Chlorpheniramine use while Breastfeeding
Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Zutripro, Ceron-DM, Coricidin HBP Cold & Flu, R-Tanna, Triaminic, Alka-Seltzer Plus Cold, Sildec-PE DM, Coricidin HBP Cough & Cold, Show all 731 »Stahist, Rynatan, Rondec, TussiCaps, Rondec-DM, Norel SR, C-Phen DM, Theraflu Flu, Cold and Cough Powder, Ceron, Ru-Hist Forte, AlleRx, Tylenol Cold, Rescon, Coricidin D, Hydrocodone CP, Deconamine, M-End DM, Dallergy PE, Sudafed PE Sinus & Allergy, Sinarest, De-Chlor DM, Cardec DM, Ed A-Hist, Cardec, Chlor-Trimeton Allergy SR, Corfen-DM, Sildec-PE, Chlorphen, NoHist, Naldecon, Histinex HC, Cardec DM Drops, Deconamine SR, AlleRx DF Dose Pack, Coricidin HBP Maximum Strength Flu, Mesehist DM, Donatussin, Poly-Tussin DM, Aller-Chlor, Phenabid DM, Bronkids, DryMax, Dehistine, Atuss DS, Allergy Relief, Kolephrin, De-Chlor DR, Triplex AD, Phena-S, LoHist-D, PE-Hist DM, Dicel, Coldcough Syrup, Norel DM, Dihydro-CP, Contac Cold and Flu Maximum Strength, Sinus & Allergy PE, C-Phen DM Drops, Ralix, Wal-finate, Chlor Trimeton Allergy Decongestant, Tylenol Allergy Multi-Symptom, PCM, DiHydro-PE, DuraHist, Advil Allergy Sinus, Quartuss, Ed A-Hist DM, Contac 12 Hour, Alka-Seltzer Plus Cold Formula, Respa-AR, Teldrin, Hydrocodone GF, Ornade Spansules, Histex, Notuss-AC, Novasus, Demazin, Anaplex, D-Amine-SR, Orlenta, Mintex, C Phen, Coughtuss, Hydrocodone HD, AlleRx DF, Ryneze, Trital DM, NeoTuss Plus, Tylenol Sinus Congestion & Pain Nighttime, Sinulin, Sinutab Ex-Strength, Codimal, Rynatuss, Qdall, Notuss, Dicel DM, AlleRx PE, Aerokid, Simplet, Pancof, Tussi-12, SudaHist, Novahistine, Rynatan Pediatric, Triant-HC, Allerest Maximum Strength, Maxichlor PSE DM, Nalspan, Mescolor, Triaminic Multi-Symptom Fever, Dex PC, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Maxichlor PEH DM, P-V-Tussin Syrup, Atuss HD, Scot-Tussin DM, CPM-PSE DM Drops, Coldex, Nalex-A, Robitussin Cough & Cold Long-Acting, Chlorex A, HyTan, Dallergy JR, Redur-PCM, Novahistine DH, Triaminic-D Multi-Symptom Cold, Coldamine, Nohist-DMX, Tylenol Cold Multi-Symptom Nighttime, Trital SR, Cold Medicine Plus, Poly Hist PD, Dexodryl, Tricom, Triaminicin, Lexuss 210 Liquid, Carbaphen 12, Histussin HC Liquid, Phena-Plus, PD-Cof, Rentamine, Atuss DM, Protid, Amilon, Tannic-12 S, Lemohist Plus, Duralex, C Phen Drops, ScopoHist, Donatussin Pediatric, Rondex, Cough Formula M Multi-Symptom, Tanafed, Nalex A 12, Children's Nyquil, Sinucon, Genacol Maximum Strength, Dristan Cold Multi Symptom Formula, Ny-Tannic, Nasohist Pediatric, Condrin, Tussend, Pancof-PD, Coldcough PD, Maxiphen ADT, Omnihist II LA, Suclor, Codeprex, Dallergy ER, CPM-PE-MSC, Duotan, Cophene No 2, Ed ChlorPed, Duradryl, Durahist PE, Vicks Formula 44 Custom Care Cough & Cold PM, Extendryl Chews, Duravent, Neutrahist PDX Drops, Mintuss DR, Hista-Vent PSE, Triphenicol, Robitussin Children's Cough & Cold Long-Acting, SymPak, Actifed Cold and Allergy, Tylenol Allergy Sinus, Singlet, Quartuss