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Omeprazole User Reviews & Ratings (Page 4)

Brand names: Prilosec, Prilosec OTC, Omesec

Omeprazole has an average rating of 4.7 out of 10 from a total of 485 reviews on Drugs.com. 32% of reviewers reported a positive experience, while 53% reported a negative experience.

Reviews for Omeprazole

  • Gert
  • Taken for 5 to 10 years
  • March 28, 2018

For GERD "When I was diagnosed with GERD and put on omeprazole it work quiet well so I stayed on it then after taking the drug for 5 years. I had something happen in my chest area like my heart fluttering and I couldn't get my breath it was like I was struggling for oxygen. This happened 2 other times and was very frightening . I changed to pantaprozole and it hasn't happened since. I just wanted to know if this as happened to anyone else after long term use ??"

7 / 10
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  • Jeff
  • November 3, 2019

For GERD "I was just prescribed Omeprazole this week. The first day I took it I thought it was magic. Suddenly my terrible, nightly heartburn was completely gone. Unfortunately, the side effects are numerous, immediate, and simply not worth it! It gave me a constant headache, messed up my sleep, made me feel a constant lingering nausea, and made me feel emotional emptiness, anxiety and sluggishness. I usually take Ibuprofen for headaches and it works very well. It would not touch the headaches caused by Omeprazole. Also, my normal remedies for feeling anxiety or stress did not work at all. I have a few go-to substances that usually totally wipe it out. Neither worked. So after very little sleep for three days, a constant headache, feeling like I needed to throw up, and a major increase in anxiety along with empty and hopeless feelings, I have stopped taking the Omeprazole. It is back to antacids for me and some needed diet changes. This stuff is horrible!!!"

1 / 10
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  • teres...
  • October 8, 2011

Prilosec (omeprazole) for GERD "I started taking Prilosec over 6 years ago. It was very effective at helping with the acid and GERD symptoms, however my Doctor prescribed two tablets a day (Over recommended dosage-due to seriousness of Gerd). I seem to be fine until I started getting horrible spasms in my sides and intestines. I broke my ankle in March and the spasms were bad and the spasms worsened. I had my calcium checked and I was dangerously low. We backed down to 1 Prilosec and the spasms disappeared. So watch your calcium with higher doses."

10 / 10
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Frequently asked questions

  • Jano
  • Taken for less than 1 month
  • November 18, 2018

For GERD "Have been taking the prescription of this drug for a week now after having been on rabeprazole 20mg for 4wks with no relief. and for the most part the omeprazole has taken away that stuck in your throat feeling. The downside is that the nausea feeling is terrible and I get stomach pain something that I didn’t have with the previous PPI. Anyone else having bad nausea?"

6 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • January 29, 2020

Prilosec (omeprazole) for Helicobacter Pylori Infection "I took Prilosec for a yr and a half. I noticed that my whole body ached. My bones hurt, if I bumped up against a door my arm was so sensitive. I felt like I was 90 years old. My joints ached and my face lost any glow. My skin was dull, flat and pale. Once I got off this, all those symptoms went away. I have bad reflux, to where I couldn't swallow or yawn. I now take apple cidar vinegar each morning and I'm fine. I take a couple tea spoons with a splash of water in a small cup when I get up, and it works! Get off Prilosec, it will age you prematurely!"

1 / 10
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Are you taking this medicine?

  • Lano
  • Taken for less than 1 month
  • August 25, 2019

For GERD "I’ve been on this medication for 3 weeks and it helped a lot with my acid reflux symptoms (lump in throat feeling). However, during the second week, I started noticing my mood changing and becoming more anxious/paranoid. Then, in the third week, had muscle aches and panic attacks. I have stopped taking this 2 days ago and am still feeling dizzy, anxious and nauseous. Anxiety/Depression sufferers beware of this medication as it definitely heightens them. I will now look for more natural solutions to GERD such as a healthier diet and smaller portions. This medication is not worth the side effects in my opinion."

