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Pitavastatin

Generic Name: pitavastatin (PIT-a-va-STAT-in)
Brand Name: Livalo

Pitavastatin is used for:

Lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL, "good") cholesterol levels. It is used along with an appropriate diet. It may also be used for other conditions as determined by your doctor.

Pitavastatin is an HMG-CoA reductase inhibitor, also known as a "statin." It works by reducing the production of certain fatty substances in the body, including cholesterol.

Do NOT use pitavastatin if:

  • you are allergic to any ingredient in pitavastatin
  • you have liver problems or unexplained abnormal liver function tests
  • you are pregnant, may become pregnant, or are breast-feeding
  • you are taking cyclosporine or gemfibrozil

Contact your doctor or health care provider right away if any of these apply to you.

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Before using pitavastatin:

Some medical conditions may interact with pitavastatin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have diabetes, kidney problems, low blood pressure, a serious infection, or a history of seizures
  • if you have muscle problems (eg, pain, weakness), an underactive thyroid, or if you are dehydrated
  • if you have metabolism, hormonal, endocrine, or electrolyte problems
  • if you drink alcohol or have a history of liver problems or alcohol abuse
  • if you are on dialysis or have recently had major surgery or a serious injury
  • if you are taking warfarin

Some MEDICINES MAY INTERACT with pitavastatin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Colchicine, cyclosporine, daptomycin, erythromycin, fibrates (eg, fenofibrate, gemfibrozil), niacin, or rifampin because they may increase the risk of pitavastatin's side effects, including muscle or kidney problems

This may not be a complete list of all interactions that may occur. Ask your health care provider if pitavastatin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use pitavastatin:

Use pitavastatin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take pitavastatin by mouth with or without food.
  • Taking pitavastatin at the same time each day will help you remember to take it.
  • Continue to take pitavastatin even if you feel well. Do not miss any doses.
  • If you miss a dose of pitavastatin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use pitavastatin.

Important safety information:

  • Pitavastatin may cause liver problems. Rarely, severe and sometimes fatal liver problems have been reported in patients taking "statin" medicine, including pitavastatin. Drinking alcohol daily or in large amounts may increase the risk of liver problems with pitavastatin. Check with your doctor before drinking alcohol while you are taking pitavastatin. Tell your doctor right away if you experience symptoms of liver problems (eg, dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness; yellowing of the skin or eyes).
  • Do NOT take more than the recommended dose without checking with your doctor. Doing so may cause an increase in the risk of severe side effects.
  • Follow the diet and exercise program given to you by your health care provider.
  • Tell your doctor or dentist that you take pitavastatin before you receive any medical or dental care, emergency care, or surgery.
  • Women who may become pregnant should use effective birth control while taking pitavastatin. Check with your doctor if you have questions about using birth control.
  • Muscle problems (myopathy) may occur with pitavastatin. Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort. Tell your doctor if you have muscle problems that persist even after your doctor has told you to stop taking pitavastatin.
  • Diabetes patients - Pitavastatin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including blood cholesterol levels and liver function, may be performed while you use pitavastatin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use pitavastatin with caution in the ELDERLY; they may be more sensitive to its effects, especially serious muscle problems.
  • Pitavastatin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use pitavastatin if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if pitavastatin is found in breast milk. Do not breast-feed while taking pitavastatin.

Possible side effects of pitavastatin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; constipation; diarrhea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine produced; confusion; memory problems; mental or mood changes (eg, depression); muscle pain, tenderness, or weakness (with or without fever or fatigue); symptoms of liver problems (eg, dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness; yellowing of the skin or eyes).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of pitavastatin:

Store pitavastatin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep pitavastatin out of the reach of children and away from pets.

General information:

  • If you have any questions about pitavastatin, please talk with your doctor, pharmacist, or other health care provider.
  • Pitavastatin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take pitavastatin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pitavastatin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pitavastatin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pitavastatin.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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