Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Chlor-Trimeton, Coricidin HBP Cold & Flu, Zutripro, Tylenol Cold, Coricidin HBP Cough & Cold, TussiCaps, Theraflu Flu, Cold and Cough Powder, Triaminic, Show all 777 »Sinarest, Triplex AD, Rondec-DM, Norel AD, Ceron-DM, Allergy Relief, Rondec, Coricidin D, Ed A-Hist, Tylenol Sinus Congestion & Pain Nighttime, Norel SR, Norel CS, Coldcough Syrup, Ed A-Hist DM, Ceron, XL-3 Cold Medicine, Actifed Cold and Allergy, Contac Cold and Flu Maximum Strength, Cardec DM, Rynatan, NoHist DM, XL-3 Xtra Cold and Cough, Cophene No 2, Chlorphen, Aller-Chlor, Sine-Off Sinus/Cold, CapCof, Pancof-PD, Demazin, Histinex HC, Advil Allergy and Congestion Relief, NoHist, Mesehist DM, Alka-Seltzer Plus Cold Formula, Sinus & Allergy PE, Sudafed PE Sinus & Allergy, Equi-Nade, Chlor-Trimeton Allergy SR, Stahist, Deconamine SR, Nalex-A, XiraTuss, Broncopectol, Quartuss, Sinucon, LoHist-D, Cold Medicine Plus, R-Tanna, Sildec-PE DM, Orlenta, Brexin LA, Simplet, Father John's Medicine Plus, Nasohist Pediatric, Vituz, Rindal-HD, Tylenol Allergy Multi-Symptom, Hydrocodone HD, Esocor P, Novasus, Coldcough PD, Nolamine, Coricidin HBP Day & Night Multi-Symptom Cold, Ralix, Duravent, Coricidin HBP Maximum Strength Flu, Pyrroxate, Allergy Multi-Symptom, AlleRx, Ru-Hist Forte, Zodryl DAC, CPM-PE-MSC, Histussin HC Liquid, RelCof PE, Relasin-HC, Triant-HC, Phena-Plus, H-C Tussive, Redur-PCM, Dexodryl Suspension, RespiVent DF, Carbaphen CH, Histinex PV, Atuss HD, Hyphed, Ed ChlorPed, Ed-Chlortan, Maxi-Tuss HC, Tanoral, PCM, Poly Hist PD, Lexuss 210 Liquid, Tri-Tannate, Naldecon, Trital DM, Ceron-DM Drops, Atuss DM, Tussar DM, Maxiphen ADT, Cerose DM, C-Phen DM, Bronkids, Rynatan Pediatric, Triphenicol, Rondex, Acta-Tabs PE, Lohist, Phenabid DM, Poly-Tussin DM, Poly-Tussin, Qual-Tussin, Hyphen-HD, Endotuss-HD, Coldex, Extendryl DM, Donatussin Pediatric, M-End DM, Rescon-DM, Despec-PD, Time-Hist QD, Hista-Vent PSE, Tricodene Sugar Free, Nalspan, Sinulin, Allerest Maximum Strength, Singlet, Allerest Sinus, Codral Cold and Flu + Cough Day and Night, Clorfed, Respa-AR, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Deconamine, Colrex, Duralex, Dura-Vent/A, Sinapils, Onset Forte, Suclor, ScopoHist Syrup, DriHist, Duradryl Chewable, AlleRx Dose Pack (PM Dose), Mintex, Re2+30, Pediox Chewable, Hayfebrol Liquid, Rhinolar, AlleRx Dose Pack, Ah-Chew Ultra Tannate, Sudal-12, Dallergy SR, Dallergy PE, Chlor-Trimeton Allergy Decongestant SR, CP-Tannic, Tavist-DA, DriHist SR, Dehistine, Dynahist-ER Pediatric, Genaphed Plus, Histade, Nohist Plus Jr, ScopoHist-PE, Nohist Plus, Atrohist Pediatric Capsule, Histex, Suphedrine Plus, Dallergy PSE, Curaler, Clorfed II, Fedahist Gyrocaps, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Amilon, Chlor-Trimeton Allergy Decongestant, Codimal-LA Half, Klerist-D, Chlorafed Timecelles, Time-Hist, Anamine TD, Rescon-Ed, Pseudochlor, Anamine, Anaplex, Relcof PSE, DryMax, Mescolor, PCM-LA, Amdry-C, Sudogest Plus, C-Phed Tannate, Coldamine, DuraHist, Xiral