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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Chlor-Trimeton, Coricidin HBP Cough & Cold, M-End DM, Coricidin HBP Cold & Flu, Triaminic, Theraflu Flu, Cold and Cough Powder, Tylenol Cold, Ed A-Hist, Show all 805 »Coricidin D, Norel AD, TussiCaps, NoHist DM, Phenagil CH, Tritan, Allergy Relief, Coldcough Syrup, Deconamine, Sinarest, Ornade Spansules, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Zutripro, C-Phen DM, Chlor-Trimeton Allergy SR, Rondec, Advil Allergy Sinus, Allergy Multi-Symptom, Dristan Cold Multi Symptom Formula, Coricidin HBP Maximum Strength Flu, Triaminic Multi-Symptom Fever, Comtrex Cold and Flu Maximum Strength Tablet, Carbaphen CH, Stahist, Naldecon, Relasin-HC, Ricotuss, Ceron-DM, Tylenol Allergy Multi-Symptom, Sudafed PE Sinus & Allergy, Ceron, Histinex HC, Dicel, Tanafed, Codral Cold and Flu + Cough Day and Night, Contac Cold + Flu (Night Formula), Contac 12 Hour, Rentamine, Contac Cold and Flu Maximum Strength, CapCof, Tuzistra XR, Cold & Cough, Triplex AD, Allerest Maximum Strength, Isophen-DF, R-Tanna, LoHist-D, Acta-Tabs PE, Cold Medicine Plus, Ed A-Hist DM, Coricidin HBP Day & Night Multi-Symptom Cold, Duadacin, Rondec-DM, Allerest PE, Lohist, Phena-S, Condrin, ScopoHist, Hydro-Tussin DHC, Triac, Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Hydrocodone CP, Linhist-LA, Vituz, Effective Strength Cough Syrup, Pancof, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Pyrroxate, QV-Allergy, Cough Formula M Multi-Symptom, Dihydro-CP, AlleRx, Endal CD, DryMax, CPM-PE-MSC, Children's Nyquil, Novahistine DH, Rentamine Pediatric, Quadratuss, Ny-Tannic, PCM-LA, Ah-chew Ultra, Actifed Cold and Allergy, Teldrin, Ru-Tuss, PCM, C Phen, Tannic-12 S, Sinodec, Scot-Tussin DM, Vicks Children’s NyQuil Cold & Cough, Coldamine, Nalex-A, Tanamine, Ru-Hist Forte, Lexuss 210, Endacof-C, Kidkare Cough/Cold, Amdry-C, Notuss, Conal, AlleRx Dose Pack, Cotabflu, Ana-Kit, Dexodryl Suspension, Aller-Chlor, Chlorphen, Dexodryl, Histalet Forte, Wal-finate, Entre-S, Rondex, Anamine, Novafed A, XL-3 Cold Medicine, Comtrex Flu Therapy, Liquituss R-DM, Sinulin, Fedahist, Chlordrine SR, Coughtuss, Brexin LA, H-C Tussive, Quindal HD, Anaplex, Quartuss DM, Dex PC, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, De-Congestine, Nasohist-DM, Singlet, Qdall, Rondex-DM Drops, Sinutab Ex-Strength, Nasohist-DM Pediatric, Novasus, Theraflu Nighttime Severe Cold & Cough Caplets, Sildec-PE DM, NoHist LQ, Xiral SR, RelCof DN PSE, Relcof PSE, Mescolor, Hista-Vent PSE, Time-Hist QD, Dallergy PSE, Virdec, AccuHist Drops, Trigofen Drops, Phenylhistine, Novahistine Elixir, Histatab Plus, RelCof CPM, Rhinatate-NF, Rynatan, Suphedrine PE Sinus & Allergy, Ricobid NR, BP Allergy JR, DuraHist, AllePak, Sonahist, Pseudo CM TR, Hydron PCS, Novahistine, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Hydrotuss HC, Tussin-V, KG-Tussin, A-G Tussin, P-V-Tussin Syrup, Maxi-Tuss HCX, Nuhist, Atuss HD, Atuss HS, Allergy DN, Q-V Tussin, Advil Children's Allergy Sinus, Dallergy JR, Relera, Allergy AM-PM Dose Pack, VisRx Dose Pack, Nolamine, Relacon-HC, Amilon, Histatab, Advil Allergy and Congestion Relief, Rhinaclear, AlleRx Dose Pack PE (PM Dose), Dehistine, Prehist D, Extendryl Chews, Extendryl SR, Histinex PV, SymPak PDX, ScopoHist-PE, JayCof-HC, DA Chewable, Omnihist L.A., Detuss, DA II, Liqui-Allergy, Ed A-Hist LA, Duravent, Duravent DA, Hista-Vent DA, Triall, Pediatex HC, Aerohist Plus, Duradryl SR, Dallergy PE, Duradryl Chewable, Dallergy SR, Nohist Plus, Nohist Plus Jr, Ah-Chew Ultra Tannate, Allergy DN PE, Tussend, Nohist PE, DriHist SR, RelCof DN PE, RelCof PE, AlleRx Dose Pack (PM Dose), ScopoHist Syrup, AH-Chew, Hyphed, Redur-PCM, Histatab PH, Chlor-Mes, DuraTan PE, Rescon Extended Release, Welltuss HC, Dallergy ER, Extendryl Seniors, PCM Allergy, Re-Drylex Jr, NoHist EXT, Rhinolar, Allergy DN II, RespiVent DF, Hexatussin, Extendryl