Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Zutripro, TussiCaps, Tylenol Cold, Alka-Seltzer Plus Cold, Anaplex, Norel CS, Show all 786 »Triplex AD, Coricidin HBP Maximum Strength Flu, Triaminic, Theraflu Flu, Cold and Cough Powder, Norel AD, Chlor-Trimeton Allergy SR, M-End DM, Duralex, Chlor-Trimeton Allergy Decongestant, Advil Allergy Sinus, Ceron-DM, Hydrocodone CP, Coricidin D, Cardec, Ordrine, Allergy Relief, Vituz, Sinarest, Norel SR, Wal-finate, Denaze, Triant-HC, Xiral SR, Chlorphen, Comtrex Allergy Sinus, Coldamine, Allergy Multi-Symptom, Coldex, Quindal HD, Rondec, Sudafed PE Sinus & Allergy, Ed A-Hist, Triac, Simplet, R-Tannamine, Time-Hist QD, Ornade Spansules, NeoTuss Plus, Stahist, Lohist, Triaminic Multi-Symptom Fever, Duadacin, XiraTuss, Alka-Seltzer Plus Cold Formula, Orlenta, Sildec-PE DM, Allerest Maximum Strength, Sinus & Allergy PE, Rynatuss Pediatric, Advil Allergy and Congestion Relief, Phenabid DM, Novasus, Omnihist L.A., Allerx Dose Pack DF, PCM, Rynatan, Actifed Cold and Allergy, C-Phen DM, XL-3 Cold Medicine, Ralix, Rondec-DM, Naldecon, Norel DM, Ru-Tuss, Histinex HC, Vanex-HD, Relacon-HC, Rentamine, Condrin, Teldrin, Enplus-HD, Chemdal HD Plus, Tannate 12 S, Sinapils, Corfen-DM, Trital DM, Cerose DM, Nolamine, Tricodene NN, Amilon, Ed A-Hist DM, NoHist DM, NoHist, NoHist LQ, Rondex, Ceron, AlleRx, Phenchlor Tannate Pediatric, Triaminic-D Multi-Symptom Cold, Atuss DS, AlleRx Dose Pack, Tritan, Codar AR, Pancof, P Chlor GG, Coldcough Syrup, R-Tannate, Atrohist Pediatric, Scot-Tussin DM, QC Cough/Cold, Chlorex A, CPM-PSE DM Drops, Ru-Hist Forte, Tanni-Hist 12 RF, Equi-Nade, Rescon Extended Release, Alumadrine, Dexodryl, Triall, Tricom, Sinutab Ex-Strength, Kolephrin, Codimal, Deconamine, Genacol Maximum Strength, Colrex, Codral Cold and Flu + Cough Day and Night, Coricidin HBP Day & Night Multi-Symptom Cold, Welltuss HC, Coricidin HBP Multi-Symptom Cold (Night), Covangesic, XL-3 Xtra Cold and Cough, Sinutab Maximum Strength Caplets, Allergy DN II, Histex, Mintex, De-Congestine, Atrohist Pediatric Capsule, Isophen-DF, Novafed A, Clorfed, Dicel, LoHist-D, Liquitussin HC Syrup, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, Histussin HC Liquid, Hydrocodone HD, Hybrid CF, Relasin-HC, RespiVent DF, aeroHist, RelCof CPM, Advil Children's Allergy Sinus, Ryneze, AlleRx DF, Dexodryl Suspension, Allergy DN, Pseudo CM TR, Allergy AM-PM Dose Pack, Notuss-Forte, Extendryl JR, Aerohist Plus, VisRx Dose Pack, Histatab, DryMax, ScopoHist, NoHist EXT, RelCof DN PSE, Relcof PSE, Q-V Tussin, Phenylhistine, Novahistine Elixir, Ny-Tannic, Ry-Tann, BP Allergy JR, Ricobid NR, Histatab Plus, Ed A-Hist LA, Ceron Drops, Allan Tannate Pediatric, Dallergy Drops, R-Tanna, Rynatan Pediatric, Relera, Dallergy JR, Hydron PCS, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Atuss HD, Cordron-HC NR, P-V-Tussin Syrup, KG-Tussin, Hyphed, Novahistine, Tussin-V, AH-Chew, A-G Tussin, Atuss HS, Sinodec, Drysec, Drize, PCM Allergy, Ex-Histine, WE Allergy, Chlor-Mes, JayCof-HC, Re-Drylex