Generic Name: plerixafor (pler-IX-a-for)
Brand Name: Mozobil
Plerixafor is used for:
Stimulating the body to release stem cells into the blood in patients with non-Hodgkin lymphoma and multiple myeloma. These stem cells are then collected and used in stem cell transplant. It is used along with granulocyte-colony stimulating factor (G-CSF). It may also be used for other conditions as determined by your doctor.
Plerixafor is a hematopoietic stem cell mobilizer. It works by blocking certain substances in the bone marrow. This allows stem cells to move from the bone marrow into the bloodstream, where they can be collected for transplant.
Do NOT use plerixafor if:
- you are allergic to any ingredient in plerixafor
- you have leukemia
Contact your doctor or health care provider right away if any of these apply to you.
Before using plerixafor:
Some medical conditions may interact with plerixafor. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have kidney problems
- if you have low blood platelet levels or a high white blood cell count
Some MEDICINES MAY INTERACT with plerixafor. However, no specific interactions with plerixafor are known at this time.
Ask your health care provider if plerixafor may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use plerixafor:
Use plerixafor as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Plerixafor is given as an injection at your doctor's office, hospital, or clinic.
- Do not use plerixafor if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of plerixafor, contact your doctor right away.
Ask your health care provider any questions you may have about how to use plerixafor.
Important safety information:
- Plerixafor may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use plerixafor with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Plerixafor may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
- Plerixafor may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Severe and sometimes life-threatening allergic reactions have occurred in patients receiving plerixafor. You will be watched closely for at least 30 minutes after you receive plerixafor. Discuss any questions or concerns with your doctor.
- Contact your doctor right away if pain occurs in the left upper stomach area or left shoulder area. These could be symptoms of an enlarged or ruptured spleen.
- Women who may become pregnant should use effective birth control while they are using plerixafor. Check with your doctor if you have questions about effective birth control.
- Lab tests, including complete blood cell counts, may be performed while you use plerixafor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use plerixafor with caution in the ELDERLY; they may be more sensitive to its effects.
- Plerixafor should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Plerixafor may cause harm to the fetus. Do not become pregnant while you are using plerixafor. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using plerixafor while you are pregnant. It is not known if plerixafor is found in breast milk. If you are or will be breast-feeding while you use plerixafor, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of plerixafor:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; dizziness; gas; headache; joint pain; nausea; pain, redness, swelling, or bruising at the injection site; stomach pain; tiredness; trouble sleeping; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, eyelids, lips, or tongue); black, tarry, or bloody stools; fainting; severe or persistent dizziness; severe stomach or shoulder pain; shortness of breath; unusual bruising or bleeding.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; light-headedness; or severe or persistent dizziness, nausea, vomiting, or diarrhea.Proper storage of plerixafor:
Plerixafor is usually handled and stored by a health care provider. If you are using plerixafor at home, store plerixafor as directed by your pharmacist or health care provider. Keep plerixafor out of the reach of children and away from pets.
- If you have any questions about plerixafor, please talk with your doctor, pharmacist, or other health care provider.
- Plerixafor is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take plerixafor or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about plerixafor. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to plerixafor. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using plerixafor.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.