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Diphenhydramine use while Breastfeeding

Drugs containing Diphenhydramine: Benadryl, Tylenol PM, Benadryl Allergy, ZzzQuil, Advil PM, Sleep, Severe Allergy and Sinus Headache, Banophen, Diphen, Unisom SleepGels, Show all 247 »Q-Dryl, Nytol, Benadryl Children's Allergy, Motrin PM, Sominex, Dicopanol, Aleve PM, Simply Sleep, Sleep Tabs, Benadryl Allergy Plus Cold, Diphenhist, Pain Relief PM Extra Strength, Calamine with Antihistamine, Benadryl Children's Allergy And Sinus, Dormin, Mucinex Fast-Max Night Time Cold & Flu, FIRST Mouthwash BLM, Ibuprofen PM, DPH, Sleepinal, Diphedryl, Dermarest, Excedrin PM, Ala-Hist, Hydramine Compound, Quenalin, Benoject-50, Diabetic Tussin Night Time Formula, Tekral, Beldin, Equate Allergy & Sinus Headache, Percogesic Extra Strength, Gestuss-HC, Headache Relief PM, Suphedrine PE Severe Cold, Percogesic Original Strength, D-Tann CT, Invarest, Hyrexin, FIRST Mary's Mouthwash, Tussinate, Itch Relief, Doans PM, Benadryl-D Children's Allergy & Sinus, Benadryl Extra Strength Itch Stopping Cream, 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Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Bayer PM, Actifed Sinus Day and Night, Ala-Hist D, Dytan-CS, D-Tann CD, Duratuss AC 12, D-Tann DM, Benadryl Cold, Benadryl Allergy Plus Sinus Headache, Dytan-DM, Endal CD (old formulation), Uni-Tann CS, Dytan-CD, Airacof, Aceta-Gesic, Acetaminophen PM Extra Strength, Total Allergy, Trux-adryl, Diphenyl, Altaryl, Nytol QuickCaps, Somnicaps, Aller-G-Time, Sleep Tab II, Sleep-Eze-3, Vicks QlearQuil Nighttime Allergy Relief, Hydramine, Tusstat, Diphenylin, Nu-Med, Alka-Seltzer PM, Sleep-ettes, Silphen Cough, Siladryl, Siladryl DAS, Siladyl SA, Alka-Seltzer Plus Allergy, Diphenadryl, Sominex Pain Relief Formula, Headache Formula PM, Excedrin PM Triple Action, Snooze Fast, Pain Reliever PM, Coricidin Night Time Cold Relief, Non-Aspirin PM Extra Strength, Pharbetol PM, Tylenol Sore Throat Nighttime, Sominex Maximum Strength Caplet, ConRx Allergy, Allergia-C, Benahist-10, Benahist-50, Calm-Aid, Diphen Cough, Diphen AF, Hydramine Cough Syrup, Bydramine, 40 Winks, Compoz Nighttime Sleep Aid

Diphenhydramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of diphenhydramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. One old study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in four women, drug levels in milk were undetectable in two and 42 and 100 mcg/L in two others at one hour after the dose. Five hours after the dose, milk levels were undetectable in two women and 20 and 100 mcg/L in two others.[1] No studies using modern assay methods have been reported.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, drowsiness was reported in 1 infant of 12 exposed to diphenhydramine in breastmilk.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. Riv Ital Ginecol. 1951;34:147-57.

2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Diphenhydramine Identification

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Administrative Information

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