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Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Norel AD, Tylenol Cold, Chlor-Trimeton Allergy SR, CapCof, Alka-Seltzer Plus Cold Formula, Show all 796 »Sinarest, Triaminic, Rondec, Sinutab Ex-Strength, Allergy Relief, TussiCaps, Theraflu Flu, Cold and Cough Powder, Coricidin D, NoHist DM, Chlorphen, Coughtuss, Clorfed, Stahist, Advil Allergy Sinus, Sinodec, PCM, SudoGest Sinus & Allergy, Sudafed PE Sinus & Allergy, Coricidin HBP Day & Night Multi-Symptom Cold, Trigofen Drops, Ed A-Hist, Rynatan, AlleRx, Lohist, Cardec, Dimetapp Children's Multi-Symptom Cold & Flu, Codimal, Cold Medicine Plus, Zutripro, Allergy Multi-Symptom, Notuss-AC, R-Tanna, Deconamine SR, Klerist-D, Wal-finate, Deconamine, PD-Cof, Ed A-Hist DM, R-Tannate, Coldcough Syrup, Vituz, Triaminic Softchews Cough & Runny Nose, Ricotuss, Sildec-PE DM, Codeprex, Hydrocodone GF, Rondec-DM, Ceron-DM, Tanoral, Norel CS, Poly-Tussin DM, Aller-Chlor, Kophane, Hydrocodone HD, Tuzistra XR, Orlenta, Tylenol Cold Multi-Symptom Nighttime, Phenylhistine DH, Vanex Forte, Vanex-HD, Novahistine, Norel SR, Detuss, Triplex AD, Condrin, Sinus & Allergy PE, Contac 12 Hour, Tussi-12, Tanamine, Carbaphen CH, AllerTan, Ru-Hist Forte, Tritan, Rentamine, Tetra Tannate Pediatric, Rynatuss, Phenylhistine, Dihydro-CP, SymPak, Quindal HD, Pancof, Tusscough DHC, Kidcare Cough and Cold, Kidkare Cough/Cold, Esocor P, Triant-HC, Relasin-HC, Atuss HD, Cordron-HC, Hyphed, Advil Allergy and Congestion Relief, RespiVent DF, Extendryl Seniors, Aerokid, Duravent, Xiral SR, Coldamine, Phenabid DM, Tanahist-D, Ceron, C-Phen DM Drops, Sinucon, QC Cough/Cold, Effective Strength Cough Syrup, Carepanto, Dallergy Drops, Demazin, Amilon, Triphenicol, VisRx Dose Pack, Nolamine, Nuhist, Allerest PE, Suphedrine PE Sinus & Allergy, Nalex-A, Naldecon, Mintex, Suclor, Chlor-Trimeton Sinus, Singlet, Allerest Sinus, Brexin LA, Allerest Maximum Strength, Sinulin, LoHist-D, Tylenol Cold Head Congestion Day and Night, Codral Cold and Flu + Cough Day and Night, Coricidin HBP Maximum Strength Flu, Comtrex Day and Night, Teldrin, Hybrid CF, XL-3 Cold Medicine, Novafed A, Protid, Norel SD, Durahist PE, Omnihist II LA, Chlor-Mes D, WE Allergy, Drysec, Ex-Histine, Ryna Liquid, AH-Chew II, Ralix, AlleRx Dose Pack PE (PM Dose), Redur-PCM, Ah-chew Ultra, Rescon Extended Release, QV-Allergy, Denaze, Dallergy ER, Drize, Duradryl JR, Extendryl Chews, DA Chewable, Omnihist L.A., Suphedrine Plus, Prehist D, ScopoHist-PE, Extendryl SR, Duravent DA, Hista-Vent DA, Sudogest Cold & Allergy, AH-Chew, Duradryl, Genaphed Plus, Hayfebrol Liquid, DA II, Liqui-Allergy, Histatab PH, Chlor-Mes, Time-Hist QD, AllePak, Rhinaclear, Amdry-C, PCM-LA, Relcof PSE, Mescolor, Hista-Vent PSE, Allergy DN, Pseudo CM TR, Resaid, Codimal-LA Half, Anamine, Fedahist Gyrocaps, Histatab, ScopoHist, Allergy AM-PM Dose Pack, Dallergy PSE, RelCof DN PSE, AlleRx Dose Pack, Rhinolar, Neutrahist Drops, DriHist, Extendryl JR, PCM Allergy, Re-Drylex