Aggrastat Dosage

Generic name: tirofiban hydrochloride
Dosage form: injection, solution

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Administer intravenously 25 mcg/kg over 3 minutes and then 0.15 mcg/kg/min (or 0.075 mcg/kg/min for patients with serum creatinine ≤60 mL/min), for up to 18 hours. This is not the regimen that was used in studies that established effectiveness of AGGRASTAT [see Clinical Studies (14)].

The instructions by weight and creatinine clearance are tabulated in Table 1.

Table 1 Dosing by Weight and CrCl

Weight
(kg)

First 3 min
All Patients
(mL)

Maintenance Infusion Rate
(mL/hr.)

CrCl >60 mL/min

CrCl ≤60 mL/min

 

30-37

17

6

3

38-45

21

7.5

3.75

46-54

25

9

4.5

55-62

29

10.5

5.25

63-70

33

12

6

71-79

37.5

13.5

6.75

80-87

42

15

7.5

88-95

46

16.5

8.25

96-104

50

18

9

105-112

54

19.5

9.75

113-120

58

21

10.5

121-128

62

22.5

11.25

129-137

66.5

24

12

138-145

71

25.5

12.75

146-153

75

27

13.5

Important Administration Instructions

  1. To open the container, first tear off its foil overpouch. The plastic may be somewhat opaque because of moisture absorption during sterilization; the opacity will diminish gradually. Check for leaks by squeezing the inner bag firmly; if any leaks are found or sterility is suspect then the solution should be discarded. Do not use unless the solution is clear and the seal is intact. Suspend the container from its eyelet support, remove the plastic protector from the outlet port, and attach a conventional administration set.
  2. You may administer AGGRASTAT in the same intravenous line as atropine sulfate, dobutamine, dopamine, epinephrine hydrochloride (HCl), famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride, and propranolol HCl. Do not administer AGGRASTAT through the same IV line as diazepam.
  3. Do not add other drugs or remove solution directly from the bag with a syringe.
  4. Do not use plastic containers in series connections; such use can result in air embolism by drawing air from the first container if it is empty of solution.
  5. Discard any unused portion left in the bag.
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