Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Chlor-Trimeton, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Zutripro, Triaminic, Tylenol Cold, Theraflu Flu, Cold and Cough Powder, TussiCaps, Show all 786 »Coldcough Syrup, Norel AD, Dallergy Drops, Triplex AD, Sinarest, Aller-Chlor, Coricidin D, Allergy Relief, Advil Allergy Sinus, CapCof, Triant-HC, Rondec-DM, Alka-Seltzer Plus Cold Formula, Sildec-PE DM, Ceron-DM, Wal-finate, Ralix, XL-3 Cold Medicine, NoHist DM, Z-Tuss AC, Stahist, Rondec, Ed A-Hist, Hydrocodone CP, Rynatan, Sudafed PE Sinus & Allergy, Qdall, Cardec DM, C-Phen DM, Deconamine, Naldecon, Xiral SR, Denaze, Sinus & Allergy PE, Rescon-DM, Singlet, Ceron, C Phen, Tanoral, Condrin, Rentamine, Nalex-A, Chlor-Trimeton Allergy SR, Triaminicin, Novasus, Norel CS, Chlorphen, Codimal, Notuss, Cough Formula M Multi-Symptom, Nalex A 12, Phena-S, Dihydro-CP, Endal CD, Pancof, Qual-Tussin Pediatric, Quad-Tuss, Demazin, ARM Allergy Relief, Quadratuss, Carbaphen CH, B-Tuss, Z-Cof HC, Coughtuss, C.P.M., C-Tanna 12, D-Amine-SR, Duralex, Dicel, Orlenta, Lexuss 210 Liquid, ChlorTan, S-T Forte 2, Z-Tuss 2, LoHist-D, Sinucon, P Chlor DM, Lohist, M-End DM, Trital DM, Norel DM, Ricotuss, Quartuss DM, P-V-Tussin Syrup, Q-V Tussin, Atuss DS, Triaminic-D Multi-Symptom Cold, PCM, Contac Cold and Flu Maximum Strength, JayCof-HC, Tussin-V, Welltuss HC, HistadecDM, C-Phen DM Drops, Histalet Forte, Tanahist-D, Advil Allergy and Congestion Relief, C Phen Drops, C-Hist-SR, QC Cough/Cold, West-Decon M, R-Tanna, Naldelate, Dallergy JR, Rondex-DM, Relera, West-Decon, AlleRx, H-C Tussive, Kidcare Cough and Cold, Children's Nyquil, Cheracol Plus, Maxichlor PSE DM, Kophane, Reme Tussin DM, Quartuss, CPM-PSE DM Drops, Rhinaclear, Mescolor, Allergy DN, Tanamine, Vanex Forte, Amilon, Demi-Cof, Donatussin DM, Dec-Chlorphen DM, Atuss DM, NeoTuss Plus, Tri-Vent DPC, Ed A-Hist DM, Phenabid DM, SymPak, Cardec DM Drops, Ana-Kit, DiHydro-PE, Vituz, Highland HC, Cophene No 2, Brexin LA, Anaplex, Allerest Maximum Strength, Actifed Cold & Sinus, Suphenamine-SR, Fedahist, Coricidin HBP Maximum Strength Flu, Allerx Dose Pack DF, Dexodryl Suspension, Duotan, Kolephrin, Histex, Tylenol Allergy Multi-Symptom, Allergy Pain Relief, Protid, Sine-Off Sinus/Cold, Alka-Seltzer Plus Cold & Flu, Vanex-HD, Comtrex Cold and Flu Maximum Strength Tablet, Suclor, Coricidin HBP Day & Night Multi-Symptom Cold, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Sinulin, Vicks NyQuil Cold & Flu Relief (Alcohol Free), Chlor-Trimeton Allergy Decongestant, Hydro-PC II, Tannic-12 S, Hydrocodone HD, Triac, Ordrine, Rynatuss, Ornade Spansules, Cytuss HC, Respa-AR, Ventuss Syrup, DuraTan PE, Nohist Plus, Triall, Nohist Plus Jr, Allergy DN PE, RelCof PE, ScopoHist Syrup, SymPak PDX, AlleRx Dose Pack (PM Dose), Ah-Chew Ultra Tannate, CPM-PE-MSC, Aerohist Plus, Duradryl SR, Dallergy PE, Rhinatate-NF, RelCof DN PE, Trigofen Drops, Dallergy SR, Duradryl Chewable, Ny-Tannic, Duravent, Novahistine, NoHist