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Fluoxetine for Major Depressive Disorder User Reviews (Page 5)

Brand names: Prozac

Fluoxetine has an average rating of 6.6 out of 10 from a total of 128 reviews for the treatment of Major Depressive Disorder. 55% of reviewers reported a positive experience, while 27% reported a negative experience.

Reviews for Fluoxetine

  • Kate...
  • Taken for less than 1 month
  • July 4, 2016

"I am taking 450 mg Bupropion daily and was still hitting the wall. Crying, fear, anger. Had lots of therapy and been on lots of antidepressants. Felt like my life was over. Saw my dr four days ago and told her I wasn't doing well. We talked and she decided to proscribe Prozac 20 mg in addition to Bupropion. I am tolerating the side effects...no appetite, nervous feeling, sketchy stomache, head feels too big...seriously! One thing: I have less body pain. Fibro was active but less so now. That's great. I am an artist and I cannot concentrate or keep my focus. Hoping that clears up soon. Will be back to report on my progress."

6 / 10
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6 Report
  • GG827
  • August 18, 2016

"I began taking Prozac in January 2016. I started out on 20mg. I noticed a positive difference in my mood (less irritable and happier) after only 1-2 weeks. After about a month I bumped up to 40 mg and things were still great. I did really great on it as far as side effects go, I had none. Things were great for 6 months and then it sort of just stopped working. my doctor bumped me up to 60mg but it did nothing. I built a tolerance for it and recently switched to trintellix. Overall, Prozac worked really great until I built a tolerance for it."

8 / 10
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6 Report
  • Anonymous
  • Taken for 1 to 6 months
  • March 1, 2018

"My 13 year old daughter started taking this med 4 weeks ago. Her depression is gone but she is feeling emotional numbness and suicidal thoughts. Both are considered side effects until the drug takes effect. I'm on the fence on what to do."

6 / 10
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4 Report

Frequently asked questions

  • Bea
  • May 25, 2019

"I started to be depressed at 18 , I had a lot of trauma in my life but I used to be really happy, I had severe hypochondria , I would cry every single day for hours straight, I hate medication but after ruling out all the possible diseases I could find I decided to try,I had nothing to loose because I was already lost. In the course of 2 years I’ve tried about 5 antidepressants and all of them gave me terrible side effects. I started Prozac with no hope , I was just sleepwalking. Slowly I started feeling better , it was really smooth , like no dramatic changes , just getting better day by day . The only side effect that really bothers me is that I don’t always feel in touch with my emotions . It helped me a lot but it’s a lot of hard work no drug can help when you don’t believe it can. I’m definitely coming off of it because I find that it blunted my emotions . Something that really helped me too was mindfulness, when you’re ready give it a try ."

8 / 10
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3 Report
  • Horrid...
  • Taken for 1 to 6 months
  • February 21, 2015

"I was diagnosed with parasuicide and major depressive disorder. I also suffer from obsessions, rather than compulsions, and have anxiety. This was supposed to be a cure-all for me until I started having VIVID nightmares that I thought only happened because I was maybe sleeping better. Turns out, Prozac made me lose sleep and I would wake up crying with my heart pounding. My brother had died, so having vivid nightmares related to him dying and other people dying was absolutely intolerable. I would lay in bed and cry because I was afraid to go to sleep. I would force myself to stay up so I didn't have to dream. It was a living nightmare. I had no idea that that was a possible side effect, and the medicine was put on my allergy list."

1 / 10
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Are you taking this medicine?

