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Plerixafor Side Effects

It is possible that some side effects of plerixafor may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to plerixafor: subcutaneous solution

As well as its needed effects, plerixafor may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking plerixafor, check with your doctor immediately:

More common
  • Bleeding gums
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • collection of blood under skin
  • coughing up blood
  • deep, dark purple bruise
  • difficulty in breathing or swallowing
  • dizziness
  • feeling of heat
  • flushing, redness of the skin
  • hard lump
  • headache
  • hives or welts
  • increased menstrual flow or vaginal bleeding
  • irritation
  • itching skin
  • nosebleeds
  • pain
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • redness of the skin
  • shortness of breath
  • skin rash
  • swelling
  • unusually warm skin
  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • fainting
  • fast heartbeat
  • swelling around the eyes
  • tightness in the chest
  • weakness
  • wheezing

Some plerixafor side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Bloated
  • diarrhea
  • difficulty in moving
  • excess air or gas in stomach or intestines
  • full feeling
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • passing gas
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness
  • vomiting
Less common
  • Acid or sour stomach
  • belching
  • difficulty having a bowel movement (stool)
  • dry mouth
  • general feeling of discomfort or illness
  • heartburn
  • increased sweating
  • indigestion
  • muscle or bone pain
  • pressure in the stomach
  • stomach discomfort, upset, or pain
  • swelling of abdominal or stomach area

For Healthcare Professionals

Applies to plerixafor: subcutaneous solution


Gastrointestinal side effects including diarrhea (37%), nausea (34%), vomiting (10%), flatulence (7%), abdominal pain, abdominal distention, dry mouth, stomach discomfort, oral hypoesthesia, constipation, and dyspepsia have been reported.[Ref]


Local side effects including injection site reactions (34%) have been reported. Mild to moderate injection site reactions at the site of subcutaneous administration of plerixafor have included erythema, hematoma, hemorrhage, induration, inflammation, irritation, pain, paresthesia, pruritus, rash, swelling, and urticaria.[Ref]


General side effects including fatigue (27%) and malaise have been reported.[Ref]

Nervous system

Nervous system side effects including headache (22%), dizziness (11%), and vasovagal reactions have been reported.[Ref]


Musculoskeletal side effects including arthralgia (13%) and musculoskeletal pain have been reported.[Ref]


Psychiatric side effects including insomnia (7%) have been reported.[Ref]


Dermatologic side effects including hyperhidrosis and erythema have been reported.[Ref]


Respiratory side effects including a case of dyspnea and a case of hypoxia have been reported.[Ref]


Ocular side effects including periorbital swelling have been reported.[Ref]


Hematologic side effects have included hyperleukocytosis (7%).


Hypersensitivity reactions have included postmarketing reports of anaphylactic reactions, including anaphylactic shock.


1. "Product Information. Mozobil (plerixafor)." Genzyme Corporation, Cambridge, MA.

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