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Aplenzin for Major Depressive Disorder User Reviews

Aplenzin has an average rating of 8.2 out of 10 from a total of 5 reviews for the treatment of Major Depressive Disorder. 80% of reviewers reported a positive experience, while 20% reported a negative experience.

Aplenzin rating summary

8.2/10 average rating

5 ratings from 5 user reviews.

Compare all 56 medications used in the treatment of Major Depressive Disorder.

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  • MSR
  • February 21, 2015

"I have been on so many meds to find one that helps. My psychiatrist finally prescribed Aplenzin. IT WORKS! My insurance company doesn't want to pay (obviously, at over $2,000/month). They insisted I switch to Welbutrin SR. I became extremly depressed with suicidal thoughts. My psychiatrist contacted the insurance company and got them to "prior approve" it so I could continue on it. I had to add Zoloft to it but I can finally live a (mostly) depression free life. I honestly don't know where I would be without it."

10 / 10
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37 Report
  • MBG
  • Taken for 6 months to 1 year
  • March 20, 2024

"I’ve had depression for 20 plus years. Been on everything with minimal help. As soon as I started on Aplenzin I felt so, so much better. 522mg was too much. It caused increased anxiety and jitters. I wish there was one in between the 300 plus one I can’t remember. 344? Anyway, it’s a magic drug. I’m lucky to have CHAMPVA. It pays in full what my other doesn’t."

10 / 10
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1 Report
  • Gracie
  • September 21, 2019

"Having gone through a boatload of antidepressants over the years, the last ones quit working. Doctor gave me samples of Aplenzin. What a difference!. A few weeks in, symptoms unrelated to depression cropped up. First thought was a drug interaction, although none of my symptoms are listed as side effects. So not on any antidepressants, and fearful of what's going to happen. Cost is major issue. Even with insurance, $20/day. God bless my doctor, as while I was taking, he loaded me up with samples."

10 / 10
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16 Report

Frequently asked questions

  • Kat
  • Taken for less than 1 month
  • January 26, 2021

"Was on generic bupropion for 6-8 weeks with no help for my motivation and fatigue. Doctor said the generic can be different and not work for some individuals. She put me on 174 mg and at first I had the worst anxiety. So bad that I had to go see a chiropractor and get help with severe back pain. So she upped my dose of Zoloft by 50mg and said to eat before taking the Aplenzin. I did and within a week I was feeling amazing. Tons more motivation and no fatigue. I’m being able to leave my house without debilitating anxiety and fear. I have GAD, PTSD, MDD. I know from being on meds since I was 15 that the side effects can be awful. Stick with it and communicate with your doctor. I’m glad I did because I feel amazing."

10 / 10
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11 Report
  • SKano
  • Taken for 1 to 6 months
  • April 8, 2019

"Tried taking in place of regular Wellbutrin due to migraines and I was able to tolerate it but made me feel flat, sad and agitated. It’s very expensive and I stopped taking it."

1 / 10
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13 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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