Jr, Allergy DN PE, SymPak PDX, ScopoHist-PE, Duradryl, Duradryl JR, Duradryl SR, CPM-PE-MSC, Histatab PH, Ah-chew Ultra, Hexatussin, Omnihist II LA, Chlor-Mes Jr, Dallergy ER, AH-Chew II, Aerokid, Durahist PE, Notuss, AlleRx Dose Pack PE (PM Dose), Redur-PCM, Chlor-Mes D, Norel SD, Extendryl Seniors, QV-Allergy, Dehistine, DriHist SR, RelCof DN PE, Nohist PE, Extendryl SR, Prehist D, DA Chewable, Extendryl Chews, DuraHist, Dallergy PSE, AllePak, Rhinaclear, Amdry-C, PCM-LA, Mescolor, Hista-Vent PSE, Duravent DA, Hista-Vent DA, Duravent, RelCof PE, Ah-Chew Ultra Tannate, Dallergy PE, Nohist Plus, Nohist Plus Jr, Liqui-Allergy, Duradryl Chewable, DA II, Rhinolar, Dallergy SR, AlleRx Dose Pack (PM Dose), DriHist, ScopoHist Syrup, DuraTan PE, Nalda-Relief Pediatric, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Fedahist, Histalet, Deconamine SR, Duotan, Durafed, Dura-Tap/PD, Fedahist Timecaps, Rinade-BID, Suphenamine-SR, Kronofed-A, ND Clear, Pseudocot-C, Deconomed SR, Chlorphedrin SR, Colfed-A, D-Amine-SR, Chlor-Trimeton Decongestant, Histade CR, Resaid, Or-Phen-Ade, Demazin, Contac 12 Hour, Dura-Vent/A, Rhinolar-EX 12, MyHist-PD, Pyrichlor PE, Phena-S 12, ARM Allergy Relief, Chlornade, Vanex Forte-R, Qdall, Dynahist ER, Allerest 12 Hour, Genamin, Decongex-3, Gencold, Rhinolar-EX, Chlordrine SR, Anamine TD, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, Suclor, Histade, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Sudal-12 Chewable, Sudal-12 Tannate, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, AccuHist Drops (old formulation), Biohist LA (old formulation), SudoGest Sinus & Allergy, Sudogest Cold & Allergy, SudaHist, Duratuss DA, Neutrahist Drops, Chlor-Trimeton Allergy Decongestant SR, Suphedrine Plus, Cophene No 2, Anamine, Klerist-D, Codimal-LA Half, Pseudochlor, Rescon-Ed, Time-Hist, Chlorafed Timecelles, Brexin LA, Fedahist Gyrocaps, Clorfed II, Ryna Liquid, Genaphed Plus, Hayfebrol Liquid, Sudogest Plus, Aller-Chlor Decongestant, Curaler, Chlorafed, Histafed LA, Conal, AllerTan, Acta-Tabs PE, Suphedrine PE Sinus & Allergy, Trigofen Drops, Hista-Vadrin, Nuhist, Sonahist, CP Dec Drops, AccuHist Drops, Tanahist-D, Nalphen, Tussend, Uni Decon, Prop-A-Hist, Sinucon, Naldelate, Nalspan, West-Decon, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, PD-Hist D, PD-Hist D Drops, Histadec, PediaTan D, CP Dec, Cardec Drops, Tannate Pediatric, C Phen, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, P-Tann D, Triaminic Cold & Allergy, Allerest PE, Rhinatate-NF, Nasohist Pediatric, Sildec-PE, Sildec-PE Drops, ChlorTan D, Rinate Pediatric, Ed ChlorPed D, Andecon Pediatric Drops, Histalet Forte, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tanamine Pediatric, Tri-Tannate, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Tanamine, Tanoral, Tri-Hist Pediatric, Tri Tann Pediatric, Poly Hist PD (old formulation), Nalex A 12, Tri-Gestan S, Triotann Pediatric, URL-Tannate, Triotann, Histatan, Triotann-S Pediatric, R-Tannamine Pediatric, Q-Hist LA, Chlortox, Linhist-L.A., C-Hist-SR, Comhist