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Semaglutide for Weight Loss (Obesity/Overweight) User Reviews

Brand names: Ozempic, Wegovy, Rybelsus

Semaglutide has an average rating of 7.2 out of 10 from a total of 576 reviews for the treatment of Weight Loss (Obesity/Overweight). 63% of reviewers reported a positive experience, while 19% reported a negative experience.

Semaglutide rating summary

7.2/10 average rating

576 ratings from 624 user reviews.

Compare all 38 medications used in the treatment of Weight Loss (Obesity/Overweight).

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Reviews for Semaglutide

  • jwillou
  • Taken for less than 1 month
  • February 27, 2023

Wegovy (semaglutide) "I have been taking Wegovy for 1 week and 2 days. Only had the .25 dosage. I have had no side effects and I have lost 8lbs. I am hoping as I increase the dosage I remain free of side effects and the weight continues to fall off. I will continue to leave feedback so people can see how it is working and hopefully it will help them make a decision. I almost didn't go through with the first injection because of all the negative reviews. I am glad that I did give it a try. If I start to get nasty side effects I will ask my doctor if I can stay at the dosage prior where there were none. I am wanting to loose 100lbs. I started at 250 @ 5'4". So far I am extremely happy!"

10 / 10
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1365 Report
  • Smithy...
  • Taken for 1 to 6 months
  • March 14, 2023

Ozempic (semaglutide) "I was hesitant to try Ozempic for weight loss (need to lose 30 lbs) because I have a lot of kids/responsibilities and don't have the time to be nauseous or debilitating diarrhea, etc. After keeping the pen in the fridge for weeks, I decided to risk an injection and I'm so happy to say I've had zero side effects except a disinterest in food. I'm on week six of the .25 dose because its enough for me and I don't see a reason to increase the dose. My lack of interest in food is liberating! For the first time in 30 years I don't go to bed kicking myself for what I've eaten or making promises to myself to make amends for overeating. Zero sugar cravings...food isn't a reward or pleasure anymore. I'm never ravenous so I make good, calm choices about what I eat. This has been life changing and a complete shift in perspective. Obviously some people have terrible side effects, but I've had none (not even a headache!)."

10 / 10
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641 Report
  • Philly
  • Taken for 6 months to 1 year
  • February 6, 2022

Wegovy (semaglutide) "6 months. -65 pounds. Hypertension gone. Pre Diabetes gone. Sleep apnea gone. Lower leg skin breakdown gone. Slow progress now. I must fight return of old eating habits. Wegovy is not for wimps. But if you really want to lose weight, this is the way to go. This is like bariatric surgery in a small needle."

10 / 10
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997 Report

Frequently asked questions

  • Lovew...
  • Taken for 1 to 2 years
  • November 5, 2022

Wegovy (semaglutide) "I started at a size XXL/pants size 16 and 213lbs. After a little over a year, I am now 125lbs and a size small/pants size 2. This drug literally reset my entire body chemistry and metabolism. I never dieted nor exercised the past year. I don’t want to lose anymore weight, so I just went down to a 1mg half dose to maintain my weight loss. I am so grateful for this medicine!"

10 / 10
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650 Report
  • Slow...
  • Taken for 1 to 6 months
  • April 3, 2023

Wegovy (semaglutide) "Starting week 9 with the second injection of 1 mg. I have lost 24 pounds in 8 weeks. The side effects happen about 3 - 4 days a week. The first weekend on .25 mg was the worst! I really thought I needed my last rites! I have had headaches, nausea, vomiting, and bowel issues but not like the first-week episode. I try to eat light the day of the shot and take it at night because it makes me tired. You have to stay positive and just buy meds that will help with side effects because the side effects will probably always happen a couple of days a week. Try to drink 1/2 gallon of water a day and stay away from red meat, fried food, fast food, (most) dairy and sugar. If you don’t you will feel sick from eating that stuff. Also only eating one cup of food every couple of hours has made a huge difference in the nausea. Stock up on SF ice pops and SF Gatorade. I am so grateful that I got Wegovy with my insurance and when I want to quit I just remember how many people would love the opportunity."

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Are you taking this medicine?

  • KS in...
  • Taken for 1 to 6 months
  • April 18, 2023

Wegovy (semaglutide) "Tomorrow I will take my 3rd shot of .5mg (previously took 3 weeks of .25mg but messed up one of the needles so moved up after only 3 weeks at that amount). I have had very minimal side effects in the 5 weeks I've been on it (lost 9.5 pounds). The side effects I get are headaches if I don't drink enough water - WATER IS KEY -- and nausea if I don't eat enough protein. 5 small protein-based meals a day seem to do the trick. Have not suffered any of the other things people talk about. I've noticed my clothes are more loose fitting than a 9-pound weight loss would normally warrant. Everyone is different - and people tend to post complaints more than praises... so don't get too stressed assuming you'll have side effects. Most people don't. I'm glad I'm on this journey."

