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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, M-End DM, Chlor-Trimeton, Theraflu Flu, Cold and Cough Powder, Norel AD, Triaminic, Tylenol Cold, Coricidin D, Show all 805 »Ed A-Hist, Coricidin HBP Cough & Cold, TussiCaps, Allergy Relief, Sudafed PE Sinus & Allergy, Ceron-DM, Coldcough Syrup, Zutripro, Cold Medicine Plus, Advil Allergy Sinus, Children's Nyquil, Coricidin HBP Maximum Strength Flu, Sinarest, PCM, Ed A-Hist DM, CapCof, Triplex AD, NoHist DM, Hydrocodone CP, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Aller-Chlor, Stahist, Phenagil CH, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Allerest Maximum Strength, Notuss-Forte, Sinutab Ex-Strength, Naldecon, Ornade Spansules, Relasin-HC, Dicel, NoHist, Lexuss 210, Endal CD, Scot-Tussin DM, Chlorex-A 12, Tylenol Allergy Multi-Symptom, Contac Cold + Flu (Night Formula), Tuzistra XR, Sinus & Allergy PE, Condrin, Vituz, Contac Cold and Flu Maximum Strength, Novahistine DH, Histinex HC, Multi Symptom Cold Relief, Ordrine, LoHist-D, Triant-HC, Teldrin, Demazin, Tannic-12 S, Singlet, Coricidin HBP Multi-Symptom Cold (Night), Deconamine, Ceron, Rondec, R-Tanna, Sonahist, Phena-S, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Tanamine, Ru-Hist Forte, Ru-Tuss, Rentamine, Quadratuss, Carbaphen CH, Poly Hist PD (old formulation), Nalex A 12, Triac, Nasohist-DM Pediatric, PCM-LA, Tricof, Ana-Kit, Coldamine, Lohist, Novahistine, Nuhist, Novasus, Exo-Tuss, CPM-PE-MSC, Dexodryl Suspension, Rescon Extended Release, Ah-chew Ultra, Coughtuss, Quindal HD, Allerest PE, Rynatan, Effective Strength Cough Syrup, Rondec-DM, Nalex-A, Linhist-LA, Endacof-C, Coldex, Rondex-DM Drops, Nasohist-DM, Actifed Cold and Allergy, Rondex, Cardec, Dex PC, Quartuss DM, Centergy DM, Tuxarin ER, Nalspan, Anaplex, Anamine, Brexin LA, Duralex, Fedahist, XL-3 Xtra Cold and Cough, Simplet, Mintex, Codral Cold and Flu + Cough Day and Night, Multi Symptom Cold (Night Formula), Coricidin HBP Day & Night Multi-Symptom Cold, Sinulin, Suclor, Novafed A, Orlenta, Sinapils, Deconamine SR, Trital SR, Triaminic Multi-Symptom Fever, Allergy Multi-Symptom, XL-3 Cold Medicine, Genacol Maximum Strength, Duadacin, Atrohist Pediatric Capsule, Durahist PE, AH-Chew II, Omnihist II LA, Aerokid, AlleRx Dose Pack PE (PM Dose), QV-Allergy, Extendryl Seniors, Redur-PCM, Chlor-Trimeton Allergy Decongestant SR, Denaze, Dallergy ER, Ralix, Drysec, Omnihist L.A., Duravent DA, Tavist-DA, Hista-Vent DA, DA Chewable, Extendryl Chews, Dynahist-ER Pediatric, Extendryl SR, Prehist D, DA II, Liqui-Allergy, Ex-Histine, WE Allergy, Chlor-Mes D, Histatab PH, Drize, AH-Chew, Duradryl, Duradryl JR, Norel SD, AlleRx Dose Pack, VisRx Dose Pack, Histatab, Amilon, Allergy AM-PM Dose Pack, ScopoHist, Rhinaclear, Allergy DN, Pseudo CM TR, Nolamine, SudoGest Sinus & Allergy, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Histafed LA, Sudogest Plus, Neutrahist Drops, Genaphed Plus, Sudogest Cold & Allergy, Ryna Liquid, AllePak, Time-Hist QD, Rhinolar, Suphedrine