Fosaprepitant Dosage
This dosage information may not include all the information needed to use Fosaprepitant safely and effectively. See additional information for Fosaprepitant.
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Usual Adult Dose for:
Usual Geriatric Dose for:
Additional dosage information:
Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced
Prevention of Nausea and Vomiting Associated with Highly Emetogenic Chemotherapy (HEC):
One day fosaprepitant regimen:
Fosaprepitant 150 mg on Day 1 only as an IV infusion over 20 to 30 minutes approximately 30 minutes prior to chemotherapy (in combination with a 5-HT3 antagonist on day 1 and dexamethasone on days 1 to 4).
Day 1: Fosaprepitant for injection: 150 mg IV; Dexamethasone: 12 mg orally; Ondansetron: 32 mg IV
Day 2: Fosaprepitant for injection: none; Dexamethasone: 8 mg orally; Ondansetron: none
Day 3: Fosaprepitant for injection: none; Dexamethasone: 8 mg orally twice daily; Ondansetron: none
Day 4: Fosaprepitant for injection: none; Dexamethasone: 8 mg orally twice daily; Ondansetron: none
Dexamethasone should be administered 30 minutes prior to chemotherapy treatment on Day 1 and in the morning on Days 2 through 4. The dose of dexamethasone accounts for drug interactions. Ondansetron should be administered 30 minutes prior to chemotherapy treatment on Day 1.
Three day fosaprepitant regimen:
Fosaprepitant 115 mg on Day 1 only as an IV infusion over 15 minutes approximately 30 minutes prior to chemotherapy (in combination with a 5-HT3 antagonist on day 1 and dexamethasone on days 1 to 4). Capsules of aprepitant 80 mg should be administered on Days 2 and 3.
Day 1: Fosaprepitant for injection: 115 mg IV; Dexamethasone: 12 mg orally; Ondansetron: 32 mg IV
Day 2: Aprepitant: 80 mg orally; Dexamethasone: 8 mg orally; Ondansetron: none
Day 3: Aprepitant: 80 mg orally; Dexamethasone: 8 mg orally; Ondansetron: none
Day 4: Aprepitant: none; Dexamethasone: 8 mg orally; Ondansetron: none
Dexamethasone should be administered 30 minutes prior to chemotherapy treatment on Day 1 and in the morning on Days 2 through 4. The dose of dexamethasone accounts for drug interactions. Ondansetron should be administered 30 minutes prior to chemotherapy treatment on Day 1.
Prevention of Nausea and Vomiting Associated with Moderately Emetogenic Chemotherapy (MEC):
Fosaprepitant 115 mg on Day 1 only as an IV infusion over 15 minutes approximately 30 minutes prior to chemotherapy (in combination with a 5-HT3 antagonist on day 1 and dexamethasone on days 1 to 4). Capsules of aprepitant 80 mg should be administered on Days 2 and 3.
Day 1: Fosaprepitant for injection: 115 mg IV; Dexamethasone: 12 mg orally; Ondansetron: 8 mg orally twice daily
Day 2: Aprepitant: 80 mg orally; Dexamethasone: none; Ondansetron: none
Day 3: Aprepitant: 80 mg orally; Dexamethasone: none; Ondansetron: none
Dexamethasone should be administered 30 minutes prior to chemotherapy treatment on Day 1. The dose of dexamethasone accounts for drug interactions. Ondansetron 8 mg capsule should be administered 30 to 60 minutes prior to chemotherapy treatment and one 8 mg capsule should be administered 8 hours after the first dose on Day 1.
Usual Geriatric Dose for Nausea/Vomiting - Chemotherapy Induced
No dosage adjustment is necessary for the elderly.
Renal Dose Adjustments
No dosage adjustment is necessary for patients with renal insufficiency.
Liver Dose Adjustments
No dosage adjustment is necessary for patients with mild to moderate hepatic insufficiency (Child-Pugh score 5 to 9). There are no clinical data in patients with severe hepatic insufficiency (Child-Pugh score greater than 9).
Precautions
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
No dosage adjustment is necessary for patients with end stage renal disease undergoing hemodialysis.
Other Comments
Fosaprepitant for injection should not be mixed or reconstituted with solutions for which physical and chemical compatibility have not been established.
