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Nitroglycerin ointment

Pronunciation

Generic Name: nitroglycerin (NYE-troe-GLIS-er-in)
Brand Name: Rectiv

Nitroglycerin ointment is used for:

Treating moderate to severe pain caused by chronic anal fissure (a tear in the skin lining the anal canal).

Nitroglycerin ointment is a nitrate. It works by relaxing (widening) blood vessels.

Do NOT use nitroglycerin ointment if:

  • you are allergic to any ingredient in nitroglycerin ointment or to other nitrates or nitrites
  • you have increased pressure in the head
  • you have severe anemia
  • you are taking avanafil, riociguat, sildenafil, tadalafil, or vardenafil

Contact your doctor or health care provider right away if any of these apply to you.

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Before using nitroglycerin ointment:

Some medical conditions may interact with nitroglycerin ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you drink alcoholic beverages
  • if you have a history of heart problems (eg, heart failure, enlarged heart, heart attack), blood vessel problems, overactive thyroid, stroke or other bleeding in the brain, or recent head injury
  • if you have migraines or recurrent headaches
  • if you have anemia, low blood pressure, dehydration, or low blood volume
  • if you take other nitroglycerin-containing products or other nitrates or nitrites

Some MEDICINES MAY INTERACT with nitroglycerin ointment. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Avanafil, beta-blockers (eg, propranolol), calcium channel blockers (eg, diltiazem), diuretics (eg, furosemide, hydrochlorothiazide), medicines for high blood pressure, riociguat, sildenafil, tadalafil, or vardenafil because the risk of low blood pressure and dizziness upon standing may be increased
  • Aspirin because it may increase the risk of nitroglycerin ointment's side effects
  • Alteplase or heparin because their effectiveness may be decreased by nitroglycerin ointment
  • Ergotamine because the risk of its side effects may be increased by nitroglycerin ointment

This may not be a complete list of all interactions that may occur. Ask your health care provider if nitroglycerin ointment may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use nitroglycerin ointment:

Use nitroglycerin ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with nitroglycerin ointment. Talk to your pharmacist if you have questions about this information.
  • Nitroglycerin ointment is only for use in the anal canal. Do not get it in your eyes, vagina, or mouth.
  • Wash hands before and after applying.
  • Before measuring your dose, place a finger covering (eg, plastic wrap, a disposable surgical glove, a finger cot) on a finger. Lay the covered finger alongside the dosing line on the carton to measure your dose. Gently squeeze the tube until a line of ointment the length of the measuring line comes out onto the covered finger.
  • Gently insert the covered finger with the ointment on it into the anal canal no further than to the first finger joint. Apply the ointment around the side of the anal canal.
  • If you cannot apply nitroglycerin ointment in the anal canal due to pain, you should apply it directly to the outside of the anus.
  • Throw away the finger covering in the trash, out of the reach of children and away from pets.
  • If you miss a dose of nitroglycerin ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use nitroglycerin ointment.

Important safety information:

  • Nitroglycerin ointment may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use nitroglycerin ointment with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT use nitroglycerin ointment more often or for longer than prescribed without checking with your doctor.
  • If your pain does not get better after using nitroglycerin ointment or if it gets worse, check with your doctor.
  • Check with your doctor before you drink alcohol while you are using nitroglycerin ointment. Drinking alcohol may increase the risk of low blood pressure with nitroglycerin ointment.
  • Nitroglycerin ointment may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Tell your doctor or dentist that you take nitroglycerin ointment before you receive any medical or dental care, emergency care, or surgery.
  • Nitroglycerin ointment may give you headaches. This should become less noticeable with time. Ask your doctor or pharmacist about ways to lessen this effect. Do not change the dose of nitroglycerin ointment without checking with your doctor.
  • Use nitroglycerin ointment with caution in the ELDERLY; they may be more sensitive to its effects.
  • Nitroglycerin ointment is not recommended for use in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using nitroglycerin ointment while you are pregnant. It is not known if nitroglycerin ointment is found in breast milk. If you are or will be breast-feeding while you are using nitroglycerin ointment, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of nitroglycerin ointment:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; faintness on standing; headache; light-headedness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); fainting; flushing; red, swollen, blistered, or peeling skin; severe or persistent dizziness, light-headedness, or headache.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of nitroglycerin ointment:

Store nitroglycerin ointment at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep the tube tightly closed. Use within 8 weeks of first opening. Keep nitroglycerin ointment out of the reach of children and away from pets.

General information:

  • If you have any questions about nitroglycerin ointment, please talk with your doctor, pharmacist, or other health care provider.
  • Nitroglycerin ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take nitroglycerin ointment or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about nitroglycerin ointment. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to nitroglycerin ointment. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using nitroglycerin ointment.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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