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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Theraflu Flu, Cold and Cough Powder, Triaminic, CapCof, Norel AD, Tylenol Cold, Show all 794 »Alka-Seltzer Plus Cold Formula, Sinarest, Chlor-Trimeton Allergy SR, Zutripro, TussiCaps, Coricidin D, Sudafed PE Sinus & Allergy, Ceron-DM, Norel SR, Rynatan, Rondec, NoHist DM, Triplex AD, Dimetapp Children's Multi-Symptom Cold & Flu, Coughtuss, R-Tanna, Naldecon, Allergy Relief, Ed A-Hist, Clorfed, Sinutab Ex-Strength, Sildec-PE DM, Tanoral, Deconamine, Triant-HC, Advil Allergy and Congestion Relief, SudoGest Sinus & Allergy, Stahist, Cardec, Hydrocodone CP, Tylenol Cold Multi-Symptom Nighttime, Coldex, Rondec-DM, Genelan NF, Trigofen Drops, Ceron, Duralex, Cardec DM Drops, XL-3 Cold Medicine, Advil Allergy Sinus, Wal-finate, Chlorphen, Coricidin HBP Day & Night Multi-Symptom Cold, PCM, XL-3 Xtra Cold and Cough, Respa-AR, Aller-Chlor, Phenylhistine DH, Detuss, Phenabid DM, Norel CS, Novasus, C.P.M., Vituz, Nalex-A, Codahistine-DH Elixir, Cold Medicine Plus, Ralix, Ed A-Hist DM, Demazin, C-Phen DM, Welltuss HC, Allergy Multi-Symptom, SymPak, Extendryl Chews, Lohist, QC Cough/Cold, Sinus & Allergy PE, AlleRx, Hydrocodone HD, Duravent, Rentamine, Amilon, Threamine DM, Teldrin, Contac 12 Hour, Condrin, Gelhist Pediatric, Ru-Tuss, Ornade Spansules, Notuss-AC, Sinucon, Tritan, Ordrine, Phena-Plus, Coldamine, Codar AR, DuraHist, Pharbechlor, Triphenicol, Quadratuss, Atuss HD, Coldcough Syrup, Qual-Tussin Pediatric, Bronkotuss, Effective Strength Cough Syrup, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Kidcare Cough and Cold, M-End DM, C-Tanna 12, Phenylhistine DH Expectorant, DryMax, AlleRx Dose Pack, T-Tanna DM, Kidkare Cough/Cold, ChlorTan, CPM-PSE DM Drops, Dura-Vent/A, Codimal, Phenylhistine, Novahistine, Tanahist-D, Rondex, C Phen, Rindal-HD, Contac Cold and Flu Maximum Strength, De-Chlor DM, P Chlor DM, Extendryl Seniors, Dehistine, Triaminic Cold & Allergy, Actifed Cold and Allergy, Tussin-V, Q-V Tussin, P-V-Tussin Syrup, Cordron-HC, Coricidin HBP Maximum Strength Flu, JayCof-HC, Dexodryl Suspension, aeroHist, RelCof CPM, Tylenol Plus Children's Multi-Symptom Cold, Pyrroxate, Childrens Tylenol Cold Plus Cough, Suclor, Sudogest Cold & Allergy, Qdall, Quartuss, Trital SR, Klerist-D, Hydron CP, Brexin LA, Anaplex, Kronofed-A-Jr, Fedahist, Echotuss-HC, Neotuss D, Alumadrine, GNP Cold Relief Plus, Reme Tussin DM, NeoTuss Plus, Dristan Cold Multi Symptom Formula, Quartuss DM, Maxiphen ADT, Cardec DM, Bronkids, C-Phen DM Drops, Time-Hist QD, AccuHist Drops, Novahistine Elixir, Amdry-C, Allergy DN, Rhinatate-NF, Rhinaclear, Nolamine, AllePak, Relera, Dallergy JR, Histatab, Nuhist, ScopoHist, VisRx Dose Pack, Allergy AM-PM Dose Pack, NoHist LQ, Sonahist, BP Allergy JR, Allerest PE, Suphedrine PE Sinus & Allergy, Pseudo CM TR, Ricobid NR, Ny-Tannic, WE Allergy, Allergy DN PE, DuraTan PE, Nohist Plus, Nohist Plus Jr, AlleRx Dose Pack (PM Dose), ScopoHist Syrup, Nohist PE, RelCof DN PE, RelCof PE, Dallergy SR, Duradryl Chewable, Triall, SymPak PDX, ScopoHist-PE, Ah-Chew Ultra Tannate, CPM-PE-MSC, Aerohist Plus, Duradryl SR, Dallergy PE, DriHist SR, Ryneze, A-G Tussin, KG-Tussin, Hydrotuss HC, Hydron PCS, Hyphed, Hexatussin, Histinex PV, Pediatex HC, Tussend, Hydrocof-HC, Cordron-HC NR, RespiVent DF, Allerx Dose Pack DF, Dexodryl, NoHist EXT, Allergy DN II, Atuss HS, Advil Children's Allergy Sinus, AlleRx DF, Sinodec, Extendryl SR, Ah-chew Ultra, Histatab PH, Chlor-Mes, PCM Allergy, Redur-PCM, AlleRx Dose Pack PE (PM Dose), Dallergy ER, QV-Allergy, Rescon Extended Release, Re-Drylex Jr, Extendryl JR, Relcof PSE, Mescolor, Hista-Vent PSE, Dallergy PSE, RelCof DN PSE, DriHist, Rhinolar, Xiral SR, Aerokid, Denaze, DA II, Liqui-Allergy, AH-Chew, Duradryl, Hista-Vent DA, Duravent DA, Prehist D, DA Chewable, Omnihist L.A., Duradryl JR, Drize, Durahist PE, Omnihist II LA, AH-Chew II, Norel SD, Chlor-Mes D, Drysec, Ex-Histine, Histatab