Generic Name: fosaprepitant (FOS-ap-RE-pi-tant)
Brand Name: Emend for Injection
Fosaprepitant pimozide is used for:
Preventing nausea and vomiting associated with certain types of cancer medicines (chemotherapy). It is used in combination with other medicines. It may also be used for other conditions as determined by your doctor.
Fosaprepitant pimozide is an antiemetic. It works by blocking certain substances in the brain, which helps to prevent nausea and vomiting.
Do NOT use fosaprepitant pimozide if:
- you are allergic to any ingredient in fosaprepitant pimozide, or if you are allergic to aprepitant or polysorbate 80
- you are taking astemizole, cisapride, pimozide, or terfenadine
Contact your doctor or health care provider right away if any of these apply to you.
Before using fosaprepitant pimozide:
Some medical conditions may interact with fosaprepitant pimozide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have liver problems
- if you currently have nausea or vomiting
Some MEDICINES MAY INTERACT with fosaprepitant pimozide. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Azole antifungals (eg, ketoconazole), diltiazem, HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, clarithromycin), nefazodone, or troleandomycin because they may increase the risk of fosaprepitant pimozide's side effects
- Carbamazepine or rifampin because they may decrease fosaprepitant pimozide's effectiveness
- Astemizole, benzodiazepines (eg, alprazolam), cisapride, corticosteroids (eg, dexamethasone), ifosfamide, narcotic pain medicines (eg, fentanyl), pimozide, terfenadine, vinblastine, or vincristine because the risk of their side effects may be increased by fosaprepitant pimozide
- Anticoagulants (eg, warfarin), hormonal contraceptives (eg, birth control pills), paroxetine, phenytoin, or tolbutamide because their effectiveness may be decreased by fosaprepitant pimozide
This may not be a complete list of all interactions that may occur. Ask your health care provider if fosaprepitant pimozide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use fosaprepitant pimozide:
Use fosaprepitant pimozide as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with fosaprepitant pimozide. Talk to your pharmacist if you have questions about this information.
- Tell your doctor if you already have nausea or vomiting before you receive fosaprepitant pimozide.
- Fosaprepitant pimozide is usually given as an injection at your doctor's office, hospital, or clinic 30 minutes before chemotherapy treatment.
- If you miss a dose of fosaprepitant pimozide, contact your doctor immediately.
Ask your health care provider any questions you may have about how to use fosaprepitant pimozide.
Important safety information:
- Fosaprepitant pimozide may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use fosaprepitant pimozide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using fosaprepitant pimozide; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using fosaprepitant pimozide. To prevent pregnancy, be sure to use an extra form of birth control (eg, condoms) while using fosaprepitant pimozide and for 1 month following the last dose of fosaprepitant pimozide.
- Lab tests, including liver function, kidney function, and white blood cell counts, may be performed while you use fosaprepitant pimozide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use fosaprepitant pimozide with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using fosaprepitant pimozide while you are pregnant. It is not known if fosaprepitant pimozide is found in breast milk. Do not breast-feed while taking fosaprepitant pimozide.
Possible side effects of fosaprepitant pimozide:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; headache; hiccups; loss of appetite; nausea; pain or hardening at the injection site; tiredness; upset stomach; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fast or irregular heartbeat; fever; shortness of breath; sore throat.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include drowsiness; headache.Proper storage of fosaprepitant pimozide:
Fosaprepitant pimozide is usually handled and stored by a health care provider. If you are using fosaprepitant pimozide at home, store fosaprepitant pimozide as directed by your pharmacist or health care provider.
- If you have any questions about fosaprepitant pimozide, please talk with your doctor, pharmacist, or other health care provider.
- Fosaprepitant pimozide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take fosaprepitant pimozide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about fosaprepitant pimozide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to fosaprepitant pimozide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using fosaprepitant pimozide.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.