Generic Name: tirofiban (tye roe FYE ban)
Brand Name: Aggrastat
What is tirofiban?
Tirofiban keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.
Tirofiban is used to prevent blood clots or heart attack in people with severe chest pain or other conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries).
Tirofiban may also be used for purposes not listed in this medication guide.
What is the most important information I should know about tirofiban?
You should not receive this medication if you have any active internal bleeding (stomach, intestines, etc), a history of bleeding or blood-clotting disorder, if you have ever had low blood platelets after being treated with tirofiban, or if you have had any type of surgery, injury, or medical emergency within the past 30 days.
What should I discuss with my health care provider before receiving tirofiban?
You should not receive this medication if you are allergic to tirofiban, or if you have:
any active internal bleeding (stomach, intestines, etc);
a history of bleeding or blood-clotting disorder;
if you have ever had low blood platelets after being treated with tirofiban; or
if you have had any type of surgery, injury, or medical emergency within the past 30 days.
To make sure tirofiban is safe for you, tell your doctor if you have:
FDA pregnancy category B. Tirofiban is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment, especially if you are also taking aspirin.
It is not known whether tirofiban passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How is tirofiban given?
Tirofiban is injected into a vein through an IV. A healthcare provider will give you this injection.
While using tirofiban, you may need frequent blood tests.
What happens if I miss a dose?
Because you will receive tirofiban in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving tirofiban?
Avoid taking aspirin or NSAIDs (nonsteroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. Taking any of these medicines during or shortly after your treatment with tirofiban may cause you to bruise or bleed easily.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Avoid drinking alcohol while receiving tirofiban. Alcohol may increase your risk of bleeding in your stomach or intestines.
Tirofiban side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tirofiban increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have:
easy bruising or bleeding (nosebleeds, bleeding gums);
bleeding around your IV or catheter; or
any bleeding that will not stop.
You may also have bleeding on the inside of your body, such as in your stomach or intestines. Call your doctor at once if you have bloody or tarry stools, or if you cough up blood or vomit that looks like coffee grounds. These could be signs of bleeding in your digestive tract.
Common side effects may include:
slow heart rate;
leg pain, pelvic pain; or
swelling, increased sweating.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Tirofiban dosing information
Usual Adult Dose for Acute Coronary Syndrome:
Initial (IV): 25 mcg/kg over 3 minutes
Maintenance (IV): 0.15 mcg/kg/min constant infusion for up to 18 hours
Indication: To reduce the rate of thrombotic cardiovascular events in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
What other drugs will affect tirofiban?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with tirofiban, especially other medications to prevent or treat blood clots such as:
dalteparin, enoxaprin, tinzaparin;
desirudin, dabigatran, fondaparinux.
warfarin, Coumadin, Jantoven.
This list is not complete. Other drugs may interact with tirofiban, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about tirofiban
- Other brands: Aggrastat
Related treatment guides
Where can I get more information?
- Your doctor pharmacist can provide more information about tirofiban.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 2.02. Revision Date: 2014-04-13, 8:31:31 PM.