Chlorpheniramine use while Breastfeeding

Drugs containing Chlorpheniramine: Tussionex Pennkinetic, Chlor-Trimeton, Alka-Seltzer Plus Cold, Coricidin HBP Cold & Flu, Zutripro, Triaminic, Allergy Relief, Tylenol Cold, Coricidin HBP Cough & Cold, TussiCaps, Show all 786 »Triplex AD, Ceron, Ceron-DM, Sinarest, Theraflu Flu, Cold and Cough Powder, Coricidin HBP Maximum Strength Flu, Rondec, Coricidin D, Anamine, Norel AD, Ed A-Hist, Kolephrin, Contac Cold and Flu Maximum Strength, Denaze, Hydrocodone HD, Sinucon, Sildec-PE DM, Rescon-DM, Chlorphen, Demazin, Alka-Seltzer Plus Cold Formula, Naldecon, Rynatan, Relera, Sinus & Allergy PE, NoHist DM, Cardec DM, Hydrocodone CP, DryMax, Stahist, Cold Medicine Plus, Norel CS, Tylenol Allergy Sinus, Simplet, Qdall, Effective Strength Cough Syrup, Teldrin, Ricotuss, Aller-Chlor, Chlor-Trimeton Allergy SR, Brexin LA, Actifed Cold and Allergy, Coughtuss, Vanex-HD, Triant-HC, Ralix, Advil Allergy Sinus, PCM, Novasus, Triaminic-D Multi-Symptom Cold, Cardec, NeoTuss Plus, Norel SR, Triphenicol, Esocor P, Phenabid DM, Norel DM, Genacol Maximum Strength, Nohist-DMX, C-Phen DM, Hybrid CF, Ornade Spansules, Balamine DM, Cardec DM Drops, Maxichlor PSE DM, Atuss DS, Rondec-DM, Dec-Chlorphen DM, Condrin, Ordrine, Kidcare Cough and Cold, Ru-Tuss, Triaminic Multi-Symptom Fever, Dehistine, M-End DM, Ed A-Hist DM, Nasohist-DM, Zotex-12D, Atuss DM, Tri-Vent DPC, Allergy Pain Relief, XL-3 Cold Medicine, Phena-S, Coldcough Syrup, HyTan, Cotabflu, Tritan, Rhinatate, Pyrroxate, Scot-Tussin DM, Chlorex A, Codral Cold and Flu + Cough Day and Night, Endacof-C, Codeprex, ChlorTan, Wal-finate, Tylenol Allergy Multi-Symptom, Amilon, Relacon-HC, De-Chlor HC, Cotab AX, Codar AR, Rhinaclear, Hydro-PC II, Multi Symptom Cold Relief, Triac, Singlet, Detuss, Sinapils, Dexodryl Suspension, Codimal, Sinutab Ex-Strength, LoHist-D, JayCof-HC, Sinulin, aeroHist, NoHist, AlleRx, Alumadrine, Duadacin, R-Tanna, C Phen, Sudafed PE Sinus & Allergy, Advil Allergy and Congestion Relief, Lohist, Dicel, Triaminicin, Cheracol Plus, Suphenamine-SR, Fedahist, Mintex, Deconamine, Deconamine SR, Isophen-DF, Orlenta, Cophene No 2, Chlor-Trimeton Allergy Decongestant, Anaplex, Ricobid NR, AlleRx Dose Pack PE (PM Dose), Redur-PCM, Suphedrine PE Sinus & Allergy, AlleRx Dose Pack, Histatab PH, Ah-chew Ultra, Rhinolar, BP Allergy JR, Extendryl JR, Chlor-Mes, NoHist LQ, Sonahist, PCM Allergy, Dallergy JR, Novahistine, DriHist, Re-Drylex Jr, Nuhist, Klerist-D, Fedahist Gyrocaps, Clorfed II, Codimal-LA Half, VisRx Dose Pack, ScopoHist, Allergy AM-PM Dose Pack, Rescon Extended Release, Histafed LA, SudaHist, Nolamine, Histatab, Curaler, Chlorafed, Sudal-12 Tannate, Coldamine, Pseudo CM TR, Mescolor, Hista-Vent PSE, Relcof PSE, Dallergy PSE, Xiral SR, RelCof DN PSE, PCM-LA, Pseudochlor, AllePak, Allergy DN, Time-Hist QD, Amdry-C, AccuHist Drops (old formulation), DuraHist, SudoGest Sinus & Allergy, Ryna Liquid, Neutrahist Drops, Duravent, DriHist SR, Dynahist ER, Ryneze, RespiVent DF, Allerx Dose Pack DF, Dexodryl, Nohist PE, RelCof DN PE, Nohist Plus, Nohist Plus Jr, Dallergy SR, DuraTan PE, Allergy DN PE, RelCof PE, ScopoHist Syrup, AlleRx Dose Pack (PM Dose), NoHist EXT, Allergy DN II, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, A-G Tussin, Q-V Tussin, Hexatussin, Hyphed, Tussin-V, Hydron PCS, Hydrocof-HC, Advil Children's Allergy Sinus, RelCof CPM, AlleRx DF, Sudogest Cold & Allergy, Atuss HS, Cordron-HC, Cordron-HC NR, Atuss HD, Duradryl Chewable, Aerohist Plus, Hayfebrol Liquid, Ex-Histine, WE Allergy, Chlor-Mes D, Allerest PE, Aller-Chlor Decongestant, Drize, Drysec, Sudogest Plus, Suphedrine Plus, Pseudoephedrine Plus, Aerokid, Dallergy ER, Extendryl Seniors, AH-Chew II, Omnihist II LA, Triaminic Softchews Cold and Allergy, Norel SD, Durahist PE, Duradryl JR, Duradryl, SymPak PDX, ScopoHist-PE, Sinodec, Triall, Ah-Chew Ultra Tannate, Duradryl SR, Dallergy PE, CPM-PE-MSC, Extendryl SR, Prehist D, DA II, Liqui-Allergy, AH-Chew, Hista-Vent DA, Duravent DA, Extendryl Chews, DA Chewable, Omnihist L.A., QV-Allergy, PediaTan D, Nalex A 12, AllerTan, Conal, Tri Tann Pediatric, Phena-Plus, Chlorex-A 12, Tri-Gestan S, Tri-Hist Pediatric, Pyrichlor PE, Poly Hist PD (old formulation), Dura-Vent/A, Resaid, Or-Phen-Ade, Rhinolar-EX 12, Histade, Phena-S 12, MyHist-PD, Suclor, Triotann Pediatric, Histatan, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Triple Tannate Pediatric, Equitan Pediatric, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Rhinatate Pediatric, Url-Tannate Pediatric, Ru-Hist Forte, Sudal-12, Re2+30, Triotann, URL-Tannate, Tanamine, R-Tannamine, Tanoral, Contac 12 Hour, ARM Allergy Relief, Pseudocot-C, Duratuss DA, Clorfed, Novafed A, Biohist LA (old formulation), Chlor-Trimeton Allergy Decongestant SR, Durafed, Histex, Histalet, Tanafed, Chlorphedrin SR, Colfed-A, D-Amine-SR, Fedahist Timecaps, Dura-Tap/PD, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Tavist-DA, Duralex, Rhinolar-EX, Genamin, Allerest 12 Hour, Gencold, Anamine TD, Chlornade, Decongex-3, Equi-Nade, Vanex Forte-R, CP-Tannic, Duotan, Kronofed-A, Rinade-BID, Chlor-Trimeton Decongestant, Histade CR, Chlordrine SR, Dynahist-ER Pediatric, ND Clear, Triotann-S, R-Tannate, Deconomed SR, CP Dec, Cardec Drops, Histadec, Tannate Pediatric, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, P-Tann D, Triaminic Cold & Allergy, Atrohist Pediatric Capsule, Allerest Maximum Strength, Sudal-12 Chewable, Time-Hist, Chlorafed Timecelles, ChlorTan D, Rescon-Ed, Genaphed Plus, Rondex Drops, Rondex, Histatab Plus, Ed A-Hist LA, Rynatan Pediatric, Novahistine Elixir, Phenylhistine, Rhinatate-NF, Trigofen Drops, AccuHist Drops, Phenchlor Tannate Pediatric, Nasohist Pediatric, Allan Tannate Pediatric, CP Dec Drops, Chlor-Mes Jr, Tanahist-D, PD-Hist D, Dallergy Drops, PD-Hist D Drops, Ceron Drops, De-Congestine, Rinate Pediatric, Comhist, Comhist LA, Q-Hist LA, Rhinacon A, Nalex-A, Vanex Forte, Pediox Chewable, NoHist-A, Chlortox, Linhist-L.A., Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, Atrohist Pediatric, West-Decon M, C-Hist-SR, Nalex-A SR, Coldex, Histalet Forte, Andecon Pediatric Drops, Hista-Vadrin, C-Phed Tannate, Welltuss HC, Ry-Tann, Sildec-PE, Ed ChlorPed D, Sildec-PE Drops, Acta-Tabs PE, Nalphen, Nalda-Relief Pediatric, Uni Decon, Prop-A-Hist, Naldelate, Nalspan, West-Decon, Nalgestic Pediatric, Sinucon Pediatric, Nalgest, Ny-Tannic, Enplus-HD, Tanni-Hist 