Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Alka-Seltzer Plus Cold, Chlor-Trimeton, Coricidin HBP Cold & Flu, Coricidin HBP Cough & Cold, Theraflu Flu, Cold and Cough Powder, Triaminic, Tylenol Cold, Norel AD, CapCof, Show all 793 »Zutripro, Alka-Seltzer Plus Cold Formula, TussiCaps, Coricidin D, Ceron-DM, Sinarest, Rondec-DM, Sudafed PE Sinus & Allergy, Rondec, Triplex AD, Chlor-Trimeton Allergy SR, Rynatan, Norel SR, Sildec-PE DM, Aller-Chlor, Coughtuss, Triant-HC, Naldecon, NoHist DM, XL-3 Cold Medicine, Dimetapp Children's Multi-Symptom Cold & Flu, Wal-finate, Duralex, Advil Allergy and Congestion Relief, Allergy Relief, Hydrocodone CP, Coldex, Cardec, R-Tanna, Ed A-Hist, Nalex-A, Rentamine, Stahist, Genelan NF, Cardec DM Drops, Ed A-Hist DM, Coricidin HBP Day & Night Multi-Symptom Cold, Novasus, Tussin-V, Coldcough Syrup, XL-3 Xtra Cold and Cough, Deconamine, Brexin LA, Norel CS, Extendryl Chews, Respa-AR, Ralix, Suclor, Qdall, Notuss, Welltuss HC, Singlet, Triaminicin, Cold Medicine Plus, Vituz, C-Phen DM, C.P.M., Sinus & Allergy PE, Z-Tuss AC, Ceron, Tanoral, AlleRx, Lohist, Trital DM, SymPak, Threamine DM, Pancof, Tanahist-D, Codahistine-DH Elixir, Quartuss, Cough Formula M Multi-Symptom, Tylenol Cold Multi-Symptom Nighttime, Hydron CP, Amilon, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Phenylhistine DH Expectorant, Echotuss-HC, Phenylhistine DH, Gelhist Pediatric, Coldamine, Phena-Plus, Phena-S, Demi-Cof, Hydrocodone HD, Ornade Spansules, Mescolor, Contac Cold and Flu Maximum Strength, DuraHist, T-Tanna DM, Rindal-HD, Ordrine, Carbaphen CH, Demazin, Quadratuss, Cytuss HC, Dura-Vent/A, Alka-Seltzer Plus Cold & Flu, HistadecDM, Reme Tussin DM, Cardec DM, C-Phen DM Drops, Rondex-DM, DiHydro-PE, Codar AR, Childrens Tylenol Cold Plus Cough, Neotuss D, Tylenol Plus Children's Multi-Symptom Cold, Phenabid DM, Bronkids, Pyrroxate, GNP Cold Relief Plus, Dristan Cold Multi Symptom Formula, Notuss-AC, De-Chlor DM, NeoTuss Plus, Quartuss DM, Maxiphen ADT, ChlorTan, Pharbechlor, P Chlor DM, C-Tanna 12, Sinutab Ex-Strength, Actifed Cold & Sinus, Kolephrin, Codimal, Q-V Tussin, JayCof-HC, Actifed Cold and Allergy, Anaplex, Sudogest Cold & Allergy, SudoGest Sinus & Allergy, Dicel, P-V-Tussin Syrup, Effective Strength Cough Syrup, Triaminic Softchews Cough & Runny Nose, Trital SR, Qual-Tussin Pediatric, AlleRx Dose Pack, Advil Allergy Sinus, Alumadrine, Dexodryl Suspension, aeroHist, RelCof CPM, Tricodene Sugar Free, Tannic-12 S, Orlenta, PCM, Dehistine, Duravent, Coricidin HBP Maximum Strength Flu, Kidcare Cough and Cold, Children's Nyquil, Triaminic-D Multi-Symptom Cold, Ru-Tuss, CPM-PSE DM Drops, M-End DM, Bronkotuss, Vicks NyQuil Cold & Flu Relief (Alcohol Free), Triaminic Cold & Allergy, Ana-Kit, Duotan, Fedahist, Kronofed-A-Jr, QC Cough/Cold, C Phen, Kophane, DryMax, Relera, Rondex, Xiral SR, Rhinolar, RelCof DN PSE, Re2+30, Histatab, Atrohist Pediatric Capsule, Suphedrine Plus, Hayfebrol Liquid, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Dynahist-ER Pediatric, Tavist-DA, Genaphed Plus, Nuhist, Ricobid NR, Suphedrine