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Podophyllum resin

Generic Name: podophyllum resin (pode-o-FIL-um)
Brand Name: Podocon and Pododerm

Podophyllum resin is used for:

Removing genital warts. It may also be used for other conditions as determined by your doctor.

Podophyllum resin is a cytotoxic agent. It works by preventing growth of the wart tissue.

Do NOT use podophyllum resin if:

  • you are allergic to any ingredient in podophyllum resin
  • you are pregnant or breast-feeding
  • you have diabetes or poor blood circulation
  • you are taking steroids (eg, prednisone)
  • you are treating bleeding warts, warts with hair growing from them, moles, or birthmarks
  • the wart to be treated or the surrounding skin is inflamed or irritated

Contact your doctor or health care provider right away if any of these apply to you.

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Before using podophyllum resin:

Some medical conditions may interact with podophyllum resin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with podophyllum resin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Steroids (eg, prednisone) because they decrease podophyllum resin's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if podophyllum resin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use podophyllum resin:

Use podophyllum resin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Podophyllum resin is usually administered at your doctor's office, hospital, or clinic. If you are using podophyllum resin at home, carefully follow the procedures taught to you by your health care provider.
  • Thoroughly clean the affected area. Use the supplied applicator to apply the medicine sparingly to the wart. Avoid contact with healthy skin. Allow to dry completely.
  • After the appropriate treatment time has elapsed, remove the dried medicine with alcohol or soap and water as directed by your doctor.
  • If you miss a dose of podophyllum resin, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use podophyllum resin.

Important safety information:

  • Podophyllum resin is for external use only. Do not get podophyllum resin in your eyes, nose, or mouth. If you get podophyllum resin in your eyes, rinse immediately with cool water.
  • Do not use podophyllum resin on bleeding warts, warts with hair growing from them, moles, or birthmarks.
  • Do not use podophyllum resin if the wart to be treated or the surrounding skin is inflamed or irritated.
  • Do not treat large areas or numerous warts at the same time.
  • PREGNANCY and BREAST-FEEDING: Use of podophyllum resin during pregnancy has resulted in birth defects, fetal death, and stillbirth. Do not use podophyllum resin if you are pregnant. If you think you may be pregnant, contact your doctor immediately. It is unknown if podophyllum resin is excreted in breast milk. Do not breast-feed while taking podophyllum resin.

Possible side effects of podophyllum resin:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with podophyllum resin. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, tingling, or numbness of the skin, hands, legs, or feet; diarrhea; fever, chills, or persistent sore throat; loss of consciousness; nausea; severe or persistent constipation; unusual bruising or bleeding; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; confusion; diarrhea; hallucinations; irritability; nausea; nervousness; stomach pain; vomiting. Podophyllum resin may be harmful if swallowed.

Proper storage of podophyllum resin:

Store podophyllum resin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Keep podophyllum resin out of the reach of children and away from pets.

General information:

  • If you have any questions about podophyllum resin, please talk with your doctor, pharmacist, or other health care provider.
  • Podophyllum resin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take podophyllum resin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about podophyllum resin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to podophyllum resin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using podophyllum resin.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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