Jr, Sudogest Plus, Aller-Chlor Decongestant, DuraHist, Curaler, Clorfed II, DryMax, Chlorafed, Chlor-Trimeton Allergy Decongestant, Histafed LA, SymPak PDX, Atrohist Pediatric Capsule, Hydrocof-HC, Cordron-HC NR, Atuss HS, Hydron PCS, Hydrotuss HC, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Rhinolar-EX 12, SudaHist, Allergy DN II, NoHist EXT, aeroHist, AlleRx DF, RelCof CPM, Advil Children's Allergy Sinus, Sudal-12 Tannate, Q-V Tussin, Tussin-V, Qdall, Pseudoephedrine Plus, Triaminic Softchews Cold and Allergy, Dynahist ER, Relacon-HC, Z-Cof HC, Maxi-Tuss HCX, AccuHist Drops (old formulation), Notuss-Forte, Tussend, Welltuss HC, Hexatussin, Pediatex HC, JayCof-HC, Notuss, Histinex PV, Allerx Dose Pack DF, Dexodryl Suspension, Sudal-12, Dura-Vent/A, Ornade Spansules, Dallergy PE, Duradryl SR, Dallergy SR, Duradryl Chewable, Aerohist Plus, Re2+30, Histade, Dynahist-ER Pediatric, Tavist-DA, Chlor-Trimeton Allergy Decongestant SR, Triall, Ah-Chew Ultra Tannate, CP-Tannic, CPM-PE-MSC, Nohist Plus Jr, Nohist Plus, De-Congestine, C-Phed Tannate, Pediox Chewable, Sudal-12 Chewable, Dicel, Dexodryl, Ryneze, Dehistine, DriHist SR, AlleRx Dose Pack (PM Dose), Allergy DN PE, DuraTan PE, ScopoHist Syrup, RelCof PE, Nohist PE, RelCof DN PE, Anaplex, Cophene No 2, Poly Hist PD (old formulation), Comhist LA, Q-Hist LA, Linhist-LA, Comhist, Histade CR, NoHist-A, Rhinacon A, Chlortox, C-Hist-SR, Pyrichlor PE, Conal, Nalex A 12, West-Decon M, Coldex, Nalex-A SR, Chlorex A, Chlor-Trimeton Decongestant, Histalet Forte, Duratuss DA, Biohist LA (old formulation), Durafed, Histalet, Fedahist, Nalda-Relief Pediatric, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, Naldelate, Andecon Pediatric Drops, Duotan, Prop-A-Hist, Uni Decon, West-Decon, Nalspan, Tri Tann Pediatric, ARM Allergy Relief, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Decongex-3, Tri-Tannate, Rhinolar-EX, Gencold, Equi-Nade, Rhinatate, Url-Tannate Pediatric, Phena-S, Triotann Pediatric, Chlorex-A 12, Histatan, Triotann, R-Tannamine, URL-Tannate, Triac, Genamin, Vanex Forte-R, Atrohist Pediatric, Rynatan-S Pediatric, Tri-Hist Pediatric, Phena-Plus, Chlornade, Ordrine, R-Tannate Pediatric, Gelhist Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Allerest 12 Hour, Tanoral Pediatric, Triotann-S Pediatric, Triotann-S, R-Tannamine Pediatric, Nalphen, DroTuss-CP, Novahistine Elixir, Histatab Plus, Ed A-Hist LA, AccuHist Drops, Rhinatate-NF, Ricobid NR, BP Allergy JR, Ny-Tannic, Rynatan Pediatric, Phenchlor Tannate Pediatric, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, PD-Hist D, Ceron Drops, Nasohist Pediatric, PD-Hist D Drops, Sonahist, NoHist LQ, Anamine TD, Chlordrine SR, ND Clear, Time-Hist, Chlorafed Timecelles, Pseudochlor, Rescon-Ed, Kronofed-A, Or-Phen-Ade, Rinade-BID, Dallergy JR, Relera, Suphenamine-SR, Isophen-DF, MyHist-PD, Phena-S 12, Rondex, Rondex Drops, ChlorTan D, Actifed Cold and Allergy, Rinate Pediatric, Triaminic Cold & Allergy, P-Tann D, CP Dec, Cardec Drops, Ed ChlorPed