Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Coricidin HBP Cold & Flu, TussiCaps, Zutripro, Tylenol Cold, Coricidin HBP Cough & Cold, Alka-Seltzer Plus Cold, Anaplex, Norel AD, Show all 785 »Allergy Relief, Norel CS, Sinarest, Vituz, Theraflu Flu, Cold and Cough Powder, Triant-HC, Triplex AD, Norel SR, Chlor-Trimeton Allergy SR, Rondec, Triaminic, M-End DM, Ceron-DM, Sudafed PE Sinus & Allergy, Coricidin D, AlleRx, Ordrine, Advil Allergy and Congestion Relief, Cardec, Chlorphen, Allergy Multi-Symptom, Duravent DA, Coldamine, Ed A-Hist, Chlor-Trimeton Allergy Decongestant, Alka-Seltzer Plus Cold Formula, NoHist, Sinutab Ex-Strength, Comtrex Allergy Sinus, Stahist, Rondec-DM, Coricidin HBP Maximum Strength Flu, Quindal HD, Histinex HC, Wal-finate, Duadacin, Triac, Teldrin, Ru-Hist Forte, Coldex, CapCof, XiraTuss, R-Tannamine, Coldcough Syrup, Contac 12 Hour, PCM, Duralex, Allerest Maximum Strength, XL-3 Cold Medicine, Sildec-PE DM, Orlenta, Novafed A, Lohist, Sinus & Allergy PE, Rynatan, XL-3 Xtra Cold and Cough, Allerx Dose Pack DF, Dexodryl, Rynatuss Pediatric, Nolamine, Dicel DM, Hydrocodone CP, Triaminic Multi-Symptom Fever, Hydrocodone HD, Coughtuss, Denaze, Ru-Tuss, Omnihist L.A., Tanni-Hist 12 RF, Tannate 12 S, Ornade Spansules, Rentamine, Demazin, Condrin, Equi-Nade, Effective Strength Cough Syrup, Norel DM, Corfen-DM, Trital DM, Atuss DM, Cerose DM, Phenabid DM, Maxiphen ADT, C-Phen DM, NeoTuss Plus, Ed ChlorPed D, Allerest PE, Ceron, Ny-Tannic, NoHist DM, Actifed Cold and Allergy, Naldecon, Nalspan, Lexuss 210 Liquid, Codar AR, Xiral SR, Zodryl AC, Novahistine DH, Pancof, Pancof-PD, R-Tannate, Scot-Tussin DM, Tricodene NN, Tricodene Forte, CPM-PSE DM Drops, Esocor P, Cold & Cough, Chlorex A, P Chlor GG, Rynatuss, Colrex, Hybrid CF, Tussend, Sinapils, Covangesic, Codimal, Simplet, Alumadrine, Coricidin HBP Day & Night Multi-Symptom Cold, Advil Allergy Sinus, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, Relacon-HC, CPM-PE-MSC, Allergy DN II, aeroHist, Genacol Maximum Strength, Kolephrin, Coricidin HBP Multi-Symptom Cold (Night), Cyndal HD, Liquitussin HC Syrup, Histex, Dicel, LoHist-D, Clorfed, Deconamine SR, Relasin-HC, Chemdal HD Plus, Deconamine, Curaler, Vanex-HD, Allan Tannate Pediatric, Chlor-Mes Jr, AlleRx DF, Extendryl JR, RelCof CPM, Dexodryl Suspension, RespiVent DF, NoHist EXT, Ryneze, Relcof PSE, RelCof DN PE, Nohist PE, Sinodec, RelCof DN PSE, Histatab, DuraTan PE, ScopoHist, Amilon, AH-Chew, Ceron Drops, DryMax, Aerohist Plus, Atuss HD, BP Allergy JR, Ricobid NR, Relera, Dallergy JR, Novahistine, Ry-Tann, Phenylhistine, Rynatan Pediatric, Histatab Plus, R-Tanna, Phenchlor Tannate Pediatric, Novahistine Elixir, Tussin-V, Q-V Tussin, Cordron-HC NR, Cordron-HC, Ed A-Hist LA, Atuss HS, Notuss-Forte, Hydrocof-HC, Hydron PCS, A-G Tussin, Dallergy Drops, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Advil Children's Allergy Sinus, Amdry-C, ScopoHist-PE, Dehistine, DriHist SR, SymPak PDX, Omnihist II LA, Ralix, AH-Chew II, Nohist Plus, Nohist Plus Jr, Duravent, RelCof