12 RF, Exratuss, Carbaphen CH, DryMax AF, XiraTuss, Tannate-12, Quad Tann, Tannic-12, Carbaphen 12, Ricobid H, TanaHist-PD, C.P.M., Chlor-Mal, Chlo-Amine, PediaTan, Teldrin HBP Allergy, Pharbechlor, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Quad Tann Pediatric, Quad Tuss Pediatric, Tannic-12 S, Tussi-12, Tussizone-12 RF, Tannate 12 S, Tussi-12S, Tustan 12S, Bellahist-D LA, Respa-AR, SymPak II, Trionate, C-Tanna 12, Rentamine, Tuss Tan, Tuss Tan Pediatric, Tetra Tannate Pediatric, Rentamine Pediatric, Rynatuss, Quad-Tuss, Rynatuss Pediatric, Quadratuss, Chlorpheniramine (Allergy), Ed Chlor-Tan, Tricodene SF, QC Cough/Cold, Primatuss 4, Tricodene Sugar Free, Vicks Children’s NyQuil Cold & Cough, Codahistine-DH Elixir, Novadyne DH, Co-Histine DH, Ryna-C, Triaminic Softchews Cough & Runny Nose, Dimetapp Children's Long Acting Cough Plus Cold, Vicks Pediatric Formula 44m Cough & Cold Relief, Triaminic Night Time Cough & Runny Nose, St. Joseph HBP Cough & Cold, SymPak DM, Vicks Children's Nyquil, Cold & Cough, Robitussin Children's Cough & Cold Long-Acting, Robitussin Cough & Cold Long-Acting, Carepanto, Phenylhistine DH Expectorant, Codehist DH, TL-Hist CM, Cotab A, Notuss-AC, CapCof, Lexuss 210 Liquid, Zodryl AC, Allergy Time, Chlor-Phenit, Z-Tuss AC, Endal CD, T- Koff, Zodryl DAC, Phenylhistine DH, Decohistine DH, Tricode AR, Dihistine DH, Pediacof, Pedituss, Demi-Cof, AccuHist LA, Ex-Tuss, Dimetapp Children's Nighttime Flu, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Alka-Seltzer Plus Flu Formula, Multi Symptom Cold (Night Formula), Dimetapp Children's Multi-Symptom Cold & Flu, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Comtrex Day and Night, Cough Formula M Multi-Symptom, Co-Apap, Alka-Seltzer Plus-D, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Allpanto-S, Theraflu Flu & Cough, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Childrens Tylenol Cold Plus Cough, Theraflu Warming Relief Caplets Nighttime Multi-Symptom Cold, Comtrex Nighttime Cold & Cough, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Coricidin HBP Multi-Symptom Cold (Night), Tylenol Plus Children's Cough & Runny Nose, Mapap Cough & Sinus Formula, Vicks NyQuil Cold & Flu Relief (Alcohol Free), Congestant, Colrex Compound, Colrex, Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Plus Children's Multi-Symptom Cold, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Tylenol Cold Head Congestion Nighttime, Tylenol Cold Multi-Symptom Nighttime, Tylenol Plus Children's Flu, Alka-Seltzer Plus Cold & Cough Formula Liquid Gels, Alka-Seltzer Plus Cold & Cough Formula Liquid, Contac Cold + Flu (Night Formula), ConRx Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Allerest Sinus, Comtrex Allergy Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tricom, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Alka-Seltzer Plus Cold & Cough Formula, Alka-Seltzer Plus Flu Formula (old formulation), Actifed Cold & Sinus, Rolatuss, Quelidrine, Chlor-Trimeton Sinus, Rhinogesic, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, GNP Cold Relief Plus, Onset Forte, Allergy Sinus PE Pain Relief, Allergy Multi-Symptom, Robitussin Peak Cold Nighttime Nasal