Chlorpheniramine use while Breastfeeding
Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Actifed, Chlor-Trimeton, Zutripro, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Tylenol Cold, Alka-Seltzer Plus Cold, Triaminic, Allergy Relief, Show all 762 »Ed A-Hist, TussiCaps, Theraflu Flu, Cold and Cough Powder, Rondec-DM, Triplex AD, Coricidin HBP Maximum Strength Flu, AlleRx, Rynatan, Ceron-DM, Chlor-Trimeton Allergy SR, Deconamine, Rondec, Deconamine SR, Sudafed PE Sinus & Allergy, Norel CS, Vituz, Norel AD, NoHist, Coldcough Syrup, Corfen-DM, Sildec-PE DM, Norel SR, Creomulsion Cough/Cold/Allergy, Coughtuss, AllePak, Donatussin Pediatric, Sildec-PE, Phenabid DM, Wal-finate, NoHist DM, Coricidin HBP Day & Night Multi-Symptom Cold, Alka-Seltzer Plus Cold Formula, NeoTuss Plus, Orlenta, Stahist, Aller-Chlor, Histinex HC, Allerest PE, Ed A-Hist DM, Mintex, C-Phen DM, Phena-S, Hydron CP, Mesehist DM, Hydrocodone CP, Chlordrine SR, Qdall, Tussi-12, Lohist, Tussin-V, Histex, DiHydro-PE, Naldecon, Nasohist Pediatric, Dicel, Sinus & Allergy PE, Cardec, Tylenol Cold Head Congestion Nighttime, Robitussin Cough & Cold Long-Acting, Novasus, AllerTan, Tanoral, Quartuss, Triant-HC, DryMax, Lexuss 210 Liquid, XL-3 Xtra Cold and Cough, Ed A-Hist LA, Triaminicin, Ahist, De-Chlor DM, Condrin, R-Tanna, Novahistine, M-End DM, Coricidin D, Contac Cold and Flu Maximum Strength, Allergy Multi-Symptom, Gendecon, Singlet, Duadacin, Triaminic-D Multi-Symptom Cold, Tylenol Allergy Sinus, Ryneze, Sinarest, Codeprex, Comtrex Severe Cold & Sinus, Onset Forte, DuraHist, AlleRx Dose Pack, Dryphen, Tylenol Sinus Congestion & Pain Nighttime, Poly-Tussin DM, PCM, Cerose DM, Tylenol Sinus Congestion and Pain Cool Burst Day Night, CP Dec DM, Chlorphen, Ornade Spansules, TanaHist-PD, Dec-Chlorphen DM, Dex PC, ChlorTan, Norel DM, Mescolor, Mintuss DR, Maxiphen ADT, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Triphenicol, Advil Allergy Sinus, Ru-Hist Forte, Phena-Plus, R-Tannate, Comtrex Nighttime Cold & Cough, Poly-Tussin, Allpanto-S, Dexodryl, Mintuss MS, Relacon-HC, R-Tannamine Pediatric, Rhinatate, Hydrocodone HD, Ventuss Syrup, Dihistine DH, Quartuss DM, Endal CD, Ditussin-HC, MyHist-PD, Carepanto, Cough Formula M Multi-Symptom, Cyndal HD, R-Tannamine, Nolamine, Cardec DM Drops, Ceron Drops, Triaminic Cold & Allergy, Novahistine DH, Donatussin DM Drops, Actifed Cold and Allergy, Phenylhistine, Atuss DS, Rynatan Pediatric, Trionate, Coldcough PD, Pseudoephedrine Plus, Tanafed, Anamine TD, Brexin LA, Allerest Maximum Strength, Suclor, Trital SR, Duotan, LoHist-D, Klerist-D, Dicel DM, Sinutab Ex-Strength, Cold Medicine Plus, Comtrex Cold and Flu Maximum Strength Tablet, Sinapils, Genamin, Triac, Kolephrin, Contac 12 Hour, Rhinolar-EX, Rescon-DM, Ceron, CPM-PE-MSC, Pancof, Rentamine, Comtrex Cold & Cough Day Night, Aerokid, Tylenol Cold Multi-Symptom Nighttime, Dallergy ER, Allergy DN PE, Dallergy JR, Phenchlor Tannate Pediatric, Relera, Neutrahist Drops, De-Congestine, Histatab Plus, Novahistine Elixir, Sudal-12 Chewable, Sudal-12 Tannate, Amilon, Duratuss DA, SudaHist, Ny-Tannic, Ry-Tann, ScopoHist, RelCof