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Sulfasalazine User Reviews & Ratings (Page 4)

Brand names: Azulfidine, Azulfidine EN-tabs

Sulfasalazine has an average rating of 5.9 out of 10 from a total of 182 reviews on Drugs.com. 47% of reviewers reported a positive experience, while 34% reported a negative experience.

Reviews for Sulfasalazine

  • GMS
  • Taken for 2 to 5 years
  • December 21, 2023

For Psoriatic Arthritis "I started on sulfasalazine 4-5 years ago after being diagnosed with psoriatic arthritis. I had serious inflammation and pain in my right hand and inflammation of some toes. After a few weeks of taking a 500 mg tablet of sulfasalazine twice a day, my symptoms improved substantially. My rheumatologist then increased my dose to 2 tablets twice a day (total of 2 grams per day). My pain disappeared and the only remnant of inflammation is a slight swelling of my right index knuckle. I have had no pain and have negligible stiffness. I have had no side effects at all. I can take the medication on an empty stomach, unlike some people. At my doctor's suggestion, I decreased the dosage a few months ago to 3 500-mg tablets per day. I had no change of symptoms, so they are now suggesting that I try 2 500-mg tablets per day (one in the morning, one at night). I started on this reduced dose a few days ago, so it is too early to tell if symptoms are changing. Overall, I've been very pleased."

10 / 10
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  • Patty...
  • Taken for 10 years or more
  • December 16, 2023

For Ulcerative Colitis, Maintenance "In 1987, I was diagnosed with moderate ulcerative colitis. I had blood in my stool, constant diarrhea, and experienced weight loss - from 100 lbs. to 85 lbs. My new doctor prescribed Watson sulfasalazine. It worked and I experienced no side effects! I still take it, but in a smaller dosage - from 4 pills twice a day to 2 pills twice a day. The brand just changed to Teva USA. I have been in remission for about 25 years!"

10 / 10
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  • RWM
  • Taken for 10 years or more
  • May 16, 2023

For Psoriatic Arthritis "I have taken Sulfasalazine for almost 20 years now with no side effect and it has definitely reduced any episodes to stiffness, skin scaliness or other conditions, associated with Psoriatic Arthritis. I have had no side effects, other than some sun sensitivity early on, but seems to be minimal now."

10 / 10
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  • Elaine
  • Taken for 1 to 6 months
  • November 5, 2021

For Rheumatoid Arthritis "Hi I have been on Sulfasalzine for 6 weeks and last 2 weeks I have been unwell, tight chest, feels like I have lump in throat. Fuzzy head and I feel so congested and generally weak and unwell. Anyone had symptoms like this?"

4 / 10
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8 Report
  • rdano
  • Taken for 6 months to 1 year
  • July 22, 2020

For Crohn's Disease "Came down with crohns disease a year ago. Dr put me on mesalamine at $400.00 a month. Told her l needed a cheaper med. Put me on sulfasalazine at 3000 mg a day but only $16.00 a month. Works just as well if not better than mesalamine."

9 / 10
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Are you taking this medicine?

  • Magnus
  • February 5, 2018

For Crohn's Disease "I took this drug every single day for 20 years and had no problems or side effects at all. I cannot get any Doctor to Prescribe it because they say it is too dangerous I say they make NO money so they want you to do the IV's that cost a fortune if you do not have insurance."

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16 Report
  • DrG
  • June 12, 2017

For Rheumatoid Arthritis "My husband has been on Sulfasalazine 2 gms a day since November 2016 for his severe RA. He developed RA in January of last year and was on Methorexate for 8 months when it was discontinued due to severe Bacteriaemia. He is also taking Minocycline. He had a probable flare at the beginning of May this year, six months after starting both drugs. At that time he also developed Atrial Fib that reverted on drugs. He was prescribed Flecainide which he took for two weeks but discontinued it due to side effects. We blamed that for his loss of appetite and weight loss - 36 lbs in six weeks. It's now three weeks since he stopped the heart drug. I'm now thinking it might be the Sulfasalazine. His RA symptoms are gone apart from a little stiffness."

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  • mls
  • Taken for 1 to 6 months
  • March 2, 2024

For Ulcerative Colitis, Maintenance "I don't know if this is related to sulfasalazine but I am fatigued all the time; have to take naps every day. With that said, all of my symptoms with regard to the colitis have gone away. It is difficult to remember to take these pills 3 times a day as I never have to take any medication, but I am relieved that the symptoms I experienced for the first five or six months have pretty much been eliminated."