SR, AllePak, Rhinaclear, Histatab, RelCof DN PSE, ScopoHist, VisRx Dose Pack, Allergy AM-PM Dose Pack, Allergy DN, Pseudo CM TR, Ryna Liquid, Duradryl SR, Neutrahist Drops, Duratuss DA, SudaHist, NoHist EXT, Dexodryl, Allergy DN II, aeroHist, Allerx Dose Pack DF, Sudal-12 Tannate, Dicel, Nohist PE, RelCof DN PE, Sinodec, DuraTan PE, AH-Chew, Extendryl JR, Aerohist Plus, Ryneze, RelCof CPM, Cordron-HC, Cordron-HC NR, Atuss HS, Hydrocof-HC, Hydron PCS, P-V-Tussin Syrup, Hydrotuss HC, Notuss-Forte, Advil Allergy Sinus, SudoGest Sinus & Allergy, Sudogest Cold & Allergy, AlleRx DF, Advil Children's Allergy Sinus, Triaminic Softchews Cold and Allergy, AccuHist Drops (old formulation), Pseudoephedrine Plus, Extendryl SR, Prehist D, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Ah-chew Ultra, QV-Allergy, Extendryl Seniors, Denaze, Aerokid, Dallergy ER, Histatab PH, Chlor-Mes, Triall, SymPak PDX, Sudal-12 Chewable, Chlordrine SR, Allergy DN PE, PCM Allergy, Re-Drylex Jr, AH-Chew II, Omnihist II LA, Hista-Vent DA, DA II, Liqui-Allergy, Duravent DA, Omnihist L.A., Extendryl Chews, DA Chewable, Duradryl, Duradryl JR, Chlor-Mes D, Norel SD, Durahist PE, WE Allergy, Ex-Histine, Drize, Drysec, De-Congestine, Relera, Genamin, Triac, Rhinolar-EX, Allerest 12 Hour, Vanex Forte-R, Chlorex A, West-Decon M, NoHist-A, Phena-S, Chlorex-A 12, R-Tannate, Triotann-S, Gencold, Gelhist Pediatric, R-Tannate Pediatric, Atrohist Pediatric, Rynatan-S Pediatric, Nalex-A SR, C-Hist-SR, Naldelate, Andecon Pediatric Drops, Histalet Forte, Prop-A-Hist, Uni Decon, Nalgest, West-Decon, Vanex Forte, Dynahist ER, Q-Hist LA, Chlortox, Linhist-L.A., Comhist LA, Comhist, Qdall, Rhinacon A, R-Tannamine Pediatric, Triotann-S Pediatric, Tri-Gestan S, Tri-Hist Pediatric, Tri Tann Pediatric, Triotann Pediatric, Histatan, Contac 12 Hour, Triotann, Or-Phen-Ade, Resaid, Nalex A 12, Phena-S 12, Ornade Spansules, Rhinolar-EX 12, Pyrichlor PE, MyHist-PD, AllerTan, Conal, ARM Allergy Relief, Teldrin, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Tanamine Pediatric, Triple Tannate Pediatric, Tanoral Pediatric, Equitan Pediatric, Url-Tannate Pediatric, Tritan, Ordrine, Condrin, Chlornade, Decongex-3, URL-Tannate, Tanamine, R-Tannamine, Sinucon Pediatric, Nalgestic Pediatric, Histadec, PediaTan D, CP Dec, Tannate Pediatric, C Phen, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, Cardec Drops, P-Tann D, Cardec, Sildec-PE Drops, Sildec-PE, Ed ChlorPed D, Rinate Pediatric, Triaminic Cold & Allergy, ChlorTan D, Rondex Drops, Chlor-Mes Jr, BP Allergy JR, Ricobid NR, Ry-Tann, Dallergy JR, Novahistine, Kronofed-A, Isophen-DF, Ny-Tannic, Phenylhistine, Dallergy Drops, Ceron Drops, Allan Tannate Pediatric, Phenchlor Tannate Pediatric, Ed A-Hist LA, Novahistine Elixir, Histatab Plus, Allerest PE, Rhinatate-NF, Tanafed, Fedahist, Histalet, Chlorafed HS Timecelles, Codimal-LA, Fedahist Timecaps, Dura-Tap/PD, Kronofed-A-Jr, Durafed, Duotan, Histade CR, Nalphen, Nalda-Relief Pediatric, Biohist LA, Chlor-Trimeton Decongestant, Novafed A, KG-Tussin, Chlorphedrin