Plus, Hayfebrol Liquid, CP-Tannic, DriHist, PCM Allergy, Re-Drylex Jr, Extendryl JR, DryMax, DuraHist, Mescolor, Hista-Vent PSE, Amdry-C, Relcof PSE, Dallergy PSE, Xiral SR, RelCof DN PSE, Chlor-Mes, Dallergy SR, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Hydron PCS, Hydrotuss HC, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Atuss HD, Atuss HS, RelCof CPM, AlleRx DF, Allergy DN II, Pseudoephedrine Plus, Advil Children's Allergy Sinus, Advil Allergy and Congestion Relief, Qdall, Q-V Tussin, Tussin-V, Maxi-Tuss HCX, Relacon-HC, Dynahist ER, Z-Cof HC, DroTuss-CP, Neo HC, Poly-Tussin HD, Liquicough HC, Notuss, Detuss, Welltuss HC, Hexatussin, Hyphed, Tussend, Pediatex HC, Histinex PV, JayCof-HC, NoHist EXT, RespiVent DF, Nohist Plus, Nohist Plus Jr, Chlorafed, Re2+30, Sudal-12, DuraTan PE, C-Phed Tannate, Pediox Chewable, Duradryl Chewable, Aerohist Plus, Triall, SymPak PDX, ScopoHist-PE, Ah-Chew Ultra Tannate, Histade, Duradryl SR, Dallergy PE, Allergy DN PE, AlleRx Dose Pack (PM Dose), AccuHist Drops (old formulation), SudaHist, Duravent, Triaminic Softchews Cold and Allergy, Ryneze, aeroHist, Allerx Dose Pack DF, Dexodryl, Dehistine, DriHist SR, Sudal-12 Tannate, Sudal-12 Chewable, De-Congestine, ScopoHist Syrup, RelCof PE, Nohist PE, RelCof DN PE, Sinodec, NoHist LQ, Duratuss DA, Biohist LA (old formulation), Durafed, Clorfed, Histalet, West-Decon M, Chlorafed HS Timecelles, Tanafed, Atrohist Pediatric, Rynatan-S Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Equitan Pediatric, R-Tannamine Pediatric, Triotann-S, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Chlorex A, Nalex-A SR, Chlorphedrin SR, NoHist-A, Rhinacon A, Colfed-A, D-Amine-SR, Vanex Forte, Pseudocot-C, Deconomed SR, Comhist, Comhist LA, Dura-Tap/PD, Kronofed-A-Jr, Codimal-LA, Fedahist Timecaps, C-Hist-SR, Q-Hist LA, Chlortox, Duotan, Chlor-Trimeton Decongestant, Rhinolar-EX 12, Dura-Vent/A, Resaid, MyHist-PD, Phena-S 12, AllerTan, Conal, Pyrichlor PE, Or-Phen-Ade, Contac 12 Hour, Equi-Nade, Gencold, Rhinolar-EX, Decongex-3, Chlornade, ARM Allergy Relief, Vanex Forte-R, Allerest 12 Hour, Tri Tann Pediatric, Phena-Plus, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tri-Tannate Pediatric, Tanamine Pediatric, Triple Tannate Pediatric, Histade CR, Tri-Tannate, Tritan, R-Tannamine, Triotann Pediatric, Tri-Gestan S, Tri-Hist Pediatric, Histatan, Triotann, Tanoral, URL-Tannate, Histalet Forte, Andecon Pediatric Drops, PD-Hist D Drops, Ceron Drops, PD-Hist D, Dallergy Drops, Nasohist Pediatric, Ed A-Hist LA, Rynatan Pediatric, Phenchlor Tannate Pediatric, Tanahist-D, Allan Tannate Pediatric, Time-Hist, Anamine TD, Chlordrine SR, Chlorafed Timecelles, Rescon-Ed, CP Dec Drops, Cophene No 2, Pseudochlor, Histatab Plus, Novahistine Elixir, Relera, Genamin, AlleRx, Dallergy JR, Klerist-D, Clorfed II, Fedahist Gyrocaps, Codimal-LA Half, Ricobid NR, Suphedrine PE Sinus & Allergy, Trigofen Drops, AccuHist Drops, Phenylhistine, Rhinatate-NF, Ny-Tannic, BP Allergy JR, Virdec, ND Clear, Chlor-Mes