PE, Norel SD, Durahist PE, Dallergy PE, Ah-Chew Ultra Tannate, Aerokid, Triall, Redur-PCM, AlleRx Dose Pack PE (PM Dose), Rondex, Chlor-Mes, Ah-chew Ultra, Histatab PH, Rescon Extended Release, QV-Allergy, Allergy DN PE, Duradryl SR, Re-Drylex Jr, Dallergy ER, PCM Allergy, Extendryl Seniors, Duradryl Chewable, DriHist, Extendryl Chews, PCM-LA, DA Chewable, Hista-Vent DA, Hista-Vent PSE, DA II, Time-Hist QD, AllePak, VisRx Dose Pack, Prehist D, Allergy AM-PM Dose Pack, Pseudo CM TR, Rhinaclear, Allergy DN, Mescolor, Dallergy PSE, Drysec, Drize, Ex-Histine, WE Allergy, ScopoHist Syrup, Chlor-Mes D, AlleRx Dose Pack (PM Dose), Dallergy SR, DuraHist, Liqui-Allergy, Duradryl, Duradryl JR, AlleRx Dose Pack, Rhinolar, Extendryl SR, Nalgestic Pediatric, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Chlorphedrin SR, Codimal-LA, Chlorafed HS Timecelles, Histalet, Fedahist, Tanafed, Colfed-A, D-Amine-SR, Kronofed-A, ND Clear, Chlordrine SR, Anamine TD, Isophen-DF, Suphenamine-SR, Deconomed SR, Pseudocot-C, Rinade-BID, Durafed, Duotan, Resaid, Or-Phen-Ade, ARM Allergy Relief, Chlornade, Dura-Vent/A, Rhinolar-EX 12, MyHist-PD, Pyrichlor PE, Phena-S 12, Decongex-3, Gencold, Dynahist ER, Histade CR, Chlor-Trimeton Decongestant, Qdall, Vanex Forte-R, Rhinolar-EX, Genamin, Allerest 12 Hour, Time-Hist, Chlorafed Timecelles, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Re2+30, Suclor, CP-Tannic, Histade, Mintex, Sudal-12 Chewable, Sudal-12 Tannate, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, AccuHist Drops (old formulation), Biohist LA (old formulation), SudoGest Sinus & Allergy, Sudogest Cold & Allergy, SudaHist, Duratuss DA, Neutrahist Drops, Dynahist-ER Pediatric, Tavist-DA, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Anamine, Cophene No 2, Brexin LA, Rescon-Ed, Pseudochlor, Chlorafed, Histafed LA, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Hayfebrol Liquid, Genaphed Plus, Aller-Chlor Decongestant, Sudogest Plus, Ryna Liquid, Conal, AllerTan, NoHist LQ, Trigofen Drops, Hista-Vadrin, Nalphen, Suphedrine PE Sinus & Allergy, Acta-Tabs PE, Tanahist-D, Sonahist, Nuhist, Nalda-Relief Pediatric, Hyphed, Sinucon, Naldelate, Andecon Pediatric Drops, Histalet Forte, Prop-A-Hist, Uni Decon, Sinucon Pediatric, Nalgest, West-Decon, AccuHist Drops, CP Dec Drops, Histadec, PediaTan D, CP Dec, Cardec Drops, Tannate Pediatric, C Phen, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, P-Tann D, Triaminic Cold & Allergy, Nasohist Pediatric, PD-Hist D Drops, PD-Hist D, Rhinatate-NF, Sildec-PE, ChlorTan D, Rinate Pediatric, Sildec-PE Drops, Vanex Forte, Nalex-A, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tri-Tannate Pediatric, Tanamine Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanamine, Tanoral, Tri-Hist Pediatric, Tri Tann Pediatric, Poly Hist PD (old formulation), Nalex A 12, Tri-Gestan S, Triotann Pediatric, URL-Tannate, Triotann, Histatan, Tanoral Pediatric, Triotann-S Pediatric, Linhist-L.A., C-Hist-SR, Nalex-A SR, West-Decon M, Chlortox, Q-Hist LA, Rhinacon