Desmopressin use while Breastfeeding

Drugs containing Desmopressin: DDAVP, Stimate, Minirin, DDAVP Nasal, DDAVP Rhinal Tube

Desmopressin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Desmopressin is excreted in negligible amounts into milk and is poorly absorbed orally by the infant, so it appears acceptable to use during breastfeeding.

Drug Levels

Maternal Levels. In a patient who was using intranasal desmopressin 10 mcg twice daily for diabetes insipidus, serum and milk levels of arginine vasopressin were measured after a dose.[1] Milk levels gradually increased from the background level of 1 ng/L to about 1.5 ng/L over the 4-hour observation period.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Several cases have been reported of mothers with diabetes insipidus using desmopressin and breastfeeding their infants.[2][3][4] In one case, the mother discontinued nursing after 2 weeks because of a low milk supply, but this was not clearly drug related.[3] Lactation sometimes improves diabetes insipidus and reduces desmopressin requirements.[2][3]

References

1. Burrow GN, Wassenaar W, Robertson GL et al. DDAVP treatment of diabetes insipidus during pregnacy and the post-partum period. Acta Endocrinol (Copenh). 1981;97:23-5. PMID: 7223315

2. Hadi HA, Mashini IS, Devoe LD. Diabetes insipidus during pregnancy complicated by preeclampsia. A case report. J Reprod Med. 1985;30:206-8. PMID: 3999072

3. Hime MC, Richardson JA. Diabetes insipidus and pregnancy. Case report, incidence and review of literature. Obstet Gynecol Surv. 1978;33:375-9. PMID: 652196

4. Wallia A, Bizhanova A, Huang W, Goldsmith SL, Gossett DR, Kopp P. Acute diabetes insipidus mediated by vasopressinase after placental abruption. J Clin Endocrinol Metab. 2013;98:881-6. PMID: 23393172

Desmopressin Identification

Substance Name

Desmopressin

CAS Registry Number

16679-58-6

Drug Class

  • Hemostatics
  • Vasopressins

Administrative Information

LactMed Record Number

439

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

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