DM, Conal, Hista-Vent DA, Neo DM Drops, Reme Tussin DM, Quelidrine, Vanex-HD, Kophane, Cyndal HD, Chlor-Mes D, Prehist D, CP Dec DM, AH-Chew, Endal-HD Plus, H-C Tussive, Donatussin DM Drops, Nasohist-DM, Father John's Medicine Plus, Tricodene NN, Hydron CP, Relasin-HC, Sildec-PE DM Drops, Vicks Children's Nyquil, Fedahist, Pseudochlor, Anamine, SudoGest Sinus & Allergy, Histalet, Sonahist, Triaminic Cold & Allergy, ChlorTan, Pharbechlor, Rhinatate-NF, Pyrichlor PE, AllerTan, Alka-Seltzer Plus Flu Formula, Ru-Tuss, Tricof, Sinapils, Tritan, Tanoral, Triotann, Nalphen, Quad-Tuss, Rondex-DM Drops, Rondex Drops, Alumadrine, Genelan NF, Triac, Ry-Tann, Gendecon, Entre-S, Atuss DR, Childrens Tylenol Cold Plus Cough, Kidcare Cough and Cold, Z-Tuss AC, Norel SD, PCM-LA, Novadyne DH, Ceron Drops, Phena-S 12, Allergy DN PE, Dallergy Drops, Effective Strength Cough Syrup, Dallergy PSE, Nohist Plus, Ana-Kit, RespiVent DF, Duradal HD, Congestant, Novahistine Elixir, Histatab Plus, Nalgestic Pediatric, West-Decon, Phenylhistine, Naldelate, Phenchlor Tannate Pediatric, Dec-Chlorphen, Hydrotuss HC, Hyphed, Notuss-Forte, Allerest PE, Histadec, PediaTan D, Relera, Histalet Forte, Hyphen-HD, Endotuss-HD, Nasatuss, Rindal-HD, Relacon-HC, Iodal HD, Ditussin-HC, Hi-Tuss HC, NoHist-A, Rhinacon A, Neo HC, Tusana-D, B-Tuss, Atuss MS, aeroHist, DCP Drops, Comtrex Allergy Sinus, TanaHist-PD, Comtrex Nighttime Flu Therapy, Endacof-C, Allergy Sinus Maximum Strength, Novafed A, Pseudocot-C, Kronofed-A-Jr, Durafed, Comtrex Sinus and Nasal, Pedituss, Sinodec, DuraTan PE, Aerohist Plus, Drysec, Denaze, Phenylhistine DH Expectorant, AlleRx PE Dose Pack, QV-Allergy, Rinade-BID, Suphenamine-SR, Duratuss DA, Sudal-12 Tannate, Pediox Chewable, AccuHist Drops, Atrohist Plus, Duradryl SR, Sudogest Cold & Allergy, DriHist, AccuHist LA, Atrohist Pediatric Capsule, Brexin LA, Chlordrine SR, Rynatuss Pediatric, Chlorafed, Aller-Chlor Decongestant, Suphedrine Plus, Tussizone-12 RF, Trionate, Tylenol Plus Children's Multi-Symptom Cold, Allerest 12 Hour, Xiral SR, Chlorex-A 12, Genamin, Centergy DM, Dec-Chlorphen DM, DM-PE-Chlor, R-Tannate, Tanamine, VisRx Dose Pack, AlleRx Dose Pack, Histatab, Rescon-DM, Tricodene Forte, AccuHist PDX Drops, Donatussin DM, Coldtuss-DR, HEB Allergy, Robitussin Peak Cold Nighttime Nasal Relief, Covangesic, Qual-Tussin, Equi-Nade, Resaid, Rhinosyn-DM, Pyrroxate, AllePak, Cerose DM, Nolamine, Comtrex Cold and Flu Maximum Strength Tablet, Alka-Seltzer Plus Cold & Cough Formula Liquid, Tussar DM, Ricobid NR, Allergy AM-PM Dose Pack, RelCof DN PSE, Relcof PSE, Ed A-Hist LA, Pseudo CM TR, Allergy DN, Amdry-C, Time-Hist QD, Rhinaclear, BP Allergy JR, R-Tannamine, Chlorafed HS Timecelles, Codimal-LA, Clorfed, Chlor-Trimeton Decongestant, Biohist LA, Dura-Tap/PD, Fedahist Timecaps, Isophen-DF, Kronofed-A, Deconomed SR, Colfed-A, Chlorphedrin SR, Histade CR, Dynahist ER, Or-Phen-Ade, ARM Allergy Relief, Dura-Vent/A, Rhinolar-EX 12, MyHist-PD, Chlornade, Ordrine, Vanex