D, Sildec-PE Drops, Ry-Tann, Hista-Vadrin, Tanafed, Maxichlor PEH, NoHist, Acta-Tabs PE, Sildec-PE, PediaTan D, Chlorafed HS Timecelles, Tannate Pediatric, Histadec, Duralex, C Phen, C Phen Drops, Dec-Chlorphen, Dec-Chlorphen Drops, Pseudocot-C, Deconomed SR, Dura-Tap/PD, Kronofed-A-Jr, Codimal-LA, Fedahist Timecaps, Chlorphedrin SR, D-Amine-SR, Colfed-A, Tri-Gestan S, Chemtussin HC, Quad Tann, Tannic-12, Carbaphen 12, Tannate-12, Quad Tann Pediatric, Quad Tuss Pediatric, Quadratuss, Rentamine Pediatric, Tuss Tan, Tuss Tan Pediatric, XiraTuss, Tanni-Hist 12 RF, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, TanaHist-PD, P-Tann, Exratuss, DryMax AF, Ricobid H, Rynatuss Pediatric, Quad-Tuss, Protuss Tablet, Ex-Tuss, AccuHist LA, Bellahist-D LA, Rolatuss-SR, Deconhist LA, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula, Atrohist Plus, Histacol LA, Ru-Tuss, Tussizone-12 RF, Tannate 12 S, Trionate, C-Tanna 12, Tannic-12 S, Tussi-12S, Respa-AR, SymPak II, Tustan 12S, Teldrin HBP Allergy, C.P.M., Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Vicks Children’s NyQuil Cold & Cough, Novadyne DH, Phenylhistine DH Expectorant, Tricode AR, Zodryl DAC, Decohistine DH, Codehist DH, Tricodene SF, Primatuss 4, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Scot-Tussin DM, St. Joseph HBP Cough & Cold, Cold & Cough, Robitussin Cough & Cold Long-Acting, Tricodene Sugar Free, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Dihistine DH, Demi-Cof, Ed Chlor-Tan, Allergy Time, Chlor-Phenit, Z-Tuss AC, ChlorTan, Chlorpheniramine (Allergy), Chlor-Mal, Chlo-Amine, PediaTan, Zodryl AC, Codar AR, Endal CD, T- Koff, Pediacof, Pedituss, Endacof-C, Lexuss 210, TL-Hist CM, Cotab A, Cotab AX, Quelidrine, Rolatuss, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Comtrex Cold and Flu Maximum Strength, Alka-Seltzer Plus Flu Formula, Multi Symptom Cold Relief, Comtrex Nighttime Cold & Cough, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Allpanto-S, Co-Apap, Childrens Tylenol Cold Plus Cough, Genacol Maximum Strength, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Theraflu Nighttime Severe Cold & Cough Caplets, Comtrex Cold & Cough Day Night, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Triaminic Multi-Symptom Fever, PediaCare Cough & Runny Nose Plus Acetaminophen, Mapap Cough & Sinus Formula, Colrex, Colrex Compound, Sinapils, Congestant, Cotabflu, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Tylenol Cold Head Congestion Nighttime, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Tylenol Plus Children's Flu, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Tylenol Plus Children's Multi-Symptom Cold, Alka-Seltzer Plus-D, Triaminic Flu, Cough & Fever, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Duadacin, Alumadrine, Covangesic, Trital SR, Rhinogesic, Comtrex Allergy Sinus, Kolephrin, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Sinarest Extra Strength, Allerest Headache Strength, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Dryphen, HEB