9 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • July 22, 2022

For Rheumatoid Arthritis "I've been on sulfasalazine for 4 weeks, I am taking 2 in the morning and 2 at night, with methotrexate and hydroxychloroquine. The first 2 weeks were great as only on one morning and one in the evening but since using this I've had more flare up worse than ever, like when I got when I first got R.A 15 yrs ago in my 30s. I feel so ill so going to cut down to 1 morning one evening. I can't move with pain in my shoulders and rib cage. Just want to be pain free again."

1 / 10
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  • Amrhy...
  • March 25, 2017

For Crohn's Disease "Have been on several medications over the years. This being one of them. Was taken off about 9 years ago. Went to many others over next 6 years. Was put on lialda 2 years ago with worsening symptoms. More pain and distended belly. Went to emergency room for 4 the time in three months. Asked my doctor about putting me back on this. I shouldn't be having this many issues. Its been 2 days on salfasazine cypro, flagyl and zofran. Stomach is half its size. Way less pain and eating chicken and stars soup. Yeah."

9 / 10
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16 Report
  • Elano
  • Taken for 1 to 6 months
  • January 10, 2020

"My medical conditions are Polymyalgia rheumatica/temperal arteritis. I have tried methotrexate ,leflunomide ,azathioprine now been taking 4 sulfasalazine daily for about 6 weeks still hoping for a significant change in pain I’m getting in buttocks lower back and muscles at back of thighs and bursa joints. Possibly some changes but inconsistent, my nurse says it’s 3 months before it reaches full potential so I’m continuing with hope ! No serious side effects apart from loss of appetite and sore mouth I’m hoping this will eventually settle along with a noticeable improvement although I find I get extremely tired and exhausted at the moment. I’m still taking 20 mg prednisolone at the moment until symptoms settle down . Hopefully this will work I have few options left to try"

8 / 10
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  • Anonymous
  • Taken for less than 1 month
  • May 24, 2022

For Ulcerative Colitis "Made me incredible dizzy to the point I had to have my hand to be touching a wall when I would be standing. Even sitting everything was spinning. That was the worst side effect. The medication didn't have time to work (only on it for a few days) because the side effects were too severe."

1 / 10
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  • Low...
  • Taken for less than 1 month
  • March 12, 2023

For Rheumatoid Arthritis "After three days of 500 mg for RA, blood pressure consistently lowered. Today 81/50 pulse 83. Taken with hydroxychloroquine (200 mg twice a day). I take metoprolol (25 mg am/ 12.5 mg pm). Avg blood pressure without sulfasalazine 110/65."

1 / 10
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  • GAR
  • Taken for 5 to 10 years
  • March 12, 2023

For Ulcerative Colitis, Maintenance "I was on another med that was new on market and is very expensive. I requested my doctor to prescribe an older, effective med that would be covered by my insurance. I've been taking this for 6–7 years, it's been working well and is covered. The only downside is I have to take it four times a day. That's not really bad but I do have to make sure to stay on schedule."

9 / 10
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  • Anak
  • Taken for 1 to 6 months
  • May 2, 2021

For Rheumatoid Arthritis "Been on sulfasalazine now for 7 weeks, along with methotrexate. Started off at 1 daily increasing to 6 daily by week 6. Feel rubbish, nausea, headaches, night sweats, poor sleep and generally exhausted. RA pain has improved but not at this cost. Need to find something else"

4 / 10
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  • Moody...
  • Taken for less than 1 month
  • September 27, 2020

For Rheumatoid Arthritis "I take oxycodone for 3 types of Arthritis and all my doctors thought SULFASALAZINE will help me. I'm also starting Prolia injection on October 6th. I'm already on nausea pills so doing ok there. So far main side effect is I am drowsy, and hurting all over but only been on one 500mg pill for 2 days and going continue and hope it helps. I have terrible inflammation all over and a lot of inflammation in my feet. They are not swollen though it's inside, going get cortisone injections in both feet October 6th also they've always helped although this time my pain is more in my toes like rubber bands are around them, hopefully all I'm doing will give me relief. I try to get out everyday with a mask on for some walking. If I stay home I get to stiff, I also fractured my hip in December."

2 / 10
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  • Rich...
  • January 13, 2016

For Psoriatic Arthritis "I was recently diagnosed with psoriatic arthritis at the age of 45. Very early stages according to my doctor. He placed me on Sulfasalazine. Started 1 pill per day for 2 weeks then 2 a day the next week then 3x per day the following week. When I made it to the 3x per day I had a terrible reaction. Severe nausea, headaches, and sensitivity to light and noticed I felt weak and was about to go to the emergency room. I stopped immediately and felt better within days. I'm diabetic and tested my blood sugar and did notice a massive drop on this medication. The symptoms I was having could have been low blood sugar. The sulfasalazine may have reacted to my metformin to cause low blood sugar. I was switched to Plaquenil."

