Skip to main content

Depakote for Bipolar Disorder User Reviews (Page 2)

Depakote has an average rating of 6.2 out of 10 from a total of 176 reviews for the treatment of Bipolar Disorder. 47% of reviewers reported a positive experience, while 29% reported a negative experience.

Reviews for Depakote

  • Anony...
  • Taken for 2 to 5 years
  • December 23, 2015

"I am honestly the happiest person ever since my Psychiatrist prescribed Depakote for me, NO MORE RAPID CYCLING!! I take two 500mg tablets about 20 minutes minutes before bed and I sleep throughout only waking up when my back aching in pain; I'll save that for my Baclofen and Prednisone post. I do not experience the manic highs as I was once did; however I still have my low days but everyone does! My low days are no where near the days when I on Trileptal or any SSRIs. I was taking Ability and Lithium for a week (this is my experience) I started seeing the world in two-dimensions, sort of like the early Nintendo characters. I freaking out!! That was it. Make sure to get blood tests every months to ensure your Depakote are in line. A "

10 / 10
Was this helpful?YesNo
77 Report
  • Tiger...
  • Taken for 6 months to 1 year
  • December 20, 2014

"I'm on Depokote 250mg in the morning and 500mg at night. I am also on olanzapine 5mg and fluoxetine 20mg which works wonders together. I have bipolar and whilst on Depokote suffered a bad spell of depression so was put on fluoxetine which has changed my life, I'm such a happier calmer person now."

10 / 10
Was this helpful?YesNo
84 Report
  • Depan...
  • Taken for 1 to 2 years
  • April 22, 2019

"No way! Been on it twice in my life. I was extremely bloated beyond recognition and in a deep mental haze. I could barely function. My doctor kept saying “you need to take care of yourself before you can care for your family”. And she was right. I got off it, weight loss has been slow but I got my face back I looked like a hamster on it and I went up 5 pant sizes on this medication. I got my energy back. On this stuff I slept all day. Off this medication I am enrolled in school and on the path to a new career and I am able to be awake to live my life off this stuff. And care for my family."

1 / 10
Was this helpful?YesNo
51 Report
  • 1ks
  • October 4, 2016

"I started depakote 3,000mg straight off when I was 15 years old I have since been taken off from it and still paying the price for it. It made me hungry constantly i gained a total of 50 pounds in 7 months I had no energy at all and no feelings no happy thoughts no sad thoughts I was literally a zombie and now I'm still seeing new doctors and switching meds all the time and I've had enough nothing is working and no one can help me I really need help and can't find it anywhere"

1 / 10
Was this helpful?YesNo
68 Report
  • busybee
  • July 6, 2010

"I am shocked to read the high amount of mg's that people are being started on. Every review I have read about Depakote it's been mainly 1000mg also 500mg. That just blows my mind! With any medicine you have to be eased into things and adjust from there! I began with 250mg, my Doctor told me that after a few weeks I could adjust it to taking 2 doses (500mg). Just to play around with it to see if I in fact needed to go higher. So I did, when changed to 500mg it made me crazy, nutty, mean and intolerable. I backed off and on 250mg again. I have been normal and perfectly stable ever since. I have yet to read a person taking the lowest dosage as a starting point. Start slow and work your way up (if needed). This medicine has been a lifesaver!"

10 / 10
Was this helpful?YesNo
104 Report

Are you taking this medicine?

  • Chris...
  • Taken for 1 to 2 years
  • August 19, 2015

"I have to say this drug did more harm then good and my body is very dependent on it. In only a year span I started having serious weight and back issues. I have never had any issues with my back but all of a sudden my bones started to get brittle. Then the disc herniations started happening, and like a domino effect entire spine was damaged. I see along of info on children or babies effected with their spine but apparently it can do the same for a grown adult. I was put on this med for anxiety and what my dr thought was bp. Turns out as time goes by dr lowers my depakote and cAme to the conclusion I do not have bp. Great.. Damage done.. Abnormal EEG. , spine damage, and severe chemical dependency .. Lost my hair , my looks, weight ."

3 / 10
Was this helpful?YesNo
73 Report
  • Anne
  • May 15, 2013

"I've been on Depakote for almost a year now. I also take Paxil and Wellbutrin. I gained around 10lbs right from the start. My weight has seemed to have stayed steady the last few months. It's extremely hard to lose it. I have been through a lot of different medications to try and treat bipolar disorder. Even with the medicines I'm on, I'm still depressed and like I don't matter. I'm very sleepy and can lay down and take a nap at any time. I started taking B Complex because I stay so sleepy. My new concern is memory. I can't think of words and dates or names like movie stars very fast and it concerns me. "

7 / 10
Was this helpful?YesNo
83 Report
  • Stephie
  • Taken for less than 1 month
  • September 13, 2018

"Today is my second day on depakote. I was freezing yesterday and it was 80 degrees. I have been on gabapentin, lithium, celexa, wellbutrin, lexapro, and so many others. I tried to commit suicide 3 weeks ago and that’s when I decided enough was enough. As soon as my oldest started ninth grade I started sleeping on the couch, having crazy mood swings, and then my daughter graduated. I slept on that couch for 6 years. My husband worked 3rd shift and me day shift. I was self medicating with hydros then when I wanted to stop that I got addicted to Suboxone. I also have a thyroid disease and had no idea that played into it. I’ve weaned myself off all drugs and now they started me out 500 mg twice a day. And my thyroid medicine. This is going to be a long road but I know it will be worth it. Please don’t give up."