10 / 10
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391 Report
  • KJF
  • Taken for 1 to 6 months
  • September 19, 2021

Wegovy (semaglutide) "I am currently on my 9th injection today, being my 8th full week being on Wegovy. I have lost a total of 40 pounds so far. Appetite is definitely curbed. Sunday’s when I take the injection and it makes me tired. A lot of gas and the occasional runs, but the weight loss is worth the side effects."

9 / 10
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767 Report

More FAQ

  • LCMel
  • Taken for 1 to 6 months
  • March 18, 2022

Wegovy (semaglutide) "Wegovy has absolutely curbed my appetite at the .25 dose, I definitely do not feel nearly as hungry as I used to. I will eat maybe 1/3 to 1/2 of what used to be a normal portion for me and get signals to stop. It has not made me sick at all unlike other reviews. I think it's a real godsend for me with COVID and menopausal weight gain."

10 / 10
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581 Report
  • Kmac
  • Taken for 1 to 6 months
  • January 10, 2022

Wegovy (semaglutide) "First of all, this does work. I lost over ten pounds in 6 weeks. The weight just fell off. Second of all, this was the worst experience I have ever had with a prescribed medication. Well, I started at the lowest dose and took that for 4 weeks before moving to the next dose which I believe was 0.5 mg. The maintenance dose is 2.4 mg I believe. How anyone makes it to the 2.4 mg is beyond me. I made it to the second dose of 0.5 mg before I threw in the towel. This stuff is WICKED. I spent 6 weeks of my life with an upset stomach, the absolute worst reflux and heartburn I have ever had, and constant nausea. I had to literally force myself to eat. Would not recommend. The side effects and the price is not worth it. Easy to lose weight when you are starving yourself and feel too sick to eat. Once I stopped it took a few days to feel better and the weight came back lightening quick plus a few. Not worth the misery in my opinion."

1 / 10
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503 Report
  • Backt...
  • Taken for 1 to 6 months
  • March 9, 2023

Wegovy (semaglutide) "I started Wegovy 6 weeks ago at .25 mg for 4 weeks, and for the last 2 weeks at 1 mg. I started at 211 lbs and am now 197 lbs, so have lost 14 lbs and counting in 6 weeks. Not bad! Symptoms I've experienced include being slightly more tired than usual on the day of the injection, and some constipation at first but I use Miralax if there's an issue and it works fine for me. I haven't had any extreme nausea, but the injection definitely makes me less hungry and there are certain foods that I feel slightly queasy even considering eating--like high-fat foods--so I don't eat them. I eat a lot more fruits and vegetables and get full very quickly. I work out 4-5 days a week, my energy has been good and I feel like I'm getting back to my old self. I'd like to be about 135 lbs eventually. Wegovy has been a lifesaver. I'm 55 years old and had considerable cravings, especially at night. I'm happy to be free of them. I hope to make my new habits permanent."

10 / 10
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282 Report
  • Goodbye...
  • Taken for 6 months to 1 year
  • May 2, 2022

Wegovy (semaglutide) "I started ozempic last June. I switched to Wegovy in September. My start weight was 216.8 pounds at 5’6”, and I’m a 50 year old, post-menopausal woman. In 9 months, I’m down to 148.2 pounds (-68 lbs; almost 35%), and went from a size 16 to a size 8. Could only take 1.0 due to kidneys not functioning normally when upped to 1.7. I do not have time to work out. I thought it would be hard to give myself a shot, but it’s so easy! Absolutely amazing! Side effects are limited appetite and sleep (especially first couple days after shot), nausea (especially when brushing teeth or smell things), and hair loss (started more around month 6). But no other diet worked after menopause and stress for over 10 years. I love my new body (something I have NEVER said)! Will stay on it forever! Excited for warmer weather and outside activities (and the strength to do things)!"

10 / 10
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400 Report
  • Julie
  • Taken for less than 1 month
  • March 20, 2023

Wegovy (semaglutide) "I've been on Wegovy for 3 weeks now. My biggest regret is that I let the negative reviews scare me from taking it for about 4 weeks. I finally decided to just do it and boy am I glad I did! This stuff is magic! It has completely curbed my appetite and I have had few side effects - mostly a metallic taste in my mouth, and increased thirst. Some very minor stomach upset but nothing that can't be dealt with. I have definitely lost weight but I'm not keeping track yet. I started with a 0.25 mg dose and will move to the 0.5 mg dose after the 4th week. If you're worried about side effects, just know that it's different for everyone and you won't know what your experience will be like until you try it."

