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Desmopressin

Pronunciation

Generic Name: desmopressin (DES-moe-PRES-in)
Brand Name: DDAVP

Desmopressin is used for:

Treating nighttime bedwetting. It is also used to manage temporarily increased thirst and urination caused by head injury or certain types of brain surgery, or to manage certain types of diabetes (cranial diabetes insipidus). It may also be used for other conditions as determined by your doctor.

Desmopressin is an antidiuretic hormone. It works by causing the kidneys to produce less urine.

Do NOT use desmopressin if:

  • you are allergic to any ingredient in desmopressin
  • you have moderate to severe kidney problems
  • you have or have a history of low blood sodium levels (salt depletion)

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

Before using desmopressin:

Some medical conditions may interact with desmopressin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have severe drowsiness
  • if you have a history of kidney problems, heart problems (eg, heart blood vessel problems), or high blood pressure
  • if you have cystic fibrosis, dehydration, fever, severe infection, vomiting or diarrhea, swelling or fluid retention, or abnormal blood electrolyte levels
  • if you are exposed to very hot weather, are physically active, or drink a lot of water
  • if you have recently had surgery in the head area

Some MEDICINES MAY INTERACT with desmopressin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Carbamazepine, chlorpromazine, lamotrigine, narcotic analgesics (eg, codeine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oxybutynin, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or tricyclic antidepressants (eg, imipramine) because the risk of fluid overload with low blood sodium levels may be increased

Ask your health care provider if desmopressin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use desmopressin:

Use desmopressin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take desmopressin by mouth with or without food.
  • If you miss a dose of desmopressin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use desmopressin.

Important safety information:

  • Desmopressin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use desmopressin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Follow the fluid intake instructions given to you by your health care provider very carefully. Serious side effects may occur if you drink too much liquid while taking desmopressin.
  • Check with your doctor if you experience infection, fever, vomiting, or diarrhea. Tell your doctor if you will be exposed to very hot weather, will be physically active, or will be increasing your water intake for any reason. The risk of low blood sodium levels may be increased.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Tell your doctor or dentist that you take desmopressin before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including urine volume or blood electrolyte levels, may be performed while you use desmopressin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use desmopressin with caution in the ELDERLY and in CHILDREN; they may be more sensitive to its effects, especially water overload. Signs of water overload may include severe or persistent nausea or headache, vomiting, or unusual weight gain.
  • Desmopressin should be used with extreme caution in CHILDREN younger than 6 years old if used for nighttime bedwetting; effectiveness for bedwetting in these children has not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using desmopressin while you are pregnant. It is not known if desmopressin is found in breast milk. If you are or will be breast-feeding while you are using desmopressin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of desmopressin:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with desmopressin. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; fainting; loss of appetite; mental or mood changes (eg, agitation, irritability); muscle weakness, spasms, or cramps; nausea; personality changes; seizures; swelling; unusual headache or restlessness; unusual tiredness or sluggishness; unusual weight gain; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; persistent headache; sudden weight gain; trouble urinating; unusual drowsiness.

Proper storage of desmopressin:

Store desmopressin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep desmopressin out of the reach of children and away from pets.

General information:

  • If you have any questions about desmopressin, please talk with your doctor, pharmacist, or other health care provider.
  • Desmopressin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take desmopressin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about desmopressin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to desmopressin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using desmopressin.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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