SR, Colfed-A, Tanahist-D, Sonahist, Nuhist, AccuHist Drops, CP Dec Drops, PD-Hist D Drops, PD-Hist D, Suphedrine PE Sinus & Allergy, NoHist LQ, Pseudocot-C, Deconomed SR, D-Amine-SR, Rinade-BID, Suphenamine-SR, Trigofen Drops, Hista-Vadrin, ND Clear, Tuss-HC, Tanni-Hist 12 RF, Exratuss, Tannic-12, DryMax AF, Tannate-12, Carbaphen 12, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Ricobid H, Pharbechlor, Wal-finate, ChlorTan, Ed Chlor-Tan, TanaHist-PD, Chlorpheniramine (Allergy), PediaTan, C.P.M., Chlor-Mal, Chlo-Amine, Tetra Tannate Pediatric, Tuss Tan Pediatric, Tussi-12, Tussizone-12 RF, Tussi-12S, Tannate 12 S, Tannic-12 S, SymPak II, AccuHist LA, Bellahist-D LA, Ru-Tuss, Trionate, C-Tanna 12, Rentamine Pediatric, Rentamine, Tuss Tan, Rynatuss, Quadratuss, Tustan 12S, Quad-Tuss, Rynatuss Pediatric, Chlor-Phenit, Topco Allergy, Tricodene SF, QC Cough/Cold, Vicks Pediatric Formula 44m Cough & Cold Relief, Effective Strength Cough Syrup, Scot-Tussin DM, Tricode AR, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Primatuss 4, Triaminic Softchews Cough & Runny Nose, Cold & Cough, St. Joseph HBP Cough & Cold, SymPak DM, Carepanto, Vicks Children's Nyquil, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Novadyne DH, Phenylhistine DH Expectorant, Codeprex, Notuss-AC, Zodryl AC, TL-Hist CM, Cotab AX, Cotab A, Teldrin HBP Allergy, Z-Tuss AC, Endacof-C, Codar AR, Endal CD, Phenylhistine DH, Decohistine DH, Codehist DH, Dihistine DH, Demi-Cof, T- Koff, Pediacof, Pedituss, Ex-Tuss, Protuss Tablet, Comtrex Maximum Strength Cold Relief, Comtrex Cold and Flu Maximum Strength, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Cold Multi-Symptom (Nighttime), Multi Symptom Cold Relief, Alka-Seltzer Plus Flu Formula, Dimetapp Children's Multi-Symptom Cold & Flu, Multi Symptom Cold (Night Formula), Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Gelpirin-CCF, Dryphen, Protid, Gendecon, Alka-Seltzer Plus-D, Triaminic Flu, Cough & Fever, Childrens Tylenol Cold Plus Cough, Theraflu Flu & Cough, Allpanto-S, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Alka-Seltzer Plus Cold & Cough Formula Liquid, Tylenol Plus Children's Cough & Runny Nose, Triaminic Multi-Symptom Fever, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Congestant, Cotabflu, Colrex Compound, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Theraflu Nighttime Severe Cold & Cough Caplets, Comtrex Cold & Cough Day Night, Dimetapp Children's Nighttime Flu, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Dristan Cold Multi Symptom Formula, Comtrex Severe Cold & Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Sinutab Ex-Strength, Tylenol Allergy Sinus, Comtrex Allergy Sinus, Codimal, Kolephrin, Triaminicin, Sinutab Maximum Strength Caplets, Atrohist Plus, Deconhist LA, Rolatuss-SR, Alka-Seltzer Plus Cold & Cough Formula, Alka-Seltzer Plus Flu Formula (old formulation), Allergy Sinus Maximum Strength, Rolatuss, Quelidrine, Tricom, Comtrex Nighttime Flu Therapy, HEB Allergy, Allergy Pain Relief, Allergy Sinus