tranexamic acid (Intravenous route)Pronunciation
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Hemostatic
Uses For tranexamic acid
Tranexamic acid injection is used to control or prevent excessive or heavy bleeding during dental procedures in patients with hemophilia. tranexamic acid is for short-term use only, usually 2 to 8 days.
Tranexamic acid injection is an antifibrinolytic agent. It works by blocking the breakdown of blood clots. It may also be used for other conditions as determined by your doctor.
tranexamic acid is available only with your doctor's prescription.
Before Using tranexamic acid
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tranexamic acid, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to tranexamic acid or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of tranexamic acid injection in children.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tranexamic acid injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving tranexamic acid injection.
|All Trimesters||B||Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving tranexamic acid, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using tranexamic acid with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Estradiol Cypionate
- Estradiol Valerate
- Ethinyl Estradiol
- Ethynodiol Diacetate
- Medroxyprogesterone Acetate
Using tranexamic acid with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Anti-Inhibitor Coagulant Complex
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of tranexamic acid. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding problems (bleeding in the brain) or
- Blood clots, active or history of or
- Head injury or
- Vision problems (problems seeing certain colors)—Should not be used in patients with these conditions.
- Blood vessel problems, history of or
- Hematuria (blood in the urine) caused by or
- Retinal artery or vein occlusion (blood clot in the eye) or
- Seizures, history of or
- Urinary tract problems (e.g., bleeding)—Use with caution. May make these conditions worse.
- Disseminated intravascular coagulation or DIC (blood clotting problem)—Should be treated under strict supervision of an experienced doctor in treating this disorder.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of tranexamic acid
A nurse or other trained health professional will give you tranexamic acid in a hospital. tranexamic acid is given through a needle placed in one of your veins.
Precautions While Using tranexamic acid
Your doctor will check the progress of you or your child closely while you are receiving tranexamic acid. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests will be needed to check for unwanted effects.
If you or your child will be receiving tranexamic acid injection for longer than several days, your doctor may want you to have your eyes checked regularly by an ophthalmologist (eye doctor). This will allow your doctor to check for unwanted effects that may be caused by tranexamic acid.
Tranexamic acid injection should not be used together with factor IX complex (e.g., BeneFIX®, Proplex® T) or anti-inhibitor coagulant concentrates (e.g., Feiba VH®). Doing so, may increase the chance of having serious side effects.
tranexamic acid may cause some people to become dizzy or less alert than they are normally. Make sure you know how you react to tranexamic acid before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
tranexamic acid Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:Rare
- blurred vision
- changes in vision
- chest pain
- dizziness or lightheadedness
- fast heartbeat
- greatly increased or decreased frequency of urination or amount of urine
- increased thirst
- loss of appetite
- nausea or vomiting
- numbness of the hands
- pain, redness, or swelling in the arm or leg
- sudden shortness of breath or troubled breathing
- Convulsions or seizures
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- trouble seeing
- unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdose
- mental depression
- muscle twitching or jerking
- nightmares or unusually vivid dreams
- rhythmic movement of the muscles
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- hives, itching, or redness of the skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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