Comparing Diphenhydramine vs Melatonin
Diphenhydramine | Melatonin |
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Diphenhydramine | Melatonin |
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Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Prescription and OTC
Supplemental melatonin is very effective at reducing symptoms of jet lag, particularly that brought about by eastward travel across five or more time zones. Melatonin may also be used to treat sleep... View more |
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More about Diphenhydramine | More about Melatonin | ||||||||
Ratings & Reviews | |||||||||
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 531 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 41% reported a negative effect. |
Melatonin has an average rating of 5.7 out of 10 from a total of 235 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 36% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
See also: diphenhydramine side effects in more detail. |
See also: melatonin side effects in more detail. |
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Generic Availability | |||||||||
Lower cost generic |
N/A |
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Pricing and Coupons * Prices are without insurance | |||||||||
View all diphenhydramine prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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Dosage Form(s) Available | |||||||||
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N/A |
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Brand Names | |||||||||
Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Bio-Melatonin, Melatonin Time Release, SGard, Sleep3 | ||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
9.3 hours |
N/A |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category N
Not classified
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Drug Interactions | |||||||||
A total of 446 drugs are known to interact with diphenhydramine:
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A total of 315 drugs are known to interact with melatonin:
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Alcohol/Food/Lifestyle Interactions | |||||||||
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Disease Interactions | |||||||||
First Approval Date | |||||||||
March 04, 1946 |
N/A |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
Related Treatment Guide | |||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.