DN PSE, Histatab, Sudogest Cold & Allergy, AccuHist Drops, Ricobid NR, BP Allergy JR, Relcof PSE, SudoGest Sinus & Allergy, ScopoHist Syrup, Drysec, Ex-Histine, WE Allergy, Drize, Duradryl JR, DA II, Liqui-Allergy, Duradryl, Chlor-Mes D, Norel SD, Denaze, Extendryl Seniors, QV-Allergy, Ralix, AH-Chew II, Durahist PE, Omnihist II LA, Hista-Vent DA, Duravent DA, Extendryl JR, Aerohist Plus, AH-Chew, NoHist EXT, RespiVent DF, aeroHist, Allerx Dose Pack DF, Dexodryl Suspension, DuraTan PE, Nohist PE, Extendryl Chews, DA Chewable, Omnihist L.A., Prehist D, Extendryl SR, RelCof DN PE, Sinodec, Rescon Extended Release, AlleRx Dose Pack PE (PM Dose), Triaminic Softchews Cold and Allergy, Coldamine, Xiral SR, Rhinolar, AlleRx Dose Pack (PM Dose), Duradryl Chewable, DriHist, Dallergy Drops, Dallergy PSE, Hista-Vent PSE, Allergy DN, Pseudo CM TR, Allergy AM-PM Dose Pack, Rhinaclear, Time-Hist QD, PCM-LA, Amdry-C, RelCof PE, Duravent, PCM Allergy, Re-Drylex Jr, Duradryl SR, Chlor-Mes, Histatab PH, Redur-PCM, Ah-chew Ultra, Triall, SymPak PDX, Nohist Plus Jr, Dallergy PE, Ah-Chew Ultra Tannate, Nohist Plus, DriHist SR, ScopoHist-PE, Dehistine, VisRx Dose Pack, Histalet Forte, ARM Allergy Relief, Teldrin, Chlornade, Demazin, Or-Phen-Ade, Rhinolar-EX 12, Dura-Vent/A, Resaid, Ordrine, Decongex-3, Ryna Liquid, Dynahist ER, Histade CR, Genaphed Plus, Vanex Forte-R, Equi-Nade, Gencold, Allerest 12 Hour, Hayfebrol Liquid, Suphedrine Plus, Triotann Pediatric, Tri-Gestan S, Tri-Hist Pediatric, Histatan, Triotann, Tritan, Tanamine, URL-Tannate, Tri Tann Pediatric, Poly Hist PD, Tavist-DA, Chlor-Trimeton Allergy Decongestant SR, Atrohist Pediatric Capsule, Phena-S 12, Pyrichlor PE, Nalex A 12, Conal, Biohist LA, Chlor-Trimeton Decongestant, Rescon-Ed, Pseudochlor, Cophene No 2, Chlorafed Timecelles, Time-Hist, Isophen-DF, Kronofed-A, ND Clear, Anaplex, Anamine, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Chlorafed, Curaler, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Suphenamine-SR, Rinade-BID, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Fedahist, Histalet, Novafed A, Durafed, Clorfed, Dura-Tap/PD, Fedahist Timecaps, Sudogest Plus, Pseudocot-C, Duralex, Deconomed SR, D-Amine-SR, Chlorphedrin SR, Colfed-A, Url-Tannate Pediatric, Rhinatate Pediatric, Acta-Tabs PE, Suphedrine PE Sinus & Allergy, NoHist LQ, Nuhist, Sonahist, PD-Hist D, CP Dec Drops, Tanahist-D, Trigofen Drops, Hista-Vadrin, West-Decon, Nalspan, Uni Decon, Nalgest, Sinucon Pediatric, Nalphen, Nalda-Relief Pediatric, Nalgestic Pediatric, PD-Hist D Drops, Rhinatate-NF, C Phen Drops, C Phen, Tannate Pediatric, Dec-Chlorphen Drops, Dec-Chlorphen, Chlor-Mes Jr, Rondex, Rondex Drops, Histadec, PediaTan D, Rinate Pediatric, Ed ChlorPed D, Sildec-PE Drops, ChlorTan D, P-Tann D, CP Dec, Cardec Drops, Prop-A-Hist, Sinucon, Chlorex-A 12, Atrohist Pediatric, Rynatan-S Pediatric, Dynahist-ER Pediatric, CP-Tannic, Coldex, West-Decon M, NoHist-A, R-Tannate Pediatric, Gelhist Pediatric, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Triple Tannate Pediatric, Equitan Pediatric, Triotann-S, Triotann-S