10 / 10
Was this helpful?YesNo
50 Report
  • Qbug
  • Taken for 1 to 6 months
  • January 10, 2014

"Depakote was given to me for onset postpartum psychosis and underlying bipolar 1 as a mood stabilizer. It did it's job. Wonderful results mentally, obsessive thoughts were all but gone and combined with my antipsychotic, it made my life much better. But, the weight gain was hellish. I have gained 11 pounds in two weeks, and am looking at switching at my appointment on Monday. So, not good if you are looking for a weight neutral mood stabilizer."

10 / 10
Was this helpful?YesNo
78 Report
  • Anonymous
  • Taken for less than 1 month
  • June 1, 2012

"I am 29 and just diagnosed with Bipolar after a horrible manic depression cycle. Its worked great to stablize my moods but I'm scared after reading everyone's weight gain stories! I will have to hitch up my diet and exercise plan more. One thing I noticed that I didn't see anyone else write is that I have these horrible and extremely vivid dreams - they seem to be my fears realized. But they are so vivid and real that they hang over me all day. Has anyone else experienced this?"

8 / 10
Was this helpful?YesNo
86 Report
  • Ivan
  • Taken for 5 to 10 years
  • June 8, 2020

"I've taken the Depakote medication since 2014 and this is the only drug which eases my symptoms without causing extreme sleepiness. Classified as mild case, most of times I experience hypomania. Upon finding closure in therapy to change mindset and behavior, I've been channeling the disposition for self development and productivity, gradually gaining confidence and control, becoming less dependent on the medication, only taking a tablet each time I'm unable to manage the irritability and distress."

10 / 10
Was this helpful?YesNo
36 Report
  • pres
  • Taken for 1 to 6 months
  • October 30, 2018

"I've been on depakote for over a month now, it has really helped me. I was diagnosed with bipolar 2 at the age of 16, I'm 21 now. This was the first medicine that I have tried. I still get down and depressed sometimes, but it is nothing like I used to. All of my suicidal thoughts have stopped, I used to have them multiple times a day. Depakote has also help very well with my anger and aggression issue, I feel as if i can live a normal life now and handle tough situations better. I would definitely recommend this medicine for anyone dealing with bipolar disorder!"

7 / 10
Was this helpful?YesNo
45 Report
  • GlowC...
  • Taken for 5 to 10 years
  • October 14, 2012

"I am a female, first diagnosed at age 19 with bipolar disorder. They first tried Zyprexa which I had a horrible reaction to. The Depakote made me feel like a zombie for months, until it brought me back down to "normal". I stayed on approx 500 mg/day for almost 6 years, then backing down to 250mg until I stopped. I had started to feel depressed at 31 and was put on Lexapro, this led to a manic episode within a few months. Alas I am back on Depakote 500mg/ day. It has saved me. Luckily no significant weight gain besides 10 lbs I lost being manic!) but I do work out and try to eat healthy."

8 / 10
Was this helpful?YesNo
77 Report
  • Bolar
  • Taken for 6 months to 1 year
  • June 30, 2014

"This medication helped my symptoms tremendously. The main issue I had (and had to stop taking the medication) was low platelet count. Please if you are on this medication have your platelets checked routinely. My therapist never told me this could be a side effect... I finally went to my family physician because I was bruising so badly."

7 / 10
Was this helpful?YesNo
68 Report
  • TLGeer
  • September 1, 2016

"I have major bi-polar disorder as well as severe depression and PTSD. This med (along with Seroquel and Wellbutrin) has been a literal lifesaver. For the first time in my life my moods are stable as well as manageable."

10 / 10
Was this helpful?YesNo
56 Report
  • clems...
  • Taken for less than 1 month
  • December 8, 2015

"I was recently diagnosed with Bipolar II. This medication has been a life saver (literally) for me. It has helped keep my emotions in check. I took another medication lamicital that caused one continuous headache that never went away. My psychiatrist started me on a low dose of that medication so I wouldn't get a deadly rash. My emotions were all over the place and I was miserable. My psychiatrist put me on Depakote. At first this medication made me sluggish and hungry. I gained 5 lbs in the first 2 weeks. Since then I have laid off the snacks and beverages and have since gotten adjusted to the meds (also taking Zoloft). Three pounds have come off without trying. Each person is different, but this has really worked for me."

10 / 10
Was this helpful?YesNo
59 Report
  • akc
  • September 27, 2014

"I started on Depakote by my new neurologist. I've had bad depressions and bipolar attacks, but about 2 yrs ago I started having seizures. This new neurologist took me off of all my medicines and just put me on a low dose of Depakote. I've been seizure free and much happier in general. The only things are the constant snacking and I seem to catch colds and flus easier. Any advice about that?"