Forte-R, Rhinolar-EX, Gencold, Decongex-3, ND Clear, Anamine TD, CP-Tannic, Histade, Dynahist-ER Pediatric, Tavist-DA, Chlor-Trimeton Allergy Decongestant SR, Re2+30, Sudal-12, Neutrahist Drops, Triaminic Softchews Cold and Allergy, Sudal-12 Chewable, De-Congestine, C-Phed Tannate, Hayfebrol Liquid, Genaphed Plus, Klerist-D, Codimal-LA Half, Rescon-Ed, Chlorafed Timecelles, Time-Hist, Fedahist Gyrocaps, Clorfed II, Ryna Liquid, Sudogest Plus, Histafed LA, Curaler, Tri Tann Pediatric, Tri-Hist Pediatric, Hista-Vadrin, Nalda-Relief Pediatric, Acta-Tabs PE, Nuhist, Tanahist-D, Sinucon Pediatric, Nalgest, Vanex Forte, Comhist, Andecon Pediatric Drops, Prop-A-Hist, Uni Decon, CP Dec Drops, PD-Hist D, CP Dec, Cardec Drops, Tannate Pediatric, Dec-Chlorphen Drops, Chlor-Mes Jr, P-Tann D, ChlorTan D, PD-Hist D Drops, Sildec-PE Drops, Ed ChlorPed D, Rinate Pediatric, Comhist LA, Q-Hist LA, Tanamine Pediatric, Tri-Tannate Pediatric, Tri-Tannate, Triple Tannate Pediatric, Equitan Pediatric, Rhinatate Pediatric, Rhinatate, Triotann Pediatric, Tri-Gestan S, Histatan, URL-Tannate, Url-Tannate Pediatric, Tanoral Pediatric, Triotann-S Pediatric, Nalex-A SR, West-Decon M, C-Hist-SR, Linhist-L.A., Chlortox, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannamine Pediatric, Triotann-S, Gelhist Pediatric, R-Tannate Pediatric, Allan Tannate Pediatric, Tuss-DS, Pediacof, Demi-Cof, T- Koff, TL-Hist CM, Cotab AX, Zodryl AC, Dihistine DH, Phenylhistine DH, Codahistine-DH Elixir, Zodryl DAC, Ryna-C, Co-Histine DH, Decohistine DH, Codehist DH, Cotab A, Topco Allergy, Ricobid H, Ahist, Exratuss, Tanni-Hist 12 RF, Tannate-12, XiraTuss, C.P.M., Chlor-Mal, Ed Chlor-Tan, Chlor-Phenit, Chlorpheniramine (Allergy), PediaTan, Chlo-Amine, Tricodene SF, QC Cough/Cold, HistadecDM, Tussplex DM, Dec-Chlorphen DM Drops, Rondex-DM, P Chlor DM, Ceron-DM Drops, Relahist-DM, Sonahist-DM, Z-Dex 12 D, NoHist-PDX, Zotex-12D, PD-Cof Drops, CP Dec-DM Drops, Uni-Tuss DM, Tri-Vent DPC, Dimetapp Children's Long Acting Cough Plus Cold, SymPak DM, Triaminic Softchews Cough & Runny Nose, Tricodene Sugar Free, Vicks Pediatric Formula 44m Cough & Cold Relief, Primatuss 4, Zotex-DM, Broncopectol, Ricotuss, Liquituss R-DM, ED DM, Extendryl DM, ChlorDex GP, Quad Tann, Quad Tann Pediatric, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Contac Severe Cold and Flu Maximum Stength, Comtrex Cold and Flu Maximum Strength, Dimetapp Children's Multi-Symptom Cold & Flu, Comtrex Maximum Strength Cold Relief, Theraflu Flu & Cough, Gelpirin-CCF, Tylenol Plus Children's Cold, Allergy Multi-Symptom, Comtrex Flu Therapy, Comtrex Severe Cold & Sinus, Dryphen, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Comtrex Nighttime Cold & Cough, Tylenol Plus Children's Cough & Runny Nose, Coricidin HBP Day & Night Multi-Symptom Cold, Mapap Cough & Sinus Formula, Colrex, Cotabflu, Colrex Compound, Tylenol Plus Children's Flu, Dimetapp Children's Nighttime Flu, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Comtrex