LQ, Sonahist, Ricobid NR, Nuhist, Allergy DN II, Atuss HS, Atuss HD, RelCof CPM, AlleRx DF, NoHist EXT, Suphedrine PE Sinus & Allergy, Ryneze, Advil Children's Allergy Sinus, Dehistine, DriHist SR, Dexodryl, aeroHist, ScopoHist-PE, BP Allergy JR, Allerest PE, RespiVent DF, Nohist PE, VisRx Dose Pack, AH-Chew II, Omnihist II LA, Rhinolar, Aerokid, AlleRx Dose Pack, Durahist PE, Norel SD, RelCof DN PSE, Dallergy PSE, DuraHist, Chlor-Mes D, DryMax, Dallergy ER, Extendryl Seniors, Histatab PH, Ah-chew Ultra, PCM Allergy, Chlor-Mes, AccuHist Drops, Redur-PCM, AlleRx Dose Pack PE (PM Dose), DriHist, QV-Allergy, Extendryl JR, Re-Drylex Jr, Rescon Extended Release, Relcof PSE, Hista-Vent PSE, Nolamine, DA II, Liqui-Allergy, Histatab, Allergy AM-PM Dose Pack, Hista-Vent DA, Duravent DA, Prehist D, Extendryl SR, Extendryl Chews, DA Chewable, Omnihist L.A., ScopoHist, Coldamine, WE Allergy, Ex-Histine, Time-Hist QD, Amdry-C, PCM-LA, AllePak, Drysec, AH-Chew, Pseudo CM TR, Duradryl, Duradryl JR, Drize, Sinodec, Ry-Tann, Histalet, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Clorfed, Duratuss DA, Biohist LA (old formulation), Deconamine SR, Novafed A, Kronofed-A-Jr, Dura-Tap/PD, Rinade-BID, Isophen-DF, Kronofed-A, ND Clear, Pseudocot-C, Deconomed SR, Fedahist Timecaps, Chlorphedrin SR, Colfed-A, Durafed, Chlor-Trimeton Decongestant, Dura-Vent/A, Resaid, Or-Phen-Ade, Contac 12 Hour, Rhinolar-EX 12, MyHist-PD, Pyrichlor PE, Poly Hist PD (old formulation), Phena-S 12, Teldrin, Chlornade, Allerest 12 Hour, Vanex Forte-R, Histade CR, Genamin, Rhinolar-EX, Decongex-3, Equi-Nade, Gencold, Chlordrine SR, Anamine TD, Histade, Mintex, Re2+30, Sudal-12, CP-Tannic, Dynahist-ER Pediatric, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Pediox Chewable, C-Phed Tannate, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Dynahist ER, AccuHist Drops (old formulation), SudaHist, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, Suphedrine Plus, Hayfebrol Liquid, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Anamine, Pseudochlor, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Curaler, Chlorafed, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Ryna Liquid, Neutrahist Drops, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Conal, AllerTan, Ed ChlorPed D, Cardec, Sildec-PE Drops, Acta-Tabs PE, Rinate Pediatric, Actifed Cold and Allergy, P-Tann D, Triaminic Cold & Allergy, ChlorTan D, Sildec-PE, NoHist, Sinucon Pediatric, Nalgest, Nalspan, Nalgestic Pediatric, Nalda-Relief Pediatric, Cordron-HC NR, Hista-Vadrin, Nalphen, Cardec Drops, CP Dec, Nasohist Pediatric, PD-Hist D Drops, Ceron Drops, PD-Hist D, Phenchlor Tannate Pediatric, Rynatan Pediatric, Novahistine Elixir, Histatab Plus, Ed A-Hist LA, Allan Tannate Pediatric, CP Dec Drops, Tannate Pediatric, Histadec, PediaTan D, Dec-Chlorphen Drops, Dec-Chlorphen, Chlor-Mes Jr, Rondex, Rondex Drops, Uni Decon, Prop-A-Hist, Rhinatate, Url-Tannate Pediatric, Tritan, R-Tannamine, Rhinatate