Also known as: Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Menopause Formula Progesterone, Prochieve, Progest, Prometrium
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
progesterone for Perimenopausal Symptoms: I am a 51 year old woman diagnosed with fibroids and have experience very heavy bleeding. With the added issue of the pre-menopausal symptoms I felt like I was losing my mind. Have been taking Progesterone 200mg for about a week and I haven't felt this good in years. No more cloudy head, joint pains and night sweats are almost gone. Best part is I'm not craving junk food and sweets.. So far so good, no weird side effects. This is the best!
13 users found this comment helpful.
progesterone for Endometriosis: I've been taking this medication for a year now and was hoping I'd get used to it but no luck. It did initially help with the wicked menstrual cramps I'd get on day 2 (vomiting from pain) but I can't take enough of it due to the side effects. I can only take it on the weekend, then it ruins my whole weekend. I feel tired, dizzy, can't think clearly, clumsy, and kinda drunk. It also stays in my system a really long time, 24-36 hour half life so I'm drunk and dizzy for that long. Bummer because it doesn't make me feel nauseous at all, like the pill does. Still, I may try the birth control pill instead. Can't really function on this and not sure I should be driving, much less working on it.
Review by Anonymous (taken for 6 months to 1 year):
Prometrium (progesterone) for Premature Labor: Early pregnancy loss was a huge issue. I have been on prometrium since day after ovulation. I am 18 weeks pregnant. Drs wanted me to stop at 14 weeks I had extra and continued. I ran out for two days and started having contractions. My Dr decided it was best to stay on prometrium due to evidence of risked preterm labor.
Review by swhitico81 (taken for less than 1 month):
Prometrium (progesterone) for Progesterone Insufficiency: I am 49 and have been on this medication for one cycle. The side effects have not been as bad as I had anticipated. I had a few mild headaches, and bit of bloating, tender breasts and a mild acne breakout, and was a bit tired a few days. I am taking it for a proliferative endometrium and after 4 days being off the medicine, I am getting a period, so it seems to be working as planned. I am taking 200 mg.
progesterone for Progesterone Insufficiency: I am using this in my FET cycle for IVF. I am 4 weeks, 4 days pregnant. I was taking 2 vaginal inserts (100mg) each per day but after blood tests came back showing a very low Progesterone level, my Dr is having me take an additional 600 mg per day in pill form (200 mg, 3x per day). My Dr warned me that I would be very tired and possibly dizzy. I have been on the pills for 3 days now and have noticed that my breast are very tender and swollen which they weren't before and it does make me a little drowsy but not bad, It's manageable. I go back on Tuesday to check my levels.
Review by Anonymous (taken for less than 1 month):
Prometrium (progesterone) for Amenorrhea: I am currently taking this medication for a missed cycle. I was told to take it at night due to the drowsiness it may cause. So far I have not noticed much of a problem with that. I have been on the pill for 5 days and the side effects are almost unbearable. I have breast tenderness, but also the muscles around my chest/back area are aching to the point of being painful. I called my doctor about this side effect and was told that the medication has not been known to cause achiness. After reading this website I see it is very possible. I have had some dizziness, sweating, and irritability as well. Either way the medication seems to be helping, but I really cannot wait to quit it!
progesterone for Progesterone Insufficiency: All day dizziness and general blah feeling. Sleep majorly disrupted and when I get it it doesn't do anything to help with the tiredness I already have. Nails grew weak and thin. Also had some numbness in places which went away when I stopped the pill.
progesterone for Perimenopausal Symptoms: I am soon to be 49 and I was feeling so bad, hotflashes, 30 pounds of weight gain in 2 yrs, insomnia, foggy brain and a very large appetite, to name a few right but saw a doctor (alternative) and he did blood work and found my testosterone was so low and my progestin. So I now take a small dose of testosterone cream and 200 mg of natural progestin and can I tell you I feel like I did in my 30's. Use progestin at night, testosterone in the morning. I have lost 12 pds in about 40 days and it continues to fall off. Sleeping like a baby, no hot flashes and I think more clearly and my memory is awesome too. I do take a lot of supplements that work with the hormones.
29 users found this comment helpful.
Prometrium (progesterone) for Endometrial Hyperplasia, Prophylaxis: I am taking this med without any estrogen for endometrial hyperplasia. I am in my first cycle of taking this and already started a period on day 9 of the 12 pills. I really hope this will eradicate my hyperplasia,
Prometrium (progesterone) for Progesterone Insufficiency: I am on 100mg dose, days 14-28 of my period or the first 12 weeks of pregnancy. The first month was great, I felt level, the only side effects felt were extreme sugar cravings and vivid, bizarre dreams. However, in month two, no cravings, extreme mood swings and ranging from a need for a lot of sleep, not wanting to get out of bed to anxiety and very little sleep. No pregnancy yet.
