlor HD, Hydrocodone CP, Liquitussin HC Syrup, Quindal HD Plus, Hi-Tuss HC, Chlorphen HD, Duradal HD, De-Chlor HC, Atuss MS, Relacon-HC NR, Tusana-D, Neo HC, Poly-Tussin HD, Phendal-HD, Echotuss-HC, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, Efasin-HD Plus, Tuss-DS, Ditussin-HC, Chemtussin HC, Endal-HD Plus, Enplus-HD, Endotuss-HD, KG-Dal HD, Hycomine Compound, Hyphen-HD, Tuss-PD, Comtussin HC, Tuss-HC, Highland HC, Uni Tuss HC, Histussin HC Liquid, Cytuss HC, KG-Dal HD Plus, Coughtuss, Ventuss Syrup, Maxi-Tuss SA, Maxi-Tuss HC, Atuss-12 DM, M-End DM, PE-Hist DM, Maxichlor PEH DM, ED DM, Poly-Tussin DM, EndaCof Drops, DCP Drops, Norel CS, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, Tri-Dex PE, Z-Dex 12 D, RE DCP Drops, Nohist-DMX, Bronkids, Donatussin DM Drops, Sonahist-DM, Re DCP, Trigofen DM Drops, Virdec DM, Zoden DM Drops, Tussplex DM, Reme Tussin DM, Zotex-DM, Neotuss D, Extendryl DM, Donatussin DM, Genelan NF, Quartuss, Broncopectol, ChlorDex GP, Qual-Tussin, Ceron-DM Drops, Rondex-DM, Neo DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, CP Dec DM, HistadecDM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, Nasohist-DM, DM-PE-Chlor, Dex PC, Tricodene Forte, Tricodene NN, Cheracol Plus, P Chlor DM, Ed A-Hist DM, Uni-Tuss DM, Mintuss DR, Trital DM, Therahist, Triphenicol, Creomulsion Pediatric, Rescon-DM, Tanafed-DM, C-Phed DM, Creomulsion Cough/Cold/Allergy, Vicks 44M Pediatric, Kophane, Threamine DM, Rhinosyn-DM, Corfen-DM, Atuss DR, Statuss DM, NoHist-PDX, Relahist-DM, Albatussin SR, Quartuss DM, Zotex-12D, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Cerose DM, Maxiphen ADT, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Norel DM, Father John's Medicine Plus, Tussar DM, Centergy DM, Atuss DM, Liquicough HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

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