5 / 10
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  • Naerf
  • Taken for 6 months to 1 year
  • April 27, 2022

For Gastritis/Duodenitis "I was given these as a ‘quick-fix’ solution after burning my oesophagus. As a fit and active 30 year old I’d never actually had heartburn in my life, but I now found myself getting it whenever I ate certain foods (which I couldn’t understand) and had the feeling of a lump in my throat. This was obviously just a side effect of the drug but it didn’t click in my head. Eventually, after an endoscopy showed Gastritis, I was switched onto Omeprazole. Taking these for 2 wks changed everything. I developed a tremor, muscle twitches where I'd literally drop my phone, jolting awake just as I'm nodding off (repeatedly all night) and feelings of anxiety/depression that I never knew existed. It's been 4months now and I'm finally getting there. You need to taper off these drugs, doctors won't even bother telling you, but when you stop your body creates more acid than before 'hyper-secretion' which can take weeks/months to adapt to - so a lot of people get caught in a vicious cycle."

1 / 10
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More FAQ

  • LUK
  • Taken for 6 months to 1 year
  • February 13, 2020

For Gastritis/Duodenitis "I was taking this medication for 10 months and I’m now into my third week of stopping. The first week-10 days off of it I suffered terrible rebound and severe stomach cramps. Thankfully through dietary changes and perseverance I can honestly say I’ve felt the best I have in a long time. Advice to anybody prescribe this medication... try and heal your condition through dietary changes and/or natural medication. This medication interferes with a natural process and long term side effects have severe consequences."

1 / 10
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  • jaimer
  • Taken for less than 1 month
  • August 23, 2012

For GERD "Within 12 hours of taking this medication I got the chills, dizziness and stomach cramps and extreme dry mouth. Within 2 hours of taking my second dose I experienced anxiety, swelling of the tongue, throat and glands, continued dizziness and extreme dry mouth and thirst, frequent urination and stomach camps."

1 / 10
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  • Teta
  • Taken for 5 to 10 years
  • January 3, 2019

For Barrett's Esophagus "Have been on omeprazole for 10 years. Take one 20 mg. Each a.m. prior to Breakfast . No acid reflux, or gas, Or unpleasant side effects. Also Very affordable. Have endoscopy Every 2-3 years. Seem to have my Condition under control. Works for me."

9 / 10
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  • Marie
  • Taken for less than 1 month
  • May 24, 2022

For Gastritis/Duodenitis "Just wanted to reach back out after leaving a review last year and after a very long recovery process after taking this drug. I had all of the negative side effects that most have mentioned here including debilitating anxiety, panic, palpitations, pins and needles, severe aches and pains that seemed to jump from one organ to another, POTS, fatigue, food sensitivities, insomnia, went from a healthy 37 year old mom to a shell of her old self after just 4 doses of this awful poison. My naturopath diagnosed a Limbic system impairment which explained it all. Toxin exposure, sensitivity to drugs/supplements, chemicals, mold exposure and a host of things can set off the Limbic/nervous system to go haywire which is exactly what this drug did to me. For those still suffering, I highly recommend a DNRS program to retrain the nervous system out of the now activated fight or flight and find yourself a good naturopath to detox. I’m all good now after this terrible pill, healing is possible! - xo"

1 / 10
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  • JesAcun
  • Taken for 1 to 6 months
  • April 4, 2021

For Hiatal Hernia "I honestly surprised how many people here are battling with depression and anxiety because of this medication. I got to say I've been on this for a month and I totally saw the difference for the better, yesterday had my last tablet and today I'm feeling the difference of the acid again. I totally believe that people who are suffering these side effects have been battling them for years now and for some reason this medicine amplified them."

9 / 10
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  • Ady
  • Taken for 10 years or more
  • January 16, 2020

Prilosec (omeprazole) for GERD "I started on Zantac and then went to Prilosec and Nexium. I was fine for years but now I am having side effects I can't live with. After taking one 20 mg pill I got chills, nausea and felt very tired. I have a hiatial hernia and not sure what to do."