Allergy, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, Allergy Sinus PE Pain Relief, Allergy Pain Relief, Gelpirin-CCF, Contac Cold + Flu (Night Formula), ConRx Allergy Sinus, GNP Cold Relief Plus, Gendecon, Tylenol Plus Children's Cold, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Alka-Seltzer Plus Cold & Flu, Comtrex Flu Therapy, Comtrex Severe Cold & Sinus, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, SymPak DM, Broncopectol, Novasus, Endagen-HD, Chemdal HD, Iodal HD, HyTan, S-T Forte 2, P Chlor GG, Donatussin Pediatric, Qual-Tussin Pediatric, Lemohist Plus, Rindal-HD, Ed-TLC, Iotussin HC, Chlorgest HD, Ed-Tuss HC, Cyndal HD, Nasatuss, Chemdal HD Plus, Efasin-HD, Guiaphen HD, Mintuss MS, Z-Tuss 2, Allfen A, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Mesehist DM, CPM-PSE DM Drops, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, Novahistine DH, DiHydro-PE, Hydro-Tussin DHC, Uni-Cof, Bronkotuss, Ana-Kit, Tricof, Duohist DH, Coldcough PD, Pancof-PD, Despec-PD, Hyphen-HD, Tuss-PD, B-Tuss, Hydro-PC II, Hydron CP, De-Chlor HD, Tussive HC, Hydrocodone CP, Hi-Tuss HC, Chlorphen HD, Duradal HD, Liquitussin HC Syrup, De-Chlor HC, Atuss MS, Relacon-HC NR, Tusana-D, Neo HC, Poly-Tussin HD, Phendal-HD, Echotuss-HC, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, Quindal HD Plus, Efasin-HD Plus, Endal-HD Plus, Enplus-HD, Comtussin HC, Tuss-HC, Exo-Tuss, Hycomine Compound, KG-Dal HD, Endotuss-HD, Ditussin-HC, Ventuss Syrup, Maxi-Tuss SA, H-C Tussive, Histussin HC Liquid, Cytuss HC, Tuss-DS, Uni Tuss HC, Highland HC, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Entre-S, Atuss DS, Maxichlor PEH DM, ED DM, Tri-Dex PE, Z-Dex 12 D, PE-Hist DM, EndaCof Drops, C-Phen DM, Robitussin Cough & Allergy, Sildec-PE DM Drops, DCP Drops, Trigofen DM Drops, Virdec DM, Bronkids, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, Nohist-DMX, RE DCP Drops, Zoden DM Drops, Re DCP, Sonahist-DM, Cardec DM, Tussplex DM, Neotuss D, Extendryl DM, Donatussin DM, Ceron-DM Drops, Zotex-DM, Genelan NF, ChlorDex GP, Qual-Tussin, Quartuss, Rondex-DM, Rondex-DM Drops, Nasohist-DM Pediatric, Cardec DM Drops, Balamine DM, Reme Tussin DM, Neo DM Drops, CP Dec DM, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, CP Dec-DM Drops, PD-Cof Drops, Tricodene NN, Cheracol Plus, Therahist, Threamine DM, Tricodene Forte, Dex PC, Mintuss DR, Trital DM, P Chlor DM, Rhinosyn-DM, Vicks 44M Pediatric, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Tanafed-DM, Rescon-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Children's Nyquil, Uni-Tuss DM, Corfen-DM, Albatussin SR, Cerose DM, Maxiphen ADT, Tussar DM, Relahist-DM, NoHist-PDX, Zotex-12D, Quartuss DM, Statuss DM, Liquituss R-DM, Centergy DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, De-Chlor DM, NeoTuss Plus, Atuss DM, Father John's Medicine Plus, Norel DM, Liquicough HC

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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