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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Coricidin HBP Cough & Cold, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Norel AD, Alka-Seltzer Plus Cold Formula, Zutripro, CapCof, Tylenol Cold, Show all 797 »Coricidin D, Sudafed PE Sinus & Allergy, Rondec, TussiCaps, Chlor-Trimeton Allergy SR, Stahist, Sinarest, Sinodec, Allergy Relief, NoHist DM, Cold Medicine Plus, Coughtuss, Ed A-Hist DM, Dristan Cold Multi Symptom Formula, Theraflu Flu, Cold and Cough Powder, Sinutab Ex-Strength, Cardec, R-Tanna, Chlor-Trimeton Sinus, Ceron-DM, PCM, Vituz, Codral Cold and Flu + Cough Day and Night, Deconamine SR, Brexin LA, Coricidin HBP Day & Night Multi-Symptom Cold, Deconamine, Chlorphen, Triplex AD, Notuss-AC, Tuzistra XR, Advil Allergy Sinus, Duralex, Tylenol Allergy Multi-Symptom, Hybrid CF, Triaminic Softchews Cough & Runny Nose, AlleRx, Ditussin-HC, Vanex Forte, Triaminic, Demazin, Kophane, Dimetapp Children's Multi-Symptom Cold & Flu, Rynatan, Ryna-C, Nuhist, Lohist, Sinus & Allergy PE, Codimal, RespiVent DF, PD-Cof, Ricotuss, Poly-Tussin DM, R-Tannate, Codeprex, Klerist-D, Mintex, Orlenta, AllerTan, Hydrocodone GF, DCP Drops, Sildec-PE DM, Esocor P, Aller-Chlor, Vanex-HD, Rondec-DM, Wal-finate, Carepanto, Effective Strength Cough Syrup, Contac 12 Hour, Condrin, Triaminic Multi-Symptom Fever, Pancof, Congestant, Carbaphen CH, Kidkare Cough/Cold, M-End DM, Tritan, Xiral SR, Poly Hist PD (old formulation), Tanamine, VisRx Dose Pack, Coldamine, Kidcare Cough and Cold, Hyphed, Rynatuss, Coldcough Syrup, Phenylhistine DH, Nalex-A, Rentamine, Tetra Tannate Pediatric, Tusscough DHC, Linhist-LA, Dihydro-CP, Tussi-12, Sinarest Extra Strength, Neotuss D, Ed A-Hist, Phenchlor Tannate Pediatric, PCM Allergy, Aerokid, Phenylhistine, Allergy Multi-Symptom, Novahistine, Naldecon, Suphedrine PE Sinus & Allergy, Novafed A, Protid, Extendryl Chews, Duravent, Tussar DM, Cerose DM, Tri-Vent DPC, Dallergy Drops, Actifed Cold and Allergy, Phenabid DM, C-Phen DM Drops, Tylenol Cold Head Congestion Day and Night, Comtrex Day and Night, Balamine DM, Norel CS, Nolamine, Allerest PE, Ru-Hist Forte, Allerest Sinus, SudoGest Sinus & Allergy, Allerest Maximum Strength, Dynahist-ER Pediatric, Suclor, Sinulin, LoHist-D, Singlet, Anaplex, Norel SR, Hydrocodone HD, Relasin-HC, Quindal HD, Ricobid NR, Rhinatate-NF, Relera, Sonahist, Ny-Tannic, DuraHist, Trigofen Drops, NoHist LQ, AccuHist Drops, ScopoHist, Dallergy JR, Rynatan Pediatric, Histatab Plus, Novahistine Elixir, PCM-LA, Time-Hist QD, BP Allergy JR, Histatab, Amdry-C, Amilon, Hista-Vent PSE, Mescolor, Pseudo CM TR, Allergy AM-PM Dose Pack, Ed A-Hist LA, Allergy DN, Dallergy PSE, Relcof PSE, AllePak, Rhinaclear, RelCof DN PSE, Drize, Dexodryl Suspension, Dexodryl, Ryneze, Dehistine, Allerx Dose Pack DF, aeroHist, RelCof CPM, AlleRx DF, Allergy DN II, NoHist EXT, DriHist SR, Nohist PE, DuraTan PE, Nohist Plus, Nohist Plus Jr, Dallergy SR, Allergy DN PE, AlleRx Dose Pack (PM Dose), RelCof DN PE, RelCof PE, ScopoHist Syrup, Advil Children's Allergy Sinus, Advil Allergy and Congestion Relief, Tussend, Welltuss HC, Hexatussin, Tussin-V, Pediatex HC, JayCof-HC, Notuss-Forte, Notuss, Detuss, Histinex PV, Q-V Tussin, A-G Tussin, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Hydrocof-HC, Hydron PCS, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Duradryl Chewable, Aerohist Plus, Denaze, Dallergy ER, Extendryl Seniors, QV-Allergy, Ralix, AH-Chew II, Chlor-Mes D, Norel SD, Durahist PE, Omnihist II LA, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Extendryl JR, DriHist, AlleRx Dose Pack, Rhinolar, Re-Drylex Jr, Chlor-Mes, Redur-PCM, Ah-chew Ultra, Histatab PH, WE Allergy, Ex-Histine, SymPak PDX, ScopoHist-PE, Extendryl SR, Prehist D, Triall, Ah-Chew Ultra Tannate, Duradryl SR, Dallergy PE, CPM-PE-MSC, DA Chewable, Omnihist L.A., Duradryl, Duradryl JR, Nasohist Pediatric, Drysec, AH-Chew, Liqui-Allergy, Duravent