12 users found this comment helpful.
progesterone for Premature Labor: After each injection I would be exhausted the next day. I would have severe depression which seemed to get worse with each injection. I'm only 25 weeks and have to continue taking it until I'm 34 weeks. Will see if it helps me go full term.
progesterone for Premature Labor: I'm taking this medication to prevent premature delivery. With EVERY injection, I have gotten a debilitating migraine, not to mention soul-crushing depression. With no other options, I have to stay on the medication until I reach 32 weeks.
Prometrium (progesterone) for Uterine Bleeding: It saved my baby. I was was showing signs of miscarrying because of my hormone levels. I took this for 12 weeks. The bleeding stopped the next day and I now have a healthy little girl!
12 users found this comment helpful.
Prometrium (progesterone) for Perimenopausal Symptoms: Taking it at 100 mg. Didn't like the dizzy feeling. Started taking it at night, much better but I feel it building up in my system over time. I wish I could take half or 3/4 as much but it is not available in those doses. I have absorption issues and the liquid form is great except I can't cut it in half. I do like what it does for my thinking, digestion, emotions etc but over time irritability, heavy-dreaming, pregnant-like feeling build-up. I am a small woman about 110lbs, 5 feet and wish smaller doses were available. A little bit goes a long way.
43 users found this comment helpful.
Prometrium (progesterone) for Progesterone Insufficiency: I'm pregnant and my lab work came back indicating I have a low progesterone level. My doctor prescribed Prometrium and initially I took the medication in the daytime, but then found that it makes me extremely tired. I decided to start taking the medicine at bedtime then started having very bizarre dreams only when I take the medication at bedtime. I informed my doctor,but he dismissed the side effect as not being related. I'm positive the side effect is from the medication. I hope this comment let other women who experience this side effect know that you are not alone. Just because it's not a listed side effect doesn't mean it can't happen.
33 users found this comment helpful.
Prometrium (progesterone) for Amenorrhea: This drug is effective at inducing a period, but it has AWFUL side effects. Basically, you will feel pregnant--tired, dizzy, hungry for junk food, and BLOATED. My breasts grew half a size within 3 days of taking. Then the rest of me caught up and I gained 5lbs in the 10 day time frame that I took this drug. But it did do what it was supposed to do, so I can't totally complain.
22 users found this comment helpful.
progesterone for Progesterone Insufficiency: I am taking progesterone suppositories to help sustain my pregnancy after a miscarriage due to insufficient progesterone levels. I began taking it at 4 wks pregnant, and am now 9 weeks along. My side effects have included drowsiness, cramping, bloating and upset stomach. A rather unfortunate side effects has also been vaginal itching and dryness that leads to major discomfort for the hour or two after I have inserted the medication. These are little issues that feel big, but in the grand scheme of things, if this medication helps me to have a healthy pregnany and baby, it will be well worth it.
15 users found this comment helpful.
Prometrium (progesterone) for Amenorrhea: Prescribed by my gynecologist to treat amenorrhea and long, heavy periods as a result of anovulation (I have polycystic ovarian syndrome which causes anovulation). Due to the anovulation, I would go several months without a period only to eventually have a period which would last anywhere from 14-35 days. The period would be much heavier than the norm, especially for the first 7-10 days. I would also have very large clot-like discharge. I take Prometrium for 21 days, then off for 7 days(which brings on my period). The only significant side effect has been hot flashes during the day, usually in the late morning I will have one bad one with profuse sweating. Then usually one in the afternoon but it's not as bad.
22 users found this comment helpful.
Prometrium (progesterone) for Progesterone Insufficiency: I'm 48, and found that this nicely balanced the issues I'm having with estrogen dominance. I've had no side effects that I can tell, but a real clearing up of the fuzzy brain, night sweats, and trouble sleeping. I love it!
58 users found this comment helpful.
Prometrium (progesterone) for Uterine Bleeding: My doctor is having me take this medication because I have excessive bleeding. So far the bleeding has stopped but I'm on day 10 and the side effects are kicking in. I have breast tenderness, stomach cramps and I makes me very tired. Overall so far it has done what it needs to do. I go off of it in 2 days I'm hoping that my body will regulate.
31 users found this comment helpful.
Prometrium (progesterone) for Seizures: This artical says it's not known what happens with overdose of Prometrium but I can tell you do not take 2 doses at once. I normally take 800mg/day for last 1/2 of my cycle to suppress catamenial seizures. It works great with no negative side effects. I take 200mg every 6 hours. I recently missed a 200mg dose so I took 400mg at once. I was completely anesthesized for a couple of hours. Body went jelly-like. Everything slowed way down to the point that words came too slowly, if at all. Family opted to take me to the ER. Later was determined I was likely not in danger of dying but was clearly knocked out for a while. Memory of much of those 2 hours is totally lost to me. Family says I was pleasant and cooperative but out of it.
33 users found this comment helpful.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Data sources include Micromedex™ (updated Dec 30th, 2013), Cerner Multum™ (updated Jan 17th, 2014), Wolters Kluwer™ (updated Mar 2nd, 2014) and others. To view content sources and attributions, refer to our editorial policy.