Plus, PCM-LA, Hista-Vadrin, Codimal-LA, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorafed HS Timecelles, Tanafed, Novafed A, Duratuss DA, Histalet, Chlorphedrin SR, Colfed-A, Isophen-DF, Kronofed-A, ND Clear, Chlordrine SR, Suphenamine-SR, Rinade-BID, D-Amine-SR, Deconomed SR, Pseudocot-C, Deconamine SR, Biohist LA (old formulation), Or-Phen-Ade, ARM Allergy Relief, Chlornade, Decongex-3, Resaid, Rhinolar-EX 12, Poly Hist PD (old formulation), Phena-S 12, MyHist-PD, Equi-Nade, Gencold, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Vanex Forte-R, Allerest 12 Hour, Rhinolar-EX, Triac, Genamin, Anamine TD, Time-Hist, Mintex, Re2+30, Sudal-12, Pediox Chewable, Histade, CP-Tannic, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, C-Phed Tannate, De-Congestine, LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Dynahist ER, AccuHist Drops (old formulation), SudaHist, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, Allerest Maximum Strength, Atrohist Pediatric Capsule, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Curaler, Anamine, Cophene No 2, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Chlorafed, Histafed LA, Genaphed Plus, Hayfebrol Liquid, Suphedrine Plus, Ryna Liquid, Neutrahist Drops, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Pyrichlor PE, Conal, NoHist, Maxichlor PEH, Ry-Tann, Notuss, Sildec-PE, Acta-Tabs PE, Rinate Pediatric, Ed ChlorPed D, Sildec-PE Drops, Nalphen, Nalda-Relief Pediatric, Uni Decon, Prop-A-Hist, Naldelate, Andecon Pediatric Drops, Nalspan, West-Decon, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, ChlorTan D, P-Tann D, Ceron Drops, PD-Hist D, Allan Tannate Pediatric, CP Dec Drops, PD-Hist D Drops, Dallergy Drops, Rynatan Pediatric, Phenchlor Tannate Pediatric, Nasohist Pediatric, Chlor-Mes Jr, Rondex Drops, PediaTan D, CP Dec, Cardec Drops, Histadec, Tannate Pediatric, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, Histalet Forte, Vanex Forte, Url-Tannate Pediatric, Tanamine, R-Tannamine, URL-Tannate, Rhinatate, Rhinatate Pediatric, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Triotann, Ru-Hist Forte, Tri-Hist Pediatric, Tri Tann Pediatric, Nalex A 12, AllerTan, Tri-Gestan S, Chlorex-A 12, Histatan, Phena-S, Triotann Pediatric, Triple Tannate Pediatric, Equitan Pediatric, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Comhist LA, Linhist-LA, NoHist-A, Rhinacon A, Comhist, Chlorex A, West-Decon M, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Triotann-S, R-Tannate, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Ed A-Hist LA, Chemtussin HC, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Tuss Tan Pediatric, Tuss Tan, Rynatuss Pediatric, Rynatuss, Rentamine Pediatric, Tannic-12, Carbaphen 12, DryMax AF, Ricobid H, P-Tann, TanaHist-PD, Carbaphen CH, Exratuss, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Quad-Tuss, Trionate, Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Alka-Seltzer Plus Cold & Cough Formula, Alka-Seltzer Plus Flu Formula (old formulation), Actifed Cold & Sinus, Rolatuss, Quelidrine, Ex-Tuss, AccuHist LA, Tannic-12 S, Tussi-12, Tussizone-12 RF, Tannate 12 S, Tussi-12S, Tustan 12S, Bellahist-D LA, Histacol LA, SymPak II, Ed ChlorPed, Ed-Chlortan, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Decohistine DH, Zodryl DAC, Demi-Cof, Dihistine DH, Tricode AR, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, Cold & Cough, Vicks Children's Nyquil, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Carepanto, Robitussin Cough & Cold Long-Acting, Primatuss 4, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Pedituss, Pediacof, Chlorpheniramine (Allergy), Ed Chlor-Tan, Allergy Time, Chlor-Phenit, PediaTan, Chlo-Amine, Topco Allergy, Teldrin HBP Allergy, Chlor-Mal, Z-Tuss AC, Zodryl AC, Endacof-C, Endal CD, T- Koff, Codeprex, Lexuss 210, TL-Hist CM, Cotab A, Cotab AX, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Flu Formula, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Comtrex Nighttime Cold & Cough, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Dimetapp Children's Nighttime Flu, Comtrex Cold and Flu Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Theraflu Flu & Cough, Allpanto-S, Comtrex Cold and Flu Maximum Strength Tablet, Cough Formula M Multi-Symptom, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Tylenol Cold Head Congestion Nighttime, Codral Cold and Flu + Cough Day and Night, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Triaminic Multi-Symptom Fever, PediaCare Cough & Runny Nose Plus Acetaminophen, Vicks NyQuil Cold & Flu Relief (Alcohol Free), Colrex, Colrex Compound, Sinapils, Congestant, Cotabflu, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Tylenol Plus Children's Flu, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Co-Apap, Alka-Seltzer Plus-D, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Singlet, Sinulin, Duadacin, Dryphen, Covangesic, Rhinogesic, Simplet, Tricom, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Comtrex Allergy Sinus Maximum Strength, Tylenol Allergy Sinus, Comtrex Allergy Sinus, Kolephrin, Allerest Sinus, HEB Allergy, Alka-Seltzer Plus Cold & Flu, Allergy Sinus PE Pain Relief, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, Allergy Pain Relief, ConRx Allergy Sinus, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Contac Cold + Flu (Night Formula), Gendecon, Tylenol Allergy Multi-Symptom, Hybrid CF, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Protid, Tylenol Plus Children's Cold, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, St. Joseph HBP Cough & Cold, SymPak DM, Guiaphen HD, Mintuss MS, Vanex-HD, Chemdal HD Plus, Efasin-HD, Ed-TLC, Endagen-HD, Chemdal HD, Iodal HD, Nasatuss, Iotussin HC, KG-Dal HD, Endotuss-HD, Ditussin-HC, Hycomine Compound, Tuss-PD, Hyphen-HD, Chlorgest HD, Ed-Tuss HC, Cyndal HD, HyTan, S-T Forte 2, Duohist DH, Tusscough DHC, Pancof, Tricof, Despec-PD, Pancof-PD, Novahistine DH, DiHydro-PE, Coldcough PD, Hydro-Tussin DHC, Dihydro-CP, Donatussin Pediatric, Lemohist Plus, Hydrocodone GF, P Chlor GG, Z-Tuss 2, Uni-Cof, Ana-Kit, Allfen A, Exo-Tuss, Endal-HD Plus, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, De-Chlor HC, De-Chlor HD, Tussive HC, B-Tuss, Hydro-PC II, Phendal-HD, Relacon-HC NR, DroTuss-CP, Z-Cof HC, Maxi-Tuss HCX, Relacon-HC, Relasin-HC, Liquicough HC, Tusana-D, Neo HC, Poly-Tussin HD, Liquitussin HC Syrup, Duradal HD, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Highland HC, Maxi-Tuss SA, Ventuss Syrup, Enplus-HD, Comtussin HC, Tuss-HC, Uni Tuss HC, H-C Tussive, Quindal HD, Hi-Tuss HC, Chlorphen HD, Quindal HD Plus, Efasin-HD Plus, Histussin HC Liquid, Cytuss HC, Tuss-DS, Duotan DM, Allres DS, Tri-Dex PE, Z-Dex 12 D, Trigofen DM Drops, Virdec DM, Ricotuss, Poly-Tussin DM, PE-Hist DM, Maxichlor PEH DM, ED DM, Zoden DM Drops, Re DCP, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Nasohist-DM, Donatussin DM Drops, Sonahist-DM, RE DCP Drops, Nohist-DMX, EndaCof Drops, DCP Drops, Donatussin DM, Ceron-DM Drops, Rondex-DM, Rondex-DM Drops, Extendryl DM, Zotex-DM, Broncopectol, ChlorDex GP, Qual-Tussin, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, Tussplex DM, Robitussin Cough & Allergy, Sildec-PE DM Drops, Balamine DM, Nasohist-DM Pediatric, HistadecDM, CP Dec DM, Neo DM Drops, Zotex-12D, NoHist-PDX, Creomulsion Pediatric, Children's Nyquil, Rescon-DM, Tanafed-DM, Creomulsion Cough/Cold/Allergy, Vicks 44M Pediatric, Therahist, Kophane, Rhinosyn-DM, C-Phed DM, Atuss-12 DM, AccuHist PDX Drops, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, Neutrahist PDX Drops, Maxichlor PSE DM, Dicel DM, Atuss DS, Entre-S, Cheracol Plus, Tricodene NN, Centergy DM, Atuss DM, Father John's Medicine Plus, Norel DM, Liquituss R-DM, Tussar DM, Relahist-DM, Albatussin SR, Cerose DM, De-Chlor DR, Coldtuss-DR, Trital DM, Dex PC, Tricodene Forte, Mintuss DR, Uni-Tuss DM, Tri-Vent DPC, Atuss DR, Corfen-DM, Notuss-Forte

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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