LA, Comhist, Vanex Forte, Nalex-A, Rhinacon A, Nalex-A SR, West-Decon M, R-Tannate Pediatric, Gelhist Pediatric, Triotann-S, Rynatan-S Pediatric, Phena-Plus, NoHist-A, Phena-S, Chlorex-A 12, Rondex Drops, Endotuss-HD, Ed ChlorPed, Pharbechlor, C.P.M., Chlor-Mal, Aller-Chlor, Ricobid H, Tannic-12, Carbaphen CH, DryMax AF, Chlo-Amine, PediaTan, Topco Allergy, Ed-Chlortan, Teldrin HBP Allergy, Allergy Time, Chlor-Phenit, TanaHist-PD, Chlorpheniramine (Allergy), ChlorTan, Ed Chlor-Tan, Exratuss, Tannate-12, Tussi-12S, Trionate, C-Tanna 12, Tustan 12S, Tussizone-12 RF, Tussi-12, Respa-AR, SymPak II, Tannic-12 S, Quad-Tuss, Quadratuss, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, Carbaphen 12, Tetra Tannate Pediatric, Tuss Tan Pediatric, Rynatuss, Rentamine Pediatric, Tuss Tan, Z-Tuss AC, Endacof-C, Primatuss 4, Tricodene Sugar Free, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Effective Strength Cough Syrup, Vicks Pediatric Formula 44m Cough & Cold Relief, Zodryl DAC, Tricode AR, Tricodene SF, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Triaminic Night Time Cough & Runny Nose, SymPak DM, Genelan NF, Zotex-DM, Vicks Children’s NyQuil Cold & Cough, St. Joseph HBP Cough & Cold, Vicks Children's Nyquil, Carepanto, Cold & Cough, Codahistine-DH Elixir, Ryna-C, Lexuss 210 Liquid, TL-Hist CM, CapCof, Endal CD, Zodryl AC, Notuss-AC, Cotab A, Cotab AX, Codeprex, T- Koff, Pediacof, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Decohistine DH, Phenylhistine DH, Pedituss, Demi-Cof, Dihistine DH, Bellahist-D LA, AccuHist LA, Contac Severe Cold and Flu Maximum Stength, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Cold Multi-Symptom (Nighttime), Comtrex Cold and Flu Maximum Strength Liquid, Childrens Tylenol Cold Plus Cough, Co-Apap, Gelpirin-CCF, Dryphen, Protid, Alka-Seltzer Plus-D, Triaminic Flu, Cough & Fever, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Allpanto-S, Dimetapp Children's Multi-Symptom Cold & Flu, Alka-Seltzer Plus Flu Formula, Tylenol Plus Children's Cough & Runny Nose, Flu Relief BP, Vicks NyQuil Cold & Flu Relief (Alcohol Free), Tylenol Plus Children's Multi-Symptom Cold, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Congestant, Cotabflu, Colrex Compound, Tylenol Plus Children's Flu, Dimetapp Children's Nighttime Flu, Comtrex Nighttime Cold & Cough, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Alka-Seltzer Plus Cold & Cough Formula Liquid, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Tylenol Cold Head Congestion Day and Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Gendecon, Dristan Cold Multi Symptom Formula, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus Maximum Strength, Singlet, Allerest Sinus, Tylenol Allergy Sinus, Cold Medicine Plus, Actifed Cold & Sinus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Ex-Tuss, Atrohist Plus, Alka-Seltzer Plus Cold & Cough Formula, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Robitussin Peak Cold Nighttime Nasal