A, Comhist, Comhist LA, NoHist-A, Phena-S, Gelhist Pediatric, Triotann-S, R-Tannamine Pediatric, R-Tannate Pediatric, Rynatan-S Pediatric, Chlorex-A 12, Phena-Plus, Atrohist Pediatric, Rondex Drops, Exo-Tuss, Aller-Chlor, Ed ChlorPed, Pharbechlor, C.P.M., Ricobid H, DryMax AF, Exratuss, Tannic-12, Carbaphen CH, Chlor-Mal, Chlo-Amine, Chlor-Phenit, Topco Allergy, Ed-Chlortan, Teldrin HBP Allergy, TanaHist-PD, Ed Chlor-Tan, PediaTan, Chlorpheniramine (Allergy), ChlorTan, Tannate-12, Carbaphen 12, Tussi-12, Tussizone-12 RF, Tussi-12S, Trionate, Tannic-12 S, SymPak II, AccuHist LA, Bellahist-D LA, Respa-AR, C-Tanna 12, Tustan 12S, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tuss Tan Pediatric, Tuss Tan, Quad-Tuss, Quadratuss, Rentamine Pediatric, Allergy Time, Z-Tuss AC, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Primatuss 4, Vicks Pediatric Formula 44m Cough & Cold Relief, Tricode AR, Tricodene SF, QC Cough/Cold, Robitussin Cough & Cold Long-Acting, Vicks Children's Nyquil, Genelan NF, Zotex-DM, Broncopectol, ChlorDex GP, SymPak DM, Triaminic Night Time Cough & Runny Nose, Carepanto, St. Joseph HBP Cough & Cold, Vicks Children’s NyQuil Cold & Cough, Zodryl DAC, Codahistine-DH Elixir, TL-Hist CM, Endal CD, T- Koff, Pediacof, Notuss-AC, Codeprex, Endacof-C, Cotab A, Cotab AX, Pedituss, Demi-Cof, Novadyne DH, Co-Histine DH, Ryna-C, Phenylhistine DH Expectorant, Codehist DH, Dihistine DH, Phenylhistine DH, Decohistine DH, Ex-Tuss, Protuss Tablet, Comtrex Maximum Strength Cold Relief, Comtrex Cold and Flu Maximum Strength, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Cold Multi-Symptom (Nighttime), Multi Symptom Cold Relief, Alka-Seltzer Plus Flu Formula, Dimetapp Children's Multi-Symptom Cold & Flu, Multi Symptom Cold (Night Formula), Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D, Gelpirin-CCF, Dryphen, Allpanto-S, Theraflu Flu & Cough, Comtrex Cold and Flu Maximum Strength Liquid, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Alka-Seltzer Plus Cold & Cough Formula Liquid, Tylenol Plus Children's Cough & Runny Nose, Flu Relief BP, Vicks NyQuil Cold & Flu Relief (Alcohol Free), Tylenol Plus Children's Multi-Symptom Cold, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Congestant, Cotabflu, Colrex Compound, Tylenol Plus Children's Flu, Dimetapp Children's Nighttime Flu, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Theraflu Nighttime Severe Cold & Cough Caplets, Comtrex Cold & Cough Day Night, Codral Cold and Flu + Cough Day and Night, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Protid, Gendecon, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Comtrex Allergy Sinus Maximum Strength, Tylenol Allergy Sinus, Singlet, Tricom, Allerest Sinus, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Alka-Seltzer Plus Cold & Cough Formula, Atrohist Plus, Deconhist LA, Rolatuss-SR, Alka-Seltzer Plus Flu Formula (old formulation), Quelidrine, Cold Medicine Plus, Actifed Cold & Sinus, Rolatuss, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Robitussin Peak