DA, Hista-Vent DA, DA II, DryMax, Nalphen, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Fedahist, Histalet, Biohist LA (old formulation), Duratuss DA, Clorfed, Dura-Tap/PD, Fedahist Timecaps, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, Pseudocot-C, Deconomed SR, Chlorphedrin SR, Colfed-A, D-Amine-SR, Durafed, Duotan, Or-Phen-Ade, ARM Allergy Relief, Teldrin, Chlornade, Resaid, Ornade Spansules, MyHist-PD, Rhinolar-EX 12, Dura-Vent/A, Ordrine, Decongex-3, Allerest 12 Hour, Vanex Forte-R, Histade CR, Chlor-Trimeton Decongestant, Genamin, Triac, Equi-Nade, Gencold, Rhinolar-EX, ND Clear, Chlordrine SR, Histade, Re2+30, Sudal-12, Pediox Chewable, CP-Tannic, Tavist-DA, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, C-Phed Tannate, De-Congestine, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Dynahist ER, AccuHist Drops (old formulation), SudaHist, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, Hayfebrol Liquid, Genaphed Plus, Cophene No 2, Anamine, Codimal-LA Half, Fedahist Gyrocaps, Pseudochlor, Rescon-Ed, Anamine TD, Time-Hist, Chlorafed Timecelles, Clorfed II, Curaler, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Sudogest Plus, Aller-Chlor Decongestant, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Phena-S 12, Pyrichlor PE, NoHist, Maxichlor PEH, Ry-Tann, Hista-Vadrin, Sildec-PE, Acta-Tabs PE, Rinate Pediatric, Ed ChlorPed D, Sildec-PE Drops, Relacon-HC, Nalda-Relief Pediatric, Uni Decon, Prop-A-Hist, Sinucon, Naldelate, Nalspan, West-Decon, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, ChlorTan D, Triaminic Cold & Allergy, CP Dec Drops, Chlor-Mes Jr, Rondex, Rondex Drops, Allan Tannate Pediatric, Tanahist-D, PD-Hist D Drops, Ceron Drops, PD-Hist D, Dec-Chlorphen, Dec-Chlorphen Drops, CP Dec, Cardec Drops, P-Tann D, PediaTan D, Histadec, C Phen Drops, C Phen, Tannate Pediatric, Andecon Pediatric Drops, Histalet Forte, Url-Tannate Pediatric, R-Tannamine, Tanoral, URL-Tannate, Rhinatate, Rhinatate Pediatric, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Triotann, Histatan, Phena-Plus, Tri Tann Pediatric, Nalex A 12, Conal, Tri-Hist Pediatric, Tri-Gestan S, Phena-S, Triotann Pediatric, Chlorex-A 12, Triple Tannate Pediatric, Equitan Pediatric, Chlortox, C-Hist-SR, Nalex-A SR, Chlorex A, Q-Hist LA, Comhist LA, NoHist-A, Rhinacon A, Comhist, Coldex, West-Decon M, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Triotann-S, Gelhist Pediatric, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Ceron, Exo-Tuss, Carbaphen 12, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Tannic-12, Quad Tann, Tuss Tan, Tuss Tan Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Exratuss, DryMax AF, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, C.P.M., Ed-Chlortan, Ed ChlorPed, Ricobid H, P-Tann, TanaHist-PD, Rentamine Pediatric, Quadratuss, AccuHist LA, Bellahist-D LA, Histacol LA, Ru-Tuss, Ex-Tuss, Protuss Tablet, Atrohist Plus, Deconhist LA, Rolatuss-SR, Respa-AR, SymPak II, Trionate, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Tannate 12 S, Tussizone-12 RF, Tustan 12S, Tussi-12S, Tannic-12 S, Chlor-Mal, Chlo-Amine, Co-Histine DH, Codahistine-DH Elixir, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, Novadyne DH, Phenylhistine DH Expectorant, Zodryl DAC, Decohistine DH, Codehist DH, QC Cough/Cold, Primatuss 4, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Cold & Cough, Robitussin Cough & Cold Long-Acting, Tricodene Sugar Free, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Tricode AR, Dihistine DH, Chlor-Phenit, Z-Tuss AC, Zodryl AC, Tuxarin ER, Allergy Time, Ed Chlor-Tan, PediaTan, Chlorpheniramine (Allergy), ChlorTan, Codar AR, TL-Hist CM, T- Koff, Pediacof, Pedituss, Demi-Cof, Endal CD, Endacof-C, Cotab A, Cotab AX, Lexuss 210, Alka-Seltzer Plus Cold & Cough Formula, Alka-Seltzer Plus Flu Formula (old formulation), Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Alka-Seltzer Plus Flu Formula, Multi Symptom Cold Relief, Comtrex