Aplenzin User Reviews & Ratings

• Chuck
• June 24, 2018

For Depression "I survived for 20 years on many medications. Wellbutrin was hideous. On it, I couldn't sit up, walk, think...like I was dying of terminal flu. Effexor helped, but not much. Soon I gave up; my wife suggested magnet therapy. (Insurance said we had to prove that medicine didn't work for 2 years.) Time's up, but I finally got an Aplenzin sample. I knew of no similarity between Aplenzin and Wellbutrin. Hours after taking a pill (522) my face lightened as if a dark veil had been lifted, my spirits soared, I had focus and motivation to accomplish tasks, and I wasn't raging as much. I haven't felt this way for 20 years...no, forever! No comparison...I have no idea about its efficacy long-term, but I rated Aplenzin 9, because of side effects (which I gladly embrace). Our chemistries are all different; different drugs effect everyone in a personal way. All I can say is...I finally found the medicine I've needed for 66 years!"

• BBano
• Taken for 1 to 6 months
• May 3, 2019

For Depression "I have been on Wellbutrin for years my doctor tried me on aplenzia 522mg I felt better and there was hope then my insurance quit paying for it. What sense does it make, to make a drug that no one can afford and give out samples and make people get false hope they things will get better. I feel this is just cruel !! But it is a good drug if some how afford it !! It was possible that I could concentrate didn't gain weight! Felt almost normal!! Thanks for letting me down"

• MDDSu...
• September 11, 2013

For Depression "I'd been on Wellbutrin/Wellbutrin SR for over 15 years and it worked great until about a year ago when I started feeling I'd built up a tolerance to it. Seeing that Aplenzin was basically the same, but in hydrobromide form instead of hydrochloride, I figured it would "trick" my body into reacting to it as a new medicine without losing the benefits. With the blessing of my psych doc, I switched and it appears to have worked. I'd give 10 stars, except for the high cost."

• MSR
• February 21, 2015

For Major Depressive Disorder "I have been on so many meds to find one that helps. My psychiatrist finally prescribed Aplenzin. IT WORKS! My insurance company doesn't want to pay (obviously, at over $2,000/month). They insisted I switch to Welbutrin SR. I became extremly depressed with suicidal thoughts. My psychiatrist contacted the insurance company and got them to "prior approve" it so I could continue on it. I had to add Zoloft to it but I can finally live a (mostly) depression free life. I honestly don't know where I would be without it."

• That...
• May 2, 2009

For Depression "I have bipolar disorder/panic attacks/anxiety/major depression - needless to say there's a lot on my plate. However, for my depression Aplenzin has been working very well. I don't get so frustrated over the extremely simple things like not finding a sock (as a personal example). Overall I think Aplenzin is good. APLENZIN gives me energy and helps my personal outlook. I take 522mg a day. I'm pleased with this medication, I do though take into consideration that I've only been on it for about a week so I am on alert for any changes. Aplenzin works great for my depression so far."

• Charlie
• December 22, 2020

For Depression "I am a 39 yr. female with depression, ADD, and hypothyroidism. I take Adderall & natural thyroid for my hypo thyroid and ADD. I have tried many drugs before for my depression including ; Zoloft, celexa, lexapro, Effexor, viibryd, Trintellix and wellbutrin. I did well on a combo of wellbutrin and Zoloft for many years but the generic forms of those meds are inconsistent & toxic. I had zero side effects on 348mg for 2 months. When I increased to 522 I began having sore muscles and eye dryness. Aplenzin gives me mental clarity, balance, motivation, and it helps control emotional eating. Before taking Aplenzin the process of thinking, planning etc drained me. I now have much more mental energy and physical energy as well. The day passes by slower which is great for me because I get more done with less effort. Everything feels so much easier like work, cleaning and running errands. Also better libido!"

• UNEEK
• September 23, 2009

For Depression "I was on Wellbutrin HCL SR 200mg for 10mos and I noticed a significant improvement with my depression. However, I started to crave cocaine because my Dopamine levels are low. My Doctor switched me to Aplenzin 348mg ER. I have been on it for 2 weeks now and I have noticed a great improvement with my concentration, ability to get projects completed and not focusing on cocaine cravings. It has helped with my emotional eating too. I actually feel like I am a normal 40 yr old married mother of 2 boys. I feel like cleaning my house instead of sitting on the couch in front of the T.V. all day. The only minimal side effect I have is increased sweating. I am hoping that this will subside after a few months of taking this medication."

• Gracie
• September 21, 2019

For Major Depressive Disorder "Having gone through a boatload of antidepressants over the years, the last ones quit working. Doctor gave me samples of Aplenzin. What a difference!. A few weeks in, symptoms unrelated to depression cropped up. First thought was a drug interaction, although none of my symptoms are listed as side effects. So not on any antidepressants, and fearful of what's going to happen. Cost is major issue. Even with insurance, $20/day. God bless my doctor, as while I was taking, he loaded me up with samples."

• MBG
• Taken for 6 months to 1 year
• March 20, 2024

For Major Depressive Disorder "I’ve had depression for 20 plus years. Been on everything with minimal help. As soon as I started on Aplenzin I felt so, so much better. 522mg was too much. It caused increased anxiety and jitters. I wish there was one in between the 300 plus one I can’t remember. 344? Anyway, it’s a magic drug. I’m lucky to have CHAMPVA. It pays in full what my other doesn’t."