PE Pain Relief, GNP Cold Relief Plus, Alka-Seltzer Plus Cold & Flu, Robitussin Peak Cold Nighttime Nasal Relief, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Contac Cold + Flu (Night Formula), Tylenol Sinus Congestion and Pain Cool Burst Day Night, ConRx Allergy Sinus, Duadacin, Alumadrine, Comtrex Sinus and Nasal, Chlor-Trimeton Sinus, Rhinogesic, Hybrid CF, Covangesic, Trital SR, Genelan NF, Zotex-DM, Nasatuss, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Chemdal HD Plus, Vanex-HD, Ed-TLC, Efasin-HD, Guiaphen HD, Cyndal HD, Tuss-PD, Enplus-HD, Comtussin HC, Hycomine Compound, Ventuss Syrup, Endal-HD Plus, Exo-Tuss, KG-Dal HD, Ditussin-HC, Chemtussin HC, Iodal HD, Chemdal HD, Allfen A, Z-Tuss 2, SymPak, Qual-Tussin Pediatric, Ana-Kit, Bronkotuss, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, P Chlor GG, Lemohist Plus, Maxi-Tuss HCX, Relacon-HC, Endagen-HD, Mintuss MS, Coughtuss, S-T Forte 2, HyTan, Hydrocodone GF, Maxi-Tuss SA, KG-Dal HD Plus, Poly-Tussin HD, Z-Cof HC, Neo HC, Liquicough HC, Tusana-D, Relacon-HC NR, Rindal HD Plus, Echotuss-HC, Phendal-HD, DroTuss-CP, Detuss, Hexatussin, Tussin-V, Q-V Tussin, Notuss, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Uni-Tricof HC, Hydro-PC II Plus, Quindal HD Plus, Quindal HD, Hi-Tuss HC, Chlorphen HD, Efasin-HD Plus, Tuss-DS, Highland HC, Uni Tuss HC, Cytuss HC, Duradal HD, Liquitussin HC Syrup, De-Chlor HD, De-Chlor HC, Atuss MS, Hydron CP, Hydro-PC II, Hydrocodone CP, Tussive HC, B-Tuss, Tricof, Pancof, Tussplex DM, C-Phen DM Drops, Sildec-PE DM Drops, Relahist-DM, Reme Tussin DM, Cardec DM Drops, HistadecDM, CP Dec DM, Neo DM Drops, Maxichlor PEH DM, Sonahist-DM, Zotex-12D, Quartuss DM, Donatussin DM Drops, Nohist-DMX, PD-Cof, PD-Cof Drops, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, Dec-Chlorphen DM Drops, Dec-Chlorphen DM, Norel DM, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Liquituss R-DM, PE-Hist DM, ChlorDex GP, ED DM, Ricotuss, Tri-Vent DPC, Atuss DR, Donatussin DM, Rondex-DM, Rondex-DM Drops, Dex PC, P Chlor DM, Corfen-DM, Uni-Tuss DM, Mintuss DR, Z-Dex 12 D, NoHist-PDX, Tanafed-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Children's Nyquil, Kidcare Cough and Cold, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Atuss DS, Maxichlor PSE DM, DiHydro-PE, Duohist DH, Tusscough DHC, Novahistine DH, CPM-PSE DM Drops, Neutrahist PDX Drops, AccuHist PDX Drops, Entre-S, Rhinosyn-DM, T-Tanna DM, Robitussin Cough & Allergy, Tri-Dex PE, Trigofen DM Drops, Virdec DM, Nasohist-DM Pediatric, RE DCP Drops, DCP Drops, Centergy DM, NeoTuss Plus, Zoden DM Drops, Kophane, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, Therahist, Cheracol Plus, Threamine DM, Tricodene Forte, Tricodene NN, A-G Tussin

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Possible Effects on Lactation

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Administrative Information

LactMed Record Number

64

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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