Altretamine Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Ovarian Cancer

260 mg/m2/day administered either for 14 or 21 consecutive days in a 28 day cycle. The total daily dose should be given as 4 divided oral doses after meals and at bedtime.

Altretamine should be temporarily discontinued (for 14 days or longer) and subsequently restarted at 200 mg/m2/day for any of the following situations:

Gastrointestinal intolerance unresponsive to symptomatic measures;
White blood count <2000/mm 3 or granulocyte count <1000/mm 3;
Platelet count <75,000/mm 3;
Progressive neurotoxicity.

If neurologic symptoms fail to stabilize on the reduced dose schedule, altretamine should be discontinued indefinitely.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Because altretamine undergoes rapid and extensive metabolism by the liver and because there are no current dosing recommendations for use in patients with liver dysfunction, altretamine is not recommended for use in patients with severe liver dysfunction.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

The effect of food on altretamine bioavailability or pharmacokinetics has not been evaluated.

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