Pill Identifier App

Diphenhydramine use while Breastfeeding

Drugs containing Diphenhydramine: Benadryl, Tylenol PM, Advil PM, Benadryl Allergy, ZzzQuil, Banophen, Sleep, Percogesic Original Strength, Diphenhist, Q-Dryl, Show all 246 »Diphen, Nytol, Unisom SleepGels, Sominex, Benadryl Children's Allergy, Pain Relief PM Extra Strength, Nervine, Aleve PM, Mucinex Fast-Max Night Time Cold & Flu, Percogesic Extra Strength, Ibuprofen PM, Dicopanol, Dormin, FIRST Mouthwash BLM, Simply Sleep, Nytol Caplet, Theraflu Nighttime Severe Cold & Cough, Headache Relief PM, Sleep-Eze-3, Motrin PM, Sleep Tabs, Compoz Nighttime Sleep Aid, Diphenydramine Quick Melt, Benadryl Allergy Sinus, Dermarest, Triaminic Night Time Cold & Cough, Benadryl Allergy Plus Cold, Benadryl Children's Allergy And Sinus, Nightime Sleepaid, Mucinex Sinus-Max Day & Night (Night), Theraflu Warming Relief Flu & Sore Throat, Diphedryl, Robitussin Night Time Cough & Cold, Legatrin PM, Calamine with Antihistamine, Ala-Hist, Unisom PM Pain, Sleep-ettes, Itch Relief, Dytan, Quenalin, Unisom SleepMelts, Benadryl Allergy Plus Sinus Headache, Sleep-ettes D, Diphendryl, Equate Allergy & Sinus Headache, CVS Allergy & Cold, Nytol QuickCaps, Anti-Itch Extra Strength, Diphenyl, Benylin Multi-Symptom, Siladryl, Tekral, Benadryl-D Children's Allergy & Sinus, Dimetapp Children's Nighttime Cold & Congestion, Pharbedryl, Sleepwell 2-nite, Sleepinal, Sominex Maximum Strength Caplet, Buckley's Bedtime, Bydramine, Hyrexin, Benadryl Extra Strength Itch Stopping Gel , Theraflu Thin Strips Nighttime Cold and Cough, Trux-adryl, Excedrin PM, Midol PM, Diabetic Tussin Night Time Formula, Tylenol Severe Allergy, Acetadryl, Dermarest Anti-Itch, Derma-Pax, Dermarest Plus, Valu-Dryl Topical, Aller-Dryl, Counteract PM Extra Strength, Mapap PM, Banophen M-S, HC-Derma-Pax, Dermamycin, Gestuss-HC, Rindal HPD, Endal HD, Dytan-HC, D-Tann HC, Hydro-DP, Wal-Nadol PM Extra Strength, Tussinate, Scot-Tussin Allergy, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Twilite, Allermax, Pardryl, Nu-Med, Help I Can't Sleep, Uni-Tann, Q-Dryl A/F, PediaCare Children's Allergy, Complete Allergy Relief, Dytuss, Miles Nervine, Tranquil Nighttime Sleep Aid, Z-Sleep, Diphenmax, Ben-Tann, Histaprin, FIRST Duke's Mouthwash, Night Time Pain, Actifed Allergy Day/Night, Tavist NightTime Allergy, Respa SA, Diabetic Tussin Night Time Cold & Flu, Respa C&C, Benadryl-D Allergy Plus Sinus, PediaCare Children's Allergy & Cold, Respa C&C IR, Benaphen Plus, Di-Delamine, Benadryl Extra Strength Spray, Banophen Anti Itch, Diphenhist Topical, Benadryl Extra Strength Itch Relief Stick, Benadryl Original Strength Itch Stopping Cream, Excedrin PM Headache, SM Anti-Itch, Benadryl Extra Strength Itch Stopping Cream, D-Tann, Pediatex-CT, Bayer Select Max Strength Night Time Pain, Contac Day and Night Cold and Flu, Delsym Children's Night Time Cough & Cold, Doans PM, FIRST BXN Mouthwash, Genapap PM, Hydramine Compound, ConRx PM, PediaCare Nighttime Multi-Symptom Cold, Sudafed PE Nighttime Nasal Decongestant, Children's Triacting Night Time, Alahist LQ, Dytan-D, Triaminic Thin Strips Night Time Cold & Cough, Diphenmax D, Diphentann-D, Uni-Tann D, Aldex-CT, FIRST Mary's Mouthwash, Diphenylin, Severe Allergy and Sinus Headache, Benadryl Severe Allergy Plus Sinus Headache, Robitussin Peak Cold Nighttime Multi-Symptom Cold, Robitussin Night Time Cough, Cold & Flu, Tylenol Allergy Multi-Symptom Nighttime, CVS Allergy & Sinus Headache, Benadryl Cold, Theraflu Warming Relief Sinus & Cold, Children's Tylenol Plus Cold And Allergy, Sudafed PE Nighttime Cold, Mucinex Children's Night Time Multi-Symptom Cold, Delsym Cough+ Cold Night Time, Theraflu Warming Relief Nighttime Severe Cold & Cough, Sudafed PE Severe Cold, Tylenol Plus Children's Cold & Allergy, Delsym Children’s Cough+ Cold Night Time, Mucinex Sinus-Max Night Time Congestion & Cough, Robitussin Multi-Symptom Cold Night Time, CounterAct Night, Suphedrine PE Severe Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Uni-Tann CS, Dytan-CD, Airacof, Endal CD (old formulation), D-Tann CD, D-Tann CT, Dytan-AT, D-Tann AT, Dytan-CS, Dytan-DM, Duratuss AC 12, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Tylenol Allergy Complete NightTime, Alka-Seltzer PM, Bayer PM, D-Tann DM, Invarest, Ala-Hist D, Anacin PM Aspirin Free, Aceta-Gesic, Aller-G-Time, Sleep Tab II, Somnicaps, Total Allergy, Alka-Seltzer Plus Allergy, Genahist, Benoject-50, Calm-Aid, Diphenadryl, Valu-Dryl, Altaryl, Siladryl DAS, Siladyl SA, Silphen Cough, Tusstat, Hydramine, Vicks QlearQuil Nighttime Allergy Relief, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Benahist-50, Benahist-10, Coricidin Night Time Cold Relief, Pain Reliever PM, Sominex Pain Relief Formula, Headache Formula PM, Tylenol Sore Throat Nighttime, Excedrin PM Triple Action, Acetaminophen PM Extra Strength, Non-Aspirin PM Extra Strength, Pharbetol PM, Snooze Fast, Triaminic Thin Strips Allergy, DPH, Aler-Dryl, Allergia-C, Diphen Cough, Diphen AF, ConRx Allergy, Hydramine Cough Syrup, 40 Winks, Ivarest

Diphenhydramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of diphenhydramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One old study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in four women, drug levels in milk were undetectable in two and 42 and 100 mcg/L in two others at one hour after the dose. Five hours after the dose, milk levels were undetectable in two women and 20 and 100 mcg/L in two others.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, drowsiness was reported in 1 infant of 12 exposed to diphenhydramine in breastmilk.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Diphenhydramine Identification

Substance Name


CAS Registry Number


Drug Class


Administrative Information

LactMed Record Number


Last Revision Date



Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.