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Promethazine Pregnancy and Breastfeeding Warnings

Promethazine is also known as: Adgan, Anergan 50, Antinaus 50, Phenadoz, Phenazine 50, Phenergan, Phenergan Fortis, Phenoject-50, Pro-Med, Promethegan, V-Gan-25, V-Gan-50

Promethazine Pregnancy Warnings

Promethazine has been assigned to pregnancy category C by the FDA. Several retrospective studies have suggested that there is no increased risk of congenital malformations in humans with the use of promethazine in pregnancy. Promethazine has been shown to impair neonatal platelet aggregation when given during labor. There are no controlled data in human pregnancy. Promethazine is only recommended for use during pregnancy when benefit outweighs risk.

See references

Promethazine Breastfeeding Warnings

There are no data on the excretion of promethazine into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Clark RB "Analgesia during labor: effect on the fetus and neonate." Clin Anesth 10 (1974): 139-55
  2. McDonald JS "Preanesthetic and intrapartal medications." Clin Obstet Gynecol 20 (1977): 447-59
  3. Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

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