7 / 10
Was this helpful?YesNo
65 Report
  • Bipolar
  • April 2, 2016

"I took Depakote 500mg for a week then increased my dose to 1000mg after the next week. The next day I began having terrible stomach pains and pains in my kidneys, especially after eating. I emailed my doctor and he told me the side effects would subside but they didn't. They actually got worse and the abdominal pain would linger all day and night. I also had a hard time sleeping, I would wake up every 1-2 hours and sleep less than 6 hours a night, along with having very vivid dreams. The dreams later got more and more violent/terrifying and I began to fall into a very deep depression, one I had never felt in my entire life. I stopped taking this medication after three weeks. I will never take this medication even if it saved my life."

1 / 10
Was this helpful?YesNo
57 Report
  • jdk
  • March 1, 2013

"I am on the 500 X 2 ER and people tell me I'm alot more calmer and they see the change, I guess I was on the depressed side of the spectrum. It may also be that I am on Celexa as well. At first I was severely drowsy, but after about seven months in it kicks in. As far as weight gain goes same there no changes. Hair loss? Was already losing it. I have been on lithium and that didn't work, tried Tegretrol as well, come to find out I am allergic, so if I can feel normal and blood tests on liver and kidney comes back fine, hey I will give Depakote 2 big thumbs up with a normal life."

10 / 10
Was this helpful?YesNo
72 Report
  • Linda...
  • Taken for less than 1 month
  • December 19, 2012

"Just been diagnosed with Bi Polar Disorder after goodness knows how many years of episodes. Took my shrink the best part of 2 years to finally diagnose me after many different anti depressants, sleepless nights, racing thoughts, and wild partying till the early hours (sometimes on my own!!!). Just started on Depakote 3 weeks ago initally on 500mg per day which didn't help my mania, now on 500mg morning, and 500mg evening which calms me down, helps me sleep, deals with my irritability and mania, and generally slows me down. I have found that I get eye jolts ... fuzziness, but for the first time in 3 years (when it all started back up!), I am beginning to feel "NORMAL". We'll see how it goes. My consultant has mentioned Lithium also."

8 / 10
Was this helpful?YesNo
72 Report
  • Anonymous
  • October 3, 2012

"Depakote has been a life saver for me. I take 250mg in the morning and 500mg at bedtime. Weight gain was minimal. 5 lbs that I have lost recently by going on the South Beach Diet. I also take 200mg Zoloft. I sleep okay, but usually need a nap in the afternoon. I look forward to my life now instead of just existing."

9 / 10
Was this helpful?YesNo
71 Report
  • theni...
  • August 11, 2010

"I've read many people have been gaining weight from this drug. This is why it is SO important you care about your health from day one and it should be a part of your lifestyle and regimen, no matter what. This way, whatever the side effects are of the medicine, you're on top of your game and won't get hit as hard. I've been on many bipolar medications which make you gain weight, but I barely noticed because I work out and eat very healthy. It's of utter importance that you lay down a solid, healthy foundation before and during therapy. The healthy lifestyle will also make the medicine work better. It's common sense."

7 / 10
Was this helpful?YesNo
76 Report
  • BellaSN
  • July 22, 2015

"This was my first medication for Bi-Polar, I'm a 40 year old woman and a long distance runner. This medication was great because it made the rapid thoughts and anxiety go away. However if you're an athlete like I am, I found this difficult as it caused extreme fatigue to the point where I was a couch potato not wanting to do anything. I gained 10 pounds in the first month and found it exhausting to run even a mile where I'm accustomed to running much more. My doctor is switching me to Topamax, today will be my first day taking it and I'm praying for good results."

5 / 10
Was this helpful?YesNo
53 Report
  • 46j15...
  • August 18, 2016

"Depikote was prescribed to me after 2 manic episodes. I've been on a lot of bipolar meds so many that have made me so depressed I spent a whole summer in bed. Depikote def saved my life. It's been a year now a little anxiety but not nearly as much as I've had in the past and a little weight gain and tiredness. But no mania and very little to no depression so thankyou depikote I rate u a 10 it's been a year and no mania :) ur a life saver I take 1500 mg though to so that might be y I'm so tired"

10 / 10
Was this helpful?YesNo
48 Report
  • qwert...
  • Taken for 5 to 10 years
  • August 26, 2017

"Love this medication, after 2-3 years of severe long lasting manic episodes finally decided to take meds full time. Hardly any side effects, very hungry, simply eat normally and you wont put weight on, the medication doesn't make you fat, eating does. Occasionally very tired and my stomach from time to time gets a little funny, just take with lots of water and food. Very calm, can concentrate, no racing thoughts, level, basically gave me my life back, works well at 750 even though I'm 80kgs, Dr upped me to 1000mg but felt too sedated so dropped back down. I move to 1000mg if I feel like I'm starting to drift a little for a few weeks then move back. However, this is the 7th med I have tried, all others have failed, never write one med off"

9 / 10
Was this helpful?YesNo
43 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Bipolar Disorder

Care guides

Symptoms and treatments

Medicine.com guides (external)