Comparing Phenergan vs Zofran
Phenergan | Zofran |
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Phenergan (promethazine) | Zofran (ondansetron) |
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Prescription only
Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. Sedation is the main side effect. Occasionally, paradoxical reactions (the opposite of what is to be expected) may... View more |
Prescription only
Zofran may be used for the treatment and prevention of nausea and vomiting caused by cancer chemotherapy, radiation, or surgery. It is approved for use in adults and children over the age of 4. A... View more |
Related suggestions Nausea/Vomiting
Popular comparisons
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More about Phenergan (promethazine) | More about Zofran (ondansetron) | ||||||||
Ratings & Reviews | |||||||||
Phenergan has an average rating of 7.3 out of 10 from a total of 146 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 23% reported a negative effect. |
Zofran has an average rating of 8.0 out of 10 from a total of 264 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 16% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
See also: Phenergan side effects in more detail. |
See also: Zofran side effects in more detail. |
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Generic Availability | |||||||||
Pricing and Coupons * Prices are without insurance | |||||||||
View all Phenergan prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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Dosage Form(s) Available | |||||||||
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Brand Names | |||||||||
Other promethazine brands include: Adgan, Anergan 50, Antinaus 50, Phenadoz, Promethegan |
N/A |
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Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
16 hours |
4 hours |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||
A total of 685 drugs are known to interact with Phenergan:
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A total of 347 drugs are known to interact with Zofran:
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Alcohol/Food/Lifestyle Interactions | |||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||
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First Approval Date | |||||||||
March 29, 1951 |
December 31, 1992 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
Related Treatment Guide | |||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.