10 / 10
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  • Beck
  • Taken for 6 months to 1 year
  • April 20, 2017

Prilosec (omeprazole) for GERD "I've been having problems for years with my stomach and GERD. I was put on prilosec and was told that it would possibly cause an upset stomach to begin with but to try to work through it. I took it for around 5 months but I could not handle it anymore. I kept stomach cramps and an upset stomach the whole time. I couldn't keep enough fluids in me to keep myself hydrated. Months later I was prescribed it again and tried it once again. Same thing but worse. I had bad blood work come back saying my kidneys weren't working right and my potassium was so low I was admitted into the Hosp. Since then my kidneys are still not OK. I've been peeing blood on and off. I am pretty sure that this medicine has messed my kidneys up. Bad stuff for me"

1 / 10
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  • fayfa...
  • Taken for 10 years or more
  • September 21, 2017

Prilosec (omeprazole) for Indigestion "I have taken this medication for over two decades and it works well. Without it I wouldn't be able to hardly eat anything. If I run out and have to wait to get my refills .. It usually takes several days before any horrible symptoms come back. I try to get my meds before that happens. It really does help in making life so much better. You can eat in a normal fashion but sensible. I try to drink plenty of water, so my meds won't be to much of a strain on my bladder & kidneys and all my organs. I know without this medicine I couldn't even drink water without suffering the consequences.. it was that bad."

10 / 10
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  • Refluxy
  • Taken for less than 1 month
  • July 25, 2021

For Hiatal Hernia "I went for an endoscopy because I have trouble swallowing. I have had this condition before and have had my esophagus stretched, no problem. This time however, I'm told I have a hiatal hernia and reflux. Mind you, other than swallowing, I have NEVER had any symptoms of reflux. No heartburn, nothing. Dr put me on this omeprazole 20mg. Very first day taking it, guess what.. I NOW have symptoms of reflux. Throat feels like it's closing, chest tight, heartburn, and it feels like food is backed up to my throat. Not a good feeling! Is it the drug, or am I having a great attack? I took it the next day and the same thing. Day 3, I did not take it, but STILL same symptoms. Today is day 4, symptoms are fading.. I'm NOT taking this anymore..I don't see anyone else here with this issue. Need to call Dr Monday.."

1 / 10
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  • RDano
  • Taken for less than 1 month
  • December 3, 2019

For GERD "I’m currently taking this drug for acid reflux and only took three pills so far 40mg. HORRIBLE SIDE EFFECTS!! Nausea, hard to swallow, anxiety is so bad right now! Can’t wait until it leaves my system!!"

1 / 10
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  • DDano
  • March 5, 2021

For Barrett's Esophagus "I was taking Pantoprazole and having serious side effects. Omeprazole is so much better so far. I have to take 20mg. 2 times daily or I get a bad headache. I have Barrett's Esophagus and its pretty bad. I have to watch what I eat or I get serious upper middle chest pain .I always have trouble with medication. Sending prayers to everyone who has this. It is not fun at all."

8 / 10
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  • Big...
  • Taken for 5 to 10 years
  • October 23, 2021

For Gastritis/Duodenitis "I have had stomach problems over the last few years. Initially caused by h pylori I was prescribed antibiotics and 20mg omeprazole after the h pylori was cleared I was recommended to stay on the 20mg of omeprazole for a period of time. 5 years later I am still stuck on this pill the side effects are horrendous I've never felt as tired in all my life I feel very depressed and low. I have severe cramps in my stomach and severe back pain in general I always have a feeling of unwellness I've also been recently diagnosed as having chronic gastritis which I am sure is a side effect from taking omeprazole for so long. However when I stop taking it for a week I feel absolutely amazing if to describe just normal however it's short lived and my acid reflux and heart burn flare up and I have to go back on the omeprazole. It's a vicious cycle I wish I had never took this drug ever in the first place I am a shadow of my former self. I would really like to know if anyone is in the same position"

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  • Susan
  • Taken for 1 to 2 years
  • November 19, 2020

