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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Alka-Seltzer Plus Cold, Coricidin HBP Cough & Cold, Coricidin HBP Cold & Flu, Allergy Relief, Norel AD, TussiCaps, CapCof, Zutripro, Show all 799 »Triplex AD, Sinarest, Chlor-Trimeton Allergy SR, Coricidin D, Tylenol Cold, Cold Medicine Plus, Sudafed PE Sinus & Allergy, Alka-Seltzer Plus Cold Formula, Stahist, Dristan Cold Multi Symptom Formula, Ed A-Hist DM, R-Tanna, Coughtuss, Deconamine SR, Deconamine, Brexin LA, NoHist DM, Codral Cold and Flu + Cough Day and Night, Tuzistra XR, Ceron-DM, Trital SR, Chlorphen, Hydrocodone GF, Wal-finate, Coricidin HBP Day & Night Multi-Symptom Cold, Rondec, DCP Drops, PCM, Sinutab Ex-Strength, Dallergy Drops, Actifed Cold and Allergy, Rynatan, Nuhist, Tanoral, Tricom, Ditussin-HC, Triaminic, Demazin, Ryna-C, Kophane, AllerTan, Aller-Chlor, Triaminic Softchews Cough & Runny Nose, Endotuss-HD, Duralex, Mintex, Orlenta, Clorfed, Cardec, Tusana-D, Suclor, Chlor-Trimeton Sinus, Balamine DM, Rondec-DM, Theraflu Flu, Cold and Cough Powder, Triall, Ricotuss, PD-Cof, PediaCare Cough & Runny Nose Plus Acetaminophen, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Advil Allergy Sinus, Neotuss D, Quartuss DM, Tylenol Allergy Multi-Symptom, Poly Hist PD (old formulation), Hybrid CF, Tri-Vent DPC, Nolamine, Mescolor, Tuxarin ER, VisRx Dose Pack, Tussin-V, Father John's Medicine Plus, Phenchlor Tannate Pediatric, Zoden DM Drops, C-Phen DM Drops, Cerose DM, Tussar DM, Vituz, Ru-Hist Forte, Lexuss 210, Triaminic Multi-Symptom Fever & Cold, Triphenicol, Kidkare Cough/Cold, Esocor P, Nalex-A, Tusscough DHC, M-End DM, Linhist-LA, Novahistine DH, Dihydro-CP, Tetra Tannate Pediatric, Allerest PE, Quartuss, Codeprex, Triaminic Multi-Symptom Fever, Coldcough Syrup, Rentamine, Rynatuss, Norel CS, Phenabid DM, PCM Allergy, SudoGest Sinus & Allergy, Relasin-HC, Extendryl Chews, Congestant, Ryna Liquid, Sinulin, Ed-TLC, Norel SR, Hyphed, Chlorgest HD, Quindal HD, Hydrocodone CP, Triant-HC, Vanex-HD, Dynahist-ER Pediatric, LoHist-D, Fedahist Gyrocaps, Prehist D, Lohist, Protid, Novafed A, Novahistine, AlleRx, Suphedrine PE Sinus & Allergy, RespiVent DF, Hydrocodone HD, Anaplex, Duravent, Sinus & Allergy PE, Sinarest Extra Strength, Phenylhistine, Tritan, Singlet, Xiral SR, RelCof DN PSE, DuraHist, DryMax, Dallergy PSE, Ed A-Hist LA, Histatab Plus, Novahistine Elixir, Ed A-Hist, NoHist LQ, Allergy AM-PM Dose Pack, BP Allergy JR, Virdec, ScopoHist, Coldamine, Ricobid NR, Histatab, Dallergy JR, Relera, Amilon, Sonahist, Ny-Tannic, Pseudo CM TR, Rhinatate-NF, Trigofen Drops, Hista-Vent PSE, AccuHist Drops, PCM-LA, Amdry-C, Allergy DN, Rhinaclear, AllePak, Time-Hist QD, Relcof PSE, Duradryl, Dexodryl Suspension, Dexodryl, Ryneze, Dehistine, Allerx Dose Pack DF, aeroHist, RelCof CPM, AlleRx DF, Allergy DN II, NoHist EXT, DriHist SR, Nohist PE, DuraTan PE, Nohist Plus, Nohist Plus Jr, Dallergy SR, Allergy DN PE, AlleRx Dose Pack (PM Dose), RelCof DN PE, RelCof