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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Chlor-Trimeton, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Norel AD, Triaminic, Alka-Seltzer Plus Cold Formula, CapCof, Tylenol Cold, Show all 798 »Sinarest, Coricidin D, Chlor-Trimeton Allergy SR, Theraflu Flu, Cold and Cough Powder, Rynatan, NoHist DM, TussiCaps, Rondec, Zutripro, Allergy Relief, Ed A-Hist, Sildec-PE DM, Sudafed PE Sinus & Allergy, Sinutab Ex-Strength, Clorfed, Sinodec, Coughtuss, Stahist, Advil Allergy Sinus, Vituz, SudoGest Sinus & Allergy, Tylenol Cold Multi-Symptom Nighttime, Chlorphen, Norel SR, XL-3 Cold Medicine, Codimal, Klerist-D, AlleRx, Trigofen Drops, Sinus & Allergy PE, Coricidin HBP Day & Night Multi-Symptom Cold, Triplex AD, Deconamine, Rondec-DM, Lohist, Wal-finate, Notuss-AC, Allergy Multi-Symptom, Dimetapp Children's Multi-Symptom Cold & Flu, Coldex, Ed A-Hist DM, Triant-HC, Contac 12 Hour, SymPak, Cold Medicine Plus, Brexin LA, Hydrocodone GF, Duralex, Cardec, Genelan NF, Condrin, Codahistine-DH Elixir, Phenylhistine DH, Duravent, Aller-Chlor, Vanex Forte, Norel CS, Kidcare Cough and Cold, Poly-Tussin DM, Extendryl Chews, R-Tannate, Coldamine, PCM, Detuss, Tanoral, Welltuss HC, Esocor P, CPM-PSE DM Drops, QC Cough/Cold, Effective Strength Cough Syrup, Bronkotuss, Tanamine, Gelhist Pediatric, Carepanto, Tritan, T-Tanna DM, DuraHist, Tricodene Sugar Free, Kidkare Cough/Cold, Carbaphen CH, Teldrin, Ordrine, Rynatuss, Demazin, Dura-Vent/A, Ru-Tuss, Tussi-12, Phenylhistine DH Expectorant, Rentamine, Coldcough Syrup, Pancof, Pharbechlor, Nolamine, Codeprex, Xiral SR, Amilon, Triphenicol, AlleRx Dose Pack, Chlor-Trimeton Sinus, aeroHist, RespiVent DF, RelCof CPM, Advil Allergy and Congestion Relief, Naldecon, Comtrex Day and Night, Ralix, Dehistine, Neotuss D, Reme Tussin DM, Phenabid DM, Cordron-HC, Q-V Tussin, Coricidin HBP Maximum Strength Flu, Atuss HD, Tylenol Cold Head Congestion Day and Night, Quartuss DM, Maxiphen ADT, De-Chlor DM, Aerokid, Dexodryl Suspension, Phenylhistine, Allerest Maximum Strength, R-Tanna, Ceron, Novahistine, Hydron CP, DryMax, Trital SR, Vanex-HD, Hydrocodone HD, Sudogest Cold & Allergy, Quartuss, Rondex, Tanahist-D, Hybrid CF, Extendryl Seniors, Allerest Sinus, Actifed Cold and Allergy, Anaplex, Sinucon, Histatab Plus, NoHist LQ, Ed A-Hist LA, Sonahist, Novahistine Elixir, Suphedrine PE Sinus & Allergy, Rhinatate-NF, AccuHist Drops, Relera, Ny-Tannic, BP Allergy JR, Allerest PE, Ricobid NR, RelCof DN PSE, Allergy DN, Nuhist, Rhinaclear, Pseudo CM TR, ScopoHist, VisRx Dose Pack, Allergy AM-PM Dose Pack, AllePak, Time-Hist QD, Relcof PSE, Dallergy PSE, Histatab, Mescolor, Hista-Vent PSE, Amdry-C, PCM-LA, Dallergy JR, AH-Chew, Dexodryl, Ryneze, DriHist SR, Nohist PE, Allerx Dose Pack DF, NoHist EXT, Advil Children's Allergy Sinus, AlleRx DF, Allergy DN II, RelCof DN PE, RelCof PE, Nohist Plus Jr, Dallergy SR, Duradryl Chewable, Nohist Plus, DuraTan PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Allergy DN PE, Atuss HS, Cordron-HC NR, Histinex PV, JayCof-HC, Pediatex HC, Notuss, Notuss-Forte, Z-Cof HC, Maxi-Tuss HCX, Relacon-HC, Tussend, Hexatussin, Hydrotuss HC, Hydron PCS, Hydrocof-HC, P-V-Tussin Syrup, KG-Tussin, Hyphed, Tussin-V, A-G Tussin, Aerohist Plus, Duradryl SR, AH-Chew II, Denaze, Dallergy ER, QV-Allergy, Omnihist II LA, Durahist PE, WE Allergy, Chlor-Mes D, Norel SD, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Re-Drylex Jr, Extendryl JR, DriHist, PCM Allergy, Chlor-Mes, Redur-PCM, Ah-chew Ultra, Histatab PH, Ex-Histine, Drysec, ScopoHist-PE, Extendryl SR, Prehist D, SymPak PDX, Triall, Dallergy PE, CPM-PE-MSC, Ah-Chew Ultra Tannate, DA Chewable, Omnihist L.A., Duradryl, Duradryl JR, Drize, Rynatan Pediatric, Liqui-Allergy, Duravent DA, Hista-Vent DA, DA II, Rhinolar, Hista-Vadrin, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Codimal-LA, Chlorafed HS Timecelles, Histalet, Fedahist, Tanafed, Chlorphedrin SR, Colfed-A, Isophen-DF, Kronofed-A, ND Clear, Chlordrine