Relief, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Allergy Pain Relief, Contac Cold + Flu (Night Formula), Pyrroxate, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Allergy Sinus PE Pain Relief, Onset Forte, Rhinogesic, Sinulin, Chlor-Trimeton Sinus, Trital SR, Sine-Off Sinus/Cold, GNP Cold Relief Plus, Tylenol Sinus Congestion and Pain Cool Burst Day Night, ConRx Allergy Sinus, Broncopectol, ChlorDex GP, Maxi-Tuss HCX, Endagen-HD, Chemdal HD, Iodal HD, Mintuss MS, Coughtuss, S-T Forte 2, HyTan, Hydrocodone GF, Rindal-HD, Ed-TLC, Ed-Tuss HC, Cyndal HD, Hyphen-HD, Tuss-PD, Chlorgest HD, Iotussin HC, Efasin-HD, Guiaphen HD, Nasatuss, Lemohist Plus, Qual-Tussin Pediatric, DiHydro-PE, Duohist DH, Despec-PD, Tusscough DHC, Pancof-PD, Novahistine DH, Esocor P, Mesehist DM, Kidkare Cough/Cold, Coldcough PD, Tricof, Allfen A, Z-Tuss 2, SymPak, Donatussin Pediatric, Ana-Kit, Bronkotuss, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, KG-Dal HD, Hycomine Compound, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, De-Chlor HC, De-Chlor HD, B-Tuss, Hydro-PC II, Hydron CP, Echotuss-HC, Phendal-HD, Liquicough HC, DroTuss-CP, Detuss, Histinex PV, Neo HC, Z-Cof HC, Relacon-HC NR, Tusana-D, Poly-Tussin HD, Tussive HC, Duradal HD, Tuss-HC, Ventuss Syrup, Maxi-Tuss SA, Maxi-Tuss HC, Comtussin HC, Endal-HD Plus, Ditussin-HC, Chemtussin HC, Exo-Tuss, KG-Dal HD Plus, Highland HC, Quindal HD Plus, Hi-Tuss HC, Chlorphen HD, Efasin-HD Plus, Tuss-DS, Uni Tuss HC, H-C Tussive, Cytuss HC, Entre-S, AccuHist PDX Drops, CP Dec DM, Neo DM Drops, Cardec DM Drops, Reme Tussin DM, HistadecDM, Dec-Chlorphen DM Drops, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Tussplex DM, Cardec DM, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, Sonahist-DM, Maxichlor PEH DM, C-Phen DM Drops, Sildec-PE DM Drops, Relahist-DM, Ceron-DM Drops, Donatussin DM, Ricotuss, PE-Hist DM, Maxiphen ADT, Tussar DM, Poly-Tussin DM, ED DM, Qual-Tussin, Quartuss, Extendryl DM, Liquituss R-DM, Atuss DM, Uni-Tuss DM, Mintuss DR, P Chlor DM, Dex PC, Atuss DR, Tri-Vent DPC, De-Chlor DM, De-Chlor DR, Coldtuss-DR, PD-Cof, Zotex-12D, Duotan DM, T-Tanna DM, Rhinosyn-DM, Vicks 44M Pediatric, Allres DS, Therahist, Threamine DM, Tricodene Forte, Cheracol Plus, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Atuss-12 DM, Dicel DM, Maxichlor PSE DM, Neutrahist PDX Drops, C-Phed DM, Tanafed-DM, Kidcare Cough and Cold, Children's Nyquil, Rescon-DM, Kophane, Triphenicol, NoHist-PDX, DCP Drops, Centergy DM, Father John's Medicine Plus, Bronkids, Z-Dex 12 D, Quartuss DM, Donatussin DM Drops, Nohist-DMX, RE DCP Drops, Nasohist-DM Pediatric, EndaCof Drops, Albatussin SR, Balamine DM, Zoden DM Drops, Virdec DM, Robitussin Cough & Allergy, Tri-Dex PE, Trigofen DM Drops, Pediatex HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Possible Effects on Lactation

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Administrative Information

LactMed Record Number

64

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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