Also known as: Zyprexa, Zyprexa Intramuscular, Zyprexa Relprevv, Zyprexa Zydis
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Compare all 137 medications used in the treatment of Depression.
Reviews for Olanzapine to treat Depression
Review by tried everything (taken for 6 months to 1 year):
Zyprexa (olanzapine): Would give this a 10. Have tried every anxiety/depression, SSRIs and MAOIs, etc. out there. One day on this and I felt wonderful, like I woke up as a new normal person. Yes you may gain a lot of weight but only if you eat carbs. You just cannot take this and eat chips, candy, etc. Lean meats, proteins and veg and you will have NO problems, the effect is worth it. If you can put the fork down, it can change your life. My Dr. warned me about the potential for weight gain, but told me he thought I had the willpower to resist the cravings to eat junk, which I did. Try it.
24 users found this comment helpful.
olanzapine: Zyprexa has been a wonder drug for me. After 10 years of serious depression and Bipolar 1 disorder and several different meds this medication saved my life. After 9 hospitalizations and 2 suicide attempts I was put on 10 mg. of Zyprexa and have been stable for 3 years. This medicine has been a Godsend!
14 users found this comment helpful.
Zyprexa (olanzapine): I have been on this medicine for about 3 weeks now. I wake up hungry, drenched in sweat, and have also gained 15 pounds. Im thinking about getting off this medication. I have also had crying spells, irritability, and mood swings, then some other days I have felt fine. Its weird. I'm going to give it a few more weeks, and if nothing improves as far as my moods i will get off of it.
15 users found this comment helpful.
Zyprexa (olanzapine): I started taking Zyprexa over two years ago for intrusive thoughts I was having as a result of Obsessive compulsive disorder/depression. While the Zyprexa helped remove intrusive thinking, it added about thirty pounds onto my slender frame, made me severely tired, and took away my sex drive. In addition to these adverse effects, I was unmotivated/uninterested in many activities that used to give me pleasure. I had a "so what" attitude about life in general. All because of this medicine. What really frightened me about taking this was my cholesterol went sky high, and my blood sugar was also very high, making me an at risk candidate for diabetes. I am finally off of this.
34 users found this comment helpful.
Zyprexa (olanzapine): I take 5 mg of Zyprexa daily. I'm almost the entire day sleepy and have the feeling of doing nothing. I can not worry, because I have to sleep for about 15 hours daily.
But I have tried everything out there, and this is the best at this moment.
26 users found this comment helpful.
olanzapine: My mother has had major depressive disorder for over 45 years. She was taking Orap and fluoxetine for most of that time, but the Orap was causing Parkinson's-like symptoms. Discontinuing Orap can produce other symptoms, of which my mother had chomping of her jaw, and excess salivation. Abilify controlled these other symptoms, but did nothing for her depression, resulting in auditory hallucinations. My mother was switched to olanzapine which is controlling the depression symptoms. She is currently taking 2.5mg upon waking, 2.5mg in mid-afternoon, and 7.5mg at bedtime. Olanzapine causes sleepiness, so normally would be taken only at night, but the daytime dosages were in hopes of controlling the post-Orap symptoms.
olanzapine: I was prescribed olanzapine as an off-label mood stabiliser for clinical depression. It took away all my positive emotions, leaving me feeling permanently "grey" and essentially soulless. I lost interest in all activities I previously found enjoyable. In four months of "treatment" I'd gained 4 stone, and couldn't stop eating. Only now am I coming off this, a process which has been extremely difficult due to a resurgence of the condition the medicine was treating.
12 users found this comment helpful.
Zyprexa (olanzapine): This medication is a great sedative, if that's what you're looking for. It's not euphoric, it just makes you sleepy. But it caused me to gain over 40 pounds in less than 2 months. I now get depressed just looking in the mirror. My doctor says it just makes you hungry, not gain weight, but the amount of weight I gained in such a short time is unnatural!
28 users found this comment helpful.
Zyprexa (olanzapine): I have taken Zyprexa 2.5 with Zoloft for years and couldn't function without this combination. It was prescribed because the Zoloft just didn't take care of the insomnia and mood swings. Zyprexa 2.5 has been a God-send.
39 users found this comment helpful.
Zyprexa (olanzapine): After taking the 2.5 dosage for 4 days I feel very irritable. I am experiencing crying spells, tiredness, extreme moodiness and just want to be alone. This medicine was prescribed for a mood disorder that I have been experiencing. I also take other anti-depressants. I don't think this is a good mix with other medicines or just not right for me.
19 users found this comment helpful.
Zyprexa (olanzapine): Found this medication very effective in my withdrawals from both alcohol and weed. It stops my racing thoughts and keeps me calm. However it does somewhat make you zombie like and unable to feel emotions.
37 users found this comment helpful.
Zyprexa (olanzapine): I took Klonopin and Paxil for 15 years to treat my anxiety disorder. I had to detox from the Klonopin this past spring. I got off the Klonopin and switched my Paxil to Lexapro (sex side effect issue). I am also a recovering alcoholic. My doctor did not want me on Benzo's anymore (says it increased alcohol cravings). I stayed on Lexapro only for 9 months, but my anxiety came back strong on just the Lexapro alone. I almost resorted to taking Xanax before I switched doctors. My new doc gave Zyprexa a chance. I am on my 7th day and I haven't felt this "normal" in 5 years. I take 5mgs at night and it has ended the "chatter" in my head, and removed my anxiety. Great medicine so far.
40 users found this comment helpful.
olanzapine: I'm on 5mg of olanzapine (as a when required medicine) it's great with sleep! You are out like a light bearing in mind I have insomnia. Although I've experienced elevated prolactin levels, so I'm probably going to have to discontinue it.
Zyprexa (olanzapine): My doctor started me on 5mg of Zyprexa and the first 2 days I slept over 14 hours falling asleep within 20 mins of taking it. By day three I couldn't sleep at all and went on for days making me feel out of control, confused, forgetful, pretty much out of it and unable to even have my daughter home with me. I was also very bloated, feeling and looking. On the start of the 7th pill/day I began swelling to the point of GOUT, had breathing problems, dry mouth, was oddly emotional/ crying a lot, and hurting badly due to the MASSIVE swelling and couldn't put on any of my pants. I quit taking the medicine but the next night it all got worse with the addition of tightening in my chest. I am now having skin irritations on my hands. This medicine is bad news.
28 users found this comment helpful.
Zyprexa (olanzapine): Developed depression and significant anxiety this fall. Doctor started me on Lexapro, but that wasn't controlling the anxiety, loss of appetite and insomnia. Added Zyprexa and almost instantly felt much, much calmer, could eat and slept well. Was very sleepy/tired for the first few days but acclimated within a week. The problem I did have was with weight gain. Thought my life had calmed down and I could do without the medicines, but have found that not to be the case. Did not have any issues weaning off the Lexapro and Zyprexa. Just started Pristiq yesterday. Hoping and praying for good things.
21 users found this comment helpful.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Data sources include Micromedex™ (updated Mar 13th, 2014), Cerner Multum™ (updated Apr 15th, 2014), Wolters Kluwer™ (updated Apr 3rd, 2014) and others. To view content sources and attributions, refer to our editorial policy.