SR, Suphenamine-SR, Rinade-BID, D-Amine-SR, Deconomed SR, Pseudocot-C, Duratuss DA, Novafed A, Chlornade, Decongex-3, Equi-Nade, Gencold, ARM Allergy Relief, Or-Phen-Ade, Rhinolar-EX 12, Ornade Spansules, Resaid, Rhinolar-EX, Triac, Duotan, Durafed, Biohist LA (old formulation), Deconamine SR, Chlor-Trimeton Decongestant, Histade CR, Genamin, Allerest 12 Hour, Vanex Forte-R, Anamine TD, Time-Hist, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, Suclor, Mintex, Dynahist-ER Pediatric, CP-Tannic, Histade, De-Congestine, Sudal-12 Chewable, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Dynahist ER, LoHist-D, AccuHist Drops (old formulation), Dicel, Sudal-12 Tannate, SudaHist, Tavist-DA, Chlor-Trimeton Allergy Decongestant SR, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Curaler, Anamine, Cophene No 2, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Chlorafed, Histafed LA, Genaphed Plus, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Ryna Liquid, Neutrahist Drops, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, MyHist-PD, Phena-S 12, Maxichlor PEH, Ry-Tann, DroTuss-CP, Nalphen, NoHist, Sildec-PE, Ed ChlorPed D, Sildec-PE Drops, Acta-Tabs PE, Nalda-Relief Pediatric, Nalgestic Pediatric, Prop-A-Hist, Naldelate, Andecon Pediatric Drops, Histalet Forte, Uni Decon, Nalspan, Sinucon Pediatric, Nalgest, West-Decon, Rinate Pediatric, ChlorTan D, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, Rondex Drops, PD-Hist D, Ceron Drops, Nasohist Pediatric, Dallergy Drops, PD-Hist D Drops, Dec-Chlorphen, Dec-Chlorphen Drops, CP Dec, Cardec Drops, P-Tann D, Triaminic Cold & Allergy, PediaTan D, Histadec, C Phen Drops, C Phen, Tannate Pediatric, NoHist-A, Nalex-A, Triotann, Ru-Hist Forte, Histatan, Phena-S, URL-Tannate, R-Tannamine, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Triotann Pediatric, Chlorex-A 12, AllerTan, Conal, Pyrichlor PE, Poly Hist PD (old formulation), Nalex A 12, Tri Tann Pediatric, Tri-Gestan S, Tri-Hist Pediatric, Phena-Plus, Tri-Tannate Pediatric, Tanamine Pediatric, Chlortox, C-Hist-SR, Nalex-A SR, Chlorex A, Q-Hist LA, Comhist LA, Rhinacon A, Comhist, Linhist-LA, West-Decon M, Atrohist Pediatric, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Tri-Tannate, Triotann-S Pediatric, R-Tannamine Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Triotann-S, Phenchlor Tannate Pediatric, Chemtussin HC, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tuss Tan Pediatric, Tuss Tan, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Rentamine Pediatric, Tannic-12, Carbaphen 12, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, DryMax AF, Exratuss, Tannate-12, XiraTuss, Tanni-Hist 12 RF, C-Tanna 12, Trionate, Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Alka-Seltzer Plus Cold & Cough Formula, Alka-Seltzer Plus Flu Formula (old formulation), Actifed Cold & Sinus, Rolatuss, Quelidrine, Ex-Tuss, AccuHist LA, Tussi-12S, Tannic-12 S, Tussizone-12 RF, Tannate 12 S, Tustan 12S, SymPak II, Bellahist-D LA, Histacol LA, Respa-AR, Ed-Chlortan, Topco Allergy, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Decohistine DH, Zodryl DAC, Pedituss, Demi-Cof, Dihistine DH, Tricode AR, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, Cold & Cough, Vicks Children's Nyquil, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Robitussin Cough & Cold Long-Acting, Robitussin Children's Cough & Cold Long-Acting, Primatuss 4, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Pediacof, T- Koff, Chlorpheniramine (Allergy), ChlorTan, Ed Chlor-Tan, Allergy Time, PediaTan, Chlo-Amine, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Chlor-Phenit, Z-Tuss AC, Tuzistra XR, Lexuss 210, Endacof-C, Endal CD, Cotab AX, Cotab A, Zodryl AC, Codar AR, TL-Hist CM, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Multi Symptom Cold Relief, Alka-Seltzer Plus Flu Formula, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Multi Symptom Cold (Night Formula), Cold Multi-Symptom (Nighttime), Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Comtrex Nighttime Cold & Cough, XL-3 Xtra Cold