Welireg Side Effects

Generic name: belzutifan

Medically reviewed by Drugs.com. Last updated on Apr 29, 2023.

Note: This document contains side effect information about belzutifan. Some dosage forms listed on this page may not apply to the brand name Welireg.

Applies to belzutifan: oral tablet.

Serious side effects of Welireg

Along with its needed effects, belzutifan (the active ingredient contained in Welireg) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking belzutifan:

More common

• Blurred vision
• change in vision
• chest tightness
• confusion
• cough
• difficulty swallowing
• dizziness
• fast heartbeat
• headache
• hives, itching, skin rash
• nervousness
• pale skin
• pounding in the ears
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• seeing flashes or sparks of light
• seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness

Other side effects of Welireg

Some side effects of belzutifan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Body aches or pain
• chills
• constipation
• difficulty in moving
• ear congestion
• fever
• loss of voice
• muscle aches, cramps, pain, or stiffness
• nausea
• pain in the joints
• sneezing
• sore throat
• stomach pain
• stuffy or runny nose
• swollen joints
• weight increased

For Healthcare Professionals

Applies to belzutifan: oral tablet.

General

The most common adverse reactions, including laboratory abnormalities, that occurred during treatment with this drug were anemia, decreased hemoglobin, fatigue, increased creatinine, dizziness, headache, increased glucose, and nausea.^[Ref]

Cardiovascular

Very common (10% or more): Hypertension (up to 16%)^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 36%), constipation (up to 21%), abdominal pain (up to 18%), diarrhea (15%)^[Ref]

Hematologic

Very common (10% or more): Anemia (90%)^[Ref]

Metabolic

Very common (10% or more): increased weight (up to 16%)^[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (up to 25%), arthralgia (up to 21%), back pain (13%)^[Ref]

Nervous system

Very common (10% or more): Headache (up to 44%), dizziness (up to 44%)^[Ref]

Ocular

Very common (10% or more): Visual impairment (including blurred vision, central retinal vein occlusion, and retinal detachment) (up to 21%)^[Ref]

Other

Very common (10% or more): Fatigue (up to 70%), peripheral edema (13%), Urinary tract infection (18%), upper respiratory tract infection (including bronchitis, sinusitis, viral upper respiratory infection) (up to 21%), increased creatinine (64%), increased glucose (34%), increased ALT (20%), increased AST (16%), decreased hemoglobin (93%), decreased leukocytes (11%)

Common (1% to 10%): Decreased corrected calcium, decreased phosphate^[Ref]

Psychiatric

Very common (10% or more): Insomnia (13%), anxiety (11%)^[Ref]

Respiratory

Very common (10% or more): Dyspnea (up to 23%)^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer