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Welireg Disease Interactions

There are 4 disease interactions with Welireg (belzutifan).

Moderate

Belzutifan (applies to Welireg) anemia

Moderate Potential Hazard, Moderate plausibility.

Belzutifan can cause severe anemia that can require a blood transfusion. Patients should be monitored for anemia before starting treatment. Withhold treatment in patients with hemoglobin below 9 g/dL. Transfuse patients as clinically indicated. Close monitoring is advised during treatment.

References

  1. (2021) "Product Information. Welireg (belzutifan)." Merck & Co., Inc
Moderate

Belzutifan (applies to Welireg) hypoxia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Pulmonary Impairment

Belzutifan can cause severe hypoxia. Oxygen saturation should be monitored before treatment initiation. Withhold treatment if pulse oximeter is less than 88% or PaO2 is 55 mmHg or less. Monitor patients closely during treatment, administer oxygen or hospitalize as clinically needed. Treatment may need to be suspended or discontinued depending on the severity of the hypoxia.

References

  1. (2021) "Product Information. Welireg (belzutifan)." Merck & Co., Inc
Moderate

Belzutifan (applies to Welireg) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Belzutifan has not been studied in patients with moderate and severe hepatic impairment. Caution is advised. No dosage modification is required in patients with mild hepatic impairment.

References

  1. (2021) "Product Information. Welireg (belzutifan)." Merck & Co., Inc
Moderate

Belzutifan (applies to Welireg) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Belzutifan has not been studied in patients with severe renal impairment. Caution is advised. No dosage modification is required in patients with mild or moderate renal impairment.

References

  1. (2021) "Product Information. Welireg (belzutifan)." Merck & Co., Inc

Welireg drug interactions

There are 386 drug interactions with Welireg (belzutifan).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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