Generic Name: hydrocortisone acetate/pramoxine (hye-droe-KOR-ti-sone ASS-eh-tate/pra-MOX-een)
Brand Name: Examples include Analpram-HC and Zypram
Zypram cream is used for:
Treating inflammation and itching of the anal area due to certain skin conditions.
Zypram cream is a combination topical corticosteroid and local anesthetic. It works by reducing skin inflammation (redness, swelling, itching, and irritation) in a way that is not exactly understood. It also decreases pain in the affected area.
Do NOT use Zypram cream if:
- you are allergic to any ingredient in Zypram cream
- you have a rectal obstruction, abscess, or perforation
Contact your doctor or health care provider right away if any of these apply to you.
Before using Zypram cream:
Some medical conditions may interact with Zypram cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin in the affected area
- if you have a parasitic, bacterial, fungal, or viral infection; diabetes; diarrhea; swelling of the esophagus; stomach or intestinal problems (eg, inflammation, blockage, ulcer, perforation, fistula, colostomy); inflammation of the lining of the abdomen; measles; tuberculosis (TB); a positive TB skin test; chickenpox; shingles; herpes infection of the eye; kidney problems; or you have received a recent vaccination
- if you have a history of congestive heart failure or heart attack
- if you have had recent intestinal surgery or procedure
Some MEDICINES MAY INTERACT with Zypram cream. Because little, if any, of Zypram cream is absorbed into the blood, the risk of it interacting with another medicine is low.
Ask your health care provider if Zypram cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Zypram cream:
Use Zypram cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Zypram cream is for use around the rectal area only.
- Wash your hands immediately before and after using Zypram cream.
- For use around the anus, apply a small amount of medicine to the affected area and rub in gently.
- If you miss a dose of Zypram cream, apply it as soon as possible. If you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Zypram cream.
Important safety information:
- Avoid getting Zypram cream in your eyes. If you get Zypram cream in your eyes, immediately flush them with cool tap water.
- If your symptoms do not get better within 2 to 3 weeks or if they get worse, check with your doctor.
- Do not use Zypram cream for other rectal conditions at a later time.
- Check with your doctor before having vaccinations while you are using Zypram cream.
- Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Zypram cream.
- Caution is advised when using Zypram cream in CHILDREN; they may be more sensitive to its effects.
- Serious side effects may occur if too much of Zypram cream is absorbed through the skin. This may be more likely to occur if you use Zypram cream over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply Zypram cream. The risk is greater in children. Do not use more than the prescribed dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zypram cream while you are pregnant. It is not known if Zypram cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Zypram cream, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Zypram cream:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dry skin; itching.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; excessive hair growth; inflamed hair follicles; inflammation around the mouth; muscle weakness; rectal pain, burning, cracking, itching, bleeding, peeling, or irritation not present before using Zypram cream; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face. Zypram cream may be harmful if swallowed.Proper storage of Zypram cream:
Store Zypram cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zypram cream out of the reach of children and away from pets.
- If you have any questions about Zypram cream, please talk with your doctor, pharmacist, or other health care provider.
- Zypram cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Zypram cream or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zypram cream. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zypram cream. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Zypram cream.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.