  • yogag...
  • Taken for 1 to 6 months
  • June 12, 2022

"I want to share my experience because I know someone's probably going through those rough beginning stages scrolling these reviews like I did. I want to be honest and say I almost gave up 3 times on this. I have given up before but I ended up having to restart the start process. Not fun! Don't do that to yourself like I did lol. Anyways I have PMDD, depression, anxiety and I suspect CPTSD from an abusive relationship. This medicine has helped me finally be able to sleep without sleeping pills or melatonin. It honestly took a little over 2 weeks to feel positive effects of this. 1 day I was able to just drive, go to the store, call people without over thinking it. Whereas before it was a struggle to do any of that. I can say I'm back to my normal self finally. I was waaaay more anxious in the beginning. I almost gave up because it made my anxiety so bad but I kept going because I knew it would help eventually and it did. I hope whoever is starting up keeps going."

10 / 10
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  • Small...
  • Taken for 6 months to 1 year
  • November 11, 2021

"I have formally been diagnosed as having treatment resistant depression. I have suffered with depression since I was 12 and am now 74. Nothing has really worked for me. One psychiatrist estimated I might get 30% improvement but I don’t think so. The side effects of most antidepressants makes the slight improvement not worth much. I have tried, I am using brand names in Canada, Prozac, doxepine, Serzone, Zoloft, Paxil, Parnate, fluvoxamine, citalopram, mirtazapine. Some many times and large doses. The longest use were fluxoamine and citalopram. I have had every possible add on and three sessions of ECT to no avail. I recently switched from citalopram to fluoxetine because I could not get off the citalopram otherwise. Now I appear to be gaining weight yet again, I have gained over 100lbs in the last 25 years, I have severe insomnia and fatigue. So how I am going to try no antidepressants. Major sources of stress in my life have died so I hope this will succeed. I am totally fed up."

2 / 10
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1 Report

More FAQ

  • Queen...
  • Taken for less than 1 month
  • March 8, 2021

Prozac (fluoxetine) "I have been on Prozac for 3 days. And last night I started having chest pain’s and I couldn’t breath . I try to eat but I get nauseous and not hungry . I called my doctor to find out if it’s normal. And I have been feeling anxious. Hope he calls me back ."

3 / 10
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  • alllt...
  • Taken for 2 to 5 years
  • February 18, 2019

"I wasn’t sure how to rate it and here’s why. I have major depression, panic disorder and OCD which this should help all these things.. Well I’ve been on it for 6 years now & there have been two instances where I tried to stop this cold turkey and it was the worst decision I’ve ever made. Withdrawal symptoms didn’t occur until 17 days in because this drug has such a long half life. However my body was so sick and weak. I was vomiting and nauseous and could barely eat anything. I couldn’t sleep at night and it was like I had restless leg syndrome. Worst thing I EVER had to deal with; good thing I was out of work both times this happened. I was so incredibly ill that it scares me so bad that I will be dependent on this drug for the rest of my life. I’m 25, don’t have any children yet. I don’t actually know if this is helping me but all I know is that every time I try to withdraw my doctor doesn’t recommend it and both times have been an actual hell."

7 / 10
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  • Idont...
  • Taken for 5 to 10 years
  • January 1, 2023

"I’ve been on Zoloft, Paxil, Citalopram, and Trazodone with no relief. Once I started Prozac, the feeling of intense depression has completely gone away. It is the only one that has worked for me. It has caused trouble sleeping in higher doses and I still struggle with motivation, but the feeling of deep, deep sadness is gone. It has literally saved my life."

8 / 10
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  • Sam
  • Taken for 6 months to 1 year
  • December 22, 2021

"I was on fluoxetine 40mg for 3 months, 20mg for a year. Don’t recommend this drug for anyone under 18 as there are so many better ones for adolescents. This medication made my panic attacks worse, restlessness, nightmares, and horrible muscle cramping and twitching. Looked like I was having a focal seizure."