Relief, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Dryphen, Covangesic, Trital SR, HEB Allergy, Alka-Seltzer Plus Cold & Flu, Protid, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Broncopectol, ChlorDex GP, Chemdal HD Plus, Nasatuss, Iotussin HC, Chlorgest HD, Mintuss MS, Guiaphen HD, Rindal-HD, Ed-TLC, Efasin-HD, Ed-Tuss HC, Cyndal HD, Chemtussin HC, Exo-Tuss, Endal-HD Plus, Hycomine Compound, Ditussin-HC, Endotuss-HD, Hyphen-HD, Tuss-PD, KG-Dal HD, Iodal HD, Chemdal HD, Dihydro-CP, Uni-Cof, Bronkotuss, Ana-Kit, Hydro-Tussin DHC, Tricof, Duohist DH, Tusscough DHC, Pancof, Allfen A, Z-Tuss 2, Hydrocodone GF, S-T Forte 2, Vituz, Endagen-HD, Lemohist Plus, Qual-Tussin Pediatric, SymPak, P Chlor GG, Donatussin Pediatric, Comtussin HC, Tuss-HC, Echotuss-HC, Phendal-HD, Relacon-HC NR, Tusana-D, Rindal HD Plus, Uni-Tricof HC, De-Chlor HD, Atuss MS, Hydro-PC II Plus, Neo HC, Poly-Tussin HD, Notuss-Forte, Notuss, Histinex PV, Pediatex HC, Maxi-Tuss HCX, Z-Cof HC, Liquicough HC, Relasin-HC, DroTuss-CP, Hydron CP, B-Tuss, Highland HC, Uni Tuss HC, H-C Tussive, Histussin HC Liquid, KG-Dal HD Plus, Histinex HC, Ventuss Syrup, Maxi-Tuss SA, Maxi-Tuss HC, Cytuss HC, Tuss-DS, Duradal HD, Liquitussin HC Syrup, Tussive HC, Chlorphen HD, Hi-Tuss HC, Efasin-HD Plus, Quindal HD Plus, Quindal HD, Despec-PD, Pancof-PD, Z-Dex 12 D, Trigofen DM Drops, Virdec DM, Zoden DM Drops, Tri-Dex PE, Poly-Tussin DM, PE-Hist DM, Maxichlor PEH DM, ED DM, Sonahist-DM, RE DCP Drops, PD-Cof, Quartuss DM, NoHist-PDX, Relahist-DM, PD-Cof Drops, CP Dec-DM Drops, Bronkids, Donatussin DM Drops, DM-PE-Chlor, EndaCof Drops, DCP Drops, Donatussin DM, Ceron-DM Drops, Rondex-DM, Rondex-DM Drops, Extendryl DM, Zotex-DM, Qual-Tussin, Quartuss, Genelan NF, Dec-Chlorphen DM Drops, HistadecDM, Robitussin Cough & Allergy, C-Phen DM Drops, Sildec-PE DM Drops, Tussplex DM, Reme Tussin DM, CP Dec DM, Neo DM Drops, Nasohist-DM Pediatric, Albatussin SR, Cerose DM, C-Phed DM, Atuss-12 DM, Dicel DM, Entre-S, Tanafed-DM, Children's Nyquil, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidkare Cough/Cold, Neutrahist PDX Drops, T-Tanna DM, Novahistine DH, DiHydro-PE, Coldcough PD, Duotan DM, Allres DS, AccuHist PDX Drops, CPM-PSE DM Drops, Mesehist DM, Rhinosyn-DM, Threamine DM, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Atuss DR, Father John's Medicine Plus, Centergy DM, Maxiphen ADT, Tussar DM, Liquituss R-DM, Corfen-DM, Uni-Tuss DM, Tricodene NN, Therahist, Kophane, Tricodene Forte, Dex PC, Mintuss DR, Trital DM, P Chlor DM, Tussend

Chlorpheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small (2 to 4 mg), occasional doses of chlorpheniramine are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

Effects on Lactation and Breastmilk

Dexchlorpheniramine in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexchlorpheniramine pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

3. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Chlorpheniramine Identification

Substance Name

Chlorpheniramine

CAS Registry Number

132-22-9

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

64

Last Revision Date

20130907

Disclaimer

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