• Kat
• Taken for less than 1 month
• January 26, 2021

For Major Depressive Disorder "Was on generic bupropion for 6-8 weeks with no help for my motivation and fatigue. Doctor said the generic can be different and not work for some individuals. She put me on 174 mg and at first I had the worst anxiety. So bad that I had to go see a chiropractor and get help with severe back pain. So she upped my dose of Zoloft by 50mg and said to eat before taking the Aplenzin. I did and within a week I was feeling amazing. Tons more motivation and no fatigue. I’m being able to leave my house without debilitating anxiety and fear. I have GAD, PTSD, MDD. I know from being on meds since I was 15 that the side effects can be awful. Stick with it and communicate with your doctor. I’m glad I did because I feel amazing."

• Not...
• February 1, 2010

For Depression "Celexa and Zoloft made me feel detached from life so I wanted to try Aplenzin. At first I thought it was the wonder drug. I felt ALIVE, full of hope and energy. I cared about my future and could get things done. I was so happy, possibly euphoric. I stood up for myself and felt in control. I thought I had found the answer. That was on the low, intro. dose (174?). Then I went up to middle, recommended dose (348?). All that good stuff disappeared. Can't sleep, feel like I'm on the verge of panic attacks. Found myself watching the colors on TV and the colors owned me. Never had this experience before. Mood swings and deeper depression now. Want that good feeling back. Have call in to doctor about going back to lower dose."

• Leocap
• Taken for less than 1 month
• January 26, 2019

For Depression "My psychiatrist gave me some samples to try. Days one and two were not bad I started feeling kind of dizzy and almost like I was in a bubble on day three. Day four was horrible I was very dizzy my joints started aching so badly I could hardly walk down stairs. I was so unbelievably cranky and mean, it was horrible! By 6 PM that night my face was bright red and I felt like I was drunk! I didn’t take one this morning and I’ve been having stomach cramps and diarrhea since this afternoon, hopefully it doesn’t take too long for this to get out of my system!"

• Sandy
• March 30, 2010

For Depression "Aplenzin unfortunately did not work for me. I have panic disorder which then sent me into a horrible state of depression. My psychiatrist first prescribed me Wellbutrin SR which I was taking twice a day. After about 3 months I started having moments where I was actually happy to be alive. At my next appointment, my psychiatrist asked if I would be intereseted in trying Aplenzin because it only needs to be taken once a day. I started off on 348 mg for three months. This was not working so he switched me to 522 mg. Two months later it is still not working. I spoke to my pharmacist who told me that I have been patient enough and if it is going to work it would have done so by now."

• Turtle...
• October 10, 2020

For Depression "I've been taking Wellbutrin (name brand only because generic doesn't do anything, plus good insurance) in one variation or another, SR's then XL's without one single side effect in all the years I've been on it. Since the Seasonal Affective Disorder gets pretty bad in the winter, I'm taking the max dose of 522mg. I started taking it October 3rd and at first, I felt like actually being productive, going for walks with my iguana, etc. I've experienced a few side effects, such as slight headache (has since gone), sore muscles (very minimal now), vision issues (just came on recently), and they're tolerable. Well, recently, the energy has ebbed somewhat and I'm back to not being as productive. It's a safe bet the SAD has begun to rear its ugly head, as it's that time of year, so there's that. My appetite has diminished enough that I'm basically back on track for following the post-bariatric surgery diet that I'd gotten away from after having had the surgery in 2015."

• Anonymous
• October 28, 2009

For Depression "I switched from Wellbutrin to Aplenzin 3 months ago. I had a good sex life before on Wellbutrin. I switched my medication instead of increasing the dose of Wellbutrin. Now that I am on Aplenzin I feel numb. I had this same feeling when on Zoloft. "

• dmrco...
• November 12, 2009

For Depression "This was not for me. I took this with Lexapro and my depression worsened and also I experienced severe mood swings. Became very angry and easy to fly off the handle. Thoughts of suicide as were more frequent. I stopped taking it after 5 weeks and noticed an almost immediate improvement in my behavior and how I felt."

• KPano
• Taken for less than 1 month
• August 4, 2021

For Depression "I was recently put on Aplenzin and I can honestly say I would rather deal with my depression without meds than deal with the side effects. I have been nauseas with no relief and have had a tension headache for 10 days now. It has helped to an extent but I have felt so ill that the cons outweigh the pros."

• syrk
• February 10, 2010

For Weight Loss (Obesity/Overweight) "It helped me curb my urges to eat."

• SKano
• Taken for 1 to 6 months
• April 8, 2019

For Major Depressive Disorder "Tried taking in place of regular Wellbutrin due to migraines and I was able to tolerate it but made me feel flat, sad and agitated. It’s very expensive and I stopped taking it."

• Liz
• Taken for less than 1 month
• September 28, 2021

For Depression "I’ve been taking Aplenzin for 3 weeks, and I have only noticed sharper concentration, smarter conversation & slight dizziness."