PE, ScopoHist Syrup, Advil Children's Allergy Sinus, Advil Allergy and Congestion Relief, Pediatex HC, Tussend, Welltuss HC, Hexatussin, JayCof-HC, Histinex PV, Notuss-Forte, Notuss, Detuss, Q-V Tussin, A-G Tussin, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Hydrocof-HC, Hydron PCS, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Duradryl Chewable, Aerohist Plus, Denaze, Aerokid, Dallergy ER, Extendryl Seniors, Ralix, AH-Chew II, Norel SD, Durahist PE, Omnihist II LA, QV-Allergy, Rescon Extended Release, Re-Drylex Jr, Extendryl JR, DriHist, AlleRx Dose Pack, Chlor-Mes, Histatab PH, AlleRx Dose Pack PE (PM Dose), Redur-PCM, Ah-chew Ultra, Chlor-Mes D, WE Allergy, ScopoHist-PE, Sinodec, Extendryl SR, DA Chewable, SymPak PDX, Ah-Chew Ultra Tannate, Duradryl SR, Dallergy PE, CPM-PE-MSC, Omnihist L.A., Duravent DA, Duradryl JR, Drize, Drysec, Ex-Histine, Rynatan Pediatric, AH-Chew, Hista-Vent DA, DA II, Liqui-Allergy, Rhinolar, Acta-Tabs PE, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Histalet, Duratuss DA, Chlor-Trimeton Decongestant, Duotan, Durafed, Biohist LA (old formulation), Kronofed-A-Jr, Dura-Tap/PD, Pseudocot-C, Rinade-BID, Suphenamine-SR, Isophen-DF, Deconomed SR, D-Amine-SR, Fedahist Timecaps, Chlorphedrin SR, Colfed-A, Histade CR, Vanex Forte-R, Resaid, Or-Phen-Ade, Contac 12 Hour, ARM Allergy Relief, Ornade Spansules, Dura-Vent/A, Phena-S 12, MyHist-PD, Rhinolar-EX 12, Teldrin, Chlornade, Rhinolar-EX, Triac, Genamin, Allerest 12 Hour, Gencold, Equi-Nade, Condrin, Ordrine, Decongex-3, Kronofed-A, ND Clear, Histade, Re2+30, Sudal-12, Pediox Chewable, CP-Tannic, Tavist-DA, Atrohist Pediatric Capsule, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, C-Phed Tannate, De-Congestine, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Dynahist ER, AccuHist Drops (old formulation), SudaHist, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, Suphedrine Plus, Hayfebrol Liquid, Pseudochlor, Cophene No 2, Anamine, Klerist-D, Rescon-Ed, Chlorafed Timecelles, Chlordrine SR, Anamine TD, Time-Hist, Codimal-LA Half, Clorfed II, Sudogest Plus, Neutrahist Drops, Sudogest Cold & Allergy, Genaphed Plus, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Curaler, Chlorafed, Histafed LA, Pyrichlor PE, Conal, Maxichlor PEH, Ry-Tann, Hista-Vadrin, Nalphen, NoHist, Sildec-PE, Rinate Pediatric, Ed ChlorPed D, Sildec-PE Drops, Nalda-Relief Pediatric, Nalgestic Pediatric, Prop-A-Hist, Sinucon, Naldelate, Andecon Pediatric Drops, Uni Decon, Nalspan, Sinucon Pediatric, Nalgest, West-Decon, ChlorTan D, Triaminic Cold & Allergy, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, Rondex, Tanahist-D, PD-Hist D, Ceron, PD-Hist D Drops, Ceron Drops, Rondex Drops, Dec-Chlorphen, PediaTan D, CP Dec, Cardec Drops, P-Tann D, Histadec, Tannate Pediatric, Dec-Chlorphen Drops, C Phen Drops, C Phen, Naldecon, Histalet Forte, Rhinatate, Url-Tannate Pediatric, Tanamine, R-Tannamine, Rhinatate Pediatric, Tri-Tannate Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanamine