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Tramadol for Restless Legs Syndrome User Reviews (Page 3)

Brand names: Tramadol Hydrochloride ER, ConZip Qdolo

Tramadol has an average rating of 8.8 out of 10 from a total of 122 reviews for the off-label treatment of Restless Legs Syndrome. 86% of reviewers reported a positive experience, while 7% reported a negative experience.

Reviews for Tramadol

  • JAH
  • Taken for 6 months to 1 year
  • June 29, 2020

"I have had RLS for over 50 years. It became "out of control" over 10 years ago and I began taking medication for it in 2009. I took Ropinerole for years, but gradually had to increase the dose until I was taking 2.5 mg. I was afraid to continue increasing the dose because what would I do when I reached the limit? My PCP finally sent me to a neurologist and I was prescribed Horizant. That was like a miracle drug and for about 9 months I was good with Horizant 600 mg and Ropinerole 2 mg. A few months ago the symptoms became worse again and I had many sleepless nights. I called the neurologist and explained my symptoms. I told her that when I took Tramadol for back pain it also stopped the RLS. I now take Tramadol 50mg along with the Horizant 600 mg and Ropinerole 2 mg. I'm wondering if when taking Tramadol it is possible to reduce the Ropinerole and/or the Horizant? Any suggestion would be appreciated."

9 / 10
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15 Report
  • JWG
  • April 8, 2012

"Fantastic. I finally got immediate relief for my restless leg syndrome after suffering for many months and taking other medicines like Horizant. This one did the trick for my legs and I sleep well again."

10 / 10
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35 Report
  • Shudh
  • December 21, 2015

"I've RLS for more than a decade. Its hereditary. My respected mother also suffered from it. From last one year it became too intensive to sleep. Requip and other drugs for RLS my neurologist gave didn't work on me. My orthopedic gave me Tramadol for lower backache. SURPRISE!! My legs stopped jumping that night. Since then I'm on it. Unfortunately it doesn't cure it so I've to take it one pill 50mg every night. Dr said Tramadol is habit forming so Now I'm trying alternative medicine like homeopathy and Ayurved. Let's see. Meanwhile thanks to Tramadol that's letting me sleep."

10 / 10
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26 Report

Frequently asked questions

  • orion...
  • Taken for 2 to 5 years
  • June 27, 2016

"I've been taking just 50mg of Tramadol for the past 4 to 5 years. I have what I consider to be pretty severe RLS, having had it since I was first made to sit in a school room all day. It's getting worse as I get older, 2 brothers and mother also suffer from it, all of us for over 50 years. I'm trying to do the least amount possible and still have it be effective.Mid-afternoon is when I first feel it in my legs and sometimes elbows. That's when I take 1/2 of the 50 mg of tramadol and an hour before bed, I take the other 1/2 along with 1requip (ropinirole) 1mg, and renatidine (antacid) to block the resulting acid reflux. This pretty much works for me but it makes me tired, though not as tired as not sleeping!"

9 / 10
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  • jacqu...
  • March 2, 2011

"I am unaware of any severely adverse reactions regarding the use of Tramadol. I use 50mg two to three times per day for arthritic pain and for restless leg syndrome. I have also found that the more you use your back and legs during the day, (exercise, walking, biking, running) the less symptomatic the restless legs syndrome is. Perhaps there is a connection between the neurological pathology of RLS and exercise. Maybe the increase in endorphins caused by exercise has something to do with it. Sorry, I digress. In the meantime, when RLS is symptomatic, Tramadol is a God send. Tramadol is quite effective as well for arthritic pain. I wouldn't take anything else."

10 / 10
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36 Report

Are you taking this medicine?

  • Mrs...
  • December 2, 2016

"Hi, I'm writing my experience and reviews to help someone out there who is suffering from RLS. When I was a teenager I knew something was wrong with my legs because I would get up in the middle of the night and do excercises until the feelings in my legs went away..my legs bothered me until I graduated from high school. When I was diagnosed with chron's Diease I was put on a medication called Simzia Shots. I took that medicine for about a year and was immediately token off it because of the side effects. This medicine damaged some of the nerves in my brain. The nerves that was damaged triggered to my legs and my symptoms returned. I suffered for about 3 months until I just couldn't take it any more. I'm on Tramadol and it works miracles."

9 / 10
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23 Report
  • DM143
  • Taken for 10 years or more
  • November 7, 2023

"It's the only drug that has worked for me the last 15 years. My only concern is its long-term use on my kidneys and liver. It is hard to get, and I have tried many, many other options but with no success."

10 / 10
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3 Report

More FAQ

  • Jonny...
  • July 13, 2010

Ultram (tramadol) "I have horrible Restless Legs Syndrome. Not just in my legs, and not just when I'm trying to sleep; I experience a horrible tension in my limbs all day. Tramadol (Ultram) completely cured it. Also, I experience chronic pain from an old injury, and Ultram is the only NON-OPIATE medication that actually helps my pain."

