Tranexamic Acid use while Breastfeeding

Drugs containing Tranexamic Acid: Lysteda, Cyklokapron

Tranexamic Acid Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the clinical use of tranexamic acid during breastfeeding. However, because amounts in breastmilk appear to be low and the drug has a half-life of about 2 hours, waiting for 3 to 4 hours after a dose before nursing again should minimize the infant dosage. However, an international consensus panel recommends against using tranexamic acid during breastfeeding.[1]

Drug Levels

Maternal Levels. Unpublished data from the manufacturer indicates that the concentration of tranexamic acid in breastmilk is 1% of the peak serum concentration 1 hour after the last dose of a 2-day treatment course.[2] Further details of the study have not been published. Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Caballero T, Farkas H, Bouillet L et al. International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency. J Allergy Clin Immunol. 2012;129:308-20. PMID: 22197274

2. Verstraete M. Clinical application of inhibitors of fibrinolysis. Drugs. 1985;29:236-61. PMID: 2580684

Tranexamic Acid Identification

Substance Name

Tranexamic Acid

CAS Registry Number

1197-18-8

Drug Class

  • Antifibrinolytic Agents

Administrative Information

LactMed Record Number

828

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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