JR, DriHist, aeroHist, Aerokid, Drysec, Ex-Histine, WE Allergy, Drize, Duradryl JR, Notuss-Forte, Duradryl, Chlor-Mes D, Norel SD, Denaze, Ryneze, Allerx Dose Pack DF, Ralix, AH-Chew II, Durahist PE, Omnihist II LA, AlleRx DF, Nalgestic Pediatric, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Histalet, Clorfed, Biohist LA (old formulation), Deconamine SR, Duratuss DA, Fedahist Timecaps, Orlenta, Duralex, Rinade-BID, Suphenamine-SR, Kronofed-A, Pseudocot-C, Deconomed SR, Chlorphedrin SR, Colfed-A, D-Amine-SR, Durafed, Duotan, Resaid, Or-Phen-Ade, Demazin, ARM Allergy Relief, Dura-Vent/A, Rhinolar-EX 12, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, Chlornade, Ordrine, Allerest 12 Hour, Vanex Forte-R, Histade CR, Chlor-Trimeton Decongestant, Genamin, Rhinolar-EX, Decongex-3, Equi-Nade, Gencold, ND Clear, Anamine TD, CP-Tannic, Histade, Mintex, Suclor, Dynahist-ER Pediatric, Tavist-DA, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Re2+30, Sudal-12, AccuHist Drops (old formulation), Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Dynahist ER, SudaHist, Sudal-12 Tannate, Pediox Chewable, C-Phed Tannate, Sudal-12 Chewable, Hayfebrol Liquid, SudoGest Sinus & Allergy, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Cophene No 2, Pseudochlor, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Curaler, Chlorafed, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, Neutrahist Drops, Sudogest Plus, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Pyrichlor PE, AllerTan, Sildec-PE, NoHist, Maxichlor PEH, Ry-Tann, Sildec-PE Drops, Cardec, ChlorTan D, Rinate Pediatric, Ed ChlorPed D, Hista-Vadrin, Nalphen, Nalspan, Uni Decon, Prop-A-Hist, Sinucon, West-Decon, Nalgest, Nalda-Relief Pediatric, Z-Cof HC, Sinucon Pediatric, Triaminic Cold & Allergy, P-Tann D, Ceron Drops, PD-Hist D, Tanahist-D, Allan Tannate Pediatric, PD-Hist D Drops, Sinus & Allergy PE, Phenchlor Tannate Pediatric, Nasohist Pediatric, Dallergy Drops, CP Dec Drops, Chlor-Mes Jr, Histadec, PediaTan D, CP Dec, Cardec Drops, Tannate Pediatric, C Phen Drops, Rondex Drops, Dec-Chlorphen, Dec-Chlorphen Drops, Naldelate, Andecon Pediatric Drops, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, R-Tannamine, Tri-Tannate Pediatric, Tanamine Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanoral, URL-Tannate, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, Tri-Gestan S, Chlorex-A 12, Triotann, Histatan, Triotann Pediatric, Tanoral Pediatric, Triotann-S Pediatric, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Comhist LA, Comhist, Vanex Forte, NoHist-A, Rhinacon A, Chlorex A, Coldex, R-Tannate, Triotann-S, R-Tannamine Pediatric, Gelhist Pediatric, R-Tannate Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, Rynatan Pediatric, Tuss-PD, Carbaphen 12, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Tannic-12, Quad Tann, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Exratuss, Tussi-12 (old formulation), Ed-Chlortan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, Ed ChlorPed, TanaHist-PD, DryMax AF, Ricobid H, P-Tann, Tuss Tan, Rynatuss, Ex-Tuss, AccuHist LA, Bellahist-D LA, Histacol LA, Protuss Tablet, Rolatuss-SR, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets, Atrohist Plus, Deconhist LA, Respa-AR, SymPak II, Trionate, C-Tanna 12, Quad-Tuss, Rynatuss Pediatric, Tannate 12 S, Tussizone-12 RF, Tustan 12S, Tussi-12S, Tussi-12, C.P.M., Chlor-Mal, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Tricodene SF, Novadyne DH, Phenylhistine DH Expectorant, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, QC Cough/Cold, Primatuss 4, Carepanto, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, St. Joseph HBP Cough & Cold, Robitussin Cough & Cold Long-Acting, Robitussin Children's Cough & Cold Long-Acting, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Tricode AR, Dihistine DH, Allergy Time, Chlor-Phenit, Z-Tuss AC, Zodryl AC, Ed Chlor-Tan, ChlorTan, Chlo-Amine, PediaTan, Chlorpheniramine (Allergy), Tuxarin