and Cough, Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Cough Formula M Multi-Symptom, Tylenol Cold Head Congestion Nighttime, Codral Cold and Flu + Cough Day and Night, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Triaminic Multi-Symptom Fever, PediaCare Cough & Runny Nose Plus Acetaminophen, Vicks NyQuil Cold & Flu Relief (Alcohol Free), Colrex, Colrex Compound, Sinapils, Congestant, Cotabflu, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Tylenol Plus Children's Flu, Tylenol Plus Children's Multi-Symptom Cold, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Allpanto-S, Co-Apap, Duadacin, Sinulin, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Alumadrine, Rhinogesic, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Dryphen, Covangesic, Singlet, Simplet, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Comtrex Allergy Sinus Maximum Strength, Tylenol Allergy Sinus, Tricom, Comtrex Allergy Sinus, Kolephrin, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Sine-Off Sinus/Cold, Allergy Pain Relief, Allergy Sinus PE Pain Relief, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, ConRx Allergy Sinus, Contac Cold + Flu (Night Formula), Alka-Seltzer Plus-D, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Relief-PE, Onset Forte, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Protid, Tylenol Sinus Congestion & Pain Nighttime, Tylenol Allergy Multi-Symptom, GNP Cold Relief Plus, Gendecon, Dristan Cold Multi Symptom Formula, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Endagen-HD, Chemdal HD, Iodal HD, Rindal-HD, Novasus, HyTan, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, S-T Forte 2, Ed-TLC, Efasin-HD, Chlorgest HD, Ed-Tuss HC, Cyndal HD, Hyphen-HD, Iotussin HC, Nasatuss, Guiaphen HD, Mintuss MS, Chemdal HD Plus, P Chlor GG, Z-Tuss 2, Allres DS, Duotan DM, Novahistine DH, DiHydro-PE, Triaminic-D Multi-Symptom Cold, Mesehist DM, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, Coldcough PD, Pancof-PD, Dihydro-CP, Uni-Cof, Ana-Kit, Allfen A, Hydro-Tussin DHC, Tricof, Despec-PD, Duohist DH, Tusscough DHC, Tuss-PD, KG-Dal HD, B-Tuss, Hydro-PC II, De-Chlor HD, De-Chlor HC, Tussive HC, Hydrocodone CP, Hi-Tuss HC, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, Atuss MS, Hydro-PC II Plus, Tusana-D, Neo HC, Poly-Tussin HD, Liquicough HC, Relacon-HC NR, Phendal-HD, Uni-Tricof HC, Rindal HD Plus, Echotuss-HC, Quindal HD, Quindal HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Ventuss Syrup, Endal-HD Plus, Exo-Tuss, Endotuss-HD, Ditussin-HC, Hycomine Compound, Maxi-Tuss SA, Maxi-Tuss HC, Histussin HC Liquid, Cytuss HC, Tuss-DS, Efasin-HD Plus, H-C Tussive, Uni Tuss HC, Histinex HC, KG-Dal HD Plus, Highland HC, Entre-S, Atuss DS, Maxichlor PEH DM, ED DM, Ricotuss, Tri-Dex PE, PE-Hist DM, EndaCof Drops, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, DCP Drops, Z-Dex 12 D, Trigofen DM Drops, Nohist-DMX, Bronkids, Donatussin DM Drops, Nasohist-DM, RE DCP Drops, Sonahist-DM, Virdec DM, Zoden DM Drops, Re DCP, C-Phen DM, Cardec DM, Extendryl DM, Donatussin DM, Ceron-DM Drops, Ceron-DM, Zotex-DM, Qual-Tussin, SymPak DM, Broncopectol, ChlorDex GP, Rondex-DM, Rondex-DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, Tussplex DM, Neo DM Drops, CP Dec DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, DM-PE-Chlor, CP Dec-DM Drops, Cheracol Plus, Therahist, Kophane, Threamine DM, Tricodene NN, Tricodene Forte, Trital DM, P Chlor DM, Dex PC, Rhinosyn-DM, Vicks 44M Pediatric, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Tanafed-DM, Rescon-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Children's Nyquil, Mintuss DR, Uni-Tuss DM, Relahist-DM, Albatussin SR, Cerose DM, Tussar DM, NoHist-PDX, Statuss DM, PD-Cof Drops, PD-Cof, Zotex-12D, Liquituss R-DM, Centergy DM, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Corfen-DM, De-Chlor DR, NeoTuss Plus, Atuss DM, Father John's Medicine Plus, Norel DM, Relasin-HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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