Jr, Suphenamine-SR, Rinade-BID, Nalphen, Isophen-DF, Tusana-D, Ry-Tann, Hista-Vadrin, Kronofed-A, Nalda-Relief Pediatric, Nalgestic Pediatric, Prop-A-Hist, Sinucon, Naldelate, Uni Decon, West-Decon, Sinucon Pediatric, Nalgest, Maxichlor PEH, Sildec-PE, Tannate Pediatric, Histadec, PediaTan D, C Phen, C Phen Drops, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, CP Dec, Cardec Drops, Ed ChlorPed D, Sildec-PE Drops, Acta-Tabs PE, Rinate Pediatric, ChlorTan D, P-Tann D, Triaminic Cold & Allergy, Curaler, Hyphen-HD, XiraTuss, Tanni-Hist 12 RF, Exratuss, Tussi-12 (old formulation), Tannate-12, Carbaphen 12, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tannic-12, DryMax AF, Ricobid H, Pharbechlor, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Topco Allergy, Ed-Chlortan, P-Tann, TanaHist-PD, Ed ChlorPed, Tetra Tannate Pediatric, Tuss Tan Pediatric, Histacol LA, Respa-AR, SymPak II, Tustan 12S, Bellahist-D LA, AccuHist LA, Deconhist LA, Rolatuss-SR, Protuss Tablet, Ex-Tuss, Tussi-12S, Tussi-12, Rynatuss Pediatric, Rynatuss, Rentamine Pediatric, Tuss Tan, Quad-Tuss, C-Tanna 12, Tussizone-12 RF, Tannate 12 S, Trionate, Chlo-Amine, Chlorphen, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Vicks Children’s NyQuil Cold & Cough, Novadyne DH, Phenylhistine DH Expectorant, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Tricodene SF, QC Cough/Cold, Robitussin Cough & Cold Long-Acting, Carepanto, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Robitussin Children's Cough & Cold Long-Acting, Dimetapp Children's Long Acting Cough Plus Cold, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Tricode AR, Dihistine DH, Ed Chlor-Tan, Allergy Time, Chlor-Phenit, Z-Tuss AC, ChlorTan, Wal-finate, Chlor-Trimeton Allergy SR, PediaTan, Chlorpheniramine (Allergy), Zodryl AC, Codar AR, T- Koff, Pediacof, Pedituss, Demi-Cof, Notuss-AC, Codeprex, TL-Hist CM, Cotab A, Cotab AX, Atrohist Plus, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Triaminic Multi-Symptom Fever & Cold, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, ConRx Allergy Sinus, Co-Apap, Allpanto-S, Comtrex Cold and Flu Maximum Strength Liquid, Childrens Tylenol Cold Plus Cough, Theraflu Flu & Cough, Cold Multi-Symptom (Nighttime), Dimetapp Children's Multi-Symptom Cold & Flu, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Tylenol Plus Children's Cough & Runny Nose, Tylenol Plus Children's Multi-Symptom Cold, Mapap Cough & Sinus Formula, PediaCare Cough & Runny Nose Plus Acetaminophen, Congestant, Cotabflu, Colrex Compound, Colrex, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Tylenol Cold Head Congestion Nighttime, Tylenol Cold Multi-Symptom Nighttime, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Allergy Pain Relief, Allergy Sinus PE Pain Relief, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Codimal, Comtrex Allergy Sinus, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tricom, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Actifed Cold & Sinus, Allergy Sinus Maximum Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Alumadrine, Rhinogesic, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, GNP