ER, Codar AR, T- Koff, Pediacof, Pedituss, Demi-Cof, Notuss-AC, Codeprex, TL-Hist CM, Cotab A, Cotab AX, Alka-Seltzer Plus Cold & Cough Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Theraflu Flu & Cough, Allpanto-S, Co-Apap, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Childrens Tylenol Cold Plus Cough, Genacol Maximum Strength, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Nighttime Cold & Cough, Tylenol Cold Head Congestion Day and Night, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), PediaCare Cough & Runny Nose Plus Acetaminophen, Colrex, Sinapils, Congestant, Colrex Compound, Tylenol Plus Children's Cough & Runny Nose, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Multi-Symptom Cold Plus Acetaminophen, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Tricom, Simplet, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Rolatuss, Quelidrine, Sinutab Maximum Strength Caplets, Triaminicin, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Alumadrine, Rhinogesic, Onset Forte, GNP Cold Relief Plus, Gendecon, Tylenol Sinus Congestion & Pain Nighttime, Relief-PE, Robitussin Peak Cold Nighttime Nasal Relief, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, Comtrex Severe Cold & Sinus, Tylenol Plus Children's Cold, Dryphen, Covangesic, Norel SR, Trital SR, HEB Allergy, Alka-Seltzer Plus Cold & Flu, Protid, Hybrid CF, Sine-Off Sinus/Cold, Robitussin Children's Nighttime Cough Long-Acting DM, SymPak DM, Endagen-HD, Chemdal HD, Iodal HD, Rindal-HD, HyTan, S-T Forte 2, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, Hydrocodone GF, Ed-TLC, Efasin-HD, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Cyndal HD, Nasatuss, Chemdal HD Plus, Guiaphen HD, Mintuss MS, Vanex-HD, P Chlor GG, SymPak, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Mesehist DM, Esocor P, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, DiHydro-PE, Coldcough PD, Uni-Cof, Bronkotuss, Allfen A, Z-Tuss 2, Tricof, Tusscough DHC, Pancof-PD, Despec-PD, Duohist DH, Hyphen-HD, Hycomine Compound, Hydron CP, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II, B-Tuss, Duradal HD, Liquitussin HC Syrup, Hydrocodone HD, Tussive HC, Hydro-PC II Plus, Triant-HC, Tusana-D, Neo HC, Poly-Tussin HD, Liquicough HC, Relacon-HC NR, Phendal-HD, Uni-Tricof HC, Rindal HD Plus, Echotuss-HC, Chlorphen HD, Hi-Tuss HC, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Exo-Tuss, Chemtussin HC, KG-Dal HD, Endotuss-HD, Ditussin-HC, Ventuss Syrup, Maxi-Tuss SA, Cytuss HC, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Histussin HC Liquid, Uni Tuss HC, Maxi-Tuss HC, KG-Dal HD Plus, Highland HC, Maxichlor PSE DM, Atuss DS, Maxichlor PEH DM, ED DM, Poly-Tussin DM, Tri-Dex PE, PE-Hist DM, EndaCof Drops, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, DCP Drops, Z-Dex 12 D, Trigofen DM Drops, RE DCP Drops, Nohist-DMX, Bronkids, Donatussin DM Drops, Sonahist-DM, Re DCP, Virdec DM, Zoden DM Drops, Phenabid DM, Cardec DM, Norel CS, Zotex-DM, Neotuss D, Extendryl DM, Donatussin DM, Genelan NF, Quartuss, Broncopectol, ChlorDex GP, Qual-Tussin, Ceron-DM Drops, Rondex-DM, Cardec DM Drops, Balamine DM, Reme Tussin DM, Tussplex DM, Neo DM Drops, CP Dec DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, DM-PE-Chlor, CP Dec-DM Drops, Cheracol Plus, Therahist, Triphenicol, Kophane, Tricodene NN, Tricodene Forte, Mintuss DR, Trital DM, P Chlor DM, Threamine DM, Rhinosyn-DM, Tanafed-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Rescon-DM, Kidcare Cough and Cold, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Uni-Tuss DM, Corfen-DM, Relahist-DM, Albatussin SR, Cerose DM, Maxiphen ADT, NoHist-PDX, Statuss DM, PD-Cof Drops, PD-Cof, Zotex-12D, Tussar DM, Centergy DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, De-Chlor DM, NeoTuss Plus, Atuss DM, Father John's Medicine Plus, Norel DM, DroTuss-CP

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

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