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Tirofiban

Generic Name: tirofiban (tye-roe-FYE-ban)
Brand Name: Aggrastat

Tirofiban is used for:

Treating unstable angina or certain types of heart attacks in combination with heparin. It may also be used for other conditions as determined by your doctor.

Tirofiban is a platelet aggregation inhibitor. It works by blocking platelets from sticking together to form blood clots.

Do NOT use tirofiban if:

  • you are allergic to any ingredient in tirofiban
  • you have a history of stroke, major surgery, physical trauma, or bleeding conditions within the last 30 days
  • you have an aneurysm, bleeding or clotting condition, malformation of the arteries or veins, or bleeding or tumors of the brain
  • you have a tear of the aorta, severe high blood pressure, or inflammation around the heart
  • you are taking another medicine of the same class (a platelet aggregation inhibitor)
  • you have had clotting problems when using tirofiban in the past

Contact your doctor or health care provider right away if any of these apply to you.

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Before using tirofiban:

Some medical conditions may interact with tirofiban. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have decreased blood platelets, high blood volume, kidney problems (eg, dialysis), or bleeding or blood vessel problems in the eye
  • if you have recently had a spinal (epidural) procedure

Some MEDICINES MAY INTERACT with tirofiban. However, no specific interactions with tirofiban are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if tirofiban may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use tirofiban:

Use tirofiban as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Tirofiban is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using tirofiban at home, carefully follow the injection procedures taught to you by your health care provider.
  • If tirofiban contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Tirofiban is only to be injected into the vein or artery.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of tirofiban, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use tirofiban.

Important safety information:

  • Tirofiban may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to tirofiban. Using tirofiban alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Tirofiban may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using tirofiban.
  • LAB TESTS, including complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use tirofiban with caution in the ELDERLY because they may be more sensitive to its effects.
  • Tirofiban is not recommended for use in CHILDREN younger than 18 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using tirofiban during pregnancy. It is unknown if tirofiban is excreted in breast milk. Do not breast-feed while taking tirofiban.

Possible side effects of tirofiban:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; leg pain; nausea; pelvic pain; sweating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bruising, pain, redness, or swelling at the injection site; changes in heart rhythm; chills; difficulty urinating; fainting; fever; numbness; tingling or weakness in the arms or legs; unusual bruising or bleeding (eg, bleeding gums, nosebleeds, bleeding in the eye, blood in the urine, black or tarry stools, coughing up blood, vomiting blood or material that looks like coffee ground).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include major and minor bleeding events.

Proper storage of tirofiban:

Tirofiban is usually handled and stored by a health care provider. If you are using tirofiban at home, store tirofiban as directed by your pharmacist or health care provider. Keep tirofiban out of the reach of children and away from pets.

General information:

  • If you have any questions about tirofiban, please talk with your doctor, pharmacist, or other health care provider.
  • Tirofiban is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take tirofiban or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about tirofiban. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to tirofiban. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using tirofiban.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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