6 / 10
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  • Anony...
  • Taken for 1 to 2 years
  • August 31, 2022

"So how to start I really don't know. This medication has been a God sent for me. It takes 4-6 weeks to kick in. Pls have faith in your Doctor. I suffer from both bipolar and schizophrenia.. I consulted many doctor my condition not got better. So I consulted my Dr he gave me medication. It took 3 years to completely recover from the diseases. I have scored 7 rank in Upsc cds. I'm decorated air force officer. Pls never lose hope"

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  • Rob
  • Taken for 1 to 2 years
  • December 15, 2021

"It gave me hope after dealing with mdd for decade. But the cost was it made me numb to life. If you ask me I would recommend u to use tricyclic antidepressants like clomipramine before giving up on life. Now I'm a happy fresh high school graduate thanks to my curiousity."

5 / 10
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  • Decker
  • Taken for less than 1 month
  • June 12, 2022

Prozac (fluoxetine) "I started with 10 mg of Prozac 3 weeks ago. I also suffer from fibromyalgia as well as neck and back issues for several years. I have been on hydrocodone for the last 4 years. For some reason my pain medication is no longer working since I started Prozac. From what I have read this is common and should be taking oxycodone. Anyone with chronic pain and take pain medication knows that taking oxycodone is taboo. I really want to stick with the Prozac after starting 20mg next week. I am hoping it will work after the increase in the next month. It probably has a lot to do with the fibromyalgia that the Prozac is taking longer to work for me. I'm just hoping that it will work in another month. I do believe my doctor will write me a prescription for the oxycodone and give it a month to see if the Prozac kicks in. If it does not, I will have to go back to the Celexa and hydrocodone I've been on that no longer works. Not sure how I can't get a response. I have not noticed any on this site."

3 / 10
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  • callm...
  • Taken for 1 to 6 months
  • March 2, 2021

"Fluoxetine cured my anxiety and stopped my panic attacks in 2 months! Didn't do much for the depression, though. Maybe if I had stayed on longer than 2 months, I would've seen improvements in the depression. But per my experience, I would rate it 10/10 for anxiety. A major side effect I experienced was nausea. Really terrible nausea. That was why I had to switch to a different antidepressant."

10 / 10
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  • wer
  • October 24, 2014

Prozac (fluoxetine) "The best SSRI, beat depression, anxiety and Obsessive Compulsive Disorder."

10 / 10
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63 Report
  • Siege
  • Taken for 2 to 5 years
  • October 19, 2020

Prozac (fluoxetine) "It made me numb. It never helped with depression, just made me never happy or smile genuinely."

1 / 10
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25 Report
  • Anonymous
  • Taken for 10 years or more
  • September 12, 2020

Prozac (fluoxetine) "A life saving medication for many years"

9 / 10
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19 Report
  • minny...
  • Taken for 10 years or more
  • May 15, 2014

Prozac (fluoxetine) "Excellent for Major Depressive Disorder, as well as some mixed anxiety disorders."

10 / 10
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37 Report
  • JFK
  • Taken for 6 months to 1 year
  • August 8, 2019

Prozac (fluoxetine) "I take 80mg of Prozac with Lamictal, and it helps a lot. But be warned, it will ruin your sex life."

9 / 10
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20 Report
  • Tomnik
  • Taken for less than 1 month
  • March 20, 2019

Prozac (fluoxetine) ".Prozac is wonderful, but because of some sexual side effects I can't give 10."

8 / 10
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17 Report
  • Tony
  • Taken for 1 to 6 months
  • July 10, 2019

Prozac (fluoxetine) "Prozac 80mg, Lamictal 200mg, & Klonopin 2mg are a great combination for my MDD. Works Great!!"

9 / 10
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13 Report
  • Anonymous
  • Taken for 1 to 6 months
  • June 17, 2020

Prozac (fluoxetine) "This drug made me so much worse. It give me bad side effects and made me even more suicidal. Not for me!"

1 / 10
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10 Report
  • Nikdick
  • January 4, 2017

Prozac (fluoxetine) "Good experience with prozac"

8 / 10
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16 Report
  • Coco
  • Taken for 1 to 2 years
  • April 15, 2020

Prozac (fluoxetine) "Didn't give zombie affect like Zoloft, still made sex bad and ED strong"

1 / 10
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10 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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