2 / 10
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17 Report
  • Jazz
  • Taken for less than 1 month
  • May 10, 2018

For Psoriatic Arthritis "Started Sulfasalazine, three weeks ago, I have been feeling quite ill, flu like, drained of energy, mornings are like the worst hangover feeling, my joints are never like before with constant pain, tiredness never leaves me, some diarrhoea, is this drug for me?"

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  • kjcs
  • Taken for 1 to 2 years
  • November 2, 2023

For Rheumatoid Arthritis "I've taken sulfasalazine for a few years and it really worked well for my rheumatoid arthritis. Recently, I've experienced swelling in my feet and lower legs. I'm wondering if this could be a side effect of the medication or the RA."

9 / 10
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2 Report
  • Selwyn
  • Taken for 1 to 6 months
  • June 28, 2022

For Rheumatoid Arthritis "After being on sulfasalazine for 7 weeks I had continually bad headaches and a spinning sensation I went to the doctor's who performed neurological tests, I failed each one and had to go to hospital. I got worse and was unable to walk, after spending 8 days in hospital, stopping sulfasalazine I was able to walk out of hospital, no headaches, no head spinning I'm awaiting test results from having an MRIscan,CTscan,and lumbar puncture, but I feel back to normal"

3 / 10
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5 Report
  • Millop
  • February 15, 2018

For Ulcerative Colitis "I had never heard something postive about this medication for colitis but I had to find out myself. From day 2 I started using sulfasalazine I got super watery bowel movement. It worsened over time including blood. My doctor told that it had to take around a month to be fully working so I kept taking them. I had to go 25-30 times and even at night. The bloating started and there was so much gas in my stomach I was in real pain. On the 4th week I got a high fever. I stopped the medication, but the fever lasted a week and I had a mild stomach bleeding. When I started it again I got a fever within 6 hours. Also my hair was falling out in chunks and my beard thinned out heavily. It worsened my life in the past 2 months. I was taking 2000mg"

1 / 10
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  • Mrs...
  • March 15, 2018

For Rheumatoid Arthritis "Diagnosed 2010 lots medications and wore ear muffs daily. In 2017 I began methotrexate and became ill along with neurotin and 2 Tylenol 2 times a day with ear muffs. Now after week 1 of just the sulfa I stop the ear muffs but when I got to week 2 and added the hydrochloriquine I needed the ear muffs again. My head hurts bad, constipated and with hair loss and more pain. So I stopped the hydrochloriquine. Today I took a pill called Ultimate Immunity along with Sulfasalizine 2 pills 2 times a day, 1prednisone, 1folic acid. I make a mustard pack and put under my feet at bed time and 1 fiber capsule no ear muffs. The moral to this is finding what works for RA and how to treat the side affects. I put mustard on a paper towel in put in the pit of my feet at night for the headaches. The fiber is for constipation the ultimate immunity is for the immune system and the rest is prescribe for the RA and hair loss I'm 2 months in and LOVING IT. In my opinion hydrochloriquine stops the sulfasalazine from working"

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  • RTRAVER
  • Taken for 5 to 10 years
  • January 21, 2013

For Inflammatory Bowel Disease "My constant infections from Mycoplasma infections are a thing of the past. This medicine has kept intestinal leakage and polyps from recurring, keeps the blood in my urine to a minimum and constant kidney infections from recurring."

10 / 10
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18 Report
  • Papa
  • Taken for 6 months to 1 year
  • April 30, 2023

For Psoriatic Arthritis "Since I’ve been taking sulfasalazine I don’t wake up with my finger joints nearly as swollen and I have more flexibility. My joints don’t ache as bad as they did before taking it. I haven’t had any side effects and I’ve been taking it for several months. I take two tablets in the morning and two at night."

9 / 10
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3 Report
  • Crohny
  • Taken for 6 months to 1 year
  • June 17, 2018

For Crohn's Disease "I was getting gastric blockages quite often that caused a lot of pain and put me in the hospital on more than one occasion. I wasn’t diagnosed with crohns until after my surgery. After surgery my GI doctor gave me a couple of prescriptions for medicine that wasn’t covered under my insurance and I could not afford. We settled on sulfasazaline. I have been taking this stuff for 8 months now. I go to the restroom now more than ever. I noticed that if I would miss a dose or two, I didn’t have to use the restroom so much. This medicine caused bloating, strange noises in my abdomen, constant diarrhea, and abdominal pain. I recently took myself off the drug and feel my best since surgery. I’m waiting for my next appointment with my GI doctor to discuss other medicine or no medicine at all."

3 / 10
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11 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.