Cold & Cough Day Night, Tylenol Cold Head Congestion Nighttime, Codral Cold and Flu + Cough Day and Night, Contac Cold+Flu Maximum Strength (night formula), Alka-Seltzer Plus Cold & Flu, Tannate 12 S, C-Tanna 12, Tussi-12S, SymPak II, Ex-Tuss, Bellahist-D LA, Tustan 12S, Quadratuss, Tetra Tannate Pediatric, Quad Tuss Pediatric, Tuss Tan Pediatric, Tuss Tan, Rentamine Pediatric, Protuss Tablet, Rolatuss-SR, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Sinus, Duadacin, Rhinogesic, Chlor-Trimeton Sinus, Allerest Headache Strength, Sinarest Extra Strength, Alka-Seltzer Plus Cold & Cough Formula, Deconhist LA, Alka-Seltzer Plus Flu Formula (old formulation), Rolatuss, Sinutab Maximum Strength Caplets, RE DCP Drops, Threamine DM, Hydron PCS, Hydrocof-HC, KG-Tussin, A-G Tussin, Tussin-V, Q-V Tussin, Cordron-HC, Cordron-HC NR, Allergy DN II, Dexodryl Suspension, RelCof CPM, Advil Children's Allergy Sinus, Atuss HS, Hexatussin, JayCof-HC, Relacon-HC NR, Poly-Tussin HD, Phendal-HD, Echotuss-HC, Uni-Tricof HC, Rindal HD Plus, Z-Cof HC, Liquicough HC, Pediatex HC, Welltuss HC, Histinex PV, Detuss, DroTuss-CP, NoHist EXT, Extendryl JR, Triall, SymPak PDX, Re-Drylex Jr, PCM Allergy, Histatab PH, Chlor-Mes, ScopoHist-PE, DriHist SR, Duradryl Chewable, ScopoHist Syrup, RelCof PE, Ah-Chew Ultra Tannate, Nohist Plus Jr, Ah-chew Ultra, Extendryl Seniors, Omnihist L.A., Duravent DA, DA Chewable, Extendryl SR, Nohist PE, RelCof DN PE, DA II, Liqui-Allergy, WE Allergy, AH-Chew II, Ex-Histine, Drize, Duradryl JR, Hydro-PC II Plus, De-Chlor HC, Z-Tuss 2, Qual-Tussin Pediatric, Allfen A, Bronkotuss, Hydro-Tussin DHC, Uni-Cof, P Chlor GG, S-T Forte 2, Endagen-HD, Chemdal HD, Poly-Tussin, Maxi-Tuss HCX, Mintuss MS, Tusscough DHC, Despec-PD, T-Tanna DM, Vicks 44M Pediatric, Duotan DM, Allres DS, Cheracol Plus, Therahist, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Esocor P, Duohist DH, Atuss-12 DM, C-Phed DM, Tanafed-DM, Ed-TLC, Efasin-HD, Hycomine Compound, Efasin-HD Plus, Cytuss HC, Uni Tuss HC, KG-Dal HD Plus, Highland HC, Quindal HD Plus, Quindal HD, Hydro-PC II, De-Chlor HD, Tussive HC, Liquitussin HC Syrup, Chlorphen HD, Maxi-Tuss HC, Maxi-Tuss SA, Ed-Tuss HC, Tuss-PD, Chlorgest HD, Iotussin HC, Guiaphen HD, Chemdal HD Plus, KG-Dal HD, Chemtussin HC, Tuss-HC, Ventuss Syrup, Comtussin HC, Enplus-HD, Exo-Tuss, Rhinolar
Chlorpheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]
Possible Effects on Lactation
Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.
Alternate Drugs to Consider
Desloratadine, Fexofenadine, Loratadine
References
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
Chlorpheniramine Identification
Substance Name
Chlorpheniramine
CAS Registry Number
132-22-9
Drug Class
Administrative Information
LactMed Record Number
64
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2010-12-07
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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