Ziagen Disease Interactions
There are 2 disease interactions with Ziagen (abacavir).
NRTIs (applies to Ziagen) hepatotoxicity
Major Potential Hazard, Moderate plausibility. Applicable conditions: Alcoholism, Liver Disease
Hepatotoxicity including lactic acidosis, severe hepatomegaly with steatosis, fulminant hepatitis, and hepatic failure has been associated with the use of some nucleoside reverse transcriptase inhibitors (NRTIs) alone or in combination with other antiretroviral agents. Therapy with NRTIs should be administered cautiously in patients with preexisting liver disease, a history of alcohol abuse, or hepatitis. Therapy should be suspended if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity occur. The use of abacavir is contraindicated in patients with moderate to severe liver dysfunction as its safety and efficacy have not been established in these patients.
References
- "Product Information. Viread (tenofovir)." Gilead Sciences SUPPL-58 (2019):
- "Product Information. Epivir (lamiVUDine)." ViiV Healthcare SUPPL-39 (2019):
- "Product Information. Videx (didanosine)." Bristol-Myers Squibb SUPPL-54 (2018):
- "Product Information. Zerit (stavudine)." Bristol-Myers Squibb SUPPL-41 (2018):
- "Product Information. Retrovir (zidovudine)." ViiV Healthcare SUPPL-59 (2020):
- "Product Information. Ziagen (abacavir)." ViiV Healthcare SUPPL-38 (2020):
- "Product Information. Baraclude (entecavir)." Bristol-Myers Squibb SUPPL-23 (2019):
Abacavir (applies to Ziagen) cardiovascular disease
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Myocardial Infarction, Hypertension, Hyperlipidemia, Diabetes Mellitus
Some clinical trials have reported increased risk of myocardial infarction in patients treated with abacavir. Although some of the findings are inconclusive, as a precaution, the underlying risk of coronary heart disease should be assessed before therapy, and action should be taken to minimize all modifiable risk factors such as hypertension, hyperlipidemia, diabetes mellitus, smoking, etc.
References
- "Product Information. Ziagen (abacavir)." Glaxo Wellcome PROD (2001):
Ziagen drug interactions
There are 49 drug interactions with Ziagen (abacavir).
Ziagen alcohol/food interactions
There are 3 alcohol/food interactions with Ziagen (abacavir).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.