10 / 10
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250 Report
  • Wegovy...
  • Taken for 1 to 6 months
  • February 8, 2022

Wegovy (semaglutide) "I'm in my second week of the 2.4mg dose of Wegovy. A lot of folks who posted mentioned cramps and nausea. I would usually experience this the first day and second day of injections early on but not so much now in the 2.4gm dose. The cure for the nausea that worked best for me was a couple bouillon cubes. Did the trick every time. Ate high protein and low carbs. Increased salads which are a key component of doing well with Wegovy and a low carb/high protein diet. I had gastric bypass in 2011 and lost quite a bit of weight which I kept off for a while, but gained almost all of it back through Covid and began Wegovy in October, 2021. As of today I have lost 67 lbs which is absolutely amazing. I am rehabbing for a knee replacement and this has been the absolute missing piece. This has removed all cravings of food, alcohol and most other things. My dosing day is Tuesday mornings and I can really tell on Monday afternoon/night as I start to get those cravings! Make good choices!"

10 / 10
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410 Report
  • Jenni...
  • Taken for 1 to 6 months
  • April 1, 2023

Ozempic (semaglutide) "I started Ozempic on 2/22/23 weighing 216 lbs as of today 4/1/2023 I am 191.2 so just about 25 lbs in 5.5 weeks!! I started out at .25 for 4 weeks then moved to .5 last week. I've been nauseous maybe 4 times, I’ve gotten a few headaches and kinda backed up about 3 days a week. I started taking magnesium at night before bed and that really helped me get more regular. I’m barely hungry and need to force myself to eat. Anyways I’m really excited and I’m looking forward to summer!"

10 / 10
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239 Report
  • Respi...
  • Taken for less than 1 month
  • February 9, 2022

Wegovy (semaglutide) "This medication has been amazingly good. Wow It's only been 4 days but my thought process of always thinking about what I am going to have for my next meal. Always food shopping Always having cravings to eat Never feeling full. THAT'S ALL CHANGED!!!! I am eating half what I did. I am only eating when I am hungry and that is less frequent. This is not in my head I know there is a change. Thank you so much. Yes of coarse 4 days is not enough time. But I am hoping that the 12 hours of thinking about food stops. Each and everyone out there knows what I mean. We are constantly thinking about what we will have for our next meal. Food shopping Collecting recipes. Eating 2 or 3 portions of food Eating between meals. Having deserts etc. Next report will be after a couple of weeks"

10 / 10
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380 Report
  • Tracey
  • Taken for 1 to 6 months
  • September 20, 2021

Wegovy (semaglutide) "I have been on Wegovy 2 months now and I'm down 17 lbs. I don’t exercise . Only thing I changed was stop drinking cokes and try eat a little better. I have found certain foods will make me nauseous. The medication pretty much tells me when I'm full if I try to push the amount I get sick to stomach. This medication works for me"

10 / 10
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387 Report
  • Sally
  • Taken for 1 to 2 years
  • March 9, 2022

Wegovy (semaglutide) "Wegovy & Ozempic (both are Semaglutide, but Wegovy is a higher dose) have been LIFE-CHANGING. It has turned off the 24/7 hunger switch in my brain. I feel “normal” around food for the first time in my life. I started with Ozempic Jan 2021 and switched to Wegovy Oct 2021 (now at full 2.4 mg dose). To date, I’ve lost 87 lbs! I have 50 lbs more to lose. I’ve had virtually zero side effects, just minor upset tummy the 1st week. I feel full/satisfied with much less food, I no longer think of food constantly, I respond dramatically less to food cues (seeing or smelling food), and I no longer get overwhelmed at restaurants/holidays because of all of the delicious food options. I’m in control. The only bummer is the price. My Wegovy coupon is about to run out and my Ins doesn’t cover it"

10 / 10
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271 Report
  • elish...
  • April 3, 2023

Wegovy (semaglutide) "Started on 0.25 mg. Had some side effects but not enough to stop taking it. Nausea, but not terrible, heartburn which was bad at times, pepto bismol sorted it out, (have some on hand). Curbed appetite, but noticed it starting to not be so effective when it was time to up the dose. I am now on 0.5 mg. The third week and I am on a new dose and there's a big change. I have heartburn most of the time, especially if I try to eat starchy carbs, (1 slice of bread). Nausea here and there, but since I took the third dose of .5 mg, I have absolutely zero appetite, I know I should eat, but 1 or 2 mouthfuls of food is enough for me. I lost 12 lbs in the first month and will weigh myself at the end of the second month. Conclusion: if you really can't stop eating, and your health is suffering, speak to your doctor about Wegovy. It's not a magic wand, but will definitely help you. Make sure you drink plenty of water throughout the day."