Pediatric, Tri-Tannate Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanamine Pediatric, URL-Tannate, Triotann, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Tri-Gestan S, Chlorex-A 12, Ru-Hist Forte, Histatan, Triotann Pediatric, Equitan Pediatric, Tanoral Pediatric, Q-Hist LA, Chlortox, Linhist-L.A., Nalex-A SR, Comhist LA, Comhist, Andecon Pediatric Drops, NoHist-A, Rhinacon A, Chlorex A, Coldex, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, R-Tannate, Gelhist Pediatric, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Phenylhistine, Ditussin-HC, Tannic-12, Carbaphen 12, Tannate-12, XiraTuss, Quad Tann, Quad Tann Pediatric, Tuss Tan Pediatric, Tetra Tannate Pediatric, Quad Tuss Pediatric, Tanni-Hist 12 RF, Exratuss, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, Ed-Chlortan, Ed ChlorPed, DryMax AF, Ricobid H, TanaHist-PD, Tuss Tan, Rentamine Pediatric, Rolatuss-SR, Protuss Tablet, Ex-Tuss, AccuHist LA, Deconhist LA, Atrohist Plus, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula, Bellahist-D LA, Ru-Tuss, Tannate 12 S, Trionate, Rynatuss Pediatric, Tussizone-12 RF, Tussi-12, SymPak II, Tustan 12S, Tussi-12S, Chlor-Mal, Chlo-Amine, Codahistine-DH Elixir, Vicks Children’s NyQuil Cold & Cough, Scot-Tussin DM, Tricodene SF, Ryna-C, Co-Histine DH, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Effective Strength Cough Syrup, Primatuss 4, Carepanto, Cold & Cough, Vicks Children's Nyquil, Robitussin Cough & Cold Long-Acting, Robitussin Children's Cough & Cold Long-Acting, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Decohistine DH, Phenylhistine DH, Zodryl AC, Codar AR, TL-Hist CM, Cotab A, Chlor-Phenit, Allergy Time, PediaTan, Chlorpheniramine (Allergy), Ed Chlor-Tan, Cotab AX, Codeprex, Dihistine DH, Tricode AR, Zodryl DAC, Pedituss, Pediacof, Notuss-AC, Endacof-C, T- Koff, Rolatuss, Cold Medicine Plus, Multi Symptom Cold Relief, Alka-Seltzer Plus Flu Formula, Dimetapp Children's Nighttime Flu, Comtrex Cold and Flu Maximum Strength, Multi Symptom Cold (Night Formula), Cold Multi-Symptom (Nighttime), Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Dimetapp Children's Multi-Symptom Cold & Flu, XL-3 Xtra Cold and Cough, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Allpanto-S, Co-Apap, Alka-Seltzer Plus-D, Theraflu Flu & Cough, Childrens Tylenol Cold Plus Cough, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Comtrex Nighttime Cold & Cough, Tylenol Cold Head Congestion Day and Night, Triaminic Multi-Symptom Fever, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Colrex, Colrex Compound, Sinapils, Congestant, Cotabflu, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Multi-Symptom Nighttime, Codral Cold and Flu + Cough Day and Night, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Chlor-Trimeton Sinus, Duadacin, Trital SR, Rhinogesic, Alumadrine, Comtrex Allergy Sinus, Allerest Sinus, Sinarest Extra Strength, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Allerest