Pediatric, Tanoral Pediatric, Chlorex A, Nalex-A SR, Comhist, Allergy DN II, C-Phed Tannate, Rhinacon A, Nalex-A, Naldelate, Andecon Pediatric Drops, Vanex Forte, Pediox Chewable, Sudal-12, Chlortox, Linhist-L.A., C-Hist-SR, Q-Hist LA, Comhist LA, Re2+30, Histade, Allan Tannate Pediatric, Histussin HC Liquid, PediaTan, Chlorpheniramine (Allergy), Ed Chlor-Tan, Chlor-Phenit, Chlo-Amine, Chlor-Mal, Ed ChlorPed, Pharbechlor, C.P.M., Topco Allergy, Z-Tuss AC, TL-Hist CM, Codar AR, CapCof, Zodryl AC, Notuss-AC, Endacof-C, Cotab A, Cotab AX, Ricobid H, Exratuss, Quadratuss, Rynatuss, Rentamine Pediatric, Rynatuss Pediatric, Quad-Tuss, Tannate 12 S, C-Tanna 12, Tustan 12S, Tuss Tan, Tuss Tan Pediatric, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Carbaphen 12, Quad Tann, Tetra Tannate Pediatric, Quad Tuss Pediatric, Quad Tann Pediatric, T- Koff, Pediacof, Genelan NF, Zotex-DM, Broncopectol, SymPak DM, Cold & Cough, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Vicks Children's Nyquil, ChlorDex GP, Qual-Tussin, Liquituss R-DM, Atuss DM, De-Chlor DR, Tussar DM, PE-Hist DM, Extendryl DM, ED DM, Ricotuss, Triaminic Softchews Cough & Runny Nose, Tricodene Sugar Free, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Codehist DH, Decohistine DH, Pedituss, Demi-Cof, Phenylhistine DH, Ryna-C, Codahistine-DH Elixir, Vicks Pediatric Formula 44m Cough & Cold Relief, Effective Strength Cough Syrup, Primatuss 4, QC Cough/Cold, Tricodene SF, Zodryl DAC, Tricode AR, Scot-Tussin DM, Tussi-12S, Tussizone-12 RF, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Severe Cold and Flu Maximum Stength, Comtrex Cold and Flu Maximum Strength, Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Comtrex Maximum Strength Cold Relief, Theraflu Flu & Cough, Triaminic Flu, Cough & Fever, Tylenol Plus Children's Cold, Pyrroxate, Contac Cold + Flu (Night Formula), Comtrex Flu Therapy, Tylenol Allergy Multi-Symptom, Gelpirin-CCF, Protid, Dristan Cold Multi Symptom Formula, Dimetapp Children's Multi-Symptom Cold & Flu, Alka-Seltzer Plus Flu Formula, Mapap Cough & Sinus Formula, Tylenol Plus Children's Cough & Runny Nose, Triaminic Multi-Symptom Fever, Vicks Formula 44 Custom Care Cough & Cold PM, Colrex, Congestant, Cotabflu, Colrex Compound, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Cold Head Congestion Day and Night, Alka-Seltzer Plus Cold & Cough Formula Liquid, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Theraflu Nighttime Severe Cold & Cough Caplets, Codral Cold and Flu + Cough Day and Night, Tylenol Plus Children's Multi-Symptom Cold, Tylenol Plus Children's Flu, Dimetapp Children's Nighttime Flu, Robitussin Peak Cold Nighttime Nasal Relief, Alka-Seltzer Plus Cold & Flu, Alka-Seltzer Plus Flu Formula (old formulation), Alka-Seltzer Plus Cold & Cough Formula, Atrohist Plus, Quelidrine, Rolatuss, Sinarest Extra Strength, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Deconhist LA, Rolatuss-SR, Ru-Tuss, SymPak II, Tannic-12 S, Respa-AR, Bellahist-D LA, Protuss Tablet, Ex-Tuss, AccuHist LA, Allerest Headache Strength, Comtrex Allergy Sinus Night and Day, Covangesic, Rhinogesic, Sinulin, ConRx