Nighttime Cold & Cough, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Allpanto-S, Co-Apap, Childrens Tylenol Cold Plus Cough, Genacol Maximum Strength, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Theraflu Nighttime Severe Cold & Cough Caplets, Comtrex Cold & Cough Day Night, PediaCare Cough & Runny Nose Plus Acetaminophen, Coricidin HBP Maximum Strength Flu, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Colrex, Sinapils, Cotabflu, Colrex Compound, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Tylenol Plus Children's Cough & Runny Nose, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Alka-Seltzer Plus-D, Triaminic Flu, Cough & Fever, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Comtrex Allergy Sinus, Comtrex Sinus and Nasal, Duadacin, Trital SR, Rhinogesic, Alumadrine, Kolephrin, Tylenol Allergy Sinus, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Rolatuss, Quelidrine, Sinutab Maximum Strength Caplets, Triaminicin, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Covangesic, Dryphen, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, Allergy Sinus PE Pain Relief, Allergy Pain Relief, Gelpirin-CCF, Contac Cold + Flu (Night Formula), ConRx Allergy Sinus, GNP Cold Relief Plus, Gendecon, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Alka-Seltzer Plus Cold & Flu, HEB Allergy, XL-3 Cold Medicine, Tylenol Plus Children's Cold, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, SymPak DM, Broncopectol, Rindal-HD, Ed-TLC, Efasin-HD, Guiaphen HD, Iodal HD, Chemdal HD, S-T Forte 2, HyTan, Novasus, Endagen-HD, Mintuss MS, Chemdal HD Plus, Hyphen-HD, Tuss-PD, KG-Dal HD, Endotuss-HD, Cyndal HD, Ed-Tuss HC, Nasatuss, Iotussin HC, Chlorgest HD, Lemohist Plus, Qual-Tussin Pediatric, DiHydro-PE, Coldcough PD, Pancof-PD, Despec-PD, Novahistine DH, T-Tanna DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, Duohist DH, Tricof, Z-Tuss 2, SymPak, P Chlor GG, Donatussin Pediatric, Allfen A, Ana-Kit, Hydro-Tussin DHC, Uni-Cof, Bronkotuss, Chemtussin HC, Hycomine Compound, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Triant-HC, De-Chlor HD, Hydron CP, Tussive HC, B-Tuss, Hydro-PC II, Uni-Tricof HC, Rindal HD Plus, Poly-Tussin HD, Liquicough HC, DroTuss-CP, Z-Cof HC, Neo HC, Tusana-D, Echotuss-HC, Phendal-HD, Relacon-HC NR, Hydrocodone CP, Liquitussin HC Syrup, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Ventuss Syrup, Tuss-HC, Endal-HD Plus, Enplus-HD, Comtussin HC, Highland HC, Uni Tuss HC, Quindal HD Plus, Hi-Tuss HC, Chlorphen HD, Duradal HD, Efasin-HD Plus, Tuss-DS, H-C Tussive, Histussin HC Liquid, Cytuss HC, Mesehist DM, CPM-PSE DM Drops, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Virdec DM, ED DM, Maxichlor PEH DM, Sildec-PE DM Drops, EndaCof Drops, PE-Hist DM, Zoden DM Drops, Re DCP, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, Donatussin DM Drops, Bronkids, Sonahist-DM, RE DCP Drops, Nohist-DMX, Robitussin Cough & Allergy, C-Phen DM, Extendryl DM, Donatussin DM, Ceron-DM Drops, Rondex-DM, Zotex-DM, Genelan NF, ChlorDex GP, Qual-Tussin, Quartuss, Rondex-DM Drops, Dec-Chlorphen DM, Cardec DM Drops, Reme Tussin DM, Tussplex DM, Cardec DM, Nasohist-DM Pediatric, Neo DM Drops, Dec-Chlorphen DM Drops, HistadecDM, CP Dec DM, Zotex-12D, Quartuss DM, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Threamine DM, Triphenicol, Tricodene NN, Cheracol Plus, Therahist, Children's Nyquil, Rescon-DM, Entre-S, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, Atuss DS, Dicel DM, Tanafed-DM, C-Phed DM, Atuss-12 DM, Tricodene Forte, Dex PC, Liquituss R-DM, Centergy DM, Atuss DM, Father John's Medicine Plus, Maxiphen ADT, Albatussin SR, Statuss DM, NoHist-PDX, Relahist-DM, Norel DM, NeoTuss Plus, Uni-Tuss DM, Mintuss DR, Trital DM, P Chlor DM, Corfen-DM, Atuss DR, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Maxi-Tuss HCX

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

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