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Daunorubicin

Generic Name: daunorubicin (daw-noe-ROO-bi-sin)
Brand Name: Cerubidine

Daunorubicin can cause tissue damage if it is injected by a route other than through the vein. Notify your doctor immediately if redness, pain, and swelling occur at or around the injection site. Daunorubicin may cause heart problems, including heart failure, or bone marrow depression, making it hard to fight off infection. Notify your doctor immediately if you develop chest pain, an irregular heartbeat, trouble breathing, swelling of the hands or feet, easy bruising or bleeding, or signs of infection, such as fever, unusual fatigue, or persistent sore throat. Tell your doctor if you have liver or kidney problems before starting treatment with daunorubicin. You may require smaller doses.


Daunorubicin is used for:

Treating certain types of cancer. It may be used in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Daunorubicin is a cytotoxic agent. It works by preventing the cancer cell from reproducing, which results in death of the cancer cell.

Do NOT use daunorubicin if:

  • you are allergic to any ingredient in daunorubicin

Contact your doctor or health care provider right away if any of these apply to you.

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Before using daunorubicin:

Some medical conditions may interact with daunorubicin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow depression, heart disease, gout, or liver or kidney problems, or if you have taken daunorubicin before

Some MEDICINES MAY INTERACT with daunorubicin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Certain medicines that act upon the liver (eg, methotrexate) or cyclosporine because the actions and side effects of daunorubicin may be increased
  • Trastuzumab because the risk of heart problems may be increased
  • Hydantoins (eg, phenytoin) because the effectiveness may be decreased and the risk of seizures may be increased by daunorubicin

This may not be a complete list of all interactions that may occur. Ask your health care provider if daunorubicin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use daunorubicin:

Use daunorubicin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Daunorubicin is usually administered as an injection at your doctor's office, hospital, or clinic.
  • If daunorubicin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of daunorubicin, contact your doctor as soon as possible.

Ask your health care provider any questions you may have about how to use daunorubicin.

Important safety information:

  • If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
  • If you get daunorubicin on your skin, wash thoroughly with soap and water.
  • Daunorubicin may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
  • Daunorubicin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Daunorubicin causes the urine to turn red. This is harmless and not a cause for concern.
  • Check with your doctor before having vaccinations while you are using daunorubicin.
  • LAB TESTS, including blood cell counts; heart, liver, and kidney function tests; and uric acid levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use daunorubicin with caution in CHILDREN because they may be more sensitive to its effects, such as heart problems.
  • PREGNANCY and BREAST-FEEDING: Daunorubicin may cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using daunorubicin during pregnancy. It is unknown if daunorubicin is excreted in breast milk. Do not breast-feed while taking daunorubicin.

Possible side effects of daunorubicin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; loss of appetite; mouth pain; nausea; sore throat; stomach pain; tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in the stools; chest pain; chills; cough or sore throat; excessive bleeding; fever; flushing; irregular heartbeat; pain, redness, or swelling at the injection site; shortness of breath; sores on the mouth or lips; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of daunorubicin:

Daunorubicin is usually handled and stored by a health care provider. If you are using daunorubicin at home, store daunorubicin as directed by your pharmacist or health care provider. Keep daunorubicin out of the reach of children and away from pets.

General information:

  • If you have any questions about daunorubicin, please talk with your doctor, pharmacist, or other health care provider.
  • Daunorubicin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take daunorubicin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about daunorubicin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to daunorubicin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using daunorubicin.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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