Pediatric, URL-Tannate, Triotann, Tri-Hist Pediatric, Phena-Plus, Tri Tann Pediatric, Nalex A 12, Tri-Gestan S, Chlorex-A 12, Histatan, Phena-S, Triotann Pediatric, Equitan Pediatric, Tanoral Pediatric, Q-Hist LA, Chlortox, C-Hist-SR, Nalex-A SR, Comhist LA, Comhist, Vanex Forte, NoHist-A, Rhinacon A, Chlorex A, Coldex, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Gelhist Pediatric, R-Tannate Pediatric, West-Decon M, Atrohist Pediatric, Rynatan-S Pediatric, Nasohist Pediatric, Tuss-PD, Quad Tann Pediatric, Quad Tann, Tannic-12, Carbaphen 12, Quad Tuss Pediatric, Tuss Tan Pediatric, Rynatuss Pediatric, Quadratuss, Rentamine Pediatric, Tuss Tan, Tannate-12, XiraTuss, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, DryMax AF, Carbaphen CH, Tanni-Hist 12 RF, Exratuss, Phenagil CH, Quad-Tuss, C-Tanna 12, Protuss Tablet, Ex-Tuss, AccuHist LA, Bellahist-D LA, Rolatuss-SR, Deconhist LA, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula, Atrohist Plus, Histacol LA, Ru-Tuss, Tussi-12, Tussizone-12 RF, Tannate 12 S, Trionate, Tannic-12 S, Tussi-12S, Respa-AR, SymPak II, Tustan 12S, Ed-Chlortan, Topco Allergy, Phenylhistine DH, Decohistine DH, Codehist DH, Phenylhistine DH Expectorant, Zodryl DAC, Tricode AR, Pedituss, Demi-Cof, Dihistine DH, Novadyne DH, Co-Histine DH, Primatuss 4, Tricodene Sugar Free, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Effective Strength Cough Syrup, QC Cough/Cold, Codahistine-DH Elixir, Vicks Children’s NyQuil Cold & Cough, Tricodene SF, Pediacof, T- Koff, PediaTan, Chlorpheniramine (Allergy), ChlorTan, Ed Chlor-Tan, Chlo-Amine, Chlor-Mal, Pharbechlor, Teldrin HBP Allergy, C.P.M., Allergy Time, Chlor-Phenit, Cotab AX, Notuss-AC, Endacof-C, Endal CD, Cotab A, TL-Hist CM, Z-Tuss AC, Zodryl AC, Codar AR, Quelidrine, Rolatuss, Alka-Seltzer Plus Flu Formula, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Comtrex Cold and Flu Maximum Strength, Multi Symptom Cold Relief, Multi Symptom Cold (Night Formula), Dimetapp Children's Multi-Symptom Cold & Flu, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Allpanto-S, Genacol Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Nighttime Cold & Cough, Tylenol Cold Head Congestion Day and Night, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Coricidin HBP Maximum Strength Flu, Colrex, Sinapils, Cotabflu, Colrex Compound, Tylenol Plus Children's Cough & Runny Nose, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, PediaCare Flu Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, PediaCare Multi-Symptom Cold Plus Acetaminophen, Co-Apap, Alka-Seltzer Plus-D, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Comtrex Allergy Sinus, Duadacin, Alumadrine, Dryphen, Covangesic, Rhinogesic, Codimal, Kolephrin, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Allerest Headache Strength, Comtrex Allergy Sinus Night and Day, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, HEB Allergy, Alka-Seltzer Plus Cold & Flu, Allergy Sinus PE Pain Relief, Allergy