Cold Relief Plus, Onset Forte, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Comtrex Flu Therapy, Tylenol Plus Children's Cold, HEB Allergy, Dryphen, Covangesic, Norel SR, Alka-Seltzer Plus Cold & Flu, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Protid, Hybrid CF, Sine-Off Sinus/Cold, Triaminic Night Time Cough & Runny Nose, St. Joseph HBP Cough & Cold, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, Hydrocodone GF, P Chlor GG, SymPak, Uni-Cof, Bronkotuss, Allfen A, Z-Tuss 2, S-T Forte 2, HyTan, Efasin-HD, Guiaphen HD, Mintuss MS, Vanex-HD, Ed-TLC, Rindal-HD, Endagen-HD, Chemdal HD, Iodal HD, Dihydro-CP, Hydro-Tussin DHC, AccuHist PDX Drops, CPM-PSE DM Drops, Esocor P, Mesehist DM, Neutrahist PDX Drops, Kidkare Cough/Cold, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Triaminic-D Multi-Symptom Cold, Allres DS, Despec-PD, Duohist DH, Tusscough DHC, Pancof, Pancof-PD, Coldcough PD, Duotan DM, T-Tanna DM, DiHydro-PE, Chemdal HD Plus, Nasatuss, Duradal HD, Liquitussin HC Syrup, Hydrocodone HD, Tussive HC, Chlorphen HD, Hi-Tuss HC, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, B-Tuss, Hydro-PC II, Uni-Tricof HC, Rindal HD Plus, Echotuss-HC, Phendal-HD, Hydro-PC II Plus, Atuss MS, Hydron CP, De-Chlor HD, De-Chlor HC, Histussin HC Liquid, H-C Tussive, Tuss-PD, KG-Dal HD, Endotuss-HD, Ditussin-HC, Hycomine Compound, Cyndal HD, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Chemtussin HC, Endal-HD Plus, Maxi-Tuss HC, KG-Dal HD Plus, Highland HC, Uni Tuss HC, Maxi-Tuss SA, Ventuss Syrup, Enplus-HD, Comtussin HC, Tuss-HC, Atuss-12 DM, C-Phed DM, DCP Drops, EndaCof Drops, PE-Hist DM, Maxichlor PEH DM, Sildec-PE DM, Sildec-PE DM Drops, Cardec DM, C-Phen DM, Robitussin Cough & Allergy, C-Phen DM Drops, ED DM, Poly-Tussin DM, Zoden DM Drops, Phenabid DM, Re DCP, Sonahist-DM, Virdec DM, Trigofen DM Drops, Ricotuss, Tri-Dex PE, Z-Dex 12 D, Norel CS, Tussplex DM, Genelan NF, Zotex-DM, Neotuss D, Extendryl DM, Quartuss, Qual-Tussin, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Broncopectol, ChlorDex GP, Donatussin DM, Ceron-DM Drops, Neo DM Drops, Cardec DM Drops, Balamine DM, Reme Tussin DM, CP Dec DM, HistadecDM, Rondex-DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, RE DCP Drops, Nohist-DMX, P Chlor DM, Tricodene Forte, Tricodene NN, Cheracol Plus, Trital DM, Mintuss DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Therahist, Triphenicol, Creomulsion Pediatric, Kidcare Cough and Cold, Rescon-DM, Tanafed-DM, Creomulsion Cough/Cold/Allergy, Vicks 44M Pediatric, Kophane, Threamine DM, Rhinosyn-DM, Coldtuss-DR, De-Chlor DR, PD-Cof, Zotex-12D, Statuss DM, NoHist-PDX, PD-Cof Drops, CP Dec-DM Drops, Bronkids, Donatussin DM Drops, DM-PE-Chlor, Relahist-DM, Albatussin SR, Father John's Medicine Plus, Norel DM, NeoTuss Plus, De-Chlor DM, Atuss DM, Liquituss R-DM, Cerose DM, Maxiphen ADT, Tussar DM, Relacon-HC NR

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

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