PE Sinus & Allergy, Sonahist, NoHist LQ, Novahistine, Dallergy JR, CP-Tannic, Histade, Time-Hist QD, AllePak, Rhinaclear, Amdry-C, PCM-LA, Relcof PSE, Hista-Vent PSE, Allergy DN, Pseudo CM TR, Nolamine, Mintex, DriHist, VisRx Dose Pack, ScopoHist, Allergy AM-PM Dose Pack, Dallergy PSE, AlleRx Dose Pack PE (PM Dose), Nohist Plus, Nohist Plus Jr, Dallergy SR, DuraTan PE, Allergy DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), Duradryl Chewable, Aerohist Plus, SymPak PDX, ScopoHist-PE, Sinodec, Triall, Ah-Chew Ultra Tannate, Duradryl SR, Dallergy PE, CPM-PE-MSC, RelCof DN PE, Nohist PE, Advil Children's Allergy Sinus, AlleRx DF, Pseudoephedrine Plus, Dynahist ER, Atuss HS, Cordron-HC, Cordron-HC NR, Atuss HD, Triaminic Softchews Cold and Allergy, LoHist-D, Dexodryl, Ryneze, DriHist SR, Allerx Dose Pack DF, RespiVent DF, AccuHist Drops (old formulation), Allergy DN II, NoHist EXT, Extendryl SR, Prehist D, Redur-PCM, Ah-chew Ultra, Histatab PH, BP Allergy JR, Rescon Extended Release, Dallergy ER, Extendryl Seniors, QV-Allergy, SudaHist, Sudal-12 Tannate, C-Phed Tannate, Pediox Chewable, Sudal-12, De-Congestine, Re-Drylex Jr, Sudal-12 Chewable, Chlor-Mes, PCM Allergy, Aerokid, Denaze, Liqui-Allergy, AH-Chew, Duradryl, DA II, Hista-Vent DA, DA Chewable, Omnihist L.A., Duravent DA, Duradryl JR, Drize, Durahist PE, Omnihist II LA, AH-Chew II, Norel SD, Chlor-Mes D, Drysec, Ex-Histine, WE Allergy, Extendryl JR, P-Tann D, Triotann Pediatric, Chlorex-A 12, Tri-Gestan S, Histatan, Time-Hist, Triotann, Ru-Hist Forte, Chlorafed Timecelles, Tri-Hist Pediatric, Tri Tann Pediatric, Phena-S 12, MyHist-PD, Anamine TD, Poly Hist PD (old formulation), Pyrichlor PE, Nalex A 12, AllerTan, Conal, URL-Tannate, R-Tannamine, Triotann-S Pediatric, Rescon-Ed, Tanoral Pediatric, R-Tannamine Pediatric, Triotann-S, Rynatan-S Pediatric, R-Tannate Pediatric, R-Tannate, Equitan Pediatric, Triple Tannate Pediatric, Url-Tannate Pediatric, Tritan, Tanamine, Rhinatate, Rhinatate Pediatric, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Chlordrine SR, Rhinolar-EX 12, Colfed-A, Chlorphedrin SR, Fedahist Timecaps, Chlor-Trimeton Decongestant, Histade CR, Pseudocot-C, Deconomed SR, D-Amine-SR, Dura-Tap/PD, Durafed, Duratuss DA, Clorfed, Histalet, Chlorafed HS Timecelles, Novafed A, Biohist LA (old formulation), Deconamine SR, Codimal-LA, Rinade-BID, Suphenamine-SR, ND Clear, Kronofed-A, Chlornade, Teldrin, ARM Allergy Relief, Resaid, Or-Phen-Ade, Contac 12 Hour, Condrin, Decongex-3, Isophen-DF, Allerest 12 Hour, Vanex Forte-R, Genamin, Triac, Equi-Nade, Gencold, Rhinolar-EX, Atrohist Pediatric, Pseudochlor, CP Dec, Cardec Drops, Tanafed, PediaTan D, Histadec, Dec-Chlorphen Drops, C Phen Drops, Tannate Pediatric, ChlorTan D, Rinate Pediatric, Maxichlor PEH, Ry-Tann, Hista-Vadrin, NoHist, Sildec-PE, Ed ChlorPed D, Sildec-PE Drops, Acta-Tabs PE, Dec-Chlorphen, Rondex Drops, Novahistine Elixir, Histatab Plus, Ed A-Hist LA, Phenylhistine, AccuHist Drops, Ny-Tannic, Rhinatate-NF, Trigofen Drops, Rynatan Pediatric, Phenchlor Tannate Pediatric, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, PD-Hist