10 / 10
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34 Report
  • Anonymous
  • March 23, 2012

"I have severe and agonizing restless legs syndrome. People say it's because of my schizophrenia medicines but I know its genetics. I went through agonizing years until I found that taking tramadol everyday completely cured it. "

9 / 10
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30 Report
  • NomanII
  • June 17, 2017

"I have been on it for years for my Peripheral Neuropathy/Restless Legs . The Tramadol manufactured in Asia is mostly junk. My Dr recommended a pharmacy that orders a name brand generic form that works good for me. They are round tablets, the capsule shaped are not as good. The cheap stuff makes me agitated and restless. I take two 50mg tablets at bedtime (100mg). It gets rid of my nerve pain caused by type II diabetes. My wife says I don't kick her any more at night. I wake up feeling euphoric and ready to take on the day. It is frequently prescribed off-label as an anti-depressant. No it does not work good on back or muscle pain. Take Ibuprofen for that. Motrin 800 works good for back pain. You can take the two drugs together."

10 / 10
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  • ccfis...
  • Taken for 10 years or more
  • December 15, 2016

"I have severe RLS. I tried requip, mirapex, neurontin, lyrica... Like many others who have posted, I had a pinched nerve in my spine (upper back, near my neck) and was prescribed Tramadol. It greatly improved my RLS !! It truly was a God-send !! I do have to take 100mg three times a day. And, if I take it too late, I do have to wait for an hour or so for the symptoms to finally diminish. Also, I have some daytime sleepiness, sluggishness. And now that my pinched nerve has become inflamed again, I have severe RLS even while taking the Tramadol. I am hoping that after having a spinal injection for inflamation, my symptoms will improve once again. Until then, here I am, up with the rest of you, enduring this aggravating condition."

8 / 10
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20 Report
  • bryan...
  • Taken for 2 to 5 years
  • December 15, 2014

"I tried everything to stop this rls and nothing worked. I would be up all night moving my legs up and down and then it started moving to my torso and I could not take it no more being up. I was finally given tramadol for my back issues but found it worked to quiet my rls. I only get 50 mg and I live normally now with it. I can't tell you of the sleepless nights I have had without it. I only take one in the morning and one in the evening. It lasts for me but sometimes it doesn't for real long periods of time. I would rather take tramadol then gabenton that is horrible! I also have nerve damage from my diabetes and it also relieves that pain needles too. Thank god for this to regain my life back."

9 / 10
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24 Report
  • armye...
  • Taken for 2 to 5 years
  • September 27, 2016

"I was prescribed this for disc pain and spinal stenosis. I realized it helps my RLS. I usually only take for back pain 2-3 mornings a week. If I have a pain free week my RLS flairs up and I take one and in 30 minutes I'm good. I DO NOT have to take 2-3 times a day every day. I have had RLS for 30 years and only found relief once I hurt back 4 yrs ago."

10 / 10
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20 Report
  • Joe
  • Taken for 2 to 5 years
  • September 30, 2023

"This is the only medication that relieves the symptoms of RLS. It is torture trying to sleep without it as my legs bounce around all night and the pain is excruciating. Now, I cannot get it and I suffer every single night averaging about 2 hours sleep. It is a shame that they think people will be addicts. If you have RLS, you need relief and all the other alternatives have serious life-threatening side effects. I wish someone would post where to get this medication. I wish I could find a doctor in Ocala, Florida that would prescribe this for me once again and I would even go outside of the VA if necessary. My original VA doctor retired and then I get this young kid, and the first thing he does is pull the Tramadol. Meanwhile, I have had two back surgeries putting a metal rod in my spine twice, and the pain from that is what caused the RLS. Now I live with RLS for life because of this young upstart. And every alternative never works, so it is just a merry-go-round of alternatives."

10 / 10
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  • Redro...
  • Taken for 5 to 10 years
  • March 22, 2016

"I also had suffered as a child with the leg movement ,also was told growing pains,and as an adult as I still had it I would pour alcohol on it an take Tylenol an in 20 minutes it was gone,an didn't come back for a few days,as I got older this has gotten so much worse ,an if you ever need a Benadryl pill lord help you cause it intenseifies the problem ten fold the tramadol helps a lot two pills a night use to be three, but now I'm on buspirone for serotonin levels, an read that tramadol raises the seratonin,that's why I take only two now but it still works good to control the rls"

10 / 10
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21 Report
  • DAB
  • September 10, 2016

"I am taking 450 mg of Tramadol per day 250 in the morning and 200 in the evening it's works most of the time on a crumbling spine but I have stopped getting RLS I have been on them for about 15 years now sometimes they don't touch the lower back pain."