9 / 10
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139 Report
  • tallg...
  • Taken for 1 to 6 months
  • December 16, 2021

Wegovy (semaglutide) "I have been on Wegovy since the end of July 2021... with difficulty finding the prescription, I have had to go a few weeks between refills so I am halfway through my fifth month. I am down 34 pounds since starting and haven't been hungry. It has been the solution to a lifetime of weight struggles! I did have hair loss start in the fourth month and have added a multivitamin to help. My hunger was so low, I asked my doctor to take me back to the month three dosage. Hoping both the vitamin and decreased dose will help with hair loss... so far it isn't noticeable to anyone but me (and my family seeing the hair on the floor/in the shower!). Even if I have had to go 1-2 weeks between doses due to backorder, I find I am still losing weight and my lack of hunger is the same. I occasionally eat "bad" foods (fast food, desserts) and haven't noticed any bad effects or issues. I just can't each much of anything so I try to focus on healthy protein and fats and lots of veggies/salads."

10 / 10
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241 Report
  • Mom...
  • Taken for 1 to 6 months
  • December 29, 2021

Wegovy (semaglutide) "Just took my last injection of month 5 1.7. I have lost about 25-30lbs along with 3-5 days a week at the gym. Definitely curbs your appetite. The nausea is very real! Each month I thought it would get easier. It’s never does. A couple times I puked for hours. Lots of belching. In the beginning a little constipation. The first day or 2 after the injection you can feel fatigue. It works for weight loss if you can tolerate the nausea. This will be my last month. I have a 6 month prescription but I can’t deal with the nausea anymore."

8 / 10
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226 Report
  • P-C
  • Taken for 6 months to 1 year
  • March 25, 2023

Wegovy (semaglutide) "Wegovy has been the most positive life-changing medication I have ever used! I lost 85 pounds in 6 months. I was lucky to not have side effects, many of my coworkers are now having my positive experience with Wegovy as well. I feel like a role model. A friend said you should be a spokesperson for Wegovy."

10 / 10
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122 Report
  • Mildred
  • Taken for 1 to 6 months
  • December 9, 2021

Wegovy (semaglutide) "I started Wegovy the end of July 2021. I was up too the second dose amount. I stopped it on October 8, 2021 because I was seeing extreme hair loss. I had called and spoke to a Wegovy rep the month before about it and they said someone was going to call me, as this was not a side effect that they knew of. No one ever called. I did look on another site and it did show hair loss. Know that hair loss with this product is real. It has been a very depressing time for me as they way I look at myself has changed because of the loss of my hair. HAIR LOSS IS REAL WITH WEGOVY"

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209 Report
  • Life...
  • Taken for 1 to 6 months
  • May 10, 2023

Wegovy (semaglutide) "So far, after 4 months, this has helped boost weight loss. At 57, I’ve been battling with the slowest metabolism on earth! It didn’t matter what I ate, when, how, how much, nothing. I started an exercise program that I promised myself I would stick with for a minimum of 2 months and I did it like an adult. Meaning I did t work out for 3 hours my first time. After 4 months, I’ve lost 50 lbs, again, I added exercise prior to starting Wegovy because I had both knees replaced. I will have nothing else replaced due to being overweight. I, personally, have had NO side effects except I’m not hungry at all. But this allows me to make better choices. Best of luck to all!"

10 / 10
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103 Report
  • Serena...
  • Taken for 1 to 6 months
  • March 1, 2022

Wegovy (semaglutide) "Seven weeks in and it’s great! I’ve lost 12 lbs already. I don’t have that many side effects to discuss, but you do have to be careful what you eat and how much you eat. If you try to eat too much food that is high in fat or high in sugar you will not feel well. You do have to listen to your stomach as you get full very quickly, if you push it you could become queasy. As long as I pay attention to this, I feel fine and have little side effects. I do inject it in my thigh as I have read that it reduces bad side effects. Perhaps that’s the key."

10 / 10
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181 Report
  • Mimi
  • Taken for 1 to 6 months
  • July 7, 2023

Ozempic (semaglutide) "Since my first injection, I have felt utterly dreadful. The nausea is one thing, but I have constant fatigue that prevents me from leading my normal life. I know it suppresses appetite, but I don’t have ANY appetite at all and cannot face food. I know if I eat, I will feel a bit better, but it’s impossible. I actually feel like I’ve been drugged. Yes, the ‘food noise’ has gone, and I no longer overeat or binge, but I feel like everything is suppressed - like I’m on a strong drug. I did 4 weeks at 0.25 and have just done one week at 0.5, but I can’t do this anymore. I feel utterly dreadful. I am so pleased it’s helping so many people, but more research is needed into why some people just can’t tolerate it."

3 / 10
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87 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.