Cold Nighttime Nasal Relief, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Allergy Pain Relief, Contac Cold + Flu (Night Formula), Pyrroxate, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Allergy Sinus PE Pain Relief, Onset Forte, Rhinogesic, Sinulin, Chlor-Trimeton Sinus, Trital SR, Sine-Off Sinus/Cold, GNP Cold Relief Plus, Tylenol Sinus Congestion and Pain Cool Burst Day Night, ConRx Allergy Sinus, Qual-Tussin, Quartuss, Ed-TLC, Efasin-HD, Guiaphen HD, Nasatuss, Rindal-HD, Iodal HD, Maxi-Tuss HCX, Endagen-HD, Chemdal HD, Iotussin HC, Chlorgest HD, Ditussin-HC, Chemtussin HC, Hycomine Compound, Endal-HD Plus, Endotuss-HD, KG-Dal HD, Ed-Tuss HC, Hyphen-HD, Tuss-PD, Mintuss MS, Hydrocodone GF, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Coldcough PD, Tusscough DHC, DiHydro-PE, Duohist DH, Despec-PD, Bronkotuss, Ana-Kit, Lemohist Plus, S-T Forte 2, HyTan, Novasus, Qual-Tussin Pediatric, Donatussin Pediatric, Allfen A, Z-Tuss 2, SymPak, Enplus-HD, Comtussin HC, Echotuss-HC, Phendal-HD, Relacon-HC NR, Tusana-D, Rindal HD Plus, Uni-Tricof HC, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Poly-Tussin HD, Z-Cof HC, Pediatex HC, Welltuss HC, JayCof-HC, Notuss, Histinex PV, Detuss, Neo HC, Liquicough HC, DroTuss-CP, De-Chlor HD, Hydron CP, Highland HC, Uni Tuss HC, H-C Tussive, Histussin HC Liquid, KG-Dal HD Plus, Maxi-Tuss HC, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Cytuss HC, Tuss-DS, Tussive HC, B-Tuss, Hydro-PC II, Duradal HD, Chlorphen HD, Efasin-HD Plus, Quindal HD Plus, Hi-Tuss HC, Kidkare Cough/Cold, Mesehist DM, Cardec DM Drops, Reme Tussin DM, Tussplex DM, Cardec DM, Neo DM Drops, CP Dec DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, C-Phen DM Drops, Sildec-PE DM Drops, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, DM-PE-Chlor, Nasohist-DM, Relahist-DM, Maxichlor PEH DM, Sonahist-DM, Rondex-DM Drops, Rondex-DM, Tussar DM, Liquituss R-DM, De-Chlor DM, De-Chlor DR, PE-Hist DM, Ricotuss, Extendryl DM, ED DM, Poly-Tussin DM, Coldtuss-DR, Tri-Vent DPC, Dex PC, Donatussin DM, Ceron-DM Drops, P Chlor DM, Ed A-Hist DM, Atuss DR, Uni-Tuss DM, Mintuss DR, Quartuss DM, Donatussin DM Drops, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, T-Tanna DM, Duotan DM, Therahist, Triaminic-D Multi-Symptom Cold, Allres DS, Kidcare Cough and Cold, Children's Nyquil, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, Entre-S, Atuss DS, Atuss-12 DM, Rescon-DM, Tanafed-DM, C-Phed DM, Cheracol Plus, Threamine DM, Centergy DM, Father John's Medicine Plus, RE DCP Drops, Nasohist-DM Pediatric, DCP Drops, NoHist-PDX, Nohist-DMX, Z-Dex 12 D, Bronkids, Robitussin Cough & Allergy, Tri-Dex PE, Balamine DM, Triphenicol, Kophane, Albatussin SR, EndaCof Drops, Trigofen DM Drops, Virdec DM, Zoden DM Drops, Hexatussin

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Possible Effects on Lactation

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Administrative Information

LactMed Record Number

64

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

Hide
(web2)