9 / 10
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20 Report
  • MikeH
  • Taken for 5 to 10 years
  • November 15, 2017

"My story is just so similar to so many on here. I have had severe leg pain in my calfs since I was about 10. I would wake up crying and when presented to a Dr I was told they were just growing pains. In my early 20s it got much worse. The pain was unbearable and the RLS drove me crazy with the not sleeping I was loosing my mind. I was given some tramadol after some dental work and immediately felt the effects of the pain being gone and the shaking and twitching was completely gone. I noticed that when I stopped taking it, by the next day the pain and twitching would return. My Dr had no problem prescribing until they made it a controlled substance."

10 / 10
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17 Report
  • chero...
  • February 11, 2012

"When I was in 8th grade, I fractured my back, and have re-fractured it 2 more times since then. I have done everything under the sun to help relieve my back pain and the only thing that has ever worked has been Tramadol. I also have restless leg and it is not just when I'm sleeping - it's all day every day, and all through the night. I used to take the Tramadol to help this and it completely cured the restless legs syndrome."

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27 Report
  • MJ Da...
  • April 8, 2016

"Sleep deprivation from RLS was becoming unbearable. One 100mg Transform 2-3 hours before bed and I slept like a baby for 4 months. Now my bigger concern us am I hooked on this? I stopped cold turkey a week ago and it's finally out of my system but the withdrawal symptoms were horrible at night. Now I am back to sleepless nights and sluggish days. I would get back on it in a heartbeat so I could sleep but am going to ask my doctor about non opioid first."

10 / 10
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  • OLD...
  • April 17, 2011

"I have tried everything for this restless leg syndrome since the middle of the 1970's, nothing has worked. Even my pain medicines that I take now for serious pain. But over the years no matter what was given to me for the restless leg syndrome it did not work until I was prescribed tramadol for some back pain after I gave birth to my daughter and I can say this much I have never woken my husband up in the middle of the night since I have taken them and I will never stop, I have had this problem since I was 8 yrs old. We all get to sleep peacefully now and my legs have never felt better. And no I do not smoke or take the pill."

10 / 10
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  • Carl
  • March 23, 2009

"My Girlfriend got me on tramadol because I had a toothache once and said it would help. Anyway to make a long story short I took it a few times and ended up getting addicted to it. It helps with RLS that I have and helps me sleep BUT when I'm without it I cannot SLEEP AT ALL. The withdrawal is horrible. I don't know if I should be mad at her for introducing this to me or mad at myself for getting addicted to it. If you are not prescribed this by a doctor, do not take it because you become dependent on it. I look back and I was never like this."

5 / 10
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30 Report
  • sahbe...
  • Taken for less than 1 month
  • September 7, 2015

"I recently started taking 50mg of Tramadol at night for severe Rls. I have been reading the horror stories associated with Requip as well as tramadol. I am hoping that 350mg of Tramadol over the course of a week will be too small of an amount to develop a dependence on but who knows! Has anyone else been able to find relief for Rls by taking a small dose of tramadol?"

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  • JerryS
  • Taken for 10 years or more
  • October 13, 2019

"I am a 62 yr old male who suffered from RLS since my youth. I tolerated it until I reached my mid 40s when I finally had to see a Dr. who sent me to a neurologist who diagnosed me with RLS. I was prescribed many of the typical RLS meds to no avail. I got no relief, until he prescribed Ultram/tramadol. I have been on it for over 15 years, and keep my dosage as low as possible, currently 250 mg a day. Tramadol relieves my symptoms if I take it early enough. Caffeine also helps me. Recently I heard that some people use diclofenac sodium for RLS. There is some evidence from the UK that this may provide relief. I would like to find another medication to alternate with the tramadol, because of augmentation."

10 / 10
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  • LizaGLW
  • April 9, 2010

"I was given Tramadol after breaking my leg quite badly. At the time the pain was so severe lower strength painkillers wouldn't have been enough but I've now been left with an addiction to tramadol where I've been withdrawing gradually over months and it's now left me with a bad case of Restless Leg Syndrome! To anyone who has never had this it's a horrible feeling where you can't rest or sleep properly because of the horrible feeling going through your legs, it feels like someone is tickling the inside of your leg and you can't sit still! I haven't slept properly in months now!"

8 / 10
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27 Report
  • Tento...
  • Taken for 10 years or more
  • November 30, 2023

"I have suffered with RLS for 40+ years. My father and son have too, but not as bad as mine. I have tried almost every treatment combination, and the only one that works for me is tramadol and mirapex. I have to take 2 mg mirapex and 100 mg tramadol together (one without the other is useless). As long as I take them an hour before bedtime, I can keep the RLS at bay. If I forget or try to not take drugs, the RLS rears its ugly head quickly, and I have to take the meds and put up with the jerking, twitching, and at times very painful legs until the drugs kick in. Sadly, RLS sufferers have to jump through hoops to get the prescriptions needed to get relief. The only 'adverse side effect' I have is the pain in the rear just to get my prescription renewed! I used to be able to see my PCP once a year for RLS, then the government got involved and I had to see my PCP every 6 months. Now I have to see him every 3 months. What's next, weekly, daily?"

10 / 10
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2 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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