Allergy Sinus, GNP Cold Relief Plus, HEB Allergy, Allergy Pain Relief, Allergy Sinus PE Pain Relief, Chlor-Trimeton Sinus, Alumadrine, Codimal, Allerest Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus, Tricom, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Coldtuss-DR, Tri-Vent DPC, H-C Tussive, Hycomine Compound, Cytuss HC, Tuss-DS, Uni Tuss HC, Highland HC, Maxi-Tuss SA, Maxi-Tuss HC, KG-Dal HD Plus, Efasin-HD Plus, Quindal HD Plus, Tussive HC, B-Tuss, Hydro-PC II, Liquitussin HC Syrup, Duradal HD, Quindal HD, Hi-Tuss HC, Chlorphen HD, Tuss-HC, Comtussin HC, Chemdal HD Plus, Nasatuss, Iotussin HC, Vanex-HD, Guiaphen HD, Rindal-HD, Ed-TLC, Efasin-HD, Chlorgest HD, Ed-Tuss HC, Exo-Tuss, Endal-HD Plus, Enplus-HD, Chemtussin HC, Endotuss-HD, Hyphen-HD, Tuss-PD, KG-Dal HD, De-Chlor HD, De-Chlor HC, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, A-G Tussin, Q-V Tussin, Notuss, Hexatussin, Hyphed, Hydron PCS, Hydrocof-HC, Advil Allergy and Congestion Relief, Advil Children's Allergy Sinus, AlleRx DF, Notuss-Forte, Atuss HS, Cordron-HC, Cordron-HC NR, Atuss HD, JayCof-HC, Welltuss HC, Phendal-HD, Relacon-HC NR, Tusana-D, Echotuss-HC, Rindal HD Plus, Atuss MS, Hydro-PC II Plus, Uni-Tricof HC, Poly-Tussin HD, Relasin-HC, Histinex PV, Pediatex HC, Tussend, Detuss, DroTuss-CP, Z-Cof HC, Neo HC, Liquicough HC, Iodal HD, Chemdal HD, Nohist-DMX, Z-Dex 12 D, Bronkids, NoHist-PDX, Zotex-12D, PD-Cof, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, DCP Drops, Centergy DM, Threamine DM, Tricodene Forte, Tricodene NN, Kophane, Robitussin Cough & Allergy, Father John's Medicine Plus, RE DCP Drops, Nasohist-DM Pediatric, Nasohist-DM, Sonahist-DM, Ceron-DM Drops, Rondex-DM, Rondex-DM Drops, Donatussin DM, P Chlor DM, Atuss DR, Uni-Tuss DM, Trital DM, Dec-Chlorphen DM Drops, HistadecDM, Sildec-PE DM Drops, Relahist-DM, Maxichlor PEH DM, C-Phen DM Drops, Cardec DM, Neo DM Drops, Reme Tussin DM, Tussplex DM, Cheracol Plus, Therahist, Bronkotuss, Ana-Kit, Allfen A, Uni-Cof, Dihydro-CP, Tusscough DHC, Tricof, Hydro-Tussin DHC, Z-Tuss 2, SymPak, Hydrocodone GF, Maxi-Tuss HCX, Endagen-HD, HyTan, S-T Forte 2, Qual-Tussin Pediatric, P Chlor GG, Lemohist Plus, Despec-PD, Duohist DH, Creomulsion Pediatric, Kidcare Cough and Cold, Children's Nyquil, Vicks 44M Pediatric, Rhinosyn-DM, Allres DS, Duotan DM, T-Tanna DM, Tanafed-DM, C-Phed DM, CPM-PSE DM Drops, Esocor P, Pancof-PD, Entre-S, AccuHist PDX Drops, Atuss-12 DM, Maxichlor PSE DM, Neutrahist PDX Drops, RelCof CPM
Chlorpheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]
Possible Effects on Lactation
Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.
Alternate Drugs to Consider
Desloratadine, Fexofenadine, Loratadine
References
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
Chlorpheniramine Identification
Substance Name
Chlorpheniramine
CAS Registry Number
132-22-9
Drug Class
Administrative Information
LactMed Record Number
64
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2012-10-02
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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