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Abacavir Pregnancy and Breastfeeding Warnings

Abacavir is also known as: Ziagen

Abacavir Pregnancy Warnings

Abacavir has been assigned to pregnancy category C by the FDA. High-dose animal studies have revealed evidence of developmental toxicity, fetal anasarca, skeletal malformations, and increased incidence of stillbirth. There are no controlled data in human pregnancy. Abacavir should only be given during pregnancy when benefit outweighs risk.

An Antiretroviral Pregnancy Registry has been established to monitor maternal-fetal outcome of abacavir exposures during pregnancy. To register patients, physicians should call 800-258-4263 (USA).

Abacavir Breastfeeding Warnings

There are no data on the excretion of abacavir into human milk; however it is excreted into rat milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, mothers should not breast-feed while taking abacavir. In addition, HIV-infected mothers should not breast-feed their infants due to the risk of transmission of HIV via breast milk.

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