D, Ceron Drops, Nasohist Pediatric, Dallergy Drops, PD-Hist D Drops, Ryna Liquid, Nalphen, Comhist, Linhist-LA, Codimal-LA Half, Rhinacon A, NoHist-A, Vanex Forte, Clorfed II, Fedahist Gyrocaps, Comhist LA, Q-Hist LA, Klerist-D, Anamine, Cophene No 2, West-Decon M, Chlorex A, Chlortox, C-Hist-SR, Nalex-A SR, Histalet Forte, Andecon Pediatric Drops, Chlorafed, Curaler, Nalda-Relief Pediatric, Histafed LA, Chlor-Trimeton Allergy Decongestant, Neutrahist Drops, Sudogest Plus, Aller-Chlor Decongestant, Nalgestic Pediatric, Sinucon Pediatric, Prop-A-Hist, Sinucon, Naldelate, Uni Decon, Nalspan, Nalgest, West-Decon, Hydrocof-HC, Allerest PE, Chemtussin HC, Tannate-12, XiraTuss, Tanni-Hist 12 RF, Exratuss, Carbaphen 12, Tannic-12, Quad Tuss Pediatric, Quad Tann Pediatric, Quad Tann, DryMax AF, Ricobid H, Teldrin HBP Allergy, Chlor-Mal, Chlo-Amine, Topco Allergy, Ed-Chlortan, P-Tann, TanaHist-PD, Ed ChlorPed, Tetra Tannate Pediatric, Tuss Tan Pediatric, Bellahist-D LA, Histacol LA, SymPak II, Tustan 12S, AccuHist LA, Ex-Tuss, Deconhist LA, Rolatuss-SR, Protuss Tablet, Tussi-12S, Tussi-12, Rynatuss, Rentamine Pediatric, Tuss Tan, Rynatuss Pediatric, Quad-Tuss, Tussizone-12 RF, Tannate 12 S, Trionate, Chlorphen, PediaTan, Primatuss 4, Dimetapp Children's Long Acting Cough Plus Cold, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Tricodene SF, Scot-Tussin DM, Co-Histine DH, Ryna-C, Vicks Children’s NyQuil Cold & Cough, Carepanto, Cold & Cough, Broncopectol, ChlorDex GP, Qual-Tussin, SymPak DM, St. Joseph HBP Cough & Cold, Vicks Children's Nyquil, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, Novadyne DH, Codehist DH, TL-Hist CM, Cotab A, Cotab AX, Lexuss 210, Zodryl AC, Chlor-Phenit, Chlorpheniramine (Allergy), Ed Chlor-Tan, Allergy Time, Codeprex, Endacof-C, Tricode AR, Zodryl DAC, Decohistine DH, Dihistine DH, Pedituss, Endal CD, T- Koff, Pediacof, Atrohist Plus, Alka-Seltzer Plus Cold & Cough Formula, Multi Symptom Cold Relief, Alka-Seltzer Plus Flu Formula, Dimetapp Children's Nighttime Flu, Comtrex Cold and Flu Maximum Strength, Multi Symptom Cold (Night Formula), Cold Multi-Symptom (Nighttime), Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Allpanto-S, Co-Apap, Alka-Seltzer Plus-D, Theraflu Flu & Cough, Genacol Maximum Strength, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Theraflu Nighttime Severe Cold & Cough Caplets, Comtrex Cold & Cough Day Night, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Triaminic Multi-Symptom Fever, PediaCare Cough & Runny Nose Plus Acetaminophen, Mapap Cough & Sinus Formula, Colrex, Colrex Compound, Sinapils, Congestant, Cotabflu, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, PediaCare Flu Plus Acetaminophen, Codral Cold and Flu + Cough Day and Night, Tylenol Cold Head Congestion Nighttime, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Multi-Symptom Cold Plus Acetaminophen, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Tylenol Plus Children's Flu, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Simplet, Tricom, Comtrex Allergy Sinus, Allerest