Headache Strength, Comtrex Allergy Sinus Night and Day, Tylenol Allergy Sinus, Sinutab Ex-Strength, Comtrex Allergy Sinus Maximum Strength, Norel SR, Covangesic, Robitussin Peak Cold Nighttime Nasal Relief, Onset Forte, GNP Cold Relief Plus, Pyrroxate, Allergy Multi-Symptom, Contac Cold + Flu (Night Formula), ConRx Allergy Sinus, Allergy Sinus PE Pain Relief, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Sinus Congestion and Pain Cool Burst Day Night, HEB Allergy, Dryphen, Hybrid CF, Tylenol Plus Children's Cold, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Hyphen-HD, Tuss-PD, KG-Dal HD, Endotuss-HD, Cyndal HD, Ed-Tuss HC, Nasatuss, Iotussin HC, Chlorgest HD, Hycomine Compound, Chemtussin HC, Maxi-Tuss SA, Maxi-Tuss HC, Histinex HC, Tuss-HC, Comtussin HC, Exo-Tuss, Endal-HD Plus, Enplus-HD, Chemdal HD Plus, Mintuss MS, Bronkotuss, Allfen A, P Chlor GG, Donatussin Pediatric, Uni-Cof, Hydro-Tussin DHC, Duohist DH, Tusscough DHC, Tricof, Lemohist Plus, Hydrocodone GF, Ed-TLC, Efasin-HD, Guiaphen HD, Rindal-HD, Iodal HD, HyTan, Endagen-HD, Chemdal HD, KG-Dal HD Plus, Uni Tuss HC, Maxi-Tuss HCX, Relacon-HC, Notuss-Forte, Detuss, DroTuss-CP, Relasin-HC, Neo HC, Poly-Tussin HD, Liquicough HC, Histinex PV, Pediatex HC, Hydrotuss HC, Hydron PCS, Hydrocof-HC, KG-Tussin, A-G Tussin, Tussend, Hexatussin, Hyphed, Tusana-D, Relacon-HC NR, Hi-Tuss HC, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, Quindal HD, Quindal HD Plus, Histussin HC Liquid, Tuss-DS, Efasin-HD Plus, Tussive HC, Hydron CP, Rindal HD Plus, Echotuss-HC, Phendal-HD, Uni-Tricof HC, Hydro-PC II Plus, De-Chlor HD, De-Chlor HC, Atuss MS, Despec-PD, Pancof-PD, Trigofen DM Drops, Virdec DM, Zoden DM Drops, Sonahist-DM, Z-Dex 12 D, Tri-Dex PE, Maxichlor PEH DM, ED DM, Poly-Tussin DM, RE DCP Drops, Nohist-DMX, PD-Cof Drops, PD-Cof, Zotex-12D, CP Dec-DM Drops, DM-PE-Chlor, Bronkids, Donatussin DM Drops, Nasohist-DM, PE-Hist DM, EndaCof Drops, Genelan NF, Zotex-DM, Extendryl DM, Ceron-DM Drops, Qual-Tussin, ChlorDex GP, St. Joseph HBP Cough & Cold, SymPak DM, Broncopectol, Rondex-DM Drops, Dec-Chlorphen DM Drops, Robitussin Cough & Allergy, Sildec-PE DM Drops, DCP Drops, Tussplex DM, Balamine DM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, NoHist-PDX, Relahist-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Entre-S, Tanafed-DM, Creomulsion Pediatric, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Kidkare Cough/Cold, Neutrahist PDX Drops, T-Tanna DM, Novahistine DH, Coldcough PD, Duotan DM, Allres DS, AccuHist PDX Drops, Esocor P, Mesehist DM, Threamine DM, Triphenicol, Centergy DM, Father John's Medicine Plus, De-Chlor DM, Liquituss R-DM, Tussar DM, Albatussin SR, Cerose DM, Maxiphen ADT, De-Chlor DR, Coldtuss-DR, Tricodene Forte, Tricodene NN, Therahist, Dex PC, Mintuss DR, Atuss DR, Corfen-DM, Uni-Tuss DM, Cordron-HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20130907

Disclaimer

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