Multi-Symptom, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Allergy Pain Relief, ConRx Allergy Sinus, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Contac Cold + Flu (Night Formula), Relief-PE, Onset Forte, Tylenol Plus Children's Cold, XL-3 Cold Medicine, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Comtrex Flu Therapy, Comtrex Severe Cold & Sinus, GNP Cold Relief Plus, Gendecon, Tylenol Sinus Congestion & Pain Nighttime, Robitussin Cough & Cold Long-Acting, Carepanto, HyTan, Novasus, Endagen-HD, Chemdal HD, S-T Forte 2, Lemohist Plus, SymPak, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Iodal HD, Rindal-HD, Iotussin HC, Ed-Tuss HC, Cyndal HD, Hyphen-HD, Nasatuss, Chemdal HD Plus, Efasin-HD, Guiaphen HD, Mintuss MS, Z-Tuss 2, Allfen A, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Mesehist DM, CPM-PSE DM Drops, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, DiHydro-PE, Coldcough PD, Hydro-Tussin DHC, Uni-Cof, Bronkotuss, Ana-Kit, Tricof, Pancof, Pancof-PD, Despec-PD, Duohist DH, Hycomine Compound, KG-Dal HD, De-Chlor HD, De-Chlor HC, Atuss MS, Hydro-PC II Plus, Hydron CP, Hydro-PC II, Liquitussin HC Syrup, Tussive HC, B-Tuss, Uni-Tricof HC, Rindal HD Plus, Liquicough HC, DroTuss-CP, Z-Cof HC, Maxi-Tuss HCX, Poly-Tussin HD, Neo HC, Echotuss-HC, Phendal-HD, Relacon-HC NR, Duradal HD, Chlorphen HD, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Maxi-Tuss HC, Comtussin HC, Enplus-HD, Chemtussin HC, Exo-Tuss, Endal-HD Plus, Histinex HC, KG-Dal HD Plus, Tuss-DS, Efasin-HD Plus, Quindal HD Plus, Hi-Tuss HC, Cytuss HC, Histussin HC Liquid, Highland HC, Uni Tuss HC, H-C Tussive, Entre-S, Atuss DS, Robitussin Cough & Allergy, Sildec-PE DM Drops, Sildec-PE DM, EndaCof Drops, C-Phen DM, Cardec DM, Cardec DM Drops, Reme Tussin DM, Tussplex DM, PE-Hist DM, Maxichlor PEH DM, Virdec DM, Re DCP, Sonahist-DM, RE DCP Drops, Trigofen DM Drops, Z-Dex 12 D, ED DM, Poly-Tussin DM, Tri-Dex PE, Nasohist-DM Pediatric, Neo DM Drops, SymPak DM, Broncopectol, ChlorDex GP, Qual-Tussin, St. Joseph HBP Cough & Cold, Scot-Tussin DM, Cold & Cough, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Genelan NF, Zotex-DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, CP Dec DM, Rondex-DM Drops, Rondex-DM, Extendryl DM, Donatussin DM, Ceron-DM Drops, Nohist-DMX, Bronkids, Tricodene NN, Cheracol Plus, Therahist, Threamine DM, Tricodene Forte, Dex PC, Mintuss DR, Trital DM, P Chlor DM, Rhinosyn-DM, Vicks 44M Pediatric, Tanafed-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Rescon-DM, Children's Nyquil, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Uni-Tuss DM, Corfen-DM, Zotex-12D, Statuss DM, NoHist-PDX, Relahist-DM, PD-Cof Drops, CP Dec-DM Drops, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, Albatussin SR, Maxiphen ADT, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Atuss DR, NeoTuss Plus, Norel DM, Liquituss R-DM, Centergy DM, Atuss DM, Relacon-HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

Disclaimer

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