Sinus, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Duadacin, Sinulin, Chlor-Trimeton Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Rolatuss, Quelidrine, Alka-Seltzer Plus Flu Formula (old formulation), Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Rhinogesic, Covangesic, Robitussin Peak Cold Nighttime Nasal Relief, Onset Forte, Gendecon, Tylenol Allergy Multi-Symptom, Allergy Multi-Symptom, Allergy Sinus PE Pain Relief, Contac Cold + Flu (Night Formula), ConRx Allergy Sinus, Allergy Pain Relief, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Tylenol Sinus Congestion and Pain Cool Burst Day Night, HEB Allergy, Dryphen, Sine-Off Sinus/Cold, Hybrid CF, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Protid, Zotex-DM, Extendryl DM, KG-Dal HD, Endotuss-HD, Ditussin-HC, Hycomine Compound, Tuss-PD, Hyphen-HD, Chlorgest HD, Ed-Tuss HC, Cyndal HD, Exo-Tuss, Endal-HD Plus, Maxi-Tuss HC, Histinex HC, KG-Dal HD Plus, Maxi-Tuss SA, Ventuss Syrup, Enplus-HD, Comtussin HC, Tuss-HC, Iotussin HC, Nasatuss, Donatussin Pediatric, Lemohist Plus, Hydrocodone GF, S-T Forte 2, P Chlor GG, Z-Tuss 2, Dihydro-CP, Uni-Cof, Allfen A, HyTan, Endagen-HD, Mintuss MS, Vanex-HD, Chemdal HD Plus, Guiaphen HD, Efasin-HD, Chemdal HD, Iodal HD, Ed-TLC, Highland HC, Uni Tuss HC, DroTuss-CP, Z-Cof HC, Maxi-Tuss HCX, Relacon-HC, Relasin-HC, Liquicough HC, Tusana-D, Neo HC, Poly-Tussin HD, Notuss-Forte, Detuss, A-G Tussin, KG-Tussin, Hydrotuss HC, Hyphed, Hexatussin, Histinex PV, Pediatex HC, Tussend, Relacon-HC NR, Phendal-HD, Quindal HD, Hi-Tuss HC, Chlorphen HD, Duradal HD, Quindal HD Plus, Efasin-HD Plus, H-C Tussive, Histussin HC Liquid, Tuss-DS, Liquitussin HC Syrup, Tussive HC, Hydro-PC II Plus, Uni-Tricof HC, Rindal HD Plus, Atuss MS, De-Chlor HC, B-Tuss, Hydro-PC II, De-Chlor HD, Hydro-Tussin DHC, Tricof, Nohist-DMX, Donatussin DM Drops, Nasohist-DM, DM-PE-Chlor, RE DCP Drops, Sonahist-DM, Trigofen DM Drops, Virdec DM, Zoden DM Drops, CP Dec-DM Drops, PD-Cof Drops, Cerose DM, Tussar DM, Liquituss R-DM, Albatussin SR, Relahist-DM, PD-Cof, Zotex-12D, NoHist-PDX, Z-Dex 12 D, Tri-Dex PE, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Balamine DM, Dec-Chlorphen DM Drops, Dec-Chlorphen DM, Donatussin DM, Ceron-DM Drops, Rondex-DM Drops, Tussplex DM, Robitussin Cough & Allergy, ED DM, Poly-Tussin DM, Ricotuss, Maxichlor PEH DM, PE-Hist DM, Sildec-PE DM Drops, DCP Drops, EndaCof Drops, Centergy DM, Atuss DM, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, Entre-S, Atuss DS, C-Phed DM, Atuss-12 DM, Dicel DM, Esocor P, Mesehist DM, Despec-PD, Duohist DH, Tusscough DHC, Pancof-PD, Coldcough PD, Allres DS, Duotan DM, Novahistine DH, Tanafed-DM, Rescon-DM, Atuss DR, Corfen-DM, Uni-Tuss DM, Mintuss DR, Tri-Vent DPC, Coldtuss-DR, Father John's Medicine Plus, Norel DM, De-Chlor DR, Dex PC, Tricodene Forte, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Rhinosyn-DM, Triphenicol, Tricodene NN, Cheracol Plus, Therahist, Hydron PCS

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20130907

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