Prilosec OTC (omeprazole) for GERD "I started taking Prilosec OTC 20mg tablets last year.... I didn't notice any side effects. My very mild GERD was definitely completely unnoticeable. I was happy.. Up until around 40 days ago. I realized that the hair loss I was experiencing was the Prilosec. The hair loss started 2 months after I began the 20mg tablets. Never had any hair loss in my life and I've taken tons of different meds over the years. I'm a female in my early 30s... I had to eliminate one other medication to come to the conclusion that it was indeed the Prilosec making me go completely bald. Hair was coming out in huge clumps in the shower... Every time I touched my hair, it fell out. My little remaining hair was also very dry & brittle. It was definitely stressful, I had no idea this could be a potential side effect of such a low dose once a day. 40 days off & the hair loss has dramatically decreased already. For me, that particular side effect was extreme, shocking, and unexpected.."

5 / 10
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  • LWM
  • December 26, 2019

For Indigestion "I was advised by my GP to take omeprazole 20mg daily. September 2019 my anxiety heightened to the point where I was unable to live on my own and I developed severe abdominal pain, muscle spasms, and extreme fatigue. I recently worked out that my acid levels had decreased drastically and I dropped from 8 Stone 7 to 7 stone 5. I ended up hospitalised on several occasions and only recently I decided to stop taking omeprazole. I’ve reintroduced more acidic foods back into my diet, I’m able to drink milk again and my stomach and mental health have improved immensely. My advice is that if you can control your stomach acid related problems thorough your diet then please use this as your first line of defence. Omeprazole just masks the symptoms and does not address the underlining issue. It’s still very early days for me but I hope and pray that I’m finally on the road to my recovery and I can start rebuilding my life once again."

1 / 10
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  • SCR
  • February 27, 2019

For GERD "This medication at 20mg was enough to relieve the symptoms of GERD but for months I started to suffer with symptoms I've never really experienced - anxiety, major lack of concentration, brain fog, aching on days where I had done no physical training. I have come off the medication for 2 weeks and already started feeling better and the side effects have disappeared, I have changed my diet to combat the GERD effects, although this hasn't completely solved it, I also take a good multivitamin now. The medication was not worth the side effects."

3 / 10
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  • weygirl
  • Taken for 2 to 5 years
  • February 22, 2022

For Hiatal Hernia "I have a para-oesophageal hiatus hernia. Omeprazole has been a god send for me. It stops the stomach area under the bottom of my rib cage from hurting; it stops Gerd, it also helps with irritation in my stomach. It works better than anything I have been prescribed (or bought over the counter.)"

10 / 10
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  • Flumpet
  • Taken for 10 years or more
  • July 26, 2017

For Barrett's Esophagus "I have had GERD and Barrett's esophagus for many years and have been taking 20mg of omeprazole every day in the morning since the drug was approved by the FDA (early 1990's?). It has changed my life by eliminating the constant pain of severe heartburn with little to no side effects (I guess I'm lucky in that respect). My ENT doc says I will need to be on this drug for the rest of my life to ward off the potential of the Barrett's turning into esophageal cancer. Not to mention the comfort I am getting and the food choices I can make that no longer bother me and trigger heartburn."

10 / 10
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  • Ardesal
  • Taken for 5 to 10 years
  • August 29, 2020

For Erosive Esophagitis "Sorry to read how this drug omeprazole has cause many people on here problems. My nickname for this is my wonder drug. Had reflux problems most of my adult life. Got to the stage food was getting stuck in my esophagus. It was a miserable time ending up with me being hospitalised. Got diagnosed with eosinophilic esophagitis and a hiatus hernia . Scarring on my esophagus from the acid reflux caused narrowing. Was put on this omeprazole. A week in to it was eating normally. Had a procedure to fix the narrowing. Was told I'd have to be on this drug 20mg daily for life. Long term it may give side effects that I've yet to experience but